2QCWA

Crystal structure of bone morphogenetic protein-6 (bmp-6)
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
104
structure length
104
Chain Sequence
TACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title BMP-3 and BMP-6 Structures Illuminate the Nature of Binding Specificity with Receptors.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Bone morphogenetic protein 6
total genus 14
structure length 104
sequence length 104
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-06-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00019 TGF_beta Transforming growth factor beta like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 2qcwA00
4YCGC 5BQ8B 1LXIA 4KV5A 5BQBA 1TZIV 2PJYA 2ARVA 5FV1V 1M4UA 2XACA 4EFVA 5F3BC 1QTYR 4LXRJ 3FUBB 1MKKA 1BMPA 4QAFC 3B4VA 1M4UL 4MIDA 2R52A 4BV4L 3P9WA 5FV2V 1FLTV 4MQWA 4KXZA 4AY9A 4MQWB 2QJAA 3BUKA 2ARPA 1VPFA 2TGIA 1NYSB 2QCQA 1RV6V 1TGKA 3IJ2A 4AY9B 1DZ7A 4YCIC 3RJRA 1TZHV 1TGJA 1WQ9A 1S4YB 3BK3A 4HQXA 4UHZA 5HK5E 5HHCA 4EC7A 1WQ9B 2VXSA 1ZKZA 1B98A 4ZFFC 1CZ8V 1QFWB 4FAOA 2BHKA 4MPLA 1KATW 3V2AA 5BPUA 4HSAA 5E4GA 2B0UA 5BQEB 2R53A 2KD3A 2QJ9A 1FZVA 1REUA 1KTZA 2FJHV 3BDYV 2X1XE 3SEKB 1LX5A 5HHDA 1BNDA 2QJBA 1ES7A 1FL7B 2QCWA 3BMPA 4XPJA 1SG1A 3EVSB 5HI4A 2V5EB 1E9JA 1BJ1V 1NYUB 1BNDB 1B8MB 4WPBA 2C7WA 1JPYA 2H64A 5BQ8D 4EDWV 4UI2B 1VPPV 2XV7A 1KLCA 2H62A 1MKGA 1BETA 1TFGA 1WQ8A 1KLAA 3S1KV 2P6AA 1QFWA 4ZBNA 2QR0C 2VPFA 5HI3A 4UI0A 1NT3A 5BQEA 4UI1A 1XWDB 2FJGV 2GH0C 2X1WA 4HQUA 4UHYA 3MJGA 4EDXV 1PDGA 3S1BV 3QB4A 5AEJA 1FL7A 2IFGE 3KFDA 4KZNA 1AGQA 4LXSJ 1B8MA 4QHUC 4X1JA 3MJKA 3QTKA 4QCIC 5F3HI 1B8KA 1WAQA 1HD4A 4N1DA 4GLSE 1HRPA 5HI5A 2GOOA 3V6BA 1REWA 1HCFA 5BQCA 4EAXA 4HR9A 1SGFB 1HRPB 3HH2A 3JVFA 5HK5A 5JZ7A 2ASKA 3E07A 1MJVA 1XWDA 5HHVA 5HHXA 1AOCA 2GNNA 1HCNA 2GYZA 1BTGA 5BQ8A 2VWEA 2GYRA 1WWWV 3EO1C 4GLNE 1HCNB
chains in the Genus database with same CATH superfamily
4YCGC 5BQ8B 1LXIA 4KV5A 5BQBA 1TZIV 2PJYA 2ARVA 5FV1V 1M4UA 2XACA 4EFVA 5F3BC 1QTYR 4LXRJ 3FUBB 1MKKA 1BMPA 4QAFC 3B4VA 1M4UL 4MIDA 2R52A 4BV4L 3P9WA 5FV2V 1FLTV 4MQWA 4KXZA 4AY9A 4MQWB 2QJAA 3BUKA 2ARPA 1VPFA 2TGIA 1NYSB 2QCQA 1RV6V 1TGKA 3IJ2A 4AY9B 1DZ7A 4YCIC 3RJRA 1TZHV 1TGJA 1WQ9A 1S4YB 3BK3A 4HQXA 4UHZA 5HK5E 5HHCA 4EC7A 1WQ9B 2VXSA 1ZKZA 1B98A 4ZFFC 1CZ8V 1QFWB 4FAOA 2BHKA 4MPLA 1KATW 3V2AA 5BPUA 4HSAA 5E4GA 2B0UA 5BQEB 2R53A 2KD3A 2QJ9A 1FZVA 1REUA 1KTZA 2FJHV 3BDYV 2X1XE 3SEKB 1LX5A 5HHDA 1BNDA 2QJBA 1ES7A 1FL7B 2QCWA 3BMPA 4XPJA 1SG1A 3EVSB 5HI4A 2V5EB 1E9JA 1BJ1V 1NYUB 1BNDB 1B8MB 4WPBA 2C7WA 1JPYA 2H64A 5BQ8D 4EDWV 4UI2B 1VPPV 2XV7A 1KLCA 2H62A 1MKGA 1BETA 1TFGA 1WQ8A 1KLAA 3S1KV 2P6AA 1QFWA 4ZBNA 2QR0C 2VPFA 5HI3A 4UI0A 1NT3A 5BQEA 4UI1A 1XWDB 2FJGV 2GH0C 2X1WA 4HQUA 4UHYA 3MJGA 4EDXV 1PDGA 3S1BV 3QB4A 5AEJA 1FL7A 2IFGE 3KFDA 4KZNA 1AGQA 4LXSJ 1B8MA 4QHUC 4X1JA 3MJKA 3QTKA 4QCIC 5F3HI 1B8KA 1WAQA 1HD4A 4N1DA 4GLSE 1HRPA 5HI5A 2GOOA 3V6BA 1REWA 1HCFA 5BQCA 4EAXA 4HR9A 1SGFB 1HRPB 3HH2A 3JVFA 5HK5A 5JZ7A 2ASKA 3E07A 1MJVA 1XWDA 5HHVA 5HHXA 1AOCA 2GNNA 1HCNA 2GYZA 1BTGA 5BQ8A 2VWEA 2GYRA 1WWWV 3EO1C 4GLNE 1HCNB
chains in the Genus database with same CATH topology
4YCGC 5BQ8B 1LXIA 4KV5A 5BQBA 1TZIV 2PJYA 2ARVA 5FV1V 1M4UA 2XACA 4EFVA 5F3BC 1QTYR 4LXRJ 3FUBB 1MKKA 1BMPA 4QAFC 3B4VA 1M4UL 4MIDA 2R52A 4BV4L 3P9WA 5FV2V 1FLTV 4MQWA 4KXZA 4AY9A 4MQWB 2QJAA 3BUKA 2ARPA 1VPFA 2TGIA 1NYSB 2QCQA 1RV6V 1TGKA 3IJ2A 4AY9B 1DZ7A 4YCIC 3RJRA 1TZHV 1TGJA 1WQ9A 1S4YB 3BK3A 4HQXA 4UHZA 5HK5E 5HHCA 4EC7A 1WQ9B 2VXSA 1ZKZA 1B98A 4ZFFC 1CZ8V 1QFWB 4FAOA 2BHKA 4MPLA 1KATW 3V2AA 5BPUA 4HSAA 5E4GA 2B0UA 5BQEB 2R53A 2KD3A 2QJ9A 1FZVA 1REUA 1KTZA 2FJHV 3BDYV 2X1XE 3SEKB 1LX5A 5HHDA 1BNDA 2QJBA 1ES7A 1FL7B 2QCWA 3BMPA 4XPJA 1SG1A 3EVSB 5HI4A 2V5EB 1E9JA 1BJ1V 1NYUB 1BNDB 1B8MB 4WPBA 2C7WA 1JPYA 2H64A 5BQ8D 4EDWV 4UI2B 1VPPV 2XV7A 1KLCA 2H62A 1MKGA 1BETA 1TFGA 1WQ8A 1KLAA 3S1KV 2P6AA 1QFWA 4ZBNA 2QR0C 2VPFA 5HI3A 4UI0A 1NT3A 5BQEA 4UI1A 1XWDB 2FJGV 2GH0C 2X1WA 4HQUA 4UHYA 3MJGA 4EDXV 1PDGA 3S1BV 3QB4A 5AEJA 1FL7A 2IFGE 3KFDA 4KZNA 1AGQA 4LXSJ 1B8MA 4QHUC 4X1JA 3MJKA 3QTKA 4QCIC 5F3HI 1B8KA 1WAQA 1HD4A 4N1DA 4GLSE 1HRPA 5HI5A 2GOOA 3V6BA 1REWA 1HCFA 5BQCA 4EAXA 4HR9A 1SGFB 1HRPB 3HH2A 3JVFA 5HK5A 5JZ7A 2ASKA 3E07A 1MJVA 1XWDA 5HHVA 5HHXA 1AOCA 2GNNA 1HCNA 2GYZA 1BTGA 5BQ8A 2VWEA 2GYRA 1WWWV 3EO1C 4GLNE 1HCNB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YCG C;  5BQ8 B;  1LXI A;  4KV5 A;  5BQB A;  1TZI V;  2PJY A;  2ARV A;  5FV1 V;  1M4U A;  2XAC A;  4EFV A;  5F3B C;  1QTY R;  4LXR J;  3FUB B;  1MKK A;  1BMP A;  4QAF C;  3B4V A;  1M4U L;  4MID A;  2R52 A;  4BV4 L;  3P9W A;  5FV2 V;  1FLT V;  4MQW A;  4KXZ A;  4AY9 A;  4MQW B;  2QJA A;  3BUK A;  2ARP A;  1VPF A;  2TGI A;  1NYS B;  2QCQ A;  1RV6 V;  1TGK A;  3IJ2 A;  4AY9 B;  1DZ7 A;  4YCI C;  3RJR A;  1TZH V;  1TGJ A;  1WQ9 A;  1S4Y B;  3BK3 A;  4HQX A;  4UHZ A;  5HK5 E;  5HHC A;  4EC7 A;  1WQ9 B;  2VXS A;  1ZKZ A;  1B98 A;  4ZFF C;  1CZ8 V;  1QFW B;  4FAO A;  2BHK A;  4MPL A;  1KAT W;  3V2A A;  5BPU A;  4HSA A;  5E4G A;  2B0U A;  5BQE B;  2R53 A;  2KD3 A;  2QJ9 A;  1FZV A;  1REU A;  1KTZ A;  2FJH V;  3BDY V;  2X1X E;  3SEK B;  1LX5 A;  5HHD A;  1BND A;  2QJB A;  1ES7 A;  1FL7 B;  2QCW A;  3BMP A;  4XPJ A;  1SG1 A;  3EVS B;  5HI4 A;  2V5E B;  1E9J A;  1BJ1 V;  1NYU B;  1BND B;  1B8M B;  4WPB A;  2C7W A;  1JPY A;  2H64 A;  5BQ8 D;  4EDW V;  4UI2 B;  1VPP V;  2XV7 A;  1KLC A;  2H62 A;  1MKG A;  1BET A;  1TFG A;  1WQ8 A;  1KLA A;  3S1K V;  2P6A A;  1QFW A;  4ZBN A;  2QR0 C;  2VPF A;  5HI3 A;  4UI0 A;  1NT3 A;  5BQE A;  4UI1 A;  1XWD B;  2FJG V;  2GH0 C;  2X1W A;  4HQU A;  4UHY A;  3MJG A;  4EDX V;  1PDG A;  3S1B V;  3QB4 A;  5AEJ A;  1FL7 A;  2IFG E;  3KFD A;  4KZN A;  1AGQ A;  4LXS J;  1B8M A;  4QHU C;  4X1J A;  3MJK A;  3QTK A;  4QCI C;  5F3H I;  1B8K A;  1WAQ A;  1HD4 A;  4N1D A;  4GLS E;  1HRP A;  5HI5 A;  2GOO A;  3V6B A;  1REW A;  1HCF A;  5BQC A;  4EAX A;  4HR9 A;  1SGF B;  1HRP B;  3HH2 A;  3JVF A;  5HK5 A;  5JZ7 A;  2ASK A;  3E07 A;  1MJV A;  1XWD A;  5HHV A;  5HHX A;  1AOC A;  2GNN A;  1HCN A;  2GYZ A;  1BTG A;  5BQ8 A;  2VWE A;  2GYR A;  1WWW V;  3EO1 C;  4GLN E;  1HCN B; 
#chains in the Genus database with same CATH topology
 4YCG C;  5BQ8 B;  1LXI A;  4KV5 A;  5BQB A;  1TZI V;  2PJY A;  2ARV A;  5FV1 V;  1M4U A;  2XAC A;  4EFV A;  5F3B C;  1QTY R;  4LXR J;  3FUB B;  1MKK A;  1BMP A;  4QAF C;  3B4V A;  1M4U L;  4MID A;  2R52 A;  4BV4 L;  3P9W A;  5FV2 V;  1FLT V;  4MQW A;  4KXZ A;  4AY9 A;  4MQW B;  2QJA A;  3BUK A;  2ARP A;  1VPF A;  2TGI A;  1NYS B;  2QCQ A;  1RV6 V;  1TGK A;  3IJ2 A;  4AY9 B;  1DZ7 A;  4YCI C;  3RJR A;  1TZH V;  1TGJ A;  1WQ9 A;  1S4Y B;  3BK3 A;  4HQX A;  4UHZ A;  5HK5 E;  5HHC A;  4EC7 A;  1WQ9 B;  2VXS A;  1ZKZ A;  1B98 A;  4ZFF C;  1CZ8 V;  1QFW B;  4FAO A;  2BHK A;  4MPL A;  1KAT W;  3V2A A;  5BPU A;  4HSA A;  5E4G A;  2B0U A;  5BQE B;  2R53 A;  2KD3 A;  2QJ9 A;  1FZV A;  1REU A;  1KTZ A;  2FJH V;  3BDY V;  2X1X E;  3SEK B;  1LX5 A;  5HHD A;  1BND A;  2QJB A;  1ES7 A;  1FL7 B;  2QCW A;  3BMP A;  4XPJ A;  1SG1 A;  3EVS B;  5HI4 A;  2V5E B;  1E9J A;  1BJ1 V;  1NYU B;  1BND B;  1B8M B;  4WPB A;  2C7W A;  1JPY A;  2H64 A;  5BQ8 D;  4EDW V;  4UI2 B;  1VPP V;  2XV7 A;  1KLC A;  2H62 A;  1MKG A;  1BET A;  1TFG A;  1WQ8 A;  1KLA A;  3S1K V;  2P6A A;  1QFW A;  4ZBN A;  2QR0 C;  2VPF A;  5HI3 A;  4UI0 A;  1NT3 A;  5BQE A;  4UI1 A;  1XWD B;  2FJG V;  2GH0 C;  2X1W A;  4HQU A;  4UHY A;  3MJG A;  4EDX V;  1PDG A;  3S1B V;  3QB4 A;  5AEJ A;  1FL7 A;  2IFG E;  3KFD A;  4KZN A;  1AGQ A;  4LXS J;  1B8M A;  4QHU C;  4X1J A;  3MJK A;  3QTK A;  4QCI C;  5F3H I;  1B8K A;  1WAQ A;  1HD4 A;  4N1D A;  4GLS E;  1HRP A;  5HI5 A;  2GOO A;  3V6B A;  1REW A;  1HCF A;  5BQC A;  4EAX A;  4HR9 A;  1SGF B;  1HRP B;  3HH2 A;  3JVF A;  5HK5 A;  5JZ7 A;  2ASK A;  3E07 A;  1MJV A;  1XWD A;  5HHV A;  5HHX A;  1AOC A;  2GNN A;  1HCN A;  2GYZ A;  1BTG A;  5BQ8 A;  2VWE A;  2GYR A;  1WWW V;  3EO1 C;  4GLN E;  1HCN B; 
#chains in the Genus database with same CATH homology
 4YCG C;  5BQ8 B;  1LXI A;  4KV5 A;  5BQB A;  1TZI V;  2PJY A;  2ARV A;  5FV1 V;  1M4U A;  2XAC A;  4EFV A;  5F3B C;  1QTY R;  4LXR J;  3FUB B;  1MKK A;  1BMP A;  4QAF C;  3B4V A;  1M4U L;  4MID A;  2R52 A;  4BV4 L;  3P9W A;  5FV2 V;  1FLT V;  4MQW A;  4KXZ A;  4AY9 A;  4MQW B;  2QJA A;  3BUK A;  2ARP A;  1VPF A;  2TGI A;  1NYS B;  2QCQ A;  1RV6 V;  1TGK A;  3IJ2 A;  4AY9 B;  1DZ7 A;  4YCI C;  3RJR A;  1TZH V;  1TGJ A;  1WQ9 A;  1S4Y B;  3BK3 A;  4HQX A;  4UHZ A;  5HK5 E;  5HHC A;  4EC7 A;  1WQ9 B;  2VXS A;  1ZKZ A;  1B98 A;  4ZFF C;  1CZ8 V;  1QFW B;  4FAO A;  2BHK A;  4MPL A;  1KAT W;  3V2A A;  5BPU A;  4HSA A;  5E4G A;  2B0U A;  5BQE B;  2R53 A;  2KD3 A;  2QJ9 A;  1FZV A;  1REU A;  1KTZ A;  2FJH V;  3BDY V;  2X1X E;  3SEK B;  1LX5 A;  5HHD A;  1BND A;  2QJB A;  1ES7 A;  1FL7 B;  2QCW A;  3BMP A;  4XPJ A;  1SG1 A;  3EVS B;  5HI4 A;  2V5E B;  1E9J A;  1BJ1 V;  1NYU B;  1BND B;  1B8M B;  4WPB A;  2C7W A;  1JPY A;  2H64 A;  5BQ8 D;  4EDW V;  4UI2 B;  1VPP V;  2XV7 A;  1KLC A;  2H62 A;  1MKG A;  1BET A;  1TFG A;  1WQ8 A;  1KLA A;  3S1K V;  2P6A A;  1QFW A;  4ZBN A;  2QR0 C;  2VPF A;  5HI3 A;  4UI0 A;  1NT3 A;  5BQE A;  4UI1 A;  1XWD B;  2FJG V;  2GH0 C;  2X1W A;  4HQU A;  4UHY A;  3MJG A;  4EDX V;  1PDG A;  3S1B V;  3QB4 A;  5AEJ A;  1FL7 A;  2IFG E;  3KFD A;  4KZN A;  1AGQ A;  4LXS J;  1B8M A;  4QHU C;  4X1J A;  3MJK A;  3QTK A;  4QCI C;  5F3H I;  1B8K A;  1WAQ A;  1HD4 A;  4N1D A;  4GLS E;  1HRP A;  5HI5 A;  2GOO A;  3V6B A;  1REW A;  1HCF A;  5BQC A;  4EAX A;  4HR9 A;  1SGF B;  1HRP B;  3HH2 A;  3JVF A;  5HK5 A;  5JZ7 A;  2ASK A;  3E07 A;  1MJV A;  1XWD A;  5HHV A;  5HHX A;  1AOC A;  2GNN A;  1HCN A;  2GYZ A;  1BTG A;  5BQ8 A;  2VWE A;  2GYR A;  1WWW V;  3EO1 C;  4GLN E;  1HCN B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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