2QJ9 | Genus

Total Genus 15

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	15
sequence length	104
structure length	104
Chain Sequence	KSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. pubmed doi rcsb
molecule keywords	Bone morphogenetic protein 2
molecule tags	Cytokine/receptor
source organism	Homo sapiens
total genus	15
structure length	104
sequence length	104
chains with identical sequence	B
ec nomenclature
pdb deposition date	2007-07-06

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00019	TGF_beta	Transforming growth factor beta like domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	2qj9A00

1MJVA 1BMPA 1XWDA 3MJKA 5HI5A 5HHDA 1KLCA 4XPJA 5AEJA 5BQ8D 2R52A 1NT3A 3P9WA 4EC7A 4KV5A 1TGJA 5FV2V 2H64A 1WAQA 2X1WA 4HQUA 1M4UL 1BTGA 1FL7A 1HCFA 2ASKA 1NYUB 3E07A 1XWDB 4GLSE 1B8KA 2VPFA 1VPPV 4EAXA 1JPYA 1WQ8A 4WPBA 1BNDB 1MKKA 1QFWB 1REWA 3KFDA 5F3HI 1HCNB 1M4UA 2QJBA 4EDWV 2R53A 3EO1C 1ZKZA 4AY9B 2VXSA 4KXZA 1RV6V 3BK3A 4GLNE 4MPLA 5F3BC 1S4YB 5HI3A 4N1DA 1BNDA 4ZBNA 2FJHV 3BMPA 2XACA 4BV4L 4UHZA 2IFGE 3QB4A 1QFWA 1B98A 1PDGA 1HCNA 4UI2B 5E4GA 1E9JA 5HK5A 1FLTV 4HR9A 4UI0A 4X1JA 4AY9A 5BPUA 4HQXA 3HH2A 5JZ7A 5HK5E 4QAFC 1WQ9B 4MIDA 1BJ1V 4MQWB 4YCGC 3SEKB 1KATW 2B0UA 1AGQA 4QHUC 1NYSB 2QCQA 3JVFA 2GH0C 1TFGA 1KTZA 5BQCA 2VWEA 5HHXA 1WWWV 1WQ9A 4UHYA 2QJ9A 2TGIA 4MQWA 2QCWA 2PJYA 2ARPA 4EFVA 2V5EB 5FV1V 2QJAA 3BUKA 4FAOA 2KD3A 1TGKA 4HSAA 5BQEB 4EDXV 1TZHV 4LXSJ 4ZFFC 5HHVA 1DZ7A 1B8MA 3EVSB 3QTKA 4YCIC 1AOCA 2GYZA 3S1BV 1VPFA 3FUBB 5BQ8B 3MJGA 1LXIA 1SGFB 5BQBA 2H62A 5BQEA 1SG1A 1HRPA 2GNNA 2FJGV 3BDYV 1CZ8V 5HHCA 5HI4A 1B8MB 2XV7A 2QR0C 1FZVA 1HD4A 2P6AA 2GOOA 3B4VA 3IJ2A 1BETA 1ES7A 1QTYR 1MKGA 1REUA 2GYRA 1HRPB 2C7WA 2ARVA 4QCIC 5BQ8A 1KLAA 3RJRA 1FL7B 3V2AA 2X1XE 3S1KV 4KZNA 4LXRJ 1TZIV 4UI1A 2BHKA 3V6BA 1LX5A
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1MJV A;  1BMP A;  1XWD A;  3MJK A;  5HI5 A;  5HHD A;  1KLC A;  4XPJ A;  5AEJ A;  5BQ8 D;  2R52 A;  1NT3 A;  3P9W A;  4EC7 A;  4KV5 A;  1TGJ A;  5FV2 V;  2H64 A;  1WAQ A;  2X1W A;  4HQU A;  1M4U L;  1BTG A;  1FL7 A;  1HCF A;  2ASK A;  1NYU B;  3E07 A;  1XWD B;  4GLS E;  1B8K A;  2VPF A;  1VPP V;  4EAX A;  1JPY A;  1WQ8 A;  4WPB A;  1BND B;  1MKK A;  1QFW B;  1REW A;  3KFD A;  5F3H I;  1HCN B;  1M4U A;  2QJB A;  4EDW V;  2R53 A;  3EO1 C;  1ZKZ A;  4AY9 B;  2VXS A;  4KXZ A;  1RV6 V;  3BK3 A;  4GLN E;  4MPL A;  5F3B C;  1S4Y B;  5HI3 A;  4N1D A;  1BND A;  4ZBN A;  2FJH V;  3BMP A;  2XAC A;  4BV4 L;  4UHZ A;  2IFG E;  3QB4 A;  1QFW A;  1B98 A;  1PDG A;  1HCN A;  4UI2 B;  5E4G A;  1E9J A;  5HK5 A;  1FLT V;  4HR9 A;  4UI0 A;  4X1J A;  4AY9 A;  5BPU A;  4HQX A;  3HH2 A;  5JZ7 A;  5HK5 E;  4QAF C;  1WQ9 B;  4MID A;  1BJ1 V;  4MQW B;  4YCG C;  3SEK B;  1KAT W;  2B0U A;  1AGQ A;  4QHU C;  1NYS B;  2QCQ A;  3JVF A;  2GH0 C;  1TFG A;  1KTZ A;  5BQC A;  2VWE A;  5HHX A;  1WWW V;  1WQ9 A;  4UHY A;  2QJ9 A;  2TGI A;  4MQW A;  2QCW A;  2PJY A;  2ARP A;  4EFV A;  2V5E B;  5FV1 V;  2QJA A;  3BUK A;  4FAO A;  2KD3 A;  1TGK A;  4HSA A;  5BQE B;  4EDX V;  1TZH V;  4LXS J;  4ZFF C;  5HHV A;  1DZ7 A;  1B8M A;  3EVS B;  3QTK A;  4YCI C;  1AOC A;  2GYZ A;  3S1B V;  1VPF A;  3FUB B;  5BQ8 B;  3MJG A;  1LXI A;  1SGF B;  5BQB A;  2H62 A;  5BQE A;  1SG1 A;  1HRP A;  2GNN A;  2FJG V;  3BDY V;  1CZ8 V;  5HHC A;  5HI4 A;  1B8M B;  2XV7 A;  2QR0 C;  1FZV A;  1HD4 A;  2P6A A;  2GOO A;  3B4V A;  3IJ2 A;  1BET A;  1ES7 A;  1QTY R;  1MKG A;  1REU A;  2GYR A;  1HRP B;  2C7W A;  2ARV A;  4QCI C;  5BQ8 A;  1KLA A;  3RJR A;  1FL7 B;  3V2A A;  2X1X E;  3S1K V;  4KZN A;  4LXR J;  1TZI V;  4UI1 A;  2BHK A;  3V6B A;  1LX5 A; 
#chains in the Genus database with same CATH topology
 1MJV A;  1BMP A;  1XWD A;  3MJK A;  5HI5 A;  5HHD A;  1KLC A;  4XPJ A;  5AEJ A;  5BQ8 D;  2R52 A;  1NT3 A;  3P9W A;  4EC7 A;  4KV5 A;  1TGJ A;  5FV2 V;  2H64 A;  1WAQ A;  2X1W A;  4HQU A;  1M4U L;  1BTG A;  1FL7 A;  1HCF A;  2ASK A;  1NYU B;  3E07 A;  1XWD B;  4GLS E;  1B8K A;  2VPF A;  1VPP V;  4EAX A;  1JPY A;  1WQ8 A;  4WPB A;  1BND B;  1MKK A;  1QFW B;  1REW A;  3KFD A;  5F3H I;  1HCN B;  1M4U A;  2QJB A;  4EDW V;  2R53 A;  3EO1 C;  1ZKZ A;  4AY9 B;  2VXS A;  4KXZ A;  1RV6 V;  3BK3 A;  4GLN E;  4MPL A;  5F3B C;  1S4Y B;  5HI3 A;  4N1D A;  1BND A;  4ZBN A;  2FJH V;  3BMP A;  2XAC A;  4BV4 L;  4UHZ A;  2IFG E;  3QB4 A;  1QFW A;  1B98 A;  1PDG A;  1HCN A;  4UI2 B;  5E4G A;  1E9J A;  5HK5 A;  1FLT V;  4HR9 A;  4UI0 A;  4X1J A;  4AY9 A;  5BPU A;  4HQX A;  3HH2 A;  5JZ7 A;  5HK5 E;  4QAF C;  1WQ9 B;  4MID A;  1BJ1 V;  4MQW B;  4YCG C;  3SEK B;  1KAT W;  2B0U A;  1AGQ A;  4QHU C;  1NYS B;  2QCQ A;  3JVF A;  2GH0 C;  1TFG A;  1KTZ A;  5BQC A;  2VWE A;  5HHX A;  1WWW V;  1WQ9 A;  4UHY A;  2QJ9 A;  2TGI A;  4MQW A;  2QCW A;  2PJY A;  2ARP A;  4EFV A;  2V5E B;  5FV1 V;  2QJA A;  3BUK A;  4FAO A;  2KD3 A;  1TGK A;  4HSA A;  5BQE B;  4EDX V;  1TZH V;  4LXS J;  4ZFF C;  5HHV A;  1DZ7 A;  1B8M A;  3EVS B;  3QTK A;  4YCI C;  1AOC A;  2GYZ A;  3S1B V;  1VPF A;  3FUB B;  5BQ8 B;  3MJG A;  1LXI A;  1SGF B;  5BQB A;  2H62 A;  5BQE A;  1SG1 A;  1HRP A;  2GNN A;  2FJG V;  3BDY V;  1CZ8 V;  5HHC A;  5HI4 A;  1B8M B;  2XV7 A;  2QR0 C;  1FZV A;  1HD4 A;  2P6A A;  2GOO A;  3B4V A;  3IJ2 A;  1BET A;  1ES7 A;  1QTY R;  1MKG A;  1REU A;  2GYR A;  1HRP B;  2C7W A;  2ARV A;  4QCI C;  5BQ8 A;  1KLA A;  3RJR A;  1FL7 B;  3V2A A;  2X1X E;  3S1K V;  4KZN A;  4LXR J;  1TZI V;  4UI1 A;  2BHK A;  3V6B A;  1LX5 A; 
#chains in the Genus database with same CATH homology
 1MJV A;  1BMP A;  1XWD A;  3MJK A;  5HI5 A;  5HHD A;  1KLC A;  4XPJ A;  5AEJ A;  5BQ8 D;  2R52 A;  1NT3 A;  3P9W A;  4EC7 A;  4KV5 A;  1TGJ A;  5FV2 V;  2H64 A;  1WAQ A;  2X1W A;  4HQU A;  1M4U L;  1BTG A;  1FL7 A;  1HCF A;  2ASK A;  1NYU B;  3E07 A;  1XWD B;  4GLS E;  1B8K A;  2VPF A;  1VPP V;  4EAX A;  1JPY A;  1WQ8 A;  4WPB A;  1BND B;  1MKK A;  1QFW B;  1REW A;  3KFD A;  5F3H I;  1HCN B;  1M4U A;  2QJB A;  4EDW V;  2R53 A;  3EO1 C;  1ZKZ A;  4AY9 B;  2VXS A;  4KXZ A;  1RV6 V;  3BK3 A;  4GLN E;  4MPL A;  5F3B C;  1S4Y B;  5HI3 A;  4N1D A;  1BND A;  4ZBN A;  2FJH V;  3BMP A;  2XAC A;  4BV4 L;  4UHZ A;  2IFG E;  3QB4 A;  1QFW A;  1B98 A;  1PDG A;  1HCN A;  4UI2 B;  5E4G A;  1E9J A;  5HK5 A;  1FLT V;  4HR9 A;  4UI0 A;  4X1J A;  4AY9 A;  5BPU A;  4HQX A;  3HH2 A;  5JZ7 A;  5HK5 E;  4QAF C;  1WQ9 B;  4MID A;  1BJ1 V;  4MQW B;  4YCG C;  3SEK B;  1KAT W;  2B0U A;  1AGQ A;  4QHU C;  1NYS B;  2QCQ A;  3JVF A;  2GH0 C;  1TFG A;  1KTZ A;  5BQC A;  2VWE A;  5HHX A;  1WWW V;  1WQ9 A;  4UHY A;  2QJ9 A;  2TGI A;  4MQW A;  2QCW A;  2PJY A;  2ARP A;  4EFV A;  2V5E B;  5FV1 V;  2QJA A;  3BUK A;  4FAO A;  2KD3 A;  1TGK A;  4HSA A;  5BQE B;  4EDX V;  1TZH V;  4LXS J;  4ZFF C;  5HHV A;  1DZ7 A;  1B8M A;  3EVS B;  3QTK A;  4YCI C;  1AOC A;  2GYZ A;  3S1B V;  1VPF A;  3FUB B;  5BQ8 B;  3MJG A;  1LXI A;  1SGF B;  5BQB A;  2H62 A;  5BQE A;  1SG1 A;  1HRP A;  2GNN A;  2FJG V;  3BDY V;  1CZ8 V;  5HHC A;  5HI4 A;  1B8M B;  2XV7 A;  2QR0 C;  1FZV A;  1HD4 A;  2P6A A;  2GOO A;  3B4V A;  3IJ2 A;  1BET A;  1ES7 A;  1QTY R;  1MKG A;  1REU A;  2GYR A;  1HRP B;  2C7W A;  2ARV A;  4QCI C;  5BQ8 A;  1KLA A;  3RJR A;  1FL7 B;  3V2A A;  2X1X E;  3S1K V;  4KZN A;  4LXR J;  1TZI V;  4UI1 A;  2BHK A;  3V6B A;  1LX5 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2QJ9A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations