2QR0 | Genus

Total Genus 13

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	13
sequence length	95
structure length	95
Chain Sequence	EVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPK

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries pubmed doi rcsb
molecule keywords	Fab-Fragment Light Chain
molecule tags	Immune system
total genus	13
structure length	95
sequence length	95
chains with identical sequence	D, I, J, O, P, U, V
ec nomenclature
pdb deposition date	2007-07-27

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
C	PF00341	PDGF	PDGF/VEGF domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	2qr0C00

4KZNA 4N1DA 4WPBA 2ARPA 1HCNB 4LXSJ 1CZ8V 5E4GA 1B98A 1HRPB 1M4UL 1FL7A 1PDGA 1WQ9B 3QB4A 2VPFA 1BMPA 4MQWA 5BQ8A 4EFVA 1FZVA 1MJVA 1TGJA 5JZ7A 3MJGA 2QCWA 1WWWV 2XV7A 4QHUC 1AGQA 4MIDA 4EC7A 2GH0C 1FL7B 5BQ8B 4UI2B 5BQ8D 3FUBB 4QCIC 1QTYR 2R52A 1TFGA 4YCGC 5HI5A 3EO1C 1BETA 5HHVA 2H64A 4EDXV 4HQXA 2H62A 2ASKA 4UHZA 2XACA 5HHDA 1KLAA 1WQ9A 2R53A 3E07A 1WAQA 1KATW 1S4YB 3V2AA 1DZ7A 5AEJA 1REUA 4X1JA 1JPYA 1M4UA 3HH2A 2FJHV 4BV4L 1LXIA 2BHKA 3IJ2A 4GLSE 2B0UA 2GYRA 1ZKZA 2V5EB 3BMPA 3S1BV 1RV6V 1B8MA 2IFGE 2QJBA 1B8KA 4HSAA 4HQUA 1MKKA 1FLTV 5HI3A 2X1XE 5BQEA 3RJRA 5BQCA 2ARVA 2X1WA 5BPUA 1B8MB 1ES7A 1LX5A 1TZHV 2QJ9A 2KD3A 1REWA 3S1KV 1NYUB 1BNDA 3P9WA 1HD4A 4EAXA 3JVFA 5BQEB 4LXRJ 2GYZA 1BJ1V 3EVSB 5F3BC 5HHCA 5HHXA 4EDWV 4HR9A 1MKGA 4ZBNA 2GOOA 2GNNA 5HK5E 2QJAA 1BNDB 4MPLA 1NYSB 2C7WA 3BUKA 1SG1A 3BK3A 2QR0C 4KXZA 2FJGV 1WQ8A 1XWDA 3V6BA 2VXSA 1E9JA 4FAOA 1QFWA 4UI0A 4UI1A 3MJKA 1KTZA 1VPFA 4YCIC 4XPJA 4KV5A 5HI4A 4AY9A 1AOCA 4UHYA 1VPPV 3SEKB 1XWDB 5FV1V 2PJYA 4ZFFC 1QFWB 1TGKA 5HK5A 1SGFB 2QCQA 4AY9B 5F3HI 1NT3A 3B4VA 1BTGA 4GLNE 3BDYV 1KLCA 3KFDA 1TZIV 3QTKA 5FV2V 2TGIA 4MQWB 1HCFA 2P6AA 2VWEA 5BQBA 1HCNA 1HRPA 4QAFC
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 4KZN A;  4N1D A;  4WPB A;  2ARP A;  1HCN B;  4LXS J;  1CZ8 V;  5E4G A;  1B98 A;  1HRP B;  1M4U L;  1FL7 A;  1PDG A;  1WQ9 B;  3QB4 A;  2VPF A;  1BMP A;  4MQW A;  5BQ8 A;  4EFV A;  1FZV A;  1MJV A;  1TGJ A;  5JZ7 A;  3MJG A;  2QCW A;  1WWW V;  2XV7 A;  4QHU C;  1AGQ A;  4MID A;  4EC7 A;  2GH0 C;  1FL7 B;  5BQ8 B;  4UI2 B;  5BQ8 D;  3FUB B;  4QCI C;  1QTY R;  2R52 A;  1TFG A;  4YCG C;  5HI5 A;  3EO1 C;  1BET A;  5HHV A;  2H64 A;  4EDX V;  4HQX A;  2H62 A;  2ASK A;  4UHZ A;  2XAC A;  5HHD A;  1KLA A;  1WQ9 A;  2R53 A;  3E07 A;  1WAQ A;  1KAT W;  1S4Y B;  3V2A A;  1DZ7 A;  5AEJ A;  1REU A;  4X1J A;  1JPY A;  1M4U A;  3HH2 A;  2FJH V;  4BV4 L;  1LXI A;  2BHK A;  3IJ2 A;  4GLS E;  2B0U A;  2GYR A;  1ZKZ A;  2V5E B;  3BMP A;  3S1B V;  1RV6 V;  1B8M A;  2IFG E;  2QJB A;  1B8K A;  4HSA A;  4HQU A;  1MKK A;  1FLT V;  5HI3 A;  2X1X E;  5BQE A;  3RJR A;  5BQC A;  2ARV A;  2X1W A;  5BPU A;  1B8M B;  1ES7 A;  1LX5 A;  1TZH V;  2QJ9 A;  2KD3 A;  1REW A;  3S1K V;  1NYU B;  1BND A;  3P9W A;  1HD4 A;  4EAX A;  3JVF A;  5BQE B;  4LXR J;  2GYZ A;  1BJ1 V;  3EVS B;  5F3B C;  5HHC A;  5HHX A;  4EDW V;  4HR9 A;  1MKG A;  4ZBN A;  2GOO A;  2GNN A;  5HK5 E;  2QJA A;  1BND B;  4MPL A;  1NYS B;  2C7W A;  3BUK A;  1SG1 A;  3BK3 A;  2QR0 C;  4KXZ A;  2FJG V;  1WQ8 A;  1XWD A;  3V6B A;  2VXS A;  1E9J A;  4FAO A;  1QFW A;  4UI0 A;  4UI1 A;  3MJK A;  1KTZ A;  1VPF A;  4YCI C;  4XPJ A;  4KV5 A;  5HI4 A;  4AY9 A;  1AOC A;  4UHY A;  1VPP V;  3SEK B;  1XWD B;  5FV1 V;  2PJY A;  4ZFF C;  1QFW B;  1TGK A;  5HK5 A;  1SGF B;  2QCQ A;  4AY9 B;  5F3H I;  1NT3 A;  3B4V A;  1BTG A;  4GLN E;  3BDY V;  1KLC A;  3KFD A;  1TZI V;  3QTK A;  5FV2 V;  2TGI A;  4MQW B;  1HCF A;  2P6A A;  2VWE A;  5BQB A;  1HCN A;  1HRP A;  4QAF C; 
#chains in the Genus database with same CATH topology
 4KZN A;  4N1D A;  4WPB A;  2ARP A;  1HCN B;  4LXS J;  1CZ8 V;  5E4G A;  1B98 A;  1HRP B;  1M4U L;  1FL7 A;  1PDG A;  1WQ9 B;  3QB4 A;  2VPF A;  1BMP A;  4MQW A;  5BQ8 A;  4EFV A;  1FZV A;  1MJV A;  1TGJ A;  5JZ7 A;  3MJG A;  2QCW A;  1WWW V;  2XV7 A;  4QHU C;  1AGQ A;  4MID A;  4EC7 A;  2GH0 C;  1FL7 B;  5BQ8 B;  4UI2 B;  5BQ8 D;  3FUB B;  4QCI C;  1QTY R;  2R52 A;  1TFG A;  4YCG C;  5HI5 A;  3EO1 C;  1BET A;  5HHV A;  2H64 A;  4EDX V;  4HQX A;  2H62 A;  2ASK A;  4UHZ A;  2XAC A;  5HHD A;  1KLA A;  1WQ9 A;  2R53 A;  3E07 A;  1WAQ A;  1KAT W;  1S4Y B;  3V2A A;  1DZ7 A;  5AEJ A;  1REU A;  4X1J A;  1JPY A;  1M4U A;  3HH2 A;  2FJH V;  4BV4 L;  1LXI A;  2BHK A;  3IJ2 A;  4GLS E;  2B0U A;  2GYR A;  1ZKZ A;  2V5E B;  3BMP A;  3S1B V;  1RV6 V;  1B8M A;  2IFG E;  2QJB A;  1B8K A;  4HSA A;  4HQU A;  1MKK A;  1FLT V;  5HI3 A;  2X1X E;  5BQE A;  3RJR A;  5BQC A;  2ARV A;  2X1W A;  5BPU A;  1B8M B;  1ES7 A;  1LX5 A;  1TZH V;  2QJ9 A;  2KD3 A;  1REW A;  3S1K V;  1NYU B;  1BND A;  3P9W A;  1HD4 A;  4EAX A;  3JVF A;  5BQE B;  4LXR J;  2GYZ A;  1BJ1 V;  3EVS B;  5F3B C;  5HHC A;  5HHX A;  4EDW V;  4HR9 A;  1MKG A;  4ZBN A;  2GOO A;  2GNN A;  5HK5 E;  2QJA A;  1BND B;  4MPL A;  1NYS B;  2C7W A;  3BUK A;  1SG1 A;  3BK3 A;  2QR0 C;  4KXZ A;  2FJG V;  1WQ8 A;  1XWD A;  3V6B A;  2VXS A;  1E9J A;  4FAO A;  1QFW A;  4UI0 A;  4UI1 A;  3MJK A;  1KTZ A;  1VPF A;  4YCI C;  4XPJ A;  4KV5 A;  5HI4 A;  4AY9 A;  1AOC A;  4UHY A;  1VPP V;  3SEK B;  1XWD B;  5FV1 V;  2PJY A;  4ZFF C;  1QFW B;  1TGK A;  5HK5 A;  1SGF B;  2QCQ A;  4AY9 B;  5F3H I;  1NT3 A;  3B4V A;  1BTG A;  4GLN E;  3BDY V;  1KLC A;  3KFD A;  1TZI V;  3QTK A;  5FV2 V;  2TGI A;  4MQW B;  1HCF A;  2P6A A;  2VWE A;  5BQB A;  1HCN A;  1HRP A;  4QAF C; 
#chains in the Genus database with same CATH homology
 4KZN A;  4N1D A;  4WPB A;  2ARP A;  1HCN B;  4LXS J;  1CZ8 V;  5E4G A;  1B98 A;  1HRP B;  1M4U L;  1FL7 A;  1PDG A;  1WQ9 B;  3QB4 A;  2VPF A;  1BMP A;  4MQW A;  5BQ8 A;  4EFV A;  1FZV A;  1MJV A;  1TGJ A;  5JZ7 A;  3MJG A;  2QCW A;  1WWW V;  2XV7 A;  4QHU C;  1AGQ A;  4MID A;  4EC7 A;  2GH0 C;  1FL7 B;  5BQ8 B;  4UI2 B;  5BQ8 D;  3FUB B;  4QCI C;  1QTY R;  2R52 A;  1TFG A;  4YCG C;  5HI5 A;  3EO1 C;  1BET A;  5HHV A;  2H64 A;  4EDX V;  4HQX A;  2H62 A;  2ASK A;  4UHZ A;  2XAC A;  5HHD A;  1KLA A;  1WQ9 A;  2R53 A;  3E07 A;  1WAQ A;  1KAT W;  1S4Y B;  3V2A A;  1DZ7 A;  5AEJ A;  1REU A;  4X1J A;  1JPY A;  1M4U A;  3HH2 A;  2FJH V;  4BV4 L;  1LXI A;  2BHK A;  3IJ2 A;  4GLS E;  2B0U A;  2GYR A;  1ZKZ A;  2V5E B;  3BMP A;  3S1B V;  1RV6 V;  1B8M A;  2IFG E;  2QJB A;  1B8K A;  4HSA A;  4HQU A;  1MKK A;  1FLT V;  5HI3 A;  2X1X E;  5BQE A;  3RJR A;  5BQC A;  2ARV A;  2X1W A;  5BPU A;  1B8M B;  1ES7 A;  1LX5 A;  1TZH V;  2QJ9 A;  2KD3 A;  1REW A;  3S1K V;  1NYU B;  1BND A;  3P9W A;  1HD4 A;  4EAX A;  3JVF A;  5BQE B;  4LXR J;  2GYZ A;  1BJ1 V;  3EVS B;  5F3B C;  5HHC A;  5HHX A;  4EDW V;  4HR9 A;  1MKG A;  4ZBN A;  2GOO A;  2GNN A;  5HK5 E;  2QJA A;  1BND B;  4MPL A;  1NYS B;  2C7W A;  3BUK A;  1SG1 A;  3BK3 A;  2QR0 C;  4KXZ A;  2FJG V;  1WQ8 A;  1XWD A;  3V6B A;  2VXS A;  1E9J A;  4FAO A;  1QFW A;  4UI0 A;  4UI1 A;  3MJK A;  1KTZ A;  1VPF A;  4YCI C;  4XPJ A;  4KV5 A;  5HI4 A;  4AY9 A;  1AOC A;  4UHY A;  1VPP V;  3SEK B;  1XWD B;  5FV1 V;  2PJY A;  4ZFF C;  1QFW B;  1TGK A;  5HK5 A;  1SGF B;  2QCQ A;  4AY9 B;  5F3H I;  1NT3 A;  3B4V A;  1BTG A;  4GLN E;  3BDY V;  1KLC A;  3KFD A;  1TZI V;  3QTK A;  5FV2 V;  2TGI A;  4MQW B;  1HCF A;  2P6A A;  2VWE A;  5BQB A;  1HCN A;  1HRP A;  4QAF C;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2QR0C

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations