2V5EB

The structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding.
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
101
structure length
101
Chain Sequence
QRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Structure of the Glial Cell Line-Derived Neurotrophic Factor-Coreceptor Complex: Insights Into Ret Signaling and Heparin Binding.
pubmed doi rcsb
molecule tags Receptor/glycoprotein complex
source organism Rattus norvegicus
molecule keywords GDNF FAMILY RECEPTOR ALPHA-1
total genus 17
structure length 101
sequence length 101
ec nomenclature
pdb deposition date 2008-10-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00019 TGF_beta Transforming growth factor beta like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 2v5eB00
1ES7A 1B8KA 2PJYA 1LX5A 1WWWV 3V2AA 1HRPA 2B0UA 4MPLA 4EDWV 4QHUC 2C7WA 4AY9B 4EC7A 5BQ8A 5BQBA 1RV6V 1TZIV 4GLNE 1LXIA 1M4UA 1M4UL 3S1BV 5JZ7A 1B98A 2R52A 1FZVA 1REUA 2ASKA 5BQEB 1WQ9A 1ZKZA 2GYRA 2QR0C 5E4GA 4UI1A 4MQWB 3V6BA 3BMPA 4YCGC 1HCFA 1HCNA 2QCQA 5HHXA 5HHCA 2KD3A 2QJAA 4XPJA 4MIDA 5BQ8D 1BJ1V 5FV2V 4EAXA 5HK5A 3MJGA 4UI2B 1DZ7A 1HD4A 2GYZA 2XACA 1TGKA 4EFVA 1QTYR 2BHKA 2GH0C 1KATW 2TGIA 4AY9A 2FJGV 4HR9A 1KLAA 4WPBA 1E9JA 5BQCA 3QB4A 4GLSE 3RJRA 1BMPA 3JVFA 2H64A 1MKGA 1BTGA 5BQEA 3P9WA 3EVSB 2H62A 1QFWB 1TZHV 3EO1C 1KLCA 2GNNA 4KXZA 2GOOA 1B8MB 1MJVA 1FL7B 1JPYA 4ZFFC 5HHDA 2ARPA 2QJBA 1MKKA 4HSAA 1HRPB 1XWDA 3IJ2A 3QTKA 4UI0A 5AEJA 5FV1V 2X1XE 3BK3A 1WAQA 1WQ8A 2P6AA 1KTZA 3BDYV 2VWEA 5HHVA 1BETA 5F3HI 2QJ9A 2VPFA 3SEKB 4LXRJ 1WQ9B 3HH2A 2R53A 4KZNA 5F3BC 3MJKA 5HI5A 1NYUB 4N1DA 2X1WA 1SGFB 1QFWA 4X1JA 5HI3A 1HCNB 4UHZA 4HQUA 4HQXA 1BNDB 4MQWA 4KV5A 2FJHV 1NT3A 1FL7A 1AOCA 3BUKA 4UHYA 1PDGA 3FUBB 5BPUA 5HK5E 3B4VA 2QCWA 4EDXV 1FLTV 1VPPV 5BQ8B 4QAFC 4YCIC 1S4YB 3KFDA 2VXSA 4ZBNA 1REWA 1TFGA 2XV7A 4FAOA 4BV4L 2ARVA 3S1KV 1CZ8V 1NYSB 2V5EB 4LXSJ 3E07A 2IFGE 1SG1A 1AGQA 5HI4A 1VPFA 1BNDA 4QCIC 1B8MA 1TGJA 1XWDB
chains in the Genus database with same CATH superfamily
1ES7A 1B8KA 2PJYA 1LX5A 1WWWV 3V2AA 1HRPA 2B0UA 4MPLA 4EDWV 4QHUC 2C7WA 4AY9B 4EC7A 5BQ8A 5BQBA 1RV6V 1TZIV 4GLNE 1LXIA 1M4UA 1M4UL 3S1BV 5JZ7A 1B98A 2R52A 1FZVA 1REUA 2ASKA 5BQEB 1WQ9A 1ZKZA 2GYRA 2QR0C 5E4GA 4UI1A 4MQWB 3V6BA 3BMPA 4YCGC 1HCFA 1HCNA 2QCQA 5HHXA 5HHCA 2KD3A 2QJAA 4XPJA 4MIDA 5BQ8D 1BJ1V 5FV2V 4EAXA 5HK5A 3MJGA 4UI2B 1DZ7A 1HD4A 2GYZA 2XACA 1TGKA 4EFVA 1QTYR 2BHKA 2GH0C 1KATW 2TGIA 4AY9A 2FJGV 4HR9A 1KLAA 4WPBA 1E9JA 5BQCA 3QB4A 4GLSE 3RJRA 1BMPA 3JVFA 2H64A 1MKGA 1BTGA 5BQEA 3P9WA 3EVSB 2H62A 1QFWB 1TZHV 3EO1C 1KLCA 2GNNA 4KXZA 2GOOA 1B8MB 1MJVA 1FL7B 1JPYA 4ZFFC 5HHDA 2ARPA 2QJBA 1MKKA 4HSAA 1HRPB 1XWDA 3IJ2A 3QTKA 4UI0A 5AEJA 5FV1V 2X1XE 3BK3A 1WAQA 1WQ8A 2P6AA 1KTZA 3BDYV 2VWEA 5HHVA 1BETA 5F3HI 2QJ9A 2VPFA 3SEKB 4LXRJ 1WQ9B 3HH2A 2R53A 4KZNA 5F3BC 3MJKA 5HI5A 1NYUB 4N1DA 2X1WA 1SGFB 1QFWA 4X1JA 5HI3A 1HCNB 4UHZA 4HQUA 4HQXA 1BNDB 4MQWA 4KV5A 2FJHV 1NT3A 1FL7A 1AOCA 3BUKA 4UHYA 1PDGA 3FUBB 5BPUA 5HK5E 3B4VA 2QCWA 4EDXV 1FLTV 1VPPV 5BQ8B 4QAFC 4YCIC 1S4YB 3KFDA 2VXSA 4ZBNA 1REWA 1TFGA 2XV7A 4FAOA 4BV4L 2ARVA 3S1KV 1CZ8V 1NYSB 2V5EB 4LXSJ 3E07A 2IFGE 1SG1A 1AGQA 5HI4A 1VPFA 1BNDA 4QCIC 1B8MA 1TGJA 1XWDB
chains in the Genus database with same CATH topology
1ES7A 1B8KA 2PJYA 1LX5A 1WWWV 3V2AA 1HRPA 2B0UA 4MPLA 4EDWV 4QHUC 2C7WA 4AY9B 4EC7A 5BQ8A 5BQBA 1RV6V 1TZIV 4GLNE 1LXIA 1M4UA 1M4UL 3S1BV 5JZ7A 1B98A 2R52A 1FZVA 1REUA 2ASKA 5BQEB 1WQ9A 1ZKZA 2GYRA 2QR0C 5E4GA 4UI1A 4MQWB 3V6BA 3BMPA 4YCGC 1HCFA 1HCNA 2QCQA 5HHXA 5HHCA 2KD3A 2QJAA 4XPJA 4MIDA 5BQ8D 1BJ1V 5FV2V 4EAXA 5HK5A 3MJGA 4UI2B 1DZ7A 1HD4A 2GYZA 2XACA 1TGKA 4EFVA 1QTYR 2BHKA 2GH0C 1KATW 2TGIA 4AY9A 2FJGV 4HR9A 1KLAA 4WPBA 1E9JA 5BQCA 3QB4A 4GLSE 3RJRA 1BMPA 3JVFA 2H64A 1MKGA 1BTGA 5BQEA 3P9WA 3EVSB 2H62A 1QFWB 1TZHV 3EO1C 1KLCA 2GNNA 4KXZA 2GOOA 1B8MB 1MJVA 1FL7B 1JPYA 4ZFFC 5HHDA 2ARPA 2QJBA 1MKKA 4HSAA 1HRPB 1XWDA 3IJ2A 3QTKA 4UI0A 5AEJA 5FV1V 2X1XE 3BK3A 1WAQA 1WQ8A 2P6AA 1KTZA 3BDYV 2VWEA 5HHVA 1BETA 5F3HI 2QJ9A 2VPFA 3SEKB 4LXRJ 1WQ9B 3HH2A 2R53A 4KZNA 5F3BC 3MJKA 5HI5A 1NYUB 4N1DA 2X1WA 1SGFB 1QFWA 4X1JA 5HI3A 1HCNB 4UHZA 4HQUA 4HQXA 1BNDB 4MQWA 4KV5A 2FJHV 1NT3A 1FL7A 1AOCA 3BUKA 4UHYA 1PDGA 3FUBB 5BPUA 5HK5E 3B4VA 2QCWA 4EDXV 1FLTV 1VPPV 5BQ8B 4QAFC 4YCIC 1S4YB 3KFDA 2VXSA 4ZBNA 1REWA 1TFGA 2XV7A 4FAOA 4BV4L 2ARVA 3S1KV 1CZ8V 1NYSB 2V5EB 4LXSJ 3E07A 2IFGE 1SG1A 1AGQA 5HI4A 1VPFA 1BNDA 4QCIC 1B8MA 1TGJA 1XWDB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ES7 A;  1B8K A;  2PJY A;  1LX5 A;  1WWW V;  3V2A A;  1HRP A;  2B0U A;  4MPL A;  4EDW V;  4QHU C;  2C7W A;  4AY9 B;  4EC7 A;  5BQ8 A;  5BQB A;  1RV6 V;  1TZI V;  4GLN E;  1LXI A;  1M4U A;  1M4U L;  3S1B V;  5JZ7 A;  1B98 A;  2R52 A;  1FZV A;  1REU A;  2ASK A;  5BQE B;  1WQ9 A;  1ZKZ A;  2GYR A;  2QR0 C;  5E4G A;  4UI1 A;  4MQW B;  3V6B A;  3BMP A;  4YCG C;  1HCF A;  1HCN A;  2QCQ A;  5HHX A;  5HHC A;  2KD3 A;  2QJA A;  4XPJ A;  4MID A;  5BQ8 D;  1BJ1 V;  5FV2 V;  4EAX A;  5HK5 A;  3MJG A;  4UI2 B;  1DZ7 A;  1HD4 A;  2GYZ A;  2XAC A;  1TGK A;  4EFV A;  1QTY R;  2BHK A;  2GH0 C;  1KAT W;  2TGI A;  4AY9 A;  2FJG V;  4HR9 A;  1KLA A;  4WPB A;  1E9J A;  5BQC A;  3QB4 A;  4GLS E;  3RJR A;  1BMP A;  3JVF A;  2H64 A;  1MKG A;  1BTG A;  5BQE A;  3P9W A;  3EVS B;  2H62 A;  1QFW B;  1TZH V;  3EO1 C;  1KLC A;  2GNN A;  4KXZ A;  2GOO A;  1B8M B;  1MJV A;  1FL7 B;  1JPY A;  4ZFF C;  5HHD A;  2ARP A;  2QJB A;  1MKK A;  4HSA A;  1HRP B;  1XWD A;  3IJ2 A;  3QTK A;  4UI0 A;  5AEJ A;  5FV1 V;  2X1X E;  3BK3 A;  1WAQ A;  1WQ8 A;  2P6A A;  1KTZ A;  3BDY V;  2VWE A;  5HHV A;  1BET A;  5F3H I;  2QJ9 A;  2VPF A;  3SEK B;  4LXR J;  1WQ9 B;  3HH2 A;  2R53 A;  4KZN A;  5F3B C;  3MJK A;  5HI5 A;  1NYU B;  4N1D A;  2X1W A;  1SGF B;  1QFW A;  4X1J A;  5HI3 A;  1HCN B;  4UHZ A;  4HQU A;  4HQX A;  1BND B;  4MQW A;  4KV5 A;  2FJH V;  1NT3 A;  1FL7 A;  1AOC A;  3BUK A;  4UHY A;  1PDG A;  3FUB B;  5BPU A;  5HK5 E;  3B4V A;  2QCW A;  4EDX V;  1FLT V;  1VPP V;  5BQ8 B;  4QAF C;  4YCI C;  1S4Y B;  3KFD A;  2VXS A;  4ZBN A;  1REW A;  1TFG A;  2XV7 A;  4FAO A;  4BV4 L;  2ARV A;  3S1K V;  1CZ8 V;  1NYS B;  2V5E B;  4LXS J;  3E07 A;  2IFG E;  1SG1 A;  1AGQ A;  5HI4 A;  1VPF A;  1BND A;  4QCI C;  1B8M A;  1TGJ A;  1XWD B; 
#chains in the Genus database with same CATH topology
 1ES7 A;  1B8K A;  2PJY A;  1LX5 A;  1WWW V;  3V2A A;  1HRP A;  2B0U A;  4MPL A;  4EDW V;  4QHU C;  2C7W A;  4AY9 B;  4EC7 A;  5BQ8 A;  5BQB A;  1RV6 V;  1TZI V;  4GLN E;  1LXI A;  1M4U A;  1M4U L;  3S1B V;  5JZ7 A;  1B98 A;  2R52 A;  1FZV A;  1REU A;  2ASK A;  5BQE B;  1WQ9 A;  1ZKZ A;  2GYR A;  2QR0 C;  5E4G A;  4UI1 A;  4MQW B;  3V6B A;  3BMP A;  4YCG C;  1HCF A;  1HCN A;  2QCQ A;  5HHX A;  5HHC A;  2KD3 A;  2QJA A;  4XPJ A;  4MID A;  5BQ8 D;  1BJ1 V;  5FV2 V;  4EAX A;  5HK5 A;  3MJG A;  4UI2 B;  1DZ7 A;  1HD4 A;  2GYZ A;  2XAC A;  1TGK A;  4EFV A;  1QTY R;  2BHK A;  2GH0 C;  1KAT W;  2TGI A;  4AY9 A;  2FJG V;  4HR9 A;  1KLA A;  4WPB A;  1E9J A;  5BQC A;  3QB4 A;  4GLS E;  3RJR A;  1BMP A;  3JVF A;  2H64 A;  1MKG A;  1BTG A;  5BQE A;  3P9W A;  3EVS B;  2H62 A;  1QFW B;  1TZH V;  3EO1 C;  1KLC A;  2GNN A;  4KXZ A;  2GOO A;  1B8M B;  1MJV A;  1FL7 B;  1JPY A;  4ZFF C;  5HHD A;  2ARP A;  2QJB A;  1MKK A;  4HSA A;  1HRP B;  1XWD A;  3IJ2 A;  3QTK A;  4UI0 A;  5AEJ A;  5FV1 V;  2X1X E;  3BK3 A;  1WAQ A;  1WQ8 A;  2P6A A;  1KTZ A;  3BDY V;  2VWE A;  5HHV A;  1BET A;  5F3H I;  2QJ9 A;  2VPF A;  3SEK B;  4LXR J;  1WQ9 B;  3HH2 A;  2R53 A;  4KZN A;  5F3B C;  3MJK A;  5HI5 A;  1NYU B;  4N1D A;  2X1W A;  1SGF B;  1QFW A;  4X1J A;  5HI3 A;  1HCN B;  4UHZ A;  4HQU A;  4HQX A;  1BND B;  4MQW A;  4KV5 A;  2FJH V;  1NT3 A;  1FL7 A;  1AOC A;  3BUK A;  4UHY A;  1PDG A;  3FUB B;  5BPU A;  5HK5 E;  3B4V A;  2QCW A;  4EDX V;  1FLT V;  1VPP V;  5BQ8 B;  4QAF C;  4YCI C;  1S4Y B;  3KFD A;  2VXS A;  4ZBN A;  1REW A;  1TFG A;  2XV7 A;  4FAO A;  4BV4 L;  2ARV A;  3S1K V;  1CZ8 V;  1NYS B;  2V5E B;  4LXS J;  3E07 A;  2IFG E;  1SG1 A;  1AGQ A;  5HI4 A;  1VPF A;  1BND A;  4QCI C;  1B8M A;  1TGJ A;  1XWD B; 
#chains in the Genus database with same CATH homology
 1ES7 A;  1B8K A;  2PJY A;  1LX5 A;  1WWW V;  3V2A A;  1HRP A;  2B0U A;  4MPL A;  4EDW V;  4QHU C;  2C7W A;  4AY9 B;  4EC7 A;  5BQ8 A;  5BQB A;  1RV6 V;  1TZI V;  4GLN E;  1LXI A;  1M4U A;  1M4U L;  3S1B V;  5JZ7 A;  1B98 A;  2R52 A;  1FZV A;  1REU A;  2ASK A;  5BQE B;  1WQ9 A;  1ZKZ A;  2GYR A;  2QR0 C;  5E4G A;  4UI1 A;  4MQW B;  3V6B A;  3BMP A;  4YCG C;  1HCF A;  1HCN A;  2QCQ A;  5HHX A;  5HHC A;  2KD3 A;  2QJA A;  4XPJ A;  4MID A;  5BQ8 D;  1BJ1 V;  5FV2 V;  4EAX A;  5HK5 A;  3MJG A;  4UI2 B;  1DZ7 A;  1HD4 A;  2GYZ A;  2XAC A;  1TGK A;  4EFV A;  1QTY R;  2BHK A;  2GH0 C;  1KAT W;  2TGI A;  4AY9 A;  2FJG V;  4HR9 A;  1KLA A;  4WPB A;  1E9J A;  5BQC A;  3QB4 A;  4GLS E;  3RJR A;  1BMP A;  3JVF A;  2H64 A;  1MKG A;  1BTG A;  5BQE A;  3P9W A;  3EVS B;  2H62 A;  1QFW B;  1TZH V;  3EO1 C;  1KLC A;  2GNN A;  4KXZ A;  2GOO A;  1B8M B;  1MJV A;  1FL7 B;  1JPY A;  4ZFF C;  5HHD A;  2ARP A;  2QJB A;  1MKK A;  4HSA A;  1HRP B;  1XWD A;  3IJ2 A;  3QTK A;  4UI0 A;  5AEJ A;  5FV1 V;  2X1X E;  3BK3 A;  1WAQ A;  1WQ8 A;  2P6A A;  1KTZ A;  3BDY V;  2VWE A;  5HHV A;  1BET A;  5F3H I;  2QJ9 A;  2VPF A;  3SEK B;  4LXR J;  1WQ9 B;  3HH2 A;  2R53 A;  4KZN A;  5F3B C;  3MJK A;  5HI5 A;  1NYU B;  4N1D A;  2X1W A;  1SGF B;  1QFW A;  4X1J A;  5HI3 A;  1HCN B;  4UHZ A;  4HQU A;  4HQX A;  1BND B;  4MQW A;  4KV5 A;  2FJH V;  1NT3 A;  1FL7 A;  1AOC A;  3BUK A;  4UHY A;  1PDG A;  3FUB B;  5BPU A;  5HK5 E;  3B4V A;  2QCW A;  4EDX V;  1FLT V;  1VPP V;  5BQ8 B;  4QAF C;  4YCI C;  1S4Y B;  3KFD A;  2VXS A;  4ZBN A;  1REW A;  1TFG A;  2XV7 A;  4FAO A;  4BV4 L;  2ARV A;  3S1K V;  1CZ8 V;  1NYS B;  2V5E B;  4LXS J;  3E07 A;  2IFG E;  1SG1 A;  1AGQ A;  5HI4 A;  1VPF A;  1BND A;  4QCI C;  1B8M A;  1TGJ A;  1XWD B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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