2V5EB

The structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding.
Total Genus 17
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
101
structure length
101
Chain Sequence
QRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title The Structure of the Glial Cell Line-Derived Neurotrophic Factor-Coreceptor Complex: Insights Into Ret Signaling and Heparin Binding.
pubmed doi rcsb
molecule tags Receptor/glycoprotein complex
source organism Rattus norvegicus
molecule keywords GDNF FAMILY RECEPTOR ALPHA-1
total genus 17
structure length 101
sequence length 101
ec nomenclature
pdb deposition date 2008-10-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00019 TGF_beta Transforming growth factor beta like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 2v5eB00
4BV4L 2R53A 5BQ8A 4AY9A 1HD4A 5F3BC 4HQUA 5BQ8D 4N1DA 3IJ2A 4QHUC 1SGFB 2V5EB 1AGQA 1PDGA 1QTYR 1TGKA 4QCIC 2QR0C 5HI4A 5BPUA 1E9JA 2QJBA 1BETA 1TGJA 1HRPB 1HCNA 4GLSE 4UI0A 5BQCA 4ZFFC 5E4GA 1REWA 3BK3A 3QTKA 1B8MA 2QCQA 1XWDA 3KFDA 4EDXV 2KD3A 1NT3A 4GLNE 3EVSB 5HHVA 1S4YB 1KLAA 1BNDB 1QFWB 2X1XE 1FL7A 4QAFC 5BQEB 1WWWV 3EO1C 1HCFA 1M4UA 2R52A 5HK5E 2XV7A 3B4VA 3MJKA 5JZ7A 2ARVA 4MPLA 1ES7A 1AOCA 1WQ9B 4UHYA 4MQWB 4YCIC 2H62A 3JVFA 1FZVA 4YCGC 5HHCA 3V6BA 1NYUB 3MJGA 1TFGA 4X1JA 4HQXA 2B0UA 3P9WA 3V2AA 5BQ8B 4AY9B 1VPFA 1BJ1V 2H64A 1SG1A 2ASKA 1BMPA 2GYZA 1VPPV 5HI3A 5BQBA 2GOOA 1TZIV 1B98A 4KZNA 1RV6V 1MJVA 2GH0C 4WPBA 1HCNB 4KXZA 1B8MB 5F3HI 1XWDB 4UHZA 2TGIA 1JPYA 3SEKB 3RJRA 5HHDA 1FL7B 5AEJA 1ZKZA 1KTZA 1FLTV 4EDWV 2BHKA 3HH2A 4EC7A 2VXSA 5HI5A 4HSAA 1B8KA 4EFVA 4XPJA 2QJAA 2QJ9A 1WAQA 3S1KV 3FUBB 1HRPA 3QB4A 4KV5A 5FV2V 4ZBNA 4EAXA 2VPFA 1KLCA 2C7WA 2VWEA 2FJHV 2GNNA 4LXRJ 1MKKA 5HHXA 1LXIA 2GYRA 2XACA 1BNDA 2PJYA 1LX5A 1MKGA 1QFWA 2FJGV 2P6AA 4UI2B 5BQEA 1KATW 1WQ8A 1DZ7A 4HR9A 1TZHV 3BDYV 5FV1V 1REUA 5HK5A 1NYSB 3E07A 4LXSJ 2X1WA 1WQ9A 3BMPA 2ARPA 4MQWA 4MIDA 1CZ8V 4UI1A 2QCWA 4FAOA 1BTGA 3S1BV 2IFGE 1M4UL 3BUKA
chains in the Genus database with same CATH superfamily
4BV4L 2R53A 5BQ8A 4AY9A 1HD4A 5F3BC 4HQUA 5BQ8D 4N1DA 3IJ2A 4QHUC 1SGFB 2V5EB 1AGQA 1PDGA 1QTYR 1TGKA 4QCIC 2QR0C 5HI4A 5BPUA 1E9JA 2QJBA 1BETA 1TGJA 1HRPB 1HCNA 4GLSE 4UI0A 5BQCA 4ZFFC 5E4GA 1REWA 3BK3A 3QTKA 1B8MA 2QCQA 1XWDA 3KFDA 4EDXV 2KD3A 1NT3A 4GLNE 3EVSB 5HHVA 1S4YB 1KLAA 1BNDB 1QFWB 2X1XE 1FL7A 4QAFC 5BQEB 1WWWV 3EO1C 1HCFA 1M4UA 2R52A 5HK5E 2XV7A 3B4VA 3MJKA 5JZ7A 2ARVA 4MPLA 1ES7A 1AOCA 1WQ9B 4UHYA 4MQWB 4YCIC 2H62A 3JVFA 1FZVA 4YCGC 5HHCA 3V6BA 1NYUB 3MJGA 1TFGA 4X1JA 4HQXA 2B0UA 3P9WA 3V2AA 5BQ8B 4AY9B 1VPFA 1BJ1V 2H64A 1SG1A 2ASKA 1BMPA 2GYZA 1VPPV 5HI3A 5BQBA 2GOOA 1TZIV 1B98A 4KZNA 1RV6V 1MJVA 2GH0C 4WPBA 1HCNB 4KXZA 1B8MB 5F3HI 1XWDB 4UHZA 2TGIA 1JPYA 3SEKB 3RJRA 5HHDA 1FL7B 5AEJA 1ZKZA 1KTZA 1FLTV 4EDWV 2BHKA 3HH2A 4EC7A 2VXSA 5HI5A 4HSAA 1B8KA 4EFVA 4XPJA 2QJAA 2QJ9A 1WAQA 3S1KV 3FUBB 1HRPA 3QB4A 4KV5A 5FV2V 4ZBNA 4EAXA 2VPFA 1KLCA 2C7WA 2VWEA 2FJHV 2GNNA 4LXRJ 1MKKA 5HHXA 1LXIA 2GYRA 2XACA 1BNDA 2PJYA 1LX5A 1MKGA 1QFWA 2FJGV 2P6AA 4UI2B 5BQEA 1KATW 1WQ8A 1DZ7A 4HR9A 1TZHV 3BDYV 5FV1V 1REUA 5HK5A 1NYSB 3E07A 4LXSJ 2X1WA 1WQ9A 3BMPA 2ARPA 4MQWA 4MIDA 1CZ8V 4UI1A 2QCWA 4FAOA 1BTGA 3S1BV 2IFGE 1M4UL 3BUKA
chains in the Genus database with same CATH topology
4BV4L 2R53A 5BQ8A 4AY9A 1HD4A 5F3BC 4HQUA 5BQ8D 4N1DA 3IJ2A 4QHUC 1SGFB 2V5EB 1AGQA 1PDGA 1QTYR 1TGKA 4QCIC 2QR0C 5HI4A 5BPUA 1E9JA 2QJBA 1BETA 1TGJA 1HRPB 1HCNA 4GLSE 4UI0A 5BQCA 4ZFFC 5E4GA 1REWA 3BK3A 3QTKA 1B8MA 2QCQA 1XWDA 3KFDA 4EDXV 2KD3A 1NT3A 4GLNE 3EVSB 5HHVA 1S4YB 1KLAA 1BNDB 1QFWB 2X1XE 1FL7A 4QAFC 5BQEB 1WWWV 3EO1C 1HCFA 1M4UA 2R52A 5HK5E 2XV7A 3B4VA 3MJKA 5JZ7A 2ARVA 4MPLA 1ES7A 1AOCA 1WQ9B 4UHYA 4MQWB 4YCIC 2H62A 3JVFA 1FZVA 4YCGC 5HHCA 3V6BA 1NYUB 3MJGA 1TFGA 4X1JA 4HQXA 2B0UA 3P9WA 3V2AA 5BQ8B 4AY9B 1VPFA 1BJ1V 2H64A 1SG1A 2ASKA 1BMPA 2GYZA 1VPPV 5HI3A 5BQBA 2GOOA 1TZIV 1B98A 4KZNA 1RV6V 1MJVA 2GH0C 4WPBA 1HCNB 4KXZA 1B8MB 5F3HI 1XWDB 4UHZA 2TGIA 1JPYA 3SEKB 3RJRA 5HHDA 1FL7B 5AEJA 1ZKZA 1KTZA 1FLTV 4EDWV 2BHKA 3HH2A 4EC7A 2VXSA 5HI5A 4HSAA 1B8KA 4EFVA 4XPJA 2QJAA 2QJ9A 1WAQA 3S1KV 3FUBB 1HRPA 3QB4A 4KV5A 5FV2V 4ZBNA 4EAXA 2VPFA 1KLCA 2C7WA 2VWEA 2FJHV 2GNNA 4LXRJ 1MKKA 5HHXA 1LXIA 2GYRA 2XACA 1BNDA 2PJYA 1LX5A 1MKGA 1QFWA 2FJGV 2P6AA 4UI2B 5BQEA 1KATW 1WQ8A 1DZ7A 4HR9A 1TZHV 3BDYV 5FV1V 1REUA 5HK5A 1NYSB 3E07A 4LXSJ 2X1WA 1WQ9A 3BMPA 2ARPA 4MQWA 4MIDA 1CZ8V 4UI1A 2QCWA 4FAOA 1BTGA 3S1BV 2IFGE 1M4UL 3BUKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BV4 L;  2R53 A;  5BQ8 A;  4AY9 A;  1HD4 A;  5F3B C;  4HQU A;  5BQ8 D;  4N1D A;  3IJ2 A;  4QHU C;  1SGF B;  2V5E B;  1AGQ A;  1PDG A;  1QTY R;  1TGK A;  4QCI C;  2QR0 C;  5HI4 A;  5BPU A;  1E9J A;  2QJB A;  1BET A;  1TGJ A;  1HRP B;  1HCN A;  4GLS E;  4UI0 A;  5BQC A;  4ZFF C;  5E4G A;  1REW A;  3BK3 A;  3QTK A;  1B8M A;  2QCQ A;  1XWD A;  3KFD A;  4EDX V;  2KD3 A;  1NT3 A;  4GLN E;  3EVS B;  5HHV A;  1S4Y B;  1KLA A;  1BND B;  1QFW B;  2X1X E;  1FL7 A;  4QAF C;  5BQE B;  1WWW V;  3EO1 C;  1HCF A;  1M4U A;  2R52 A;  5HK5 E;  2XV7 A;  3B4V A;  3MJK A;  5JZ7 A;  2ARV A;  4MPL A;  1ES7 A;  1AOC A;  1WQ9 B;  4UHY A;  4MQW B;  4YCI C;  2H62 A;  3JVF A;  1FZV A;  4YCG C;  5HHC A;  3V6B A;  1NYU B;  3MJG A;  1TFG A;  4X1J A;  4HQX A;  2B0U A;  3P9W A;  3V2A A;  5BQ8 B;  4AY9 B;  1VPF A;  1BJ1 V;  2H64 A;  1SG1 A;  2ASK A;  1BMP A;  2GYZ A;  1VPP V;  5HI3 A;  5BQB A;  2GOO A;  1TZI V;  1B98 A;  4KZN A;  1RV6 V;  1MJV A;  2GH0 C;  4WPB A;  1HCN B;  4KXZ A;  1B8M B;  5F3H I;  1XWD B;  4UHZ A;  2TGI A;  1JPY A;  3SEK B;  3RJR A;  5HHD A;  1FL7 B;  5AEJ A;  1ZKZ A;  1KTZ A;  1FLT V;  4EDW V;  2BHK A;  3HH2 A;  4EC7 A;  2VXS A;  5HI5 A;  4HSA A;  1B8K A;  4EFV A;  4XPJ A;  2QJA A;  2QJ9 A;  1WAQ A;  3S1K V;  3FUB B;  1HRP A;  3QB4 A;  4KV5 A;  5FV2 V;  4ZBN A;  4EAX A;  2VPF A;  1KLC A;  2C7W A;  2VWE A;  2FJH V;  2GNN A;  4LXR J;  1MKK A;  5HHX A;  1LXI A;  2GYR A;  2XAC A;  1BND A;  2PJY A;  1LX5 A;  1MKG A;  1QFW A;  2FJG V;  2P6A A;  4UI2 B;  5BQE A;  1KAT W;  1WQ8 A;  1DZ7 A;  4HR9 A;  1TZH V;  3BDY V;  5FV1 V;  1REU A;  5HK5 A;  1NYS B;  3E07 A;  4LXS J;  2X1W A;  1WQ9 A;  3BMP A;  2ARP A;  4MQW A;  4MID A;  1CZ8 V;  4UI1 A;  2QCW A;  4FAO A;  1BTG A;  3S1B V;  2IFG E;  1M4U L;  3BUK A; 
#chains in the Genus database with same CATH topology
 4BV4 L;  2R53 A;  5BQ8 A;  4AY9 A;  1HD4 A;  5F3B C;  4HQU A;  5BQ8 D;  4N1D A;  3IJ2 A;  4QHU C;  1SGF B;  2V5E B;  1AGQ A;  1PDG A;  1QTY R;  1TGK A;  4QCI C;  2QR0 C;  5HI4 A;  5BPU A;  1E9J A;  2QJB A;  1BET A;  1TGJ A;  1HRP B;  1HCN A;  4GLS E;  4UI0 A;  5BQC A;  4ZFF C;  5E4G A;  1REW A;  3BK3 A;  3QTK A;  1B8M A;  2QCQ A;  1XWD A;  3KFD A;  4EDX V;  2KD3 A;  1NT3 A;  4GLN E;  3EVS B;  5HHV A;  1S4Y B;  1KLA A;  1BND B;  1QFW B;  2X1X E;  1FL7 A;  4QAF C;  5BQE B;  1WWW V;  3EO1 C;  1HCF A;  1M4U A;  2R52 A;  5HK5 E;  2XV7 A;  3B4V A;  3MJK A;  5JZ7 A;  2ARV A;  4MPL A;  1ES7 A;  1AOC A;  1WQ9 B;  4UHY A;  4MQW B;  4YCI C;  2H62 A;  3JVF A;  1FZV A;  4YCG C;  5HHC A;  3V6B A;  1NYU B;  3MJG A;  1TFG A;  4X1J A;  4HQX A;  2B0U A;  3P9W A;  3V2A A;  5BQ8 B;  4AY9 B;  1VPF A;  1BJ1 V;  2H64 A;  1SG1 A;  2ASK A;  1BMP A;  2GYZ A;  1VPP V;  5HI3 A;  5BQB A;  2GOO A;  1TZI V;  1B98 A;  4KZN A;  1RV6 V;  1MJV A;  2GH0 C;  4WPB A;  1HCN B;  4KXZ A;  1B8M B;  5F3H I;  1XWD B;  4UHZ A;  2TGI A;  1JPY A;  3SEK B;  3RJR A;  5HHD A;  1FL7 B;  5AEJ A;  1ZKZ A;  1KTZ A;  1FLT V;  4EDW V;  2BHK A;  3HH2 A;  4EC7 A;  2VXS A;  5HI5 A;  4HSA A;  1B8K A;  4EFV A;  4XPJ A;  2QJA A;  2QJ9 A;  1WAQ A;  3S1K V;  3FUB B;  1HRP A;  3QB4 A;  4KV5 A;  5FV2 V;  4ZBN A;  4EAX A;  2VPF A;  1KLC A;  2C7W A;  2VWE A;  2FJH V;  2GNN A;  4LXR J;  1MKK A;  5HHX A;  1LXI A;  2GYR A;  2XAC A;  1BND A;  2PJY A;  1LX5 A;  1MKG A;  1QFW A;  2FJG V;  2P6A A;  4UI2 B;  5BQE A;  1KAT W;  1WQ8 A;  1DZ7 A;  4HR9 A;  1TZH V;  3BDY V;  5FV1 V;  1REU A;  5HK5 A;  1NYS B;  3E07 A;  4LXS J;  2X1W A;  1WQ9 A;  3BMP A;  2ARP A;  4MQW A;  4MID A;  1CZ8 V;  4UI1 A;  2QCW A;  4FAO A;  1BTG A;  3S1B V;  2IFG E;  1M4U L;  3BUK A; 
#chains in the Genus database with same CATH homology
 4BV4 L;  2R53 A;  5BQ8 A;  4AY9 A;  1HD4 A;  5F3B C;  4HQU A;  5BQ8 D;  4N1D A;  3IJ2 A;  4QHU C;  1SGF B;  2V5E B;  1AGQ A;  1PDG A;  1QTY R;  1TGK A;  4QCI C;  2QR0 C;  5HI4 A;  5BPU A;  1E9J A;  2QJB A;  1BET A;  1TGJ A;  1HRP B;  1HCN A;  4GLS E;  4UI0 A;  5BQC A;  4ZFF C;  5E4G A;  1REW A;  3BK3 A;  3QTK A;  1B8M A;  2QCQ A;  1XWD A;  3KFD A;  4EDX V;  2KD3 A;  1NT3 A;  4GLN E;  3EVS B;  5HHV A;  1S4Y B;  1KLA A;  1BND B;  1QFW B;  2X1X E;  1FL7 A;  4QAF C;  5BQE B;  1WWW V;  3EO1 C;  1HCF A;  1M4U A;  2R52 A;  5HK5 E;  2XV7 A;  3B4V A;  3MJK A;  5JZ7 A;  2ARV A;  4MPL A;  1ES7 A;  1AOC A;  1WQ9 B;  4UHY A;  4MQW B;  4YCI C;  2H62 A;  3JVF A;  1FZV A;  4YCG C;  5HHC A;  3V6B A;  1NYU B;  3MJG A;  1TFG A;  4X1J A;  4HQX A;  2B0U A;  3P9W A;  3V2A A;  5BQ8 B;  4AY9 B;  1VPF A;  1BJ1 V;  2H64 A;  1SG1 A;  2ASK A;  1BMP A;  2GYZ A;  1VPP V;  5HI3 A;  5BQB A;  2GOO A;  1TZI V;  1B98 A;  4KZN A;  1RV6 V;  1MJV A;  2GH0 C;  4WPB A;  1HCN B;  4KXZ A;  1B8M B;  5F3H I;  1XWD B;  4UHZ A;  2TGI A;  1JPY A;  3SEK B;  3RJR A;  5HHD A;  1FL7 B;  5AEJ A;  1ZKZ A;  1KTZ A;  1FLT V;  4EDW V;  2BHK A;  3HH2 A;  4EC7 A;  2VXS A;  5HI5 A;  4HSA A;  1B8K A;  4EFV A;  4XPJ A;  2QJA A;  2QJ9 A;  1WAQ A;  3S1K V;  3FUB B;  1HRP A;  3QB4 A;  4KV5 A;  5FV2 V;  4ZBN A;  4EAX A;  2VPF A;  1KLC A;  2C7W A;  2VWE A;  2FJH V;  2GNN A;  4LXR J;  1MKK A;  5HHX A;  1LXI A;  2GYR A;  2XAC A;  1BND A;  2PJY A;  1LX5 A;  1MKG A;  1QFW A;  2FJG V;  2P6A A;  4UI2 B;  5BQE A;  1KAT W;  1WQ8 A;  1DZ7 A;  4HR9 A;  1TZH V;  3BDY V;  5FV1 V;  1REU A;  5HK5 A;  1NYS B;  3E07 A;  4LXS J;  2X1W A;  1WQ9 A;  3BMP A;  2ARP A;  4MQW A;  4MID A;  1CZ8 V;  4UI1 A;  2QCW A;  4FAO A;  1BTG A;  3S1B V;  2IFG E;  1M4U L;  3BUK A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...