2VWEA

Crystal structure of vascular endothelial growth factor-b in complex with a neutralizing antibody fab fragment
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
97
structure length
97
Chain Sequence
QRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralising Antibody Fab Fragment.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords VASCULAR ENDOTHELIAL GROWTH FACTOR B
total genus 11
structure length 97
sequence length 97
chains with identical sequence B
ec nomenclature
pdb deposition date 2008-06-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00341 PDGF PDGF/VEGF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 2vweA00
5JZ7A 4X1JA 1BNDB 1TZHV 5BQ8B 1CZ8V 1HD4A 4KV5A 5BPUA 2QJBA 4FAOA 1BMPA 2QCWA 2QJ9A 5F3HI 1BJ1V 4LXSJ 1FLTV 1WQ9A 3BMPA 5BQ8D 1REWA 4HSAA 2FJHV 4QCIC 3P9WA 4EFVA 3IJ2A 5HHVA 1HRPB 4GLNE 1M4UA 5HK5A 3HH2A 4UI1A 1XWDA 1BTGA 1MKGA 5FV1V 4BV4L 1MKKA 1DZ7A 5FV2V 3B4VA 3MJKA 5BQEA 1HCNA 4EAXA 1TGJA 4EDWV 4ZBNA 2GYRA 3S1KV 5HI3A 4UHZA 1JPYA 1NT3A 4GLSE 1ZKZA 3BK3A 2VWEA 4ZFFC 1SG1A 2IFGE 2VXSA 2C7WA 1S4YB 3EO1C 4HQXA 1FL7A 1B8MA 1LXIA 1MJVA 4QHUC 1LX5A 4AY9A 1QFWB 2FJGV 2ASKA 2H62A 4MQWA 2XACA 2TGIA 1BNDA 5BQ8A 2XV7A 1B98A 2X1WA 4UHYA 1TZIV 4QAFC 4XPJA 3SEKB 5HI5A 1TFGA 1E9JA 1KTZA 5BQCA 4HR9A 2ARPA 4HQUA 1HCFA 2QJAA 1M4UL 1ES7A 1WWWV 4YCGC 2P6AA 2X1XE 3BDYV 3MJGA 1HRPA 1WQ9B 2H64A 1REUA 3QB4A 1VPPV 1NYUB 3V6BA 2QR0C 5AEJA 1NYSB 1WAQA 3QTKA 4N1DA 2B0UA 2GOOA 1BETA 2GNNA 1KATW 5HK5E 1PDGA 2V5EB 5HHDA 4KXZA 3V2AA 5HI4A 1XWDB 1VPFA 2QCQA 1TGKA 3KFDA 3RJRA 5HHXA 5BQEB 1QTYR 4UI0A 1HCNB 2GYZA 5HHCA 1RV6V 2VPFA 4WPBA 1B8KA 1FZVA 3FUBB 1KLAA 2KD3A 2GH0C 5BQBA 1KLCA 3S1BV 3EVSB 5F3BC 4MIDA 1QFWA 4MPLA 3BUKA 3E07A 4EC7A 2BHKA 1AGQA 4EDXV 4KZNA 1WQ8A 1FL7B 1B8MB 1SGFB 2R53A 4UI2B 5E4GA 1AOCA 2ARVA 4YCIC 4AY9B 2R52A 4LXRJ 2PJYA 3JVFA 4MQWB
chains in the Genus database with same CATH superfamily
5JZ7A 4X1JA 1BNDB 1TZHV 5BQ8B 1CZ8V 1HD4A 4KV5A 5BPUA 2QJBA 4FAOA 1BMPA 2QCWA 2QJ9A 5F3HI 1BJ1V 4LXSJ 1FLTV 1WQ9A 3BMPA 5BQ8D 1REWA 4HSAA 2FJHV 4QCIC 3P9WA 4EFVA 3IJ2A 5HHVA 1HRPB 4GLNE 1M4UA 5HK5A 3HH2A 4UI1A 1XWDA 1BTGA 1MKGA 5FV1V 4BV4L 1MKKA 1DZ7A 5FV2V 3B4VA 3MJKA 5BQEA 1HCNA 4EAXA 1TGJA 4EDWV 4ZBNA 2GYRA 3S1KV 5HI3A 4UHZA 1JPYA 1NT3A 4GLSE 1ZKZA 3BK3A 2VWEA 4ZFFC 1SG1A 2IFGE 2VXSA 2C7WA 1S4YB 3EO1C 4HQXA 1FL7A 1B8MA 1LXIA 1MJVA 4QHUC 1LX5A 4AY9A 1QFWB 2FJGV 2ASKA 2H62A 4MQWA 2XACA 2TGIA 1BNDA 5BQ8A 2XV7A 1B98A 2X1WA 4UHYA 1TZIV 4QAFC 4XPJA 3SEKB 5HI5A 1TFGA 1E9JA 1KTZA 5BQCA 4HR9A 2ARPA 4HQUA 1HCFA 2QJAA 1M4UL 1ES7A 1WWWV 4YCGC 2P6AA 2X1XE 3BDYV 3MJGA 1HRPA 1WQ9B 2H64A 1REUA 3QB4A 1VPPV 1NYUB 3V6BA 2QR0C 5AEJA 1NYSB 1WAQA 3QTKA 4N1DA 2B0UA 2GOOA 1BETA 2GNNA 1KATW 5HK5E 1PDGA 2V5EB 5HHDA 4KXZA 3V2AA 5HI4A 1XWDB 1VPFA 2QCQA 1TGKA 3KFDA 3RJRA 5HHXA 5BQEB 1QTYR 4UI0A 1HCNB 2GYZA 5HHCA 1RV6V 2VPFA 4WPBA 1B8KA 1FZVA 3FUBB 1KLAA 2KD3A 2GH0C 5BQBA 1KLCA 3S1BV 3EVSB 5F3BC 4MIDA 1QFWA 4MPLA 3BUKA 3E07A 4EC7A 2BHKA 1AGQA 4EDXV 4KZNA 1WQ8A 1FL7B 1B8MB 1SGFB 2R53A 4UI2B 5E4GA 1AOCA 2ARVA 4YCIC 4AY9B 2R52A 4LXRJ 2PJYA 3JVFA 4MQWB
chains in the Genus database with same CATH topology
5JZ7A 4X1JA 1BNDB 1TZHV 5BQ8B 1CZ8V 1HD4A 4KV5A 5BPUA 2QJBA 4FAOA 1BMPA 2QCWA 2QJ9A 5F3HI 1BJ1V 4LXSJ 1FLTV 1WQ9A 3BMPA 5BQ8D 1REWA 4HSAA 2FJHV 4QCIC 3P9WA 4EFVA 3IJ2A 5HHVA 1HRPB 4GLNE 1M4UA 5HK5A 3HH2A 4UI1A 1XWDA 1BTGA 1MKGA 5FV1V 4BV4L 1MKKA 1DZ7A 5FV2V 3B4VA 3MJKA 5BQEA 1HCNA 4EAXA 1TGJA 4EDWV 4ZBNA 2GYRA 3S1KV 5HI3A 4UHZA 1JPYA 1NT3A 4GLSE 1ZKZA 3BK3A 2VWEA 4ZFFC 1SG1A 2IFGE 2VXSA 2C7WA 1S4YB 3EO1C 4HQXA 1FL7A 1B8MA 1LXIA 1MJVA 4QHUC 1LX5A 4AY9A 1QFWB 2FJGV 2ASKA 2H62A 4MQWA 2XACA 2TGIA 1BNDA 5BQ8A 2XV7A 1B98A 2X1WA 4UHYA 1TZIV 4QAFC 4XPJA 3SEKB 5HI5A 1TFGA 1E9JA 1KTZA 5BQCA 4HR9A 2ARPA 4HQUA 1HCFA 2QJAA 1M4UL 1ES7A 1WWWV 4YCGC 2P6AA 2X1XE 3BDYV 3MJGA 1HRPA 1WQ9B 2H64A 1REUA 3QB4A 1VPPV 1NYUB 3V6BA 2QR0C 5AEJA 1NYSB 1WAQA 3QTKA 4N1DA 2B0UA 2GOOA 1BETA 2GNNA 1KATW 5HK5E 1PDGA 2V5EB 5HHDA 4KXZA 3V2AA 5HI4A 1XWDB 1VPFA 2QCQA 1TGKA 3KFDA 3RJRA 5HHXA 5BQEB 1QTYR 4UI0A 1HCNB 2GYZA 5HHCA 1RV6V 2VPFA 4WPBA 1B8KA 1FZVA 3FUBB 1KLAA 2KD3A 2GH0C 5BQBA 1KLCA 3S1BV 3EVSB 5F3BC 4MIDA 1QFWA 4MPLA 3BUKA 3E07A 4EC7A 2BHKA 1AGQA 4EDXV 4KZNA 1WQ8A 1FL7B 1B8MB 1SGFB 2R53A 4UI2B 5E4GA 1AOCA 2ARVA 4YCIC 4AY9B 2R52A 4LXRJ 2PJYA 3JVFA 4MQWB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5JZ7 A;  4X1J A;  1BND B;  1TZH V;  5BQ8 B;  1CZ8 V;  1HD4 A;  4KV5 A;  5BPU A;  2QJB A;  4FAO A;  1BMP A;  2QCW A;  2QJ9 A;  5F3H I;  1BJ1 V;  4LXS J;  1FLT V;  1WQ9 A;  3BMP A;  5BQ8 D;  1REW A;  4HSA A;  2FJH V;  4QCI C;  3P9W A;  4EFV A;  3IJ2 A;  5HHV A;  1HRP B;  4GLN E;  1M4U A;  5HK5 A;  3HH2 A;  4UI1 A;  1XWD A;  1BTG A;  1MKG A;  5FV1 V;  4BV4 L;  1MKK A;  1DZ7 A;  5FV2 V;  3B4V A;  3MJK A;  5BQE A;  1HCN A;  4EAX A;  1TGJ A;  4EDW V;  4ZBN A;  2GYR A;  3S1K V;  5HI3 A;  4UHZ A;  1JPY A;  1NT3 A;  4GLS E;  1ZKZ A;  3BK3 A;  2VWE A;  4ZFF C;  1SG1 A;  2IFG E;  2VXS A;  2C7W A;  1S4Y B;  3EO1 C;  4HQX A;  1FL7 A;  1B8M A;  1LXI A;  1MJV A;  4QHU C;  1LX5 A;  4AY9 A;  1QFW B;  2FJG V;  2ASK A;  2H62 A;  4MQW A;  2XAC A;  2TGI A;  1BND A;  5BQ8 A;  2XV7 A;  1B98 A;  2X1W A;  4UHY A;  1TZI V;  4QAF C;  4XPJ A;  3SEK B;  5HI5 A;  1TFG A;  1E9J A;  1KTZ A;  5BQC A;  4HR9 A;  2ARP A;  4HQU A;  1HCF A;  2QJA A;  1M4U L;  1ES7 A;  1WWW V;  4YCG C;  2P6A A;  2X1X E;  3BDY V;  3MJG A;  1HRP A;  1WQ9 B;  2H64 A;  1REU A;  3QB4 A;  1VPP V;  1NYU B;  3V6B A;  2QR0 C;  5AEJ A;  1NYS B;  1WAQ A;  3QTK A;  4N1D A;  2B0U A;  2GOO A;  1BET A;  2GNN A;  1KAT W;  5HK5 E;  1PDG A;  2V5E B;  5HHD A;  4KXZ A;  3V2A A;  5HI4 A;  1XWD B;  1VPF A;  2QCQ A;  1TGK A;  3KFD A;  3RJR A;  5HHX A;  5BQE B;  1QTY R;  4UI0 A;  1HCN B;  2GYZ A;  5HHC A;  1RV6 V;  2VPF A;  4WPB A;  1B8K A;  1FZV A;  3FUB B;  1KLA A;  2KD3 A;  2GH0 C;  5BQB A;  1KLC A;  3S1B V;  3EVS B;  5F3B C;  4MID A;  1QFW A;  4MPL A;  3BUK A;  3E07 A;  4EC7 A;  2BHK A;  1AGQ A;  4EDX V;  4KZN A;  1WQ8 A;  1FL7 B;  1B8M B;  1SGF B;  2R53 A;  4UI2 B;  5E4G A;  1AOC A;  2ARV A;  4YCI C;  4AY9 B;  2R52 A;  4LXR J;  2PJY A;  3JVF A;  4MQW B; 
#chains in the Genus database with same CATH topology
 5JZ7 A;  4X1J A;  1BND B;  1TZH V;  5BQ8 B;  1CZ8 V;  1HD4 A;  4KV5 A;  5BPU A;  2QJB A;  4FAO A;  1BMP A;  2QCW A;  2QJ9 A;  5F3H I;  1BJ1 V;  4LXS J;  1FLT V;  1WQ9 A;  3BMP A;  5BQ8 D;  1REW A;  4HSA A;  2FJH V;  4QCI C;  3P9W A;  4EFV A;  3IJ2 A;  5HHV A;  1HRP B;  4GLN E;  1M4U A;  5HK5 A;  3HH2 A;  4UI1 A;  1XWD A;  1BTG A;  1MKG A;  5FV1 V;  4BV4 L;  1MKK A;  1DZ7 A;  5FV2 V;  3B4V A;  3MJK A;  5BQE A;  1HCN A;  4EAX A;  1TGJ A;  4EDW V;  4ZBN A;  2GYR A;  3S1K V;  5HI3 A;  4UHZ A;  1JPY A;  1NT3 A;  4GLS E;  1ZKZ A;  3BK3 A;  2VWE A;  4ZFF C;  1SG1 A;  2IFG E;  2VXS A;  2C7W A;  1S4Y B;  3EO1 C;  4HQX A;  1FL7 A;  1B8M A;  1LXI A;  1MJV A;  4QHU C;  1LX5 A;  4AY9 A;  1QFW B;  2FJG V;  2ASK A;  2H62 A;  4MQW A;  2XAC A;  2TGI A;  1BND A;  5BQ8 A;  2XV7 A;  1B98 A;  2X1W A;  4UHY A;  1TZI V;  4QAF C;  4XPJ A;  3SEK B;  5HI5 A;  1TFG A;  1E9J A;  1KTZ A;  5BQC A;  4HR9 A;  2ARP A;  4HQU A;  1HCF A;  2QJA A;  1M4U L;  1ES7 A;  1WWW V;  4YCG C;  2P6A A;  2X1X E;  3BDY V;  3MJG A;  1HRP A;  1WQ9 B;  2H64 A;  1REU A;  3QB4 A;  1VPP V;  1NYU B;  3V6B A;  2QR0 C;  5AEJ A;  1NYS B;  1WAQ A;  3QTK A;  4N1D A;  2B0U A;  2GOO A;  1BET A;  2GNN A;  1KAT W;  5HK5 E;  1PDG A;  2V5E B;  5HHD A;  4KXZ A;  3V2A A;  5HI4 A;  1XWD B;  1VPF A;  2QCQ A;  1TGK A;  3KFD A;  3RJR A;  5HHX A;  5BQE B;  1QTY R;  4UI0 A;  1HCN B;  2GYZ A;  5HHC A;  1RV6 V;  2VPF A;  4WPB A;  1B8K A;  1FZV A;  3FUB B;  1KLA A;  2KD3 A;  2GH0 C;  5BQB A;  1KLC A;  3S1B V;  3EVS B;  5F3B C;  4MID A;  1QFW A;  4MPL A;  3BUK A;  3E07 A;  4EC7 A;  2BHK A;  1AGQ A;  4EDX V;  4KZN A;  1WQ8 A;  1FL7 B;  1B8M B;  1SGF B;  2R53 A;  4UI2 B;  5E4G A;  1AOC A;  2ARV A;  4YCI C;  4AY9 B;  2R52 A;  4LXR J;  2PJY A;  3JVF A;  4MQW B; 
#chains in the Genus database with same CATH homology
 5JZ7 A;  4X1J A;  1BND B;  1TZH V;  5BQ8 B;  1CZ8 V;  1HD4 A;  4KV5 A;  5BPU A;  2QJB A;  4FAO A;  1BMP A;  2QCW A;  2QJ9 A;  5F3H I;  1BJ1 V;  4LXS J;  1FLT V;  1WQ9 A;  3BMP A;  5BQ8 D;  1REW A;  4HSA A;  2FJH V;  4QCI C;  3P9W A;  4EFV A;  3IJ2 A;  5HHV A;  1HRP B;  4GLN E;  1M4U A;  5HK5 A;  3HH2 A;  4UI1 A;  1XWD A;  1BTG A;  1MKG A;  5FV1 V;  4BV4 L;  1MKK A;  1DZ7 A;  5FV2 V;  3B4V A;  3MJK A;  5BQE A;  1HCN A;  4EAX A;  1TGJ A;  4EDW V;  4ZBN A;  2GYR A;  3S1K V;  5HI3 A;  4UHZ A;  1JPY A;  1NT3 A;  4GLS E;  1ZKZ A;  3BK3 A;  2VWE A;  4ZFF C;  1SG1 A;  2IFG E;  2VXS A;  2C7W A;  1S4Y B;  3EO1 C;  4HQX A;  1FL7 A;  1B8M A;  1LXI A;  1MJV A;  4QHU C;  1LX5 A;  4AY9 A;  1QFW B;  2FJG V;  2ASK A;  2H62 A;  4MQW A;  2XAC A;  2TGI A;  1BND A;  5BQ8 A;  2XV7 A;  1B98 A;  2X1W A;  4UHY A;  1TZI V;  4QAF C;  4XPJ A;  3SEK B;  5HI5 A;  1TFG A;  1E9J A;  1KTZ A;  5BQC A;  4HR9 A;  2ARP A;  4HQU A;  1HCF A;  2QJA A;  1M4U L;  1ES7 A;  1WWW V;  4YCG C;  2P6A A;  2X1X E;  3BDY V;  3MJG A;  1HRP A;  1WQ9 B;  2H64 A;  1REU A;  3QB4 A;  1VPP V;  1NYU B;  3V6B A;  2QR0 C;  5AEJ A;  1NYS B;  1WAQ A;  3QTK A;  4N1D A;  2B0U A;  2GOO A;  1BET A;  2GNN A;  1KAT W;  5HK5 E;  1PDG A;  2V5E B;  5HHD A;  4KXZ A;  3V2A A;  5HI4 A;  1XWD B;  1VPF A;  2QCQ A;  1TGK A;  3KFD A;  3RJR A;  5HHX A;  5BQE B;  1QTY R;  4UI0 A;  1HCN B;  2GYZ A;  5HHC A;  1RV6 V;  2VPF A;  4WPB A;  1B8K A;  1FZV A;  3FUB B;  1KLA A;  2KD3 A;  2GH0 C;  5BQB A;  1KLC A;  3S1B V;  3EVS B;  5F3B C;  4MID A;  1QFW A;  4MPL A;  3BUK A;  3E07 A;  4EC7 A;  2BHK A;  1AGQ A;  4EDX V;  4KZN A;  1WQ8 A;  1FL7 B;  1B8M B;  1SGF B;  2R53 A;  4UI2 B;  5E4G A;  1AOC A;  2ARV A;  4YCI C;  4AY9 B;  2R52 A;  4LXR J;  2PJY A;  3JVF A;  4MQW B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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