4AY9A

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
88
structure length
88
Chain Sequence
QDCPECTLQENPLFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of Follicle-Stimulating Hormone in Complex with the Entire Ectodomain of its Receptor.
pubmed doi rcsb
molecule tags Hormone/receptor
source organism Homo sapiens
molecule keywords GLYCOPROTEIN HORMONES, ALPHA POLYPEPTIDE
total genus 8
structure length 88
sequence length 88
chains with identical sequence D, G
ec nomenclature
pdb deposition date 2012-06-19
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 4ay9A00
5FV2V 4HR9A 1B8MA 4QAFC 2TGIA 1BNDA 3IJ2A 1TGKA 3MJGA 5FV1V 4QHUC 2H62A 1CZ8V 1SG1A 3BK3A 5HHCA 5HI3A 1E9JA 2BHKA 1RV6V 1BMPA 1REUA 2XACA 1FZVA 1XWDB 1ZKZA 1SGFB 5BQ8B 2ARPA 4FAOA 1FL7B 4XPJA 1XWDA 1AGQA 1FL7A 1TZIV 2VXSA 1KTZA 1PDGA 1KATW 1HCNB 2IFGE 1JPYA 3V6BA 2X1XE 2QCQA 2ASKA 5BQBA 3SEKB 1QFWB 3QTKA 3P9WA 4EAXA 1QFWA 2VPFA 2FJHV 4UHYA 4EDXV 2QR0C 1LX5A 4HSAA 1ES7A 5HI5A 3BUKA 4LXSJ 2C7WA 2V5EB 1LXIA 1M4UL 1BTGA 1HD4A 1WQ8A 1AOCA 1WWWV 2GYRA 5F3BC 5HHXA 1BJ1V 2KD3A 2ARVA 2B0UA 5BQ8A 5F3HI 3EVSB 1HRPB 1NT3A 1HCNA 4EDWV 1WQ9B 1HRPA 4N1DA 3EO1C 1REWA 3QB4A 3BDYV 4GLSE 4MQWB 4BV4L 4KV5A 4KZNA 2GOOA 2VWEA 4LXRJ 3S1KV 4UI1A 2GYZA 4MQWA 2R52A 4WPBA 1NYUB 5HHVA 5HK5A 1VPFA 1NYSB 3FUBB 2P6AA 1WAQA 4X1JA 3B4VA 3HH2A 2R53A 5E4GA 4GLNE 5BQEB 4HQXA 1FLTV 4YCIC 1KLAA 2XV7A 2X1WA 4UHZA 3V2AA 1BNDB 1TZHV 4AY9B 3JVFA 1S4YB 4ZBNA 3KFDA 1MKKA 2QCWA 3BMPA 3RJRA 4EC7A 1B98A 1KLCA 4AY9A 2QJBA 1MKGA 3E07A 1VPPV 3MJKA 4HQUA 2H64A 5BQ8D 2QJAA 2PJYA 1WQ9A 2GNNA 5BPUA 1B8KA 1TFGA 5AEJA 1MJVA 4ZFFC 2GH0C 1TGJA 4QCIC 4EFVA 1M4UA 4KXZA 1QTYR 5BQCA 4MPLA 1DZ7A 5HK5E 5JZ7A 2FJGV 3S1BV 1BETA 4MIDA 5BQEA 5HI4A 5HHDA 2QJ9A 1HCFA 4YCGC 4UI0A 4UI2B 1B8MB
chains in the Genus database with same CATH superfamily
5FV2V 4HR9A 1B8MA 4QAFC 2TGIA 1BNDA 3IJ2A 1TGKA 3MJGA 5FV1V 4QHUC 2H62A 1CZ8V 1SG1A 3BK3A 5HHCA 5HI3A 1E9JA 2BHKA 1RV6V 1BMPA 1REUA 2XACA 1FZVA 1XWDB 1ZKZA 1SGFB 5BQ8B 2ARPA 4FAOA 1FL7B 4XPJA 1XWDA 1AGQA 1FL7A 1TZIV 2VXSA 1KTZA 1PDGA 1KATW 1HCNB 2IFGE 1JPYA 3V6BA 2X1XE 2QCQA 2ASKA 5BQBA 3SEKB 1QFWB 3QTKA 3P9WA 4EAXA 1QFWA 2VPFA 2FJHV 4UHYA 4EDXV 2QR0C 1LX5A 4HSAA 1ES7A 5HI5A 3BUKA 4LXSJ 2C7WA 2V5EB 1LXIA 1M4UL 1BTGA 1HD4A 1WQ8A 1AOCA 1WWWV 2GYRA 5F3BC 5HHXA 1BJ1V 2KD3A 2ARVA 2B0UA 5BQ8A 5F3HI 3EVSB 1HRPB 1NT3A 1HCNA 4EDWV 1WQ9B 1HRPA 4N1DA 3EO1C 1REWA 3QB4A 3BDYV 4GLSE 4MQWB 4BV4L 4KV5A 4KZNA 2GOOA 2VWEA 4LXRJ 3S1KV 4UI1A 2GYZA 4MQWA 2R52A 4WPBA 1NYUB 5HHVA 5HK5A 1VPFA 1NYSB 3FUBB 2P6AA 1WAQA 4X1JA 3B4VA 3HH2A 2R53A 5E4GA 4GLNE 5BQEB 4HQXA 1FLTV 4YCIC 1KLAA 2XV7A 2X1WA 4UHZA 3V2AA 1BNDB 1TZHV 4AY9B 3JVFA 1S4YB 4ZBNA 3KFDA 1MKKA 2QCWA 3BMPA 3RJRA 4EC7A 1B98A 1KLCA 4AY9A 2QJBA 1MKGA 3E07A 1VPPV 3MJKA 4HQUA 2H64A 5BQ8D 2QJAA 2PJYA 1WQ9A 2GNNA 5BPUA 1B8KA 1TFGA 5AEJA 1MJVA 4ZFFC 2GH0C 1TGJA 4QCIC 4EFVA 1M4UA 4KXZA 1QTYR 5BQCA 4MPLA 1DZ7A 5HK5E 5JZ7A 2FJGV 3S1BV 1BETA 4MIDA 5BQEA 5HI4A 5HHDA 2QJ9A 1HCFA 4YCGC 4UI0A 4UI2B 1B8MB
chains in the Genus database with same CATH topology
5FV2V 4HR9A 1B8MA 4QAFC 2TGIA 1BNDA 3IJ2A 1TGKA 3MJGA 5FV1V 4QHUC 2H62A 1CZ8V 1SG1A 3BK3A 5HHCA 5HI3A 1E9JA 2BHKA 1RV6V 1BMPA 1REUA 2XACA 1FZVA 1XWDB 1ZKZA 1SGFB 5BQ8B 2ARPA 4FAOA 1FL7B 4XPJA 1XWDA 1AGQA 1FL7A 1TZIV 2VXSA 1KTZA 1PDGA 1KATW 1HCNB 2IFGE 1JPYA 3V6BA 2X1XE 2QCQA 2ASKA 5BQBA 3SEKB 1QFWB 3QTKA 3P9WA 4EAXA 1QFWA 2VPFA 2FJHV 4UHYA 4EDXV 2QR0C 1LX5A 4HSAA 1ES7A 5HI5A 3BUKA 4LXSJ 2C7WA 2V5EB 1LXIA 1M4UL 1BTGA 1HD4A 1WQ8A 1AOCA 1WWWV 2GYRA 5F3BC 5HHXA 1BJ1V 2KD3A 2ARVA 2B0UA 5BQ8A 5F3HI 3EVSB 1HRPB 1NT3A 1HCNA 4EDWV 1WQ9B 1HRPA 4N1DA 3EO1C 1REWA 3QB4A 3BDYV 4GLSE 4MQWB 4BV4L 4KV5A 4KZNA 2GOOA 2VWEA 4LXRJ 3S1KV 4UI1A 2GYZA 4MQWA 2R52A 4WPBA 1NYUB 5HHVA 5HK5A 1VPFA 1NYSB 3FUBB 2P6AA 1WAQA 4X1JA 3B4VA 3HH2A 2R53A 5E4GA 4GLNE 5BQEB 4HQXA 1FLTV 4YCIC 1KLAA 2XV7A 2X1WA 4UHZA 3V2AA 1BNDB 1TZHV 4AY9B 3JVFA 1S4YB 4ZBNA 3KFDA 1MKKA 2QCWA 3BMPA 3RJRA 4EC7A 1B98A 1KLCA 4AY9A 2QJBA 1MKGA 3E07A 1VPPV 3MJKA 4HQUA 2H64A 5BQ8D 2QJAA 2PJYA 1WQ9A 2GNNA 5BPUA 1B8KA 1TFGA 5AEJA 1MJVA 4ZFFC 2GH0C 1TGJA 4QCIC 4EFVA 1M4UA 4KXZA 1QTYR 5BQCA 4MPLA 1DZ7A 5HK5E 5JZ7A 2FJGV 3S1BV 1BETA 4MIDA 5BQEA 5HI4A 5HHDA 2QJ9A 1HCFA 4YCGC 4UI0A 4UI2B 1B8MB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FV2 V;  4HR9 A;  1B8M A;  4QAF C;  2TGI A;  1BND A;  3IJ2 A;  1TGK A;  3MJG A;  5FV1 V;  4QHU C;  2H62 A;  1CZ8 V;  1SG1 A;  3BK3 A;  5HHC A;  5HI3 A;  1E9J A;  2BHK A;  1RV6 V;  1BMP A;  1REU A;  2XAC A;  1FZV A;  1XWD B;  1ZKZ A;  1SGF B;  5BQ8 B;  2ARP A;  4FAO A;  1FL7 B;  4XPJ A;  1XWD A;  1AGQ A;  1FL7 A;  1TZI V;  2VXS A;  1KTZ A;  1PDG A;  1KAT W;  1HCN B;  2IFG E;  1JPY A;  3V6B A;  2X1X E;  2QCQ A;  2ASK A;  5BQB A;  3SEK B;  1QFW B;  3QTK A;  3P9W A;  4EAX A;  1QFW A;  2VPF A;  2FJH V;  4UHY A;  4EDX V;  2QR0 C;  1LX5 A;  4HSA A;  1ES7 A;  5HI5 A;  3BUK A;  4LXS J;  2C7W A;  2V5E B;  1LXI A;  1M4U L;  1BTG A;  1HD4 A;  1WQ8 A;  1AOC A;  1WWW V;  2GYR A;  5F3B C;  5HHX A;  1BJ1 V;  2KD3 A;  2ARV A;  2B0U A;  5BQ8 A;  5F3H I;  3EVS B;  1HRP B;  1NT3 A;  1HCN A;  4EDW V;  1WQ9 B;  1HRP A;  4N1D A;  3EO1 C;  1REW A;  3QB4 A;  3BDY V;  4GLS E;  4MQW B;  4BV4 L;  4KV5 A;  4KZN A;  2GOO A;  2VWE A;  4LXR J;  3S1K V;  4UI1 A;  2GYZ A;  4MQW A;  2R52 A;  4WPB A;  1NYU B;  5HHV A;  5HK5 A;  1VPF A;  1NYS B;  3FUB B;  2P6A A;  1WAQ A;  4X1J A;  3B4V A;  3HH2 A;  2R53 A;  5E4G A;  4GLN E;  5BQE B;  4HQX A;  1FLT V;  4YCI C;  1KLA A;  2XV7 A;  2X1W A;  4UHZ A;  3V2A A;  1BND B;  1TZH V;  4AY9 B;  3JVF A;  1S4Y B;  4ZBN A;  3KFD A;  1MKK A;  2QCW A;  3BMP A;  3RJR A;  4EC7 A;  1B98 A;  1KLC A;  4AY9 A;  2QJB A;  1MKG A;  3E07 A;  1VPP V;  3MJK A;  4HQU A;  2H64 A;  5BQ8 D;  2QJA A;  2PJY A;  1WQ9 A;  2GNN A;  5BPU A;  1B8K A;  1TFG A;  5AEJ A;  1MJV A;  4ZFF C;  2GH0 C;  1TGJ A;  4QCI C;  4EFV A;  1M4U A;  4KXZ A;  1QTY R;  5BQC A;  4MPL A;  1DZ7 A;  5HK5 E;  5JZ7 A;  2FJG V;  3S1B V;  1BET A;  4MID A;  5BQE A;  5HI4 A;  5HHD A;  2QJ9 A;  1HCF A;  4YCG C;  4UI0 A;  4UI2 B;  1B8M B; 
#chains in the Genus database with same CATH topology
 5FV2 V;  4HR9 A;  1B8M A;  4QAF C;  2TGI A;  1BND A;  3IJ2 A;  1TGK A;  3MJG A;  5FV1 V;  4QHU C;  2H62 A;  1CZ8 V;  1SG1 A;  3BK3 A;  5HHC A;  5HI3 A;  1E9J A;  2BHK A;  1RV6 V;  1BMP A;  1REU A;  2XAC A;  1FZV A;  1XWD B;  1ZKZ A;  1SGF B;  5BQ8 B;  2ARP A;  4FAO A;  1FL7 B;  4XPJ A;  1XWD A;  1AGQ A;  1FL7 A;  1TZI V;  2VXS A;  1KTZ A;  1PDG A;  1KAT W;  1HCN B;  2IFG E;  1JPY A;  3V6B A;  2X1X E;  2QCQ A;  2ASK A;  5BQB A;  3SEK B;  1QFW B;  3QTK A;  3P9W A;  4EAX A;  1QFW A;  2VPF A;  2FJH V;  4UHY A;  4EDX V;  2QR0 C;  1LX5 A;  4HSA A;  1ES7 A;  5HI5 A;  3BUK A;  4LXS J;  2C7W A;  2V5E B;  1LXI A;  1M4U L;  1BTG A;  1HD4 A;  1WQ8 A;  1AOC A;  1WWW V;  2GYR A;  5F3B C;  5HHX A;  1BJ1 V;  2KD3 A;  2ARV A;  2B0U A;  5BQ8 A;  5F3H I;  3EVS B;  1HRP B;  1NT3 A;  1HCN A;  4EDW V;  1WQ9 B;  1HRP A;  4N1D A;  3EO1 C;  1REW A;  3QB4 A;  3BDY V;  4GLS E;  4MQW B;  4BV4 L;  4KV5 A;  4KZN A;  2GOO A;  2VWE A;  4LXR J;  3S1K V;  4UI1 A;  2GYZ A;  4MQW A;  2R52 A;  4WPB A;  1NYU B;  5HHV A;  5HK5 A;  1VPF A;  1NYS B;  3FUB B;  2P6A A;  1WAQ A;  4X1J A;  3B4V A;  3HH2 A;  2R53 A;  5E4G A;  4GLN E;  5BQE B;  4HQX A;  1FLT V;  4YCI C;  1KLA A;  2XV7 A;  2X1W A;  4UHZ A;  3V2A A;  1BND B;  1TZH V;  4AY9 B;  3JVF A;  1S4Y B;  4ZBN A;  3KFD A;  1MKK A;  2QCW A;  3BMP A;  3RJR A;  4EC7 A;  1B98 A;  1KLC A;  4AY9 A;  2QJB A;  1MKG A;  3E07 A;  1VPP V;  3MJK A;  4HQU A;  2H64 A;  5BQ8 D;  2QJA A;  2PJY A;  1WQ9 A;  2GNN A;  5BPU A;  1B8K A;  1TFG A;  5AEJ A;  1MJV A;  4ZFF C;  2GH0 C;  1TGJ A;  4QCI C;  4EFV A;  1M4U A;  4KXZ A;  1QTY R;  5BQC A;  4MPL A;  1DZ7 A;  5HK5 E;  5JZ7 A;  2FJG V;  3S1B V;  1BET A;  4MID A;  5BQE A;  5HI4 A;  5HHD A;  2QJ9 A;  1HCF A;  4YCG C;  4UI0 A;  4UI2 B;  1B8M B; 
#chains in the Genus database with same CATH homology
 5FV2 V;  4HR9 A;  1B8M A;  4QAF C;  2TGI A;  1BND A;  3IJ2 A;  1TGK A;  3MJG A;  5FV1 V;  4QHU C;  2H62 A;  1CZ8 V;  1SG1 A;  3BK3 A;  5HHC A;  5HI3 A;  1E9J A;  2BHK A;  1RV6 V;  1BMP A;  1REU A;  2XAC A;  1FZV A;  1XWD B;  1ZKZ A;  1SGF B;  5BQ8 B;  2ARP A;  4FAO A;  1FL7 B;  4XPJ A;  1XWD A;  1AGQ A;  1FL7 A;  1TZI V;  2VXS A;  1KTZ A;  1PDG A;  1KAT W;  1HCN B;  2IFG E;  1JPY A;  3V6B A;  2X1X E;  2QCQ A;  2ASK A;  5BQB A;  3SEK B;  1QFW B;  3QTK A;  3P9W A;  4EAX A;  1QFW A;  2VPF A;  2FJH V;  4UHY A;  4EDX V;  2QR0 C;  1LX5 A;  4HSA A;  1ES7 A;  5HI5 A;  3BUK A;  4LXS J;  2C7W A;  2V5E B;  1LXI A;  1M4U L;  1BTG A;  1HD4 A;  1WQ8 A;  1AOC A;  1WWW V;  2GYR A;  5F3B C;  5HHX A;  1BJ1 V;  2KD3 A;  2ARV A;  2B0U A;  5BQ8 A;  5F3H I;  3EVS B;  1HRP B;  1NT3 A;  1HCN A;  4EDW V;  1WQ9 B;  1HRP A;  4N1D A;  3EO1 C;  1REW A;  3QB4 A;  3BDY V;  4GLS E;  4MQW B;  4BV4 L;  4KV5 A;  4KZN A;  2GOO A;  2VWE A;  4LXR J;  3S1K V;  4UI1 A;  2GYZ A;  4MQW A;  2R52 A;  4WPB A;  1NYU B;  5HHV A;  5HK5 A;  1VPF A;  1NYS B;  3FUB B;  2P6A A;  1WAQ A;  4X1J A;  3B4V A;  3HH2 A;  2R53 A;  5E4G A;  4GLN E;  5BQE B;  4HQX A;  1FLT V;  4YCI C;  1KLA A;  2XV7 A;  2X1W A;  4UHZ A;  3V2A A;  1BND B;  1TZH V;  4AY9 B;  3JVF A;  1S4Y B;  4ZBN A;  3KFD A;  1MKK A;  2QCW A;  3BMP A;  3RJR A;  4EC7 A;  1B98 A;  1KLC A;  4AY9 A;  2QJB A;  1MKG A;  3E07 A;  1VPP V;  3MJK A;  4HQU A;  2H64 A;  5BQ8 D;  2QJA A;  2PJY A;  1WQ9 A;  2GNN A;  5BPU A;  1B8K A;  1TFG A;  5AEJ A;  1MJV A;  4ZFF C;  2GH0 C;  1TGJ A;  4QCI C;  4EFV A;  1M4U A;  4KXZ A;  1QTY R;  5BQC A;  4MPL A;  1DZ7 A;  5HK5 E;  5JZ7 A;  2FJG V;  3S1B V;  1BET A;  4MID A;  5BQE A;  5HI4 A;  5HHD A;  2QJ9 A;  1HCF A;  4YCG C;  4UI0 A;  4UI2 B;  1B8M B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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