4EC7A

Cobra ngf in complex with lipid
Total Genus 15
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
108
structure length
108
Chain Sequence
GEHSVCDSVSAWVTKTTATDIKGNTVTVMENVNLDNKVYKEYFFETKCKNPNPEPSGCRGIDSSHWNSYCTETDTFIKALTMEGNQASWRFIRIETACVCVITKKKGN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structural and functional insights into lipid-bound nerve growth factors
pubmed doi rcsb
molecule tags Hormone
molecule keywords Venom nerve growth factor
total genus 15
structure length 108
sequence length 108
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-03-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00243 NGF Nerve growth factor family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 4ec7A00
1REWA 5BQ8A 1WWWV 4HSAA 4UHZA 1WQ8A 4ZFFC 1B8MA 5BQ8D 4UI0A 1VPFA 1BNDB 4KV5A 5E4GA 2XV7A 5F3BC 1FL7A 2VXSA 2C7WA 3SEKB 4QAFC 2QJBA 1B8KA 1B98A 1SGFB 2QCQA 1TGKA 3EO1C 5HK5E 1BJ1V 1WQ9A 3V2AA 4WPBA 2H62A 4MIDA 1QTYR 2GYRA 5BQEB 1PDGA 1E9JA 4GLSE 1FZVA 1FLTV 1CZ8V 2XACA 1HRPA 1B8MB 1XWDB 4KZNA 3P9WA 4FAOA 2V5EB 1TZHV 1XWDA 4BV4L 4HR9A 3FUBB 2ASKA 2KD3A 4YCGC 4EC7A 1FL7B 4UHYA 2P6AA 3BK3A 4HQUA 1KLAA 1MKGA 1BETA 1QFWB 3S1KV 1LXIA 5F3HI 1QFWA 3B4VA 5HHCA 1SG1A 4HQXA 2R53A 1WQ9B 4GLNE 4ZBNA 1HD4A 3EVSB 1RV6V 3MJGA 4UI1A 4AY9A 2VPFA 2H64A 3BMPA 2GOOA 2IFGE 1AOCA 3QTKA 1BTGA 1DZ7A 4EDXV 1ZKZA 4MQWA 1HRPB 5HHVA 5FV2V 1REUA 2B0UA 1TFGA 1HCFA 1MKKA 2ARPA 5BQCA 2GYZA 1VPPV 5HI3A 1M4UA 3QB4A 2QJAA 3IJ2A 2PJYA 5HHXA 4EAXA 3E07A 4MPLA 4YCIC 5AEJA 2FJHV 5BPUA 1HCNB 4QCIC 1KTZA 4AY9B 1JPYA 4LXSJ 3MJKA 4X1JA 1HCNA 3BUKA 3S1BV 2R52A 1NYUB 4EDWV 4MQWB 4N1DA 2ARVA 1S4YB 1BMPA 1LX5A 1TZIV 4KXZA 4QHUC 1ES7A 2QR0C 4EFVA 3JVFA 3HH2A 2GH0C 4UI2B 1WAQA 2TGIA 5FV1V 1MJVA 5HK5A 1BNDA 4LXRJ 3RJRA 2VWEA 2X1XE 3V6BA 2GNNA 3KFDA 4XPJA 3BDYV 1AGQA 5HI5A 2QCWA 1NT3A 5JZ7A 1KATW 2QJ9A 5HHDA 1TGJA 1M4UL 1NYSB 2X1WA 5HI4A 2BHKA 5BQBA 5BQEA 5BQ8B 1KLCA 2FJGV
chains in the Genus database with same CATH superfamily
1REWA 5BQ8A 1WWWV 4HSAA 4UHZA 1WQ8A 4ZFFC 1B8MA 5BQ8D 4UI0A 1VPFA 1BNDB 4KV5A 5E4GA 2XV7A 5F3BC 1FL7A 2VXSA 2C7WA 3SEKB 4QAFC 2QJBA 1B8KA 1B98A 1SGFB 2QCQA 1TGKA 3EO1C 5HK5E 1BJ1V 1WQ9A 3V2AA 4WPBA 2H62A 4MIDA 1QTYR 2GYRA 5BQEB 1PDGA 1E9JA 4GLSE 1FZVA 1FLTV 1CZ8V 2XACA 1HRPA 1B8MB 1XWDB 4KZNA 3P9WA 4FAOA 2V5EB 1TZHV 1XWDA 4BV4L 4HR9A 3FUBB 2ASKA 2KD3A 4YCGC 4EC7A 1FL7B 4UHYA 2P6AA 3BK3A 4HQUA 1KLAA 1MKGA 1BETA 1QFWB 3S1KV 1LXIA 5F3HI 1QFWA 3B4VA 5HHCA 1SG1A 4HQXA 2R53A 1WQ9B 4GLNE 4ZBNA 1HD4A 3EVSB 1RV6V 3MJGA 4UI1A 4AY9A 2VPFA 2H64A 3BMPA 2GOOA 2IFGE 1AOCA 3QTKA 1BTGA 1DZ7A 4EDXV 1ZKZA 4MQWA 1HRPB 5HHVA 5FV2V 1REUA 2B0UA 1TFGA 1HCFA 1MKKA 2ARPA 5BQCA 2GYZA 1VPPV 5HI3A 1M4UA 3QB4A 2QJAA 3IJ2A 2PJYA 5HHXA 4EAXA 3E07A 4MPLA 4YCIC 5AEJA 2FJHV 5BPUA 1HCNB 4QCIC 1KTZA 4AY9B 1JPYA 4LXSJ 3MJKA 4X1JA 1HCNA 3BUKA 3S1BV 2R52A 1NYUB 4EDWV 4MQWB 4N1DA 2ARVA 1S4YB 1BMPA 1LX5A 1TZIV 4KXZA 4QHUC 1ES7A 2QR0C 4EFVA 3JVFA 3HH2A 2GH0C 4UI2B 1WAQA 2TGIA 5FV1V 1MJVA 5HK5A 1BNDA 4LXRJ 3RJRA 2VWEA 2X1XE 3V6BA 2GNNA 3KFDA 4XPJA 3BDYV 1AGQA 5HI5A 2QCWA 1NT3A 5JZ7A 1KATW 2QJ9A 5HHDA 1TGJA 1M4UL 1NYSB 2X1WA 5HI4A 2BHKA 5BQBA 5BQEA 5BQ8B 1KLCA 2FJGV
chains in the Genus database with same CATH topology
1REWA 5BQ8A 1WWWV 4HSAA 4UHZA 1WQ8A 4ZFFC 1B8MA 5BQ8D 4UI0A 1VPFA 1BNDB 4KV5A 5E4GA 2XV7A 5F3BC 1FL7A 2VXSA 2C7WA 3SEKB 4QAFC 2QJBA 1B8KA 1B98A 1SGFB 2QCQA 1TGKA 3EO1C 5HK5E 1BJ1V 1WQ9A 3V2AA 4WPBA 2H62A 4MIDA 1QTYR 2GYRA 5BQEB 1PDGA 1E9JA 4GLSE 1FZVA 1FLTV 1CZ8V 2XACA 1HRPA 1B8MB 1XWDB 4KZNA 3P9WA 4FAOA 2V5EB 1TZHV 1XWDA 4BV4L 4HR9A 3FUBB 2ASKA 2KD3A 4YCGC 4EC7A 1FL7B 4UHYA 2P6AA 3BK3A 4HQUA 1KLAA 1MKGA 1BETA 1QFWB 3S1KV 1LXIA 5F3HI 1QFWA 3B4VA 5HHCA 1SG1A 4HQXA 2R53A 1WQ9B 4GLNE 4ZBNA 1HD4A 3EVSB 1RV6V 3MJGA 4UI1A 4AY9A 2VPFA 2H64A 3BMPA 2GOOA 2IFGE 1AOCA 3QTKA 1BTGA 1DZ7A 4EDXV 1ZKZA 4MQWA 1HRPB 5HHVA 5FV2V 1REUA 2B0UA 1TFGA 1HCFA 1MKKA 2ARPA 5BQCA 2GYZA 1VPPV 5HI3A 1M4UA 3QB4A 2QJAA 3IJ2A 2PJYA 5HHXA 4EAXA 3E07A 4MPLA 4YCIC 5AEJA 2FJHV 5BPUA 1HCNB 4QCIC 1KTZA 4AY9B 1JPYA 4LXSJ 3MJKA 4X1JA 1HCNA 3BUKA 3S1BV 2R52A 1NYUB 4EDWV 4MQWB 4N1DA 2ARVA 1S4YB 1BMPA 1LX5A 1TZIV 4KXZA 4QHUC 1ES7A 2QR0C 4EFVA 3JVFA 3HH2A 2GH0C 4UI2B 1WAQA 2TGIA 5FV1V 1MJVA 5HK5A 1BNDA 4LXRJ 3RJRA 2VWEA 2X1XE 3V6BA 2GNNA 3KFDA 4XPJA 3BDYV 1AGQA 5HI5A 2QCWA 1NT3A 5JZ7A 1KATW 2QJ9A 5HHDA 1TGJA 1M4UL 1NYSB 2X1WA 5HI4A 2BHKA 5BQBA 5BQEA 5BQ8B 1KLCA 2FJGV
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1REW A;  5BQ8 A;  1WWW V;  4HSA A;  4UHZ A;  1WQ8 A;  4ZFF C;  1B8M A;  5BQ8 D;  4UI0 A;  1VPF A;  1BND B;  4KV5 A;  5E4G A;  2XV7 A;  5F3B C;  1FL7 A;  2VXS A;  2C7W A;  3SEK B;  4QAF C;  2QJB A;  1B8K A;  1B98 A;  1SGF B;  2QCQ A;  1TGK A;  3EO1 C;  5HK5 E;  1BJ1 V;  1WQ9 A;  3V2A A;  4WPB A;  2H62 A;  4MID A;  1QTY R;  2GYR A;  5BQE B;  1PDG A;  1E9J A;  4GLS E;  1FZV A;  1FLT V;  1CZ8 V;  2XAC A;  1HRP A;  1B8M B;  1XWD B;  4KZN A;  3P9W A;  4FAO A;  2V5E B;  1TZH V;  1XWD A;  4BV4 L;  4HR9 A;  3FUB B;  2ASK A;  2KD3 A;  4YCG C;  4EC7 A;  1FL7 B;  4UHY A;  2P6A A;  3BK3 A;  4HQU A;  1KLA A;  1MKG A;  1BET A;  1QFW B;  3S1K V;  1LXI A;  5F3H I;  1QFW A;  3B4V A;  5HHC A;  1SG1 A;  4HQX A;  2R53 A;  1WQ9 B;  4GLN E;  4ZBN A;  1HD4 A;  3EVS B;  1RV6 V;  3MJG A;  4UI1 A;  4AY9 A;  2VPF A;  2H64 A;  3BMP A;  2GOO A;  2IFG E;  1AOC A;  3QTK A;  1BTG A;  1DZ7 A;  4EDX V;  1ZKZ A;  4MQW A;  1HRP B;  5HHV A;  5FV2 V;  1REU A;  2B0U A;  1TFG A;  1HCF A;  1MKK A;  2ARP A;  5BQC A;  2GYZ A;  1VPP V;  5HI3 A;  1M4U A;  3QB4 A;  2QJA A;  3IJ2 A;  2PJY A;  5HHX A;  4EAX A;  3E07 A;  4MPL A;  4YCI C;  5AEJ A;  2FJH V;  5BPU A;  1HCN B;  4QCI C;  1KTZ A;  4AY9 B;  1JPY A;  4LXS J;  3MJK A;  4X1J A;  1HCN A;  3BUK A;  3S1B V;  2R52 A;  1NYU B;  4EDW V;  4MQW B;  4N1D A;  2ARV A;  1S4Y B;  1BMP A;  1LX5 A;  1TZI V;  4KXZ A;  4QHU C;  1ES7 A;  2QR0 C;  4EFV A;  3JVF A;  3HH2 A;  2GH0 C;  4UI2 B;  1WAQ A;  2TGI A;  5FV1 V;  1MJV A;  5HK5 A;  1BND A;  4LXR J;  3RJR A;  2VWE A;  2X1X E;  3V6B A;  2GNN A;  3KFD A;  4XPJ A;  3BDY V;  1AGQ A;  5HI5 A;  2QCW A;  1NT3 A;  5JZ7 A;  1KAT W;  2QJ9 A;  5HHD A;  1TGJ A;  1M4U L;  1NYS B;  2X1W A;  5HI4 A;  2BHK A;  5BQB A;  5BQE A;  5BQ8 B;  1KLC A;  2FJG V; 
#chains in the Genus database with same CATH topology
 1REW A;  5BQ8 A;  1WWW V;  4HSA A;  4UHZ A;  1WQ8 A;  4ZFF C;  1B8M A;  5BQ8 D;  4UI0 A;  1VPF A;  1BND B;  4KV5 A;  5E4G A;  2XV7 A;  5F3B C;  1FL7 A;  2VXS A;  2C7W A;  3SEK B;  4QAF C;  2QJB A;  1B8K A;  1B98 A;  1SGF B;  2QCQ A;  1TGK A;  3EO1 C;  5HK5 E;  1BJ1 V;  1WQ9 A;  3V2A A;  4WPB A;  2H62 A;  4MID A;  1QTY R;  2GYR A;  5BQE B;  1PDG A;  1E9J A;  4GLS E;  1FZV A;  1FLT V;  1CZ8 V;  2XAC A;  1HRP A;  1B8M B;  1XWD B;  4KZN A;  3P9W A;  4FAO A;  2V5E B;  1TZH V;  1XWD A;  4BV4 L;  4HR9 A;  3FUB B;  2ASK A;  2KD3 A;  4YCG C;  4EC7 A;  1FL7 B;  4UHY A;  2P6A A;  3BK3 A;  4HQU A;  1KLA A;  1MKG A;  1BET A;  1QFW B;  3S1K V;  1LXI A;  5F3H I;  1QFW A;  3B4V A;  5HHC A;  1SG1 A;  4HQX A;  2R53 A;  1WQ9 B;  4GLN E;  4ZBN A;  1HD4 A;  3EVS B;  1RV6 V;  3MJG A;  4UI1 A;  4AY9 A;  2VPF A;  2H64 A;  3BMP A;  2GOO A;  2IFG E;  1AOC A;  3QTK A;  1BTG A;  1DZ7 A;  4EDX V;  1ZKZ A;  4MQW A;  1HRP B;  5HHV A;  5FV2 V;  1REU A;  2B0U A;  1TFG A;  1HCF A;  1MKK A;  2ARP A;  5BQC A;  2GYZ A;  1VPP V;  5HI3 A;  1M4U A;  3QB4 A;  2QJA A;  3IJ2 A;  2PJY A;  5HHX A;  4EAX A;  3E07 A;  4MPL A;  4YCI C;  5AEJ A;  2FJH V;  5BPU A;  1HCN B;  4QCI C;  1KTZ A;  4AY9 B;  1JPY A;  4LXS J;  3MJK A;  4X1J A;  1HCN A;  3BUK A;  3S1B V;  2R52 A;  1NYU B;  4EDW V;  4MQW B;  4N1D A;  2ARV A;  1S4Y B;  1BMP A;  1LX5 A;  1TZI V;  4KXZ A;  4QHU C;  1ES7 A;  2QR0 C;  4EFV A;  3JVF A;  3HH2 A;  2GH0 C;  4UI2 B;  1WAQ A;  2TGI A;  5FV1 V;  1MJV A;  5HK5 A;  1BND A;  4LXR J;  3RJR A;  2VWE A;  2X1X E;  3V6B A;  2GNN A;  3KFD A;  4XPJ A;  3BDY V;  1AGQ A;  5HI5 A;  2QCW A;  1NT3 A;  5JZ7 A;  1KAT W;  2QJ9 A;  5HHD A;  1TGJ A;  1M4U L;  1NYS B;  2X1W A;  5HI4 A;  2BHK A;  5BQB A;  5BQE A;  5BQ8 B;  1KLC A;  2FJG V; 
#chains in the Genus database with same CATH homology
 1REW A;  5BQ8 A;  1WWW V;  4HSA A;  4UHZ A;  1WQ8 A;  4ZFF C;  1B8M A;  5BQ8 D;  4UI0 A;  1VPF A;  1BND B;  4KV5 A;  5E4G A;  2XV7 A;  5F3B C;  1FL7 A;  2VXS A;  2C7W A;  3SEK B;  4QAF C;  2QJB A;  1B8K A;  1B98 A;  1SGF B;  2QCQ A;  1TGK A;  3EO1 C;  5HK5 E;  1BJ1 V;  1WQ9 A;  3V2A A;  4WPB A;  2H62 A;  4MID A;  1QTY R;  2GYR A;  5BQE B;  1PDG A;  1E9J A;  4GLS E;  1FZV A;  1FLT V;  1CZ8 V;  2XAC A;  1HRP A;  1B8M B;  1XWD B;  4KZN A;  3P9W A;  4FAO A;  2V5E B;  1TZH V;  1XWD A;  4BV4 L;  4HR9 A;  3FUB B;  2ASK A;  2KD3 A;  4YCG C;  4EC7 A;  1FL7 B;  4UHY A;  2P6A A;  3BK3 A;  4HQU A;  1KLA A;  1MKG A;  1BET A;  1QFW B;  3S1K V;  1LXI A;  5F3H I;  1QFW A;  3B4V A;  5HHC A;  1SG1 A;  4HQX A;  2R53 A;  1WQ9 B;  4GLN E;  4ZBN A;  1HD4 A;  3EVS B;  1RV6 V;  3MJG A;  4UI1 A;  4AY9 A;  2VPF A;  2H64 A;  3BMP A;  2GOO A;  2IFG E;  1AOC A;  3QTK A;  1BTG A;  1DZ7 A;  4EDX V;  1ZKZ A;  4MQW A;  1HRP B;  5HHV A;  5FV2 V;  1REU A;  2B0U A;  1TFG A;  1HCF A;  1MKK A;  2ARP A;  5BQC A;  2GYZ A;  1VPP V;  5HI3 A;  1M4U A;  3QB4 A;  2QJA A;  3IJ2 A;  2PJY A;  5HHX A;  4EAX A;  3E07 A;  4MPL A;  4YCI C;  5AEJ A;  2FJH V;  5BPU A;  1HCN B;  4QCI C;  1KTZ A;  4AY9 B;  1JPY A;  4LXS J;  3MJK A;  4X1J A;  1HCN A;  3BUK A;  3S1B V;  2R52 A;  1NYU B;  4EDW V;  4MQW B;  4N1D A;  2ARV A;  1S4Y B;  1BMP A;  1LX5 A;  1TZI V;  4KXZ A;  4QHU C;  1ES7 A;  2QR0 C;  4EFV A;  3JVF A;  3HH2 A;  2GH0 C;  4UI2 B;  1WAQ A;  2TGI A;  5FV1 V;  1MJV A;  5HK5 A;  1BND A;  4LXR J;  3RJR A;  2VWE A;  2X1X E;  3V6B A;  2GNN A;  3KFD A;  4XPJ A;  3BDY V;  1AGQ A;  5HI5 A;  2QCW A;  1NT3 A;  5JZ7 A;  1KAT W;  2QJ9 A;  5HHD A;  1TGJ A;  1M4U L;  1NYS B;  2X1W A;  5HI4 A;  2BHK A;  5BQB A;  5BQE A;  5BQ8 B;  1KLC A;  2FJG V; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...