4LXRJ

Structure of the toll - spatzle complex, a molecular hub in drosophila development and innate immunity
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
106
structure length
64
Chain Sequence
DERFLCRSIRKLVAIQIEECEGADQPCDFAANFPQSYNPICKQHYTQKIPSCCKCALKTGLEHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity.
pubmed doi rcsb
molecule tags Immune system/cytokine
source organism Drosophila melanogaster
molecule keywords Protein toll
total genus 9
structure length 64
sequence length 106
chains with identical sequence K
ec nomenclature
pdb deposition date 2013-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
J PF16077 Spaetzle Spaetzle
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 4lxrJ00
1REWA 1ZKZA 2R53A 3RJRA 3BMPA 4BV4L 1B8MA 1TGKA 1BNDB 5HHXA 4UI1A 5BQBA 4KXZA 4XPJA 4MIDA 3V2AA 4EFVA 4EDXV 4AY9A 2FJHV 2KD3A 2GYRA 2QCWA 3V6BA 1SGFB 2H64A 5BQ8A 1KLCA 1WQ9A 1VPFA 2VWEA 1B8KA 1M4UA 4QHUC 5FV1V 2XV7A 1KATW 4AY9B 4FAOA 5AEJA 4LXSJ 4UHZA 4N1DA 1QFWB 1E9JA 4MQWB 2PJYA 5BQCA 3BK3A 3B4VA 4EAXA 5F3BC 1CZ8V 3MJGA 1TGJA 4HQXA 2GNNA 1SG1A 4YCIC 4KZNA 1XWDA 4ZFFC 2QJAA 3E07A 3P9WA 4GLSE 1RV6V 5BQEB 2BHKA 5HHVA 3S1KV 3EVSB 4KV5A 5HK5E 1B8MB 2ASKA 2C7WA 2H62A 4QCIC 3JVFA 5HI5A 1QTYR 1BJ1V 1MKGA 5BPUA 4EC7A 5HHDA 4HQUA 1REUA 2VXSA 1XWDB 1TFGA 4UHYA 1NYUB 3SEKB 2XACA 1AOCA 3QTKA 5BQ8B 4WPBA 3EO1C 2QJBA 1KTZA 2ARPA 4HSAA 1WQ9B 1FL7A 4HR9A 2QCQA 4QAFC 3BDYV 1NT3A 1HRPA 1VPPV 3MJKA 3S1BV 1BETA 2B0UA 1AGQA 1TZIV 1HCFA 5BQ8D 1FLTV 4ZBNA 5JZ7A 1WAQA 4UI0A 1S4YB 1FL7B 2GYZA 1DZ7A 3BUKA 5FV2V 1HRPB 2QJ9A 4YCGC 1PDGA 2GH0C 5E4GA 1MKKA 1LX5A 1FZVA 1HCNA 4UI2B 4EDWV 1HD4A 1TZHV 1JPYA 1B98A 1M4UL 2ARVA 1WWWV 5F3HI 1ES7A 2GOOA 5HK5A 2X1WA 4X1JA 1LXIA 2P6AA 3QB4A 1QFWA 2FJGV 4MQWA 1HCNB 2TGIA 3KFDA 3FUBB 5HI3A 4GLNE 2QR0C 1BMPA 1KLAA 1BNDA 5HI4A 4MPLA 3HH2A 2X1XE 1WQ8A 1MJVA 3IJ2A 4LXRJ 2VPFA 5HHCA 2V5EB 1BTGA 5BQEA 2R52A 2IFGE 1NYSB
chains in the Genus database with same CATH superfamily
1REWA 1ZKZA 2R53A 3RJRA 3BMPA 4BV4L 1B8MA 1TGKA 1BNDB 5HHXA 4UI1A 5BQBA 4KXZA 4XPJA 4MIDA 3V2AA 4EFVA 4EDXV 4AY9A 2FJHV 2KD3A 2GYRA 2QCWA 3V6BA 1SGFB 2H64A 5BQ8A 1KLCA 1WQ9A 1VPFA 2VWEA 1B8KA 1M4UA 4QHUC 5FV1V 2XV7A 1KATW 4AY9B 4FAOA 5AEJA 4LXSJ 4UHZA 4N1DA 1QFWB 1E9JA 4MQWB 2PJYA 5BQCA 3BK3A 3B4VA 4EAXA 5F3BC 1CZ8V 3MJGA 1TGJA 4HQXA 2GNNA 1SG1A 4YCIC 4KZNA 1XWDA 4ZFFC 2QJAA 3E07A 3P9WA 4GLSE 1RV6V 5BQEB 2BHKA 5HHVA 3S1KV 3EVSB 4KV5A 5HK5E 1B8MB 2ASKA 2C7WA 2H62A 4QCIC 3JVFA 5HI5A 1QTYR 1BJ1V 1MKGA 5BPUA 4EC7A 5HHDA 4HQUA 1REUA 2VXSA 1XWDB 1TFGA 4UHYA 1NYUB 3SEKB 2XACA 1AOCA 3QTKA 5BQ8B 4WPBA 3EO1C 2QJBA 1KTZA 2ARPA 4HSAA 1WQ9B 1FL7A 4HR9A 2QCQA 4QAFC 3BDYV 1NT3A 1HRPA 1VPPV 3MJKA 3S1BV 1BETA 2B0UA 1AGQA 1TZIV 1HCFA 5BQ8D 1FLTV 4ZBNA 5JZ7A 1WAQA 4UI0A 1S4YB 1FL7B 2GYZA 1DZ7A 3BUKA 5FV2V 1HRPB 2QJ9A 4YCGC 1PDGA 2GH0C 5E4GA 1MKKA 1LX5A 1FZVA 1HCNA 4UI2B 4EDWV 1HD4A 1TZHV 1JPYA 1B98A 1M4UL 2ARVA 1WWWV 5F3HI 1ES7A 2GOOA 5HK5A 2X1WA 4X1JA 1LXIA 2P6AA 3QB4A 1QFWA 2FJGV 4MQWA 1HCNB 2TGIA 3KFDA 3FUBB 5HI3A 4GLNE 2QR0C 1BMPA 1KLAA 1BNDA 5HI4A 4MPLA 3HH2A 2X1XE 1WQ8A 1MJVA 3IJ2A 4LXRJ 2VPFA 5HHCA 2V5EB 1BTGA 5BQEA 2R52A 2IFGE 1NYSB
chains in the Genus database with same CATH topology
1REWA 1ZKZA 2R53A 3RJRA 3BMPA 4BV4L 1B8MA 1TGKA 1BNDB 5HHXA 4UI1A 5BQBA 4KXZA 4XPJA 4MIDA 3V2AA 4EFVA 4EDXV 4AY9A 2FJHV 2KD3A 2GYRA 2QCWA 3V6BA 1SGFB 2H64A 5BQ8A 1KLCA 1WQ9A 1VPFA 2VWEA 1B8KA 1M4UA 4QHUC 5FV1V 2XV7A 1KATW 4AY9B 4FAOA 5AEJA 4LXSJ 4UHZA 4N1DA 1QFWB 1E9JA 4MQWB 2PJYA 5BQCA 3BK3A 3B4VA 4EAXA 5F3BC 1CZ8V 3MJGA 1TGJA 4HQXA 2GNNA 1SG1A 4YCIC 4KZNA 1XWDA 4ZFFC 2QJAA 3E07A 3P9WA 4GLSE 1RV6V 5BQEB 2BHKA 5HHVA 3S1KV 3EVSB 4KV5A 5HK5E 1B8MB 2ASKA 2C7WA 2H62A 4QCIC 3JVFA 5HI5A 1QTYR 1BJ1V 1MKGA 5BPUA 4EC7A 5HHDA 4HQUA 1REUA 2VXSA 1XWDB 1TFGA 4UHYA 1NYUB 3SEKB 2XACA 1AOCA 3QTKA 5BQ8B 4WPBA 3EO1C 2QJBA 1KTZA 2ARPA 4HSAA 1WQ9B 1FL7A 4HR9A 2QCQA 4QAFC 3BDYV 1NT3A 1HRPA 1VPPV 3MJKA 3S1BV 1BETA 2B0UA 1AGQA 1TZIV 1HCFA 5BQ8D 1FLTV 4ZBNA 5JZ7A 1WAQA 4UI0A 1S4YB 1FL7B 2GYZA 1DZ7A 3BUKA 5FV2V 1HRPB 2QJ9A 4YCGC 1PDGA 2GH0C 5E4GA 1MKKA 1LX5A 1FZVA 1HCNA 4UI2B 4EDWV 1HD4A 1TZHV 1JPYA 1B98A 1M4UL 2ARVA 1WWWV 5F3HI 1ES7A 2GOOA 5HK5A 2X1WA 4X1JA 1LXIA 2P6AA 3QB4A 1QFWA 2FJGV 4MQWA 1HCNB 2TGIA 3KFDA 3FUBB 5HI3A 4GLNE 2QR0C 1BMPA 1KLAA 1BNDA 5HI4A 4MPLA 3HH2A 2X1XE 1WQ8A 1MJVA 3IJ2A 4LXRJ 2VPFA 5HHCA 2V5EB 1BTGA 5BQEA 2R52A 2IFGE 1NYSB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1REW A;  1ZKZ A;  2R53 A;  3RJR A;  3BMP A;  4BV4 L;  1B8M A;  1TGK A;  1BND B;  5HHX A;  4UI1 A;  5BQB A;  4KXZ A;  4XPJ A;  4MID A;  3V2A A;  4EFV A;  4EDX V;  4AY9 A;  2FJH V;  2KD3 A;  2GYR A;  2QCW A;  3V6B A;  1SGF B;  2H64 A;  5BQ8 A;  1KLC A;  1WQ9 A;  1VPF A;  2VWE A;  1B8K A;  1M4U A;  4QHU C;  5FV1 V;  2XV7 A;  1KAT W;  4AY9 B;  4FAO A;  5AEJ A;  4LXS J;  4UHZ A;  4N1D A;  1QFW B;  1E9J A;  4MQW B;  2PJY A;  5BQC A;  3BK3 A;  3B4V A;  4EAX A;  5F3B C;  1CZ8 V;  3MJG A;  1TGJ A;  4HQX A;  2GNN A;  1SG1 A;  4YCI C;  4KZN A;  1XWD A;  4ZFF C;  2QJA A;  3E07 A;  3P9W A;  4GLS E;  1RV6 V;  5BQE B;  2BHK A;  5HHV A;  3S1K V;  3EVS B;  4KV5 A;  5HK5 E;  1B8M B;  2ASK A;  2C7W A;  2H62 A;  4QCI C;  3JVF A;  5HI5 A;  1QTY R;  1BJ1 V;  1MKG A;  5BPU A;  4EC7 A;  5HHD A;  4HQU A;  1REU A;  2VXS A;  1XWD B;  1TFG A;  4UHY A;  1NYU B;  3SEK B;  2XAC A;  1AOC A;  3QTK A;  5BQ8 B;  4WPB A;  3EO1 C;  2QJB A;  1KTZ A;  2ARP A;  4HSA A;  1WQ9 B;  1FL7 A;  4HR9 A;  2QCQ A;  4QAF C;  3BDY V;  1NT3 A;  1HRP A;  1VPP V;  3MJK A;  3S1B V;  1BET A;  2B0U A;  1AGQ A;  1TZI V;  1HCF A;  5BQ8 D;  1FLT V;  4ZBN A;  5JZ7 A;  1WAQ A;  4UI0 A;  1S4Y B;  1FL7 B;  2GYZ A;  1DZ7 A;  3BUK A;  5FV2 V;  1HRP B;  2QJ9 A;  4YCG C;  1PDG A;  2GH0 C;  5E4G A;  1MKK A;  1LX5 A;  1FZV A;  1HCN A;  4UI2 B;  4EDW V;  1HD4 A;  1TZH V;  1JPY A;  1B98 A;  1M4U L;  2ARV A;  1WWW V;  5F3H I;  1ES7 A;  2GOO A;  5HK5 A;  2X1W A;  4X1J A;  1LXI A;  2P6A A;  3QB4 A;  1QFW A;  2FJG V;  4MQW A;  1HCN B;  2TGI A;  3KFD A;  3FUB B;  5HI3 A;  4GLN E;  2QR0 C;  1BMP A;  1KLA A;  1BND A;  5HI4 A;  4MPL A;  3HH2 A;  2X1X E;  1WQ8 A;  1MJV A;  3IJ2 A;  4LXR J;  2VPF A;  5HHC A;  2V5E B;  1BTG A;  5BQE A;  2R52 A;  2IFG E;  1NYS B; 
#chains in the Genus database with same CATH topology
 1REW A;  1ZKZ A;  2R53 A;  3RJR A;  3BMP A;  4BV4 L;  1B8M A;  1TGK A;  1BND B;  5HHX A;  4UI1 A;  5BQB A;  4KXZ A;  4XPJ A;  4MID A;  3V2A A;  4EFV A;  4EDX V;  4AY9 A;  2FJH V;  2KD3 A;  2GYR A;  2QCW A;  3V6B A;  1SGF B;  2H64 A;  5BQ8 A;  1KLC A;  1WQ9 A;  1VPF A;  2VWE A;  1B8K A;  1M4U A;  4QHU C;  5FV1 V;  2XV7 A;  1KAT W;  4AY9 B;  4FAO A;  5AEJ A;  4LXS J;  4UHZ A;  4N1D A;  1QFW B;  1E9J A;  4MQW B;  2PJY A;  5BQC A;  3BK3 A;  3B4V A;  4EAX A;  5F3B C;  1CZ8 V;  3MJG A;  1TGJ A;  4HQX A;  2GNN A;  1SG1 A;  4YCI C;  4KZN A;  1XWD A;  4ZFF C;  2QJA A;  3E07 A;  3P9W A;  4GLS E;  1RV6 V;  5BQE B;  2BHK A;  5HHV A;  3S1K V;  3EVS B;  4KV5 A;  5HK5 E;  1B8M B;  2ASK A;  2C7W A;  2H62 A;  4QCI C;  3JVF A;  5HI5 A;  1QTY R;  1BJ1 V;  1MKG A;  5BPU A;  4EC7 A;  5HHD A;  4HQU A;  1REU A;  2VXS A;  1XWD B;  1TFG A;  4UHY A;  1NYU B;  3SEK B;  2XAC A;  1AOC A;  3QTK A;  5BQ8 B;  4WPB A;  3EO1 C;  2QJB A;  1KTZ A;  2ARP A;  4HSA A;  1WQ9 B;  1FL7 A;  4HR9 A;  2QCQ A;  4QAF C;  3BDY V;  1NT3 A;  1HRP A;  1VPP V;  3MJK A;  3S1B V;  1BET A;  2B0U A;  1AGQ A;  1TZI V;  1HCF A;  5BQ8 D;  1FLT V;  4ZBN A;  5JZ7 A;  1WAQ A;  4UI0 A;  1S4Y B;  1FL7 B;  2GYZ A;  1DZ7 A;  3BUK A;  5FV2 V;  1HRP B;  2QJ9 A;  4YCG C;  1PDG A;  2GH0 C;  5E4G A;  1MKK A;  1LX5 A;  1FZV A;  1HCN A;  4UI2 B;  4EDW V;  1HD4 A;  1TZH V;  1JPY A;  1B98 A;  1M4U L;  2ARV A;  1WWW V;  5F3H I;  1ES7 A;  2GOO A;  5HK5 A;  2X1W A;  4X1J A;  1LXI A;  2P6A A;  3QB4 A;  1QFW A;  2FJG V;  4MQW A;  1HCN B;  2TGI A;  3KFD A;  3FUB B;  5HI3 A;  4GLN E;  2QR0 C;  1BMP A;  1KLA A;  1BND A;  5HI4 A;  4MPL A;  3HH2 A;  2X1X E;  1WQ8 A;  1MJV A;  3IJ2 A;  4LXR J;  2VPF A;  5HHC A;  2V5E B;  1BTG A;  5BQE A;  2R52 A;  2IFG E;  1NYS B; 
#chains in the Genus database with same CATH homology
 1REW A;  1ZKZ A;  2R53 A;  3RJR A;  3BMP A;  4BV4 L;  1B8M A;  1TGK A;  1BND B;  5HHX A;  4UI1 A;  5BQB A;  4KXZ A;  4XPJ A;  4MID A;  3V2A A;  4EFV A;  4EDX V;  4AY9 A;  2FJH V;  2KD3 A;  2GYR A;  2QCW A;  3V6B A;  1SGF B;  2H64 A;  5BQ8 A;  1KLC A;  1WQ9 A;  1VPF A;  2VWE A;  1B8K A;  1M4U A;  4QHU C;  5FV1 V;  2XV7 A;  1KAT W;  4AY9 B;  4FAO A;  5AEJ A;  4LXS J;  4UHZ A;  4N1D A;  1QFW B;  1E9J A;  4MQW B;  2PJY A;  5BQC A;  3BK3 A;  3B4V A;  4EAX A;  5F3B C;  1CZ8 V;  3MJG A;  1TGJ A;  4HQX A;  2GNN A;  1SG1 A;  4YCI C;  4KZN A;  1XWD A;  4ZFF C;  2QJA A;  3E07 A;  3P9W A;  4GLS E;  1RV6 V;  5BQE B;  2BHK A;  5HHV A;  3S1K V;  3EVS B;  4KV5 A;  5HK5 E;  1B8M B;  2ASK A;  2C7W A;  2H62 A;  4QCI C;  3JVF A;  5HI5 A;  1QTY R;  1BJ1 V;  1MKG A;  5BPU A;  4EC7 A;  5HHD A;  4HQU A;  1REU A;  2VXS A;  1XWD B;  1TFG A;  4UHY A;  1NYU B;  3SEK B;  2XAC A;  1AOC A;  3QTK A;  5BQ8 B;  4WPB A;  3EO1 C;  2QJB A;  1KTZ A;  2ARP A;  4HSA A;  1WQ9 B;  1FL7 A;  4HR9 A;  2QCQ A;  4QAF C;  3BDY V;  1NT3 A;  1HRP A;  1VPP V;  3MJK A;  3S1B V;  1BET A;  2B0U A;  1AGQ A;  1TZI V;  1HCF A;  5BQ8 D;  1FLT V;  4ZBN A;  5JZ7 A;  1WAQ A;  4UI0 A;  1S4Y B;  1FL7 B;  2GYZ A;  1DZ7 A;  3BUK A;  5FV2 V;  1HRP B;  2QJ9 A;  4YCG C;  1PDG A;  2GH0 C;  5E4G A;  1MKK A;  1LX5 A;  1FZV A;  1HCN A;  4UI2 B;  4EDW V;  1HD4 A;  1TZH V;  1JPY A;  1B98 A;  1M4U L;  2ARV A;  1WWW V;  5F3H I;  1ES7 A;  2GOO A;  5HK5 A;  2X1W A;  4X1J A;  1LXI A;  2P6A A;  3QB4 A;  1QFW A;  2FJG V;  4MQW A;  1HCN B;  2TGI A;  3KFD A;  3FUB B;  5HI3 A;  4GLN E;  2QR0 C;  1BMP A;  1KLA A;  1BND A;  5HI4 A;  4MPL A;  3HH2 A;  2X1X E;  1WQ8 A;  1MJV A;  3IJ2 A;  4LXR J;  2VPF A;  5HHC A;  2V5E B;  1BTG A;  5BQE A;  2R52 A;  2IFG E;  1NYS B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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