4MQWB

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (p31)
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
109
structure length
109
Chain Sequence
NSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPSYCSFGEM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Glycoprotein hormones, alpha polypeptide
total genus 11
structure length 109
sequence length 109
chains with identical sequence E, H
ec nomenclature
pdb deposition date 2013-09-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 4mqwB00
1KTZA 1TGJA 1XWDA 3QTKA 2IFGE 5HI5A 5HI3A 4LXSJ 2P6AA 1ZKZA 1KLAA 1VPPV 2X1WA 5FV2V 1HCNA 1DZ7A 2PJYA 4GLSE 2QR0C 4HQUA 1PDGA 1KATW 5BQ8B 1MJVA 3V2AA 4FAOA 3BDYV 4YCIC 1QFWB 5BQ8A 3BK3A 4HQXA 1MKKA 4MQWB 4KXZA 5HHDA 2GOOA 5BQEB 3BMPA 2BHKA 1FL7B 1REWA 1BNDB 2QJAA 5F3BC 1REUA 2FJGV 1FL7A 4GLNE 1BNDA 1S4YB 5E4GA 2B0UA 1BMPA 3E07A 4MIDA 1BJ1V 1B8KA 2VWEA 1WQ9B 2VPFA 5BQBA 1WWWV 2GYRA 1FZVA 1NYUB 4EDXV 4UI1A 1RV6V 2VXSA 3S1BV 4EAXA 5BQCA 4UI2B 1QFWA 5FV1V 2TGIA 1M4UA 1BTGA 1B8MB 1TZIV 1LXIA 1TFGA 2H62A 2KD3A 3B4VA 2QCQA 2X1XE 4HR9A 4QHUC 3FUBB 4MQWA 4EDWV 5AEJA 1CZ8V 3KFDA 1B8MA 4QCIC 1WAQA 1HCFA 3EO1C 3HH2A 5BQEA 1E9JA 4HSAA 1NT3A 4UHZA 2QCWA 4AY9B 4KV5A 3IJ2A 4LXRJ 4AY9A 1SG1A 3V6BA 1WQ8A 4KZNA 4N1DA 1JPYA 1AOCA 5HHCA 3S1KV 5BQ8D 1WQ9A 1KLCA 4X1JA 1FLTV 4UHYA 1HRPB 1TZHV 2R53A 4ZFFC 2GYZA 4QAFC 1LX5A 1NYSB 2GH0C 5HI4A 5HHXA 1M4UL 4MPLA 1XWDB 4XPJA 5HK5E 3QB4A 1BETA 1HCNB 2V5EB 2H64A 3P9WA 4UI0A 2QJ9A 2ARVA 2GNNA 4ZBNA 4YCGC 4EC7A 5JZ7A 3RJRA 2ASKA 3EVSB 5HK5A 5BPUA 2QJBA 4WPBA 2FJHV 5HHVA 4BV4L 1VPFA 3SEKB 2R52A 3JVFA 2C7WA 2ARPA 1ES7A 3MJKA 1HRPA 2XACA 2XV7A 1TGKA 4EFVA 1AGQA 3MJGA 1SGFB 3BUKA 1QTYR 5F3HI 1MKGA 1B98A 1HD4A
chains in the Genus database with same CATH superfamily
1KTZA 1TGJA 1XWDA 3QTKA 2IFGE 5HI5A 5HI3A 4LXSJ 2P6AA 1ZKZA 1KLAA 1VPPV 2X1WA 5FV2V 1HCNA 1DZ7A 2PJYA 4GLSE 2QR0C 4HQUA 1PDGA 1KATW 5BQ8B 1MJVA 3V2AA 4FAOA 3BDYV 4YCIC 1QFWB 5BQ8A 3BK3A 4HQXA 1MKKA 4MQWB 4KXZA 5HHDA 2GOOA 5BQEB 3BMPA 2BHKA 1FL7B 1REWA 1BNDB 2QJAA 5F3BC 1REUA 2FJGV 1FL7A 4GLNE 1BNDA 1S4YB 5E4GA 2B0UA 1BMPA 3E07A 4MIDA 1BJ1V 1B8KA 2VWEA 1WQ9B 2VPFA 5BQBA 1WWWV 2GYRA 1FZVA 1NYUB 4EDXV 4UI1A 1RV6V 2VXSA 3S1BV 4EAXA 5BQCA 4UI2B 1QFWA 5FV1V 2TGIA 1M4UA 1BTGA 1B8MB 1TZIV 1LXIA 1TFGA 2H62A 2KD3A 3B4VA 2QCQA 2X1XE 4HR9A 4QHUC 3FUBB 4MQWA 4EDWV 5AEJA 1CZ8V 3KFDA 1B8MA 4QCIC 1WAQA 1HCFA 3EO1C 3HH2A 5BQEA 1E9JA 4HSAA 1NT3A 4UHZA 2QCWA 4AY9B 4KV5A 3IJ2A 4LXRJ 4AY9A 1SG1A 3V6BA 1WQ8A 4KZNA 4N1DA 1JPYA 1AOCA 5HHCA 3S1KV 5BQ8D 1WQ9A 1KLCA 4X1JA 1FLTV 4UHYA 1HRPB 1TZHV 2R53A 4ZFFC 2GYZA 4QAFC 1LX5A 1NYSB 2GH0C 5HI4A 5HHXA 1M4UL 4MPLA 1XWDB 4XPJA 5HK5E 3QB4A 1BETA 1HCNB 2V5EB 2H64A 3P9WA 4UI0A 2QJ9A 2ARVA 2GNNA 4ZBNA 4YCGC 4EC7A 5JZ7A 3RJRA 2ASKA 3EVSB 5HK5A 5BPUA 2QJBA 4WPBA 2FJHV 5HHVA 4BV4L 1VPFA 3SEKB 2R52A 3JVFA 2C7WA 2ARPA 1ES7A 3MJKA 1HRPA 2XACA 2XV7A 1TGKA 4EFVA 1AGQA 3MJGA 1SGFB 3BUKA 1QTYR 5F3HI 1MKGA 1B98A 1HD4A
chains in the Genus database with same CATH topology
1KTZA 1TGJA 1XWDA 3QTKA 2IFGE 5HI5A 5HI3A 4LXSJ 2P6AA 1ZKZA 1KLAA 1VPPV 2X1WA 5FV2V 1HCNA 1DZ7A 2PJYA 4GLSE 2QR0C 4HQUA 1PDGA 1KATW 5BQ8B 1MJVA 3V2AA 4FAOA 3BDYV 4YCIC 1QFWB 5BQ8A 3BK3A 4HQXA 1MKKA 4MQWB 4KXZA 5HHDA 2GOOA 5BQEB 3BMPA 2BHKA 1FL7B 1REWA 1BNDB 2QJAA 5F3BC 1REUA 2FJGV 1FL7A 4GLNE 1BNDA 1S4YB 5E4GA 2B0UA 1BMPA 3E07A 4MIDA 1BJ1V 1B8KA 2VWEA 1WQ9B 2VPFA 5BQBA 1WWWV 2GYRA 1FZVA 1NYUB 4EDXV 4UI1A 1RV6V 2VXSA 3S1BV 4EAXA 5BQCA 4UI2B 1QFWA 5FV1V 2TGIA 1M4UA 1BTGA 1B8MB 1TZIV 1LXIA 1TFGA 2H62A 2KD3A 3B4VA 2QCQA 2X1XE 4HR9A 4QHUC 3FUBB 4MQWA 4EDWV 5AEJA 1CZ8V 3KFDA 1B8MA 4QCIC 1WAQA 1HCFA 3EO1C 3HH2A 5BQEA 1E9JA 4HSAA 1NT3A 4UHZA 2QCWA 4AY9B 4KV5A 3IJ2A 4LXRJ 4AY9A 1SG1A 3V6BA 1WQ8A 4KZNA 4N1DA 1JPYA 1AOCA 5HHCA 3S1KV 5BQ8D 1WQ9A 1KLCA 4X1JA 1FLTV 4UHYA 1HRPB 1TZHV 2R53A 4ZFFC 2GYZA 4QAFC 1LX5A 1NYSB 2GH0C 5HI4A 5HHXA 1M4UL 4MPLA 1XWDB 4XPJA 5HK5E 3QB4A 1BETA 1HCNB 2V5EB 2H64A 3P9WA 4UI0A 2QJ9A 2ARVA 2GNNA 4ZBNA 4YCGC 4EC7A 5JZ7A 3RJRA 2ASKA 3EVSB 5HK5A 5BPUA 2QJBA 4WPBA 2FJHV 5HHVA 4BV4L 1VPFA 3SEKB 2R52A 3JVFA 2C7WA 2ARPA 1ES7A 3MJKA 1HRPA 2XACA 2XV7A 1TGKA 4EFVA 1AGQA 3MJGA 1SGFB 3BUKA 1QTYR 5F3HI 1MKGA 1B98A 1HD4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KTZ A;  1TGJ A;  1XWD A;  3QTK A;  2IFG E;  5HI5 A;  5HI3 A;  4LXS J;  2P6A A;  1ZKZ A;  1KLA A;  1VPP V;  2X1W A;  5FV2 V;  1HCN A;  1DZ7 A;  2PJY A;  4GLS E;  2QR0 C;  4HQU A;  1PDG A;  1KAT W;  5BQ8 B;  1MJV A;  3V2A A;  4FAO A;  3BDY V;  4YCI C;  1QFW B;  5BQ8 A;  3BK3 A;  4HQX A;  1MKK A;  4MQW B;  4KXZ A;  5HHD A;  2GOO A;  5BQE B;  3BMP A;  2BHK A;  1FL7 B;  1REW A;  1BND B;  2QJA A;  5F3B C;  1REU A;  2FJG V;  1FL7 A;  4GLN E;  1BND A;  1S4Y B;  5E4G A;  2B0U A;  1BMP A;  3E07 A;  4MID A;  1BJ1 V;  1B8K A;  2VWE A;  1WQ9 B;  2VPF A;  5BQB A;  1WWW V;  2GYR A;  1FZV A;  1NYU B;  4EDX V;  4UI1 A;  1RV6 V;  2VXS A;  3S1B V;  4EAX A;  5BQC A;  4UI2 B;  1QFW A;  5FV1 V;  2TGI A;  1M4U A;  1BTG A;  1B8M B;  1TZI V;  1LXI A;  1TFG A;  2H62 A;  2KD3 A;  3B4V A;  2QCQ A;  2X1X E;  4HR9 A;  4QHU C;  3FUB B;  4MQW A;  4EDW V;  5AEJ A;  1CZ8 V;  3KFD A;  1B8M A;  4QCI C;  1WAQ A;  1HCF A;  3EO1 C;  3HH2 A;  5BQE A;  1E9J A;  4HSA A;  1NT3 A;  4UHZ A;  2QCW A;  4AY9 B;  4KV5 A;  3IJ2 A;  4LXR J;  4AY9 A;  1SG1 A;  3V6B A;  1WQ8 A;  4KZN A;  4N1D A;  1JPY A;  1AOC A;  5HHC A;  3S1K V;  5BQ8 D;  1WQ9 A;  1KLC A;  4X1J A;  1FLT V;  4UHY A;  1HRP B;  1TZH V;  2R53 A;  4ZFF C;  2GYZ A;  4QAF C;  1LX5 A;  1NYS B;  2GH0 C;  5HI4 A;  5HHX A;  1M4U L;  4MPL A;  1XWD B;  4XPJ A;  5HK5 E;  3QB4 A;  1BET A;  1HCN B;  2V5E B;  2H64 A;  3P9W A;  4UI0 A;  2QJ9 A;  2ARV A;  2GNN A;  4ZBN A;  4YCG C;  4EC7 A;  5JZ7 A;  3RJR A;  2ASK A;  3EVS B;  5HK5 A;  5BPU A;  2QJB A;  4WPB A;  2FJH V;  5HHV A;  4BV4 L;  1VPF A;  3SEK B;  2R52 A;  3JVF A;  2C7W A;  2ARP A;  1ES7 A;  3MJK A;  1HRP A;  2XAC A;  2XV7 A;  1TGK A;  4EFV A;  1AGQ A;  3MJG A;  1SGF B;  3BUK A;  1QTY R;  5F3H I;  1MKG A;  1B98 A;  1HD4 A; 
#chains in the Genus database with same CATH topology
 1KTZ A;  1TGJ A;  1XWD A;  3QTK A;  2IFG E;  5HI5 A;  5HI3 A;  4LXS J;  2P6A A;  1ZKZ A;  1KLA A;  1VPP V;  2X1W A;  5FV2 V;  1HCN A;  1DZ7 A;  2PJY A;  4GLS E;  2QR0 C;  4HQU A;  1PDG A;  1KAT W;  5BQ8 B;  1MJV A;  3V2A A;  4FAO A;  3BDY V;  4YCI C;  1QFW B;  5BQ8 A;  3BK3 A;  4HQX A;  1MKK A;  4MQW B;  4KXZ A;  5HHD A;  2GOO A;  5BQE B;  3BMP A;  2BHK A;  1FL7 B;  1REW A;  1BND B;  2QJA A;  5F3B C;  1REU A;  2FJG V;  1FL7 A;  4GLN E;  1BND A;  1S4Y B;  5E4G A;  2B0U A;  1BMP A;  3E07 A;  4MID A;  1BJ1 V;  1B8K A;  2VWE A;  1WQ9 B;  2VPF A;  5BQB A;  1WWW V;  2GYR A;  1FZV A;  1NYU B;  4EDX V;  4UI1 A;  1RV6 V;  2VXS A;  3S1B V;  4EAX A;  5BQC A;  4UI2 B;  1QFW A;  5FV1 V;  2TGI A;  1M4U A;  1BTG A;  1B8M B;  1TZI V;  1LXI A;  1TFG A;  2H62 A;  2KD3 A;  3B4V A;  2QCQ A;  2X1X E;  4HR9 A;  4QHU C;  3FUB B;  4MQW A;  4EDW V;  5AEJ A;  1CZ8 V;  3KFD A;  1B8M A;  4QCI C;  1WAQ A;  1HCF A;  3EO1 C;  3HH2 A;  5BQE A;  1E9J A;  4HSA A;  1NT3 A;  4UHZ A;  2QCW A;  4AY9 B;  4KV5 A;  3IJ2 A;  4LXR J;  4AY9 A;  1SG1 A;  3V6B A;  1WQ8 A;  4KZN A;  4N1D A;  1JPY A;  1AOC A;  5HHC A;  3S1K V;  5BQ8 D;  1WQ9 A;  1KLC A;  4X1J A;  1FLT V;  4UHY A;  1HRP B;  1TZH V;  2R53 A;  4ZFF C;  2GYZ A;  4QAF C;  1LX5 A;  1NYS B;  2GH0 C;  5HI4 A;  5HHX A;  1M4U L;  4MPL A;  1XWD B;  4XPJ A;  5HK5 E;  3QB4 A;  1BET A;  1HCN B;  2V5E B;  2H64 A;  3P9W A;  4UI0 A;  2QJ9 A;  2ARV A;  2GNN A;  4ZBN A;  4YCG C;  4EC7 A;  5JZ7 A;  3RJR A;  2ASK A;  3EVS B;  5HK5 A;  5BPU A;  2QJB A;  4WPB A;  2FJH V;  5HHV A;  4BV4 L;  1VPF A;  3SEK B;  2R52 A;  3JVF A;  2C7W A;  2ARP A;  1ES7 A;  3MJK A;  1HRP A;  2XAC A;  2XV7 A;  1TGK A;  4EFV A;  1AGQ A;  3MJG A;  1SGF B;  3BUK A;  1QTY R;  5F3H I;  1MKG A;  1B98 A;  1HD4 A; 
#chains in the Genus database with same CATH homology
 1KTZ A;  1TGJ A;  1XWD A;  3QTK A;  2IFG E;  5HI5 A;  5HI3 A;  4LXS J;  2P6A A;  1ZKZ A;  1KLA A;  1VPP V;  2X1W A;  5FV2 V;  1HCN A;  1DZ7 A;  2PJY A;  4GLS E;  2QR0 C;  4HQU A;  1PDG A;  1KAT W;  5BQ8 B;  1MJV A;  3V2A A;  4FAO A;  3BDY V;  4YCI C;  1QFW B;  5BQ8 A;  3BK3 A;  4HQX A;  1MKK A;  4MQW B;  4KXZ A;  5HHD A;  2GOO A;  5BQE B;  3BMP A;  2BHK A;  1FL7 B;  1REW A;  1BND B;  2QJA A;  5F3B C;  1REU A;  2FJG V;  1FL7 A;  4GLN E;  1BND A;  1S4Y B;  5E4G A;  2B0U A;  1BMP A;  3E07 A;  4MID A;  1BJ1 V;  1B8K A;  2VWE A;  1WQ9 B;  2VPF A;  5BQB A;  1WWW V;  2GYR A;  1FZV A;  1NYU B;  4EDX V;  4UI1 A;  1RV6 V;  2VXS A;  3S1B V;  4EAX A;  5BQC A;  4UI2 B;  1QFW A;  5FV1 V;  2TGI A;  1M4U A;  1BTG A;  1B8M B;  1TZI V;  1LXI A;  1TFG A;  2H62 A;  2KD3 A;  3B4V A;  2QCQ A;  2X1X E;  4HR9 A;  4QHU C;  3FUB B;  4MQW A;  4EDW V;  5AEJ A;  1CZ8 V;  3KFD A;  1B8M A;  4QCI C;  1WAQ A;  1HCF A;  3EO1 C;  3HH2 A;  5BQE A;  1E9J A;  4HSA A;  1NT3 A;  4UHZ A;  2QCW A;  4AY9 B;  4KV5 A;  3IJ2 A;  4LXR J;  4AY9 A;  1SG1 A;  3V6B A;  1WQ8 A;  4KZN A;  4N1D A;  1JPY A;  1AOC A;  5HHC A;  3S1K V;  5BQ8 D;  1WQ9 A;  1KLC A;  4X1J A;  1FLT V;  4UHY A;  1HRP B;  1TZH V;  2R53 A;  4ZFF C;  2GYZ A;  4QAF C;  1LX5 A;  1NYS B;  2GH0 C;  5HI4 A;  5HHX A;  1M4U L;  4MPL A;  1XWD B;  4XPJ A;  5HK5 E;  3QB4 A;  1BET A;  1HCN B;  2V5E B;  2H64 A;  3P9W A;  4UI0 A;  2QJ9 A;  2ARV A;  2GNN A;  4ZBN A;  4YCG C;  4EC7 A;  5JZ7 A;  3RJR A;  2ASK A;  3EVS B;  5HK5 A;  5BPU A;  2QJB A;  4WPB A;  2FJH V;  5HHV A;  4BV4 L;  1VPF A;  3SEK B;  2R52 A;  3JVF A;  2C7W A;  2ARP A;  1ES7 A;  3MJK A;  1HRP A;  2XAC A;  2XV7 A;  1TGK A;  4EFV A;  1AGQ A;  3MJG A;  1SGF B;  3BUK A;  1QTY R;  5F3H I;  1MKG A;  1B98 A;  1HD4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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