4X1JA

X-ray crystal structure of the dimeric bmp antagonist nbl1
Total Genus 7
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
7
sequence length
96
structure length
83
Chain Sequence
DKSAWCEAKNITQIVGHSGCEAKSIQNRACLGQCFSYSVPNTFVHCDSCMPAQSMWEIVTLECPGVDKLVEKILHCSCQACGK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of Neuroblastoma Suppressor of Tumorigenicity 1 (NBL1): INSIGHTS FOR THE FUNCTIONAL VARIABILITY ACROSS BONE MORPHOGENETIC PROTEIN (BMP) ANTAGONISTS.
pubmed doi rcsb
molecule tags Bmp binding protein
source organism Homo sapiens
molecule keywords Neuroblastoma suppressor of tumorigenicity 1
total genus 7
structure length 83
sequence length 96
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-11-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03045 DAN DAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 4x1jA00
2GYRA 3FUBB 5JZ7A 3MJKA 1HCNB 1BNDA 3S1KV 4X1JA 5HK5A 5HHDA 4MQWB 2IFGE 2VXSA 3EVSB 1E9JA 1B98A 3P9WA 4KV5A 2X1XE 1TZIV 4AY9A 3BDYV 1LXIA 1MKKA 3IJ2A 1TZHV 1XWDB 5F3HI 3QTKA 1CZ8V 2H64A 1HCFA 4XPJA 1QTYR 4KXZA 5HI4A 5BQBA 5AEJA 4UI0A 5HK5E 1KLAA 4HQUA 2X1WA 2XV7A 1HD4A 5BQEB 1VPFA 4FAOA 1WQ8A 1FZVA 4YCGC 1MJVA 5BQ8B 4UHYA 1KATW 4HR9A 4QCIC 3SEKB 1BJ1V 5HHCA 1RV6V 1REUA 4HSAA 2BHKA 5E4GA 5BQCA 1B8MB 4MPLA 1PDGA 4MQWA 4QHUC 2VPFA 4LXSJ 2PJYA 4MIDA 5HHXA 1AGQA 3HH2A 1QFWB 1NT3A 1BETA 1FL7A 2V5EB 2XACA 5FV2V 1M4UA 1B8KA 3BK3A 3MJGA 2QJ9A 1XWDA 2B0UA 1HRPB 1M4UL 2QCQA 4EAXA 2GNNA 1BMPA 2VWEA 4GLNE 3JVFA 4UHZA 1TGKA 1BNDB 4EC7A 1TGJA 2FJHV 1S4YB 1MKGA 2R52A 1DZ7A 4HQXA 1REWA 1WQ9B 4AY9B 2TGIA 2P6AA 4QAFC 5FV1V 1HCNA 4N1DA 1BTGA 2GYZA 2FJGV 1KLCA 1KTZA 1SG1A 4WPBA 1WAQA 1NYSB 2GH0C 2C7WA 4EDXV 3KFDA 4EFVA 1FLTV 2KD3A 5F3BC 1VPPV 2QJBA 4ZFFC 1AOCA 1HRPA 4UI1A 2QCWA 4ZBNA 1ES7A 5HI3A 3BMPA 2ARVA 4UI2B 5BQEA 3B4VA 4KZNA 5BQ8A 1WWWV 2ASKA 2R53A 4GLSE 1FL7B 2QJAA 5HI5A 3RJRA 1WQ9A 1LX5A 5HHVA 1ZKZA 4BV4L 5BPUA 1B8MA 3QB4A 2H62A 2ARPA 3V2AA 1SGFB 2GOOA 3E07A 5BQ8D 4LXRJ 1QFWA 2QR0C 3S1BV 4EDWV 3BUKA 3V6BA 1JPYA 1NYUB 3EO1C 1TFGA 4YCIC
chains in the Genus database with same CATH superfamily
2GYRA 3FUBB 5JZ7A 3MJKA 1HCNB 1BNDA 3S1KV 4X1JA 5HK5A 5HHDA 4MQWB 2IFGE 2VXSA 3EVSB 1E9JA 1B98A 3P9WA 4KV5A 2X1XE 1TZIV 4AY9A 3BDYV 1LXIA 1MKKA 3IJ2A 1TZHV 1XWDB 5F3HI 3QTKA 1CZ8V 2H64A 1HCFA 4XPJA 1QTYR 4KXZA 5HI4A 5BQBA 5AEJA 4UI0A 5HK5E 1KLAA 4HQUA 2X1WA 2XV7A 1HD4A 5BQEB 1VPFA 4FAOA 1WQ8A 1FZVA 4YCGC 1MJVA 5BQ8B 4UHYA 1KATW 4HR9A 4QCIC 3SEKB 1BJ1V 5HHCA 1RV6V 1REUA 4HSAA 2BHKA 5E4GA 5BQCA 1B8MB 4MPLA 1PDGA 4MQWA 4QHUC 2VPFA 4LXSJ 2PJYA 4MIDA 5HHXA 1AGQA 3HH2A 1QFWB 1NT3A 1BETA 1FL7A 2V5EB 2XACA 5FV2V 1M4UA 1B8KA 3BK3A 3MJGA 2QJ9A 1XWDA 2B0UA 1HRPB 1M4UL 2QCQA 4EAXA 2GNNA 1BMPA 2VWEA 4GLNE 3JVFA 4UHZA 1TGKA 1BNDB 4EC7A 1TGJA 2FJHV 1S4YB 1MKGA 2R52A 1DZ7A 4HQXA 1REWA 1WQ9B 4AY9B 2TGIA 2P6AA 4QAFC 5FV1V 1HCNA 4N1DA 1BTGA 2GYZA 2FJGV 1KLCA 1KTZA 1SG1A 4WPBA 1WAQA 1NYSB 2GH0C 2C7WA 4EDXV 3KFDA 4EFVA 1FLTV 2KD3A 5F3BC 1VPPV 2QJBA 4ZFFC 1AOCA 1HRPA 4UI1A 2QCWA 4ZBNA 1ES7A 5HI3A 3BMPA 2ARVA 4UI2B 5BQEA 3B4VA 4KZNA 5BQ8A 1WWWV 2ASKA 2R53A 4GLSE 1FL7B 2QJAA 5HI5A 3RJRA 1WQ9A 1LX5A 5HHVA 1ZKZA 4BV4L 5BPUA 1B8MA 3QB4A 2H62A 2ARPA 3V2AA 1SGFB 2GOOA 3E07A 5BQ8D 4LXRJ 1QFWA 2QR0C 3S1BV 4EDWV 3BUKA 3V6BA 1JPYA 1NYUB 3EO1C 1TFGA 4YCIC
chains in the Genus database with same CATH topology
2GYRA 3FUBB 5JZ7A 3MJKA 1HCNB 1BNDA 3S1KV 4X1JA 5HK5A 5HHDA 4MQWB 2IFGE 2VXSA 3EVSB 1E9JA 1B98A 3P9WA 4KV5A 2X1XE 1TZIV 4AY9A 3BDYV 1LXIA 1MKKA 3IJ2A 1TZHV 1XWDB 5F3HI 3QTKA 1CZ8V 2H64A 1HCFA 4XPJA 1QTYR 4KXZA 5HI4A 5BQBA 5AEJA 4UI0A 5HK5E 1KLAA 4HQUA 2X1WA 2XV7A 1HD4A 5BQEB 1VPFA 4FAOA 1WQ8A 1FZVA 4YCGC 1MJVA 5BQ8B 4UHYA 1KATW 4HR9A 4QCIC 3SEKB 1BJ1V 5HHCA 1RV6V 1REUA 4HSAA 2BHKA 5E4GA 5BQCA 1B8MB 4MPLA 1PDGA 4MQWA 4QHUC 2VPFA 4LXSJ 2PJYA 4MIDA 5HHXA 1AGQA 3HH2A 1QFWB 1NT3A 1BETA 1FL7A 2V5EB 2XACA 5FV2V 1M4UA 1B8KA 3BK3A 3MJGA 2QJ9A 1XWDA 2B0UA 1HRPB 1M4UL 2QCQA 4EAXA 2GNNA 1BMPA 2VWEA 4GLNE 3JVFA 4UHZA 1TGKA 1BNDB 4EC7A 1TGJA 2FJHV 1S4YB 1MKGA 2R52A 1DZ7A 4HQXA 1REWA 1WQ9B 4AY9B 2TGIA 2P6AA 4QAFC 5FV1V 1HCNA 4N1DA 1BTGA 2GYZA 2FJGV 1KLCA 1KTZA 1SG1A 4WPBA 1WAQA 1NYSB 2GH0C 2C7WA 4EDXV 3KFDA 4EFVA 1FLTV 2KD3A 5F3BC 1VPPV 2QJBA 4ZFFC 1AOCA 1HRPA 4UI1A 2QCWA 4ZBNA 1ES7A 5HI3A 3BMPA 2ARVA 4UI2B 5BQEA 3B4VA 4KZNA 5BQ8A 1WWWV 2ASKA 2R53A 4GLSE 1FL7B 2QJAA 5HI5A 3RJRA 1WQ9A 1LX5A 5HHVA 1ZKZA 4BV4L 5BPUA 1B8MA 3QB4A 2H62A 2ARPA 3V2AA 1SGFB 2GOOA 3E07A 5BQ8D 4LXRJ 1QFWA 2QR0C 3S1BV 4EDWV 3BUKA 3V6BA 1JPYA 1NYUB 3EO1C 1TFGA 4YCIC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GYR A;  3FUB B;  5JZ7 A;  3MJK A;  1HCN B;  1BND A;  3S1K V;  4X1J A;  5HK5 A;  5HHD A;  4MQW B;  2IFG E;  2VXS A;  3EVS B;  1E9J A;  1B98 A;  3P9W A;  4KV5 A;  2X1X E;  1TZI V;  4AY9 A;  3BDY V;  1LXI A;  1MKK A;  3IJ2 A;  1TZH V;  1XWD B;  5F3H I;  3QTK A;  1CZ8 V;  2H64 A;  1HCF A;  4XPJ A;  1QTY R;  4KXZ A;  5HI4 A;  5BQB A;  5AEJ A;  4UI0 A;  5HK5 E;  1KLA A;  4HQU A;  2X1W A;  2XV7 A;  1HD4 A;  5BQE B;  1VPF A;  4FAO A;  1WQ8 A;  1FZV A;  4YCG C;  1MJV A;  5BQ8 B;  4UHY A;  1KAT W;  4HR9 A;  4QCI C;  3SEK B;  1BJ1 V;  5HHC A;  1RV6 V;  1REU A;  4HSA A;  2BHK A;  5E4G A;  5BQC A;  1B8M B;  4MPL A;  1PDG A;  4MQW A;  4QHU C;  2VPF A;  4LXS J;  2PJY A;  4MID A;  5HHX A;  1AGQ A;  3HH2 A;  1QFW B;  1NT3 A;  1BET A;  1FL7 A;  2V5E B;  2XAC A;  5FV2 V;  1M4U A;  1B8K A;  3BK3 A;  3MJG A;  2QJ9 A;  1XWD A;  2B0U A;  1HRP B;  1M4U L;  2QCQ A;  4EAX A;  2GNN A;  1BMP A;  2VWE A;  4GLN E;  3JVF A;  4UHZ A;  1TGK A;  1BND B;  4EC7 A;  1TGJ A;  2FJH V;  1S4Y B;  1MKG A;  2R52 A;  1DZ7 A;  4HQX A;  1REW A;  1WQ9 B;  4AY9 B;  2TGI A;  2P6A A;  4QAF C;  5FV1 V;  1HCN A;  4N1D A;  1BTG A;  2GYZ A;  2FJG V;  1KLC A;  1KTZ A;  1SG1 A;  4WPB A;  1WAQ A;  1NYS B;  2GH0 C;  2C7W A;  4EDX V;  3KFD A;  4EFV A;  1FLT V;  2KD3 A;  5F3B C;  1VPP V;  2QJB A;  4ZFF C;  1AOC A;  1HRP A;  4UI1 A;  2QCW A;  4ZBN A;  1ES7 A;  5HI3 A;  3BMP A;  2ARV A;  4UI2 B;  5BQE A;  3B4V A;  4KZN A;  5BQ8 A;  1WWW V;  2ASK A;  2R53 A;  4GLS E;  1FL7 B;  2QJA A;  5HI5 A;  3RJR A;  1WQ9 A;  1LX5 A;  5HHV A;  1ZKZ A;  4BV4 L;  5BPU A;  1B8M A;  3QB4 A;  2H62 A;  2ARP A;  3V2A A;  1SGF B;  2GOO A;  3E07 A;  5BQ8 D;  4LXR J;  1QFW A;  2QR0 C;  3S1B V;  4EDW V;  3BUK A;  3V6B A;  1JPY A;  1NYU B;  3EO1 C;  1TFG A;  4YCI C; 
#chains in the Genus database with same CATH topology
 2GYR A;  3FUB B;  5JZ7 A;  3MJK A;  1HCN B;  1BND A;  3S1K V;  4X1J A;  5HK5 A;  5HHD A;  4MQW B;  2IFG E;  2VXS A;  3EVS B;  1E9J A;  1B98 A;  3P9W A;  4KV5 A;  2X1X E;  1TZI V;  4AY9 A;  3BDY V;  1LXI A;  1MKK A;  3IJ2 A;  1TZH V;  1XWD B;  5F3H I;  3QTK A;  1CZ8 V;  2H64 A;  1HCF A;  4XPJ A;  1QTY R;  4KXZ A;  5HI4 A;  5BQB A;  5AEJ A;  4UI0 A;  5HK5 E;  1KLA A;  4HQU A;  2X1W A;  2XV7 A;  1HD4 A;  5BQE B;  1VPF A;  4FAO A;  1WQ8 A;  1FZV A;  4YCG C;  1MJV A;  5BQ8 B;  4UHY A;  1KAT W;  4HR9 A;  4QCI C;  3SEK B;  1BJ1 V;  5HHC A;  1RV6 V;  1REU A;  4HSA A;  2BHK A;  5E4G A;  5BQC A;  1B8M B;  4MPL A;  1PDG A;  4MQW A;  4QHU C;  2VPF A;  4LXS J;  2PJY A;  4MID A;  5HHX A;  1AGQ A;  3HH2 A;  1QFW B;  1NT3 A;  1BET A;  1FL7 A;  2V5E B;  2XAC A;  5FV2 V;  1M4U A;  1B8K A;  3BK3 A;  3MJG A;  2QJ9 A;  1XWD A;  2B0U A;  1HRP B;  1M4U L;  2QCQ A;  4EAX A;  2GNN A;  1BMP A;  2VWE A;  4GLN E;  3JVF A;  4UHZ A;  1TGK A;  1BND B;  4EC7 A;  1TGJ A;  2FJH V;  1S4Y B;  1MKG A;  2R52 A;  1DZ7 A;  4HQX A;  1REW A;  1WQ9 B;  4AY9 B;  2TGI A;  2P6A A;  4QAF C;  5FV1 V;  1HCN A;  4N1D A;  1BTG A;  2GYZ A;  2FJG V;  1KLC A;  1KTZ A;  1SG1 A;  4WPB A;  1WAQ A;  1NYS B;  2GH0 C;  2C7W A;  4EDX V;  3KFD A;  4EFV A;  1FLT V;  2KD3 A;  5F3B C;  1VPP V;  2QJB A;  4ZFF C;  1AOC A;  1HRP A;  4UI1 A;  2QCW A;  4ZBN A;  1ES7 A;  5HI3 A;  3BMP A;  2ARV A;  4UI2 B;  5BQE A;  3B4V A;  4KZN A;  5BQ8 A;  1WWW V;  2ASK A;  2R53 A;  4GLS E;  1FL7 B;  2QJA A;  5HI5 A;  3RJR A;  1WQ9 A;  1LX5 A;  5HHV A;  1ZKZ A;  4BV4 L;  5BPU A;  1B8M A;  3QB4 A;  2H62 A;  2ARP A;  3V2A A;  1SGF B;  2GOO A;  3E07 A;  5BQ8 D;  4LXR J;  1QFW A;  2QR0 C;  3S1B V;  4EDW V;  3BUK A;  3V6B A;  1JPY A;  1NYU B;  3EO1 C;  1TFG A;  4YCI C; 
#chains in the Genus database with same CATH homology
 2GYR A;  3FUB B;  5JZ7 A;  3MJK A;  1HCN B;  1BND A;  3S1K V;  4X1J A;  5HK5 A;  5HHD A;  4MQW B;  2IFG E;  2VXS A;  3EVS B;  1E9J A;  1B98 A;  3P9W A;  4KV5 A;  2X1X E;  1TZI V;  4AY9 A;  3BDY V;  1LXI A;  1MKK A;  3IJ2 A;  1TZH V;  1XWD B;  5F3H I;  3QTK A;  1CZ8 V;  2H64 A;  1HCF A;  4XPJ A;  1QTY R;  4KXZ A;  5HI4 A;  5BQB A;  5AEJ A;  4UI0 A;  5HK5 E;  1KLA A;  4HQU A;  2X1W A;  2XV7 A;  1HD4 A;  5BQE B;  1VPF A;  4FAO A;  1WQ8 A;  1FZV A;  4YCG C;  1MJV A;  5BQ8 B;  4UHY A;  1KAT W;  4HR9 A;  4QCI C;  3SEK B;  1BJ1 V;  5HHC A;  1RV6 V;  1REU A;  4HSA A;  2BHK A;  5E4G A;  5BQC A;  1B8M B;  4MPL A;  1PDG A;  4MQW A;  4QHU C;  2VPF A;  4LXS J;  2PJY A;  4MID A;  5HHX A;  1AGQ A;  3HH2 A;  1QFW B;  1NT3 A;  1BET A;  1FL7 A;  2V5E B;  2XAC A;  5FV2 V;  1M4U A;  1B8K A;  3BK3 A;  3MJG A;  2QJ9 A;  1XWD A;  2B0U A;  1HRP B;  1M4U L;  2QCQ A;  4EAX A;  2GNN A;  1BMP A;  2VWE A;  4GLN E;  3JVF A;  4UHZ A;  1TGK A;  1BND B;  4EC7 A;  1TGJ A;  2FJH V;  1S4Y B;  1MKG A;  2R52 A;  1DZ7 A;  4HQX A;  1REW A;  1WQ9 B;  4AY9 B;  2TGI A;  2P6A A;  4QAF C;  5FV1 V;  1HCN A;  4N1D A;  1BTG A;  2GYZ A;  2FJG V;  1KLC A;  1KTZ A;  1SG1 A;  4WPB A;  1WAQ A;  1NYS B;  2GH0 C;  2C7W A;  4EDX V;  3KFD A;  4EFV A;  1FLT V;  2KD3 A;  5F3B C;  1VPP V;  2QJB A;  4ZFF C;  1AOC A;  1HRP A;  4UI1 A;  2QCW A;  4ZBN A;  1ES7 A;  5HI3 A;  3BMP A;  2ARV A;  4UI2 B;  5BQE A;  3B4V A;  4KZN A;  5BQ8 A;  1WWW V;  2ASK A;  2R53 A;  4GLS E;  1FL7 B;  2QJA A;  5HI5 A;  3RJR A;  1WQ9 A;  1LX5 A;  5HHV A;  1ZKZ A;  4BV4 L;  5BPU A;  1B8M A;  3QB4 A;  2H62 A;  2ARP A;  3V2A A;  1SGF B;  2GOO A;  3E07 A;  5BQ8 D;  4LXR J;  1QFW A;  2QR0 C;  3S1B V;  4EDW V;  3BUK A;  3V6B A;  1JPY A;  1NYU B;  3EO1 C;  1TFG A;  4YCI C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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