4HQXA

Crystal structure of human pdgf-bb in complex with a modified nucleotide aptamer (somamer sl4)
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
95
structure length
95
Chain Sequence
IAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCET
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
pubmed doi rcsb
molecule keywords Platelet-derived growth factor subunit B
molecule tags Hormone/dna
source organism Homo sapiens
total genus 11
structure length 95
sequence length 95
ec nomenclature
pdb deposition date 2012-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00341 PDGF PDGF/VEGF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 4hqxA00
5FV1V 2GOOA 4EFVA 5HI5A 3BMPA 1FZVA 2P6AA 4QHUC 1B8MA 2BHKA 2QCQA 5E4GA 1WQ8A 5HHDA 4FAOA 4UHYA 1XWDA 5HI3A 5HHVA 3FUBB 4GLNE 5HHCA 4MQWB 2R53A 3V2AA 2V5EB 1BNDB 1MKGA 1LX5A 1BMPA 4HSAA 4KXZA 1KTZA 4HQUA 5BQEA 5BQEB 2ARPA 4EDXV 4N1DA 1NT3A 4LXRJ 3QB4A 3IJ2A 1LXIA 3EO1C 5BQ8D 1SGFB 4YCIC 1REWA 2XV7A 1CZ8V 2GH0C 3V6BA 1VPFA 4ZFFC 1BJ1V 4EDWV 2H64A 1PDGA 4UHZA 4YCGC 4EC7A 5AEJA 3P9WA 3BUKA 4MQWA 1WAQA 5FV2V 1BNDA 1B98A 2GYRA 3RJRA 1MKKA 2B0UA 2C7WA 5BQCA 5HI4A 1E9JA 2FJHV 1RV6V 3SEKB 1WWWV 2VWEA 4QCIC 3MJGA 3HH2A 4KV5A 4QAFC 5HHXA 1KLCA 1TZHV 2TGIA 1M4UL 1B8KA 2QCWA 1FLTV 1HCFA 4UI2B 5HK5E 4LXSJ 2QJBA 1TGKA 1AGQA 2ASKA 1M4UA 2QJAA 5BQ8B 3JVFA 1ES7A 2XACA 1BETA 2PJYA 1S4YB 2IFGE 4XPJA 4MPLA 3KFDA 1REUA 4UI0A 4EAXA 1ZKZA 1QFWB 3EVSB 1FL7B 1HCNA 1HCNB 3BK3A 3B4VA 1JPYA 1QTYR 4AY9B 4BV4L 4ZBNA 4UI1A 2VPFA 4X1JA 2VXSA 1NYUB 2QR0C 3S1KV 1KATW 1AOCA 2R52A 2ARVA 3E07A 2KD3A 1TZIV 4GLSE 1NYSB 5HK5A 1KLAA 1B8MB 4HQXA 5F3BC 1BTGA 4WPBA 2GNNA 4MIDA 1XWDB 1HD4A 5BQ8A 2X1WA 1TGJA 4KZNA 5BPUA 3BDYV 1HRPA 1HRPB 1SG1A 3MJKA 5F3HI 2FJGV 2X1XE 1QFWA 5BQBA 3QTKA 2H62A 1FL7A 1MJVA 2QJ9A 4AY9A 4HR9A 3S1BV 1WQ9A 1WQ9B 2GYZA 5JZ7A 1VPPV 1DZ7A 1TFGA
chains in the Genus database with same CATH superfamily
5FV1V 2GOOA 4EFVA 5HI5A 3BMPA 1FZVA 2P6AA 4QHUC 1B8MA 2BHKA 2QCQA 5E4GA 1WQ8A 5HHDA 4FAOA 4UHYA 1XWDA 5HI3A 5HHVA 3FUBB 4GLNE 5HHCA 4MQWB 2R53A 3V2AA 2V5EB 1BNDB 1MKGA 1LX5A 1BMPA 4HSAA 4KXZA 1KTZA 4HQUA 5BQEA 5BQEB 2ARPA 4EDXV 4N1DA 1NT3A 4LXRJ 3QB4A 3IJ2A 1LXIA 3EO1C 5BQ8D 1SGFB 4YCIC 1REWA 2XV7A 1CZ8V 2GH0C 3V6BA 1VPFA 4ZFFC 1BJ1V 4EDWV 2H64A 1PDGA 4UHZA 4YCGC 4EC7A 5AEJA 3P9WA 3BUKA 4MQWA 1WAQA 5FV2V 1BNDA 1B98A 2GYRA 3RJRA 1MKKA 2B0UA 2C7WA 5BQCA 5HI4A 1E9JA 2FJHV 1RV6V 3SEKB 1WWWV 2VWEA 4QCIC 3MJGA 3HH2A 4KV5A 4QAFC 5HHXA 1KLCA 1TZHV 2TGIA 1M4UL 1B8KA 2QCWA 1FLTV 1HCFA 4UI2B 5HK5E 4LXSJ 2QJBA 1TGKA 1AGQA 2ASKA 1M4UA 2QJAA 5BQ8B 3JVFA 1ES7A 2XACA 1BETA 2PJYA 1S4YB 2IFGE 4XPJA 4MPLA 3KFDA 1REUA 4UI0A 4EAXA 1ZKZA 1QFWB 3EVSB 1FL7B 1HCNA 1HCNB 3BK3A 3B4VA 1JPYA 1QTYR 4AY9B 4BV4L 4ZBNA 4UI1A 2VPFA 4X1JA 2VXSA 1NYUB 2QR0C 3S1KV 1KATW 1AOCA 2R52A 2ARVA 3E07A 2KD3A 1TZIV 4GLSE 1NYSB 5HK5A 1KLAA 1B8MB 4HQXA 5F3BC 1BTGA 4WPBA 2GNNA 4MIDA 1XWDB 1HD4A 5BQ8A 2X1WA 1TGJA 4KZNA 5BPUA 3BDYV 1HRPA 1HRPB 1SG1A 3MJKA 5F3HI 2FJGV 2X1XE 1QFWA 5BQBA 3QTKA 2H62A 1FL7A 1MJVA 2QJ9A 4AY9A 4HR9A 3S1BV 1WQ9A 1WQ9B 2GYZA 5JZ7A 1VPPV 1DZ7A 1TFGA
chains in the Genus database with same CATH topology
5FV1V 2GOOA 4EFVA 5HI5A 3BMPA 1FZVA 2P6AA 4QHUC 1B8MA 2BHKA 2QCQA 5E4GA 1WQ8A 5HHDA 4FAOA 4UHYA 1XWDA 5HI3A 5HHVA 3FUBB 4GLNE 5HHCA 4MQWB 2R53A 3V2AA 2V5EB 1BNDB 1MKGA 1LX5A 1BMPA 4HSAA 4KXZA 1KTZA 4HQUA 5BQEA 5BQEB 2ARPA 4EDXV 4N1DA 1NT3A 4LXRJ 3QB4A 3IJ2A 1LXIA 3EO1C 5BQ8D 1SGFB 4YCIC 1REWA 2XV7A 1CZ8V 2GH0C 3V6BA 1VPFA 4ZFFC 1BJ1V 4EDWV 2H64A 1PDGA 4UHZA 4YCGC 4EC7A 5AEJA 3P9WA 3BUKA 4MQWA 1WAQA 5FV2V 1BNDA 1B98A 2GYRA 3RJRA 1MKKA 2B0UA 2C7WA 5BQCA 5HI4A 1E9JA 2FJHV 1RV6V 3SEKB 1WWWV 2VWEA 4QCIC 3MJGA 3HH2A 4KV5A 4QAFC 5HHXA 1KLCA 1TZHV 2TGIA 1M4UL 1B8KA 2QCWA 1FLTV 1HCFA 4UI2B 5HK5E 4LXSJ 2QJBA 1TGKA 1AGQA 2ASKA 1M4UA 2QJAA 5BQ8B 3JVFA 1ES7A 2XACA 1BETA 2PJYA 1S4YB 2IFGE 4XPJA 4MPLA 3KFDA 1REUA 4UI0A 4EAXA 1ZKZA 1QFWB 3EVSB 1FL7B 1HCNA 1HCNB 3BK3A 3B4VA 1JPYA 1QTYR 4AY9B 4BV4L 4ZBNA 4UI1A 2VPFA 4X1JA 2VXSA 1NYUB 2QR0C 3S1KV 1KATW 1AOCA 2R52A 2ARVA 3E07A 2KD3A 1TZIV 4GLSE 1NYSB 5HK5A 1KLAA 1B8MB 4HQXA 5F3BC 1BTGA 4WPBA 2GNNA 4MIDA 1XWDB 1HD4A 5BQ8A 2X1WA 1TGJA 4KZNA 5BPUA 3BDYV 1HRPA 1HRPB 1SG1A 3MJKA 5F3HI 2FJGV 2X1XE 1QFWA 5BQBA 3QTKA 2H62A 1FL7A 1MJVA 2QJ9A 4AY9A 4HR9A 3S1BV 1WQ9A 1WQ9B 2GYZA 5JZ7A 1VPPV 1DZ7A 1TFGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FV1 V;  2GOO A;  4EFV A;  5HI5 A;  3BMP A;  1FZV A;  2P6A A;  4QHU C;  1B8M A;  2BHK A;  2QCQ A;  5E4G A;  1WQ8 A;  5HHD A;  4FAO A;  4UHY A;  1XWD A;  5HI3 A;  5HHV A;  3FUB B;  4GLN E;  5HHC A;  4MQW B;  2R53 A;  3V2A A;  2V5E B;  1BND B;  1MKG A;  1LX5 A;  1BMP A;  4HSA A;  4KXZ A;  1KTZ A;  4HQU A;  5BQE A;  5BQE B;  2ARP A;  4EDX V;  4N1D A;  1NT3 A;  4LXR J;  3QB4 A;  3IJ2 A;  1LXI A;  3EO1 C;  5BQ8 D;  1SGF B;  4YCI C;  1REW A;  2XV7 A;  1CZ8 V;  2GH0 C;  3V6B A;  1VPF A;  4ZFF C;  1BJ1 V;  4EDW V;  2H64 A;  1PDG A;  4UHZ A;  4YCG C;  4EC7 A;  5AEJ A;  3P9W A;  3BUK A;  4MQW A;  1WAQ A;  5FV2 V;  1BND A;  1B98 A;  2GYR A;  3RJR A;  1MKK A;  2B0U A;  2C7W A;  5BQC A;  5HI4 A;  1E9J A;  2FJH V;  1RV6 V;  3SEK B;  1WWW V;  2VWE A;  4QCI C;  3MJG A;  3HH2 A;  4KV5 A;  4QAF C;  5HHX A;  1KLC A;  1TZH V;  2TGI A;  1M4U L;  1B8K A;  2QCW A;  1FLT V;  1HCF A;  4UI2 B;  5HK5 E;  4LXS J;  2QJB A;  1TGK A;  1AGQ A;  2ASK A;  1M4U A;  2QJA A;  5BQ8 B;  3JVF A;  1ES7 A;  2XAC A;  1BET A;  2PJY A;  1S4Y B;  2IFG E;  4XPJ A;  4MPL A;  3KFD A;  1REU A;  4UI0 A;  4EAX A;  1ZKZ A;  1QFW B;  3EVS B;  1FL7 B;  1HCN A;  1HCN B;  3BK3 A;  3B4V A;  1JPY A;  1QTY R;  4AY9 B;  4BV4 L;  4ZBN A;  4UI1 A;  2VPF A;  4X1J A;  2VXS A;  1NYU B;  2QR0 C;  3S1K V;  1KAT W;  1AOC A;  2R52 A;  2ARV A;  3E07 A;  2KD3 A;  1TZI V;  4GLS E;  1NYS B;  5HK5 A;  1KLA A;  1B8M B;  4HQX A;  5F3B C;  1BTG A;  4WPB A;  2GNN A;  4MID A;  1XWD B;  1HD4 A;  5BQ8 A;  2X1W A;  1TGJ A;  4KZN A;  5BPU A;  3BDY V;  1HRP A;  1HRP B;  1SG1 A;  3MJK A;  5F3H I;  2FJG V;  2X1X E;  1QFW A;  5BQB A;  3QTK A;  2H62 A;  1FL7 A;  1MJV A;  2QJ9 A;  4AY9 A;  4HR9 A;  3S1B V;  1WQ9 A;  1WQ9 B;  2GYZ A;  5JZ7 A;  1VPP V;  1DZ7 A;  1TFG A; 
#chains in the Genus database with same CATH topology
 5FV1 V;  2GOO A;  4EFV A;  5HI5 A;  3BMP A;  1FZV A;  2P6A A;  4QHU C;  1B8M A;  2BHK A;  2QCQ A;  5E4G A;  1WQ8 A;  5HHD A;  4FAO A;  4UHY A;  1XWD A;  5HI3 A;  5HHV A;  3FUB B;  4GLN E;  5HHC A;  4MQW B;  2R53 A;  3V2A A;  2V5E B;  1BND B;  1MKG A;  1LX5 A;  1BMP A;  4HSA A;  4KXZ A;  1KTZ A;  4HQU A;  5BQE A;  5BQE B;  2ARP A;  4EDX V;  4N1D A;  1NT3 A;  4LXR J;  3QB4 A;  3IJ2 A;  1LXI A;  3EO1 C;  5BQ8 D;  1SGF B;  4YCI C;  1REW A;  2XV7 A;  1CZ8 V;  2GH0 C;  3V6B A;  1VPF A;  4ZFF C;  1BJ1 V;  4EDW V;  2H64 A;  1PDG A;  4UHZ A;  4YCG C;  4EC7 A;  5AEJ A;  3P9W A;  3BUK A;  4MQW A;  1WAQ A;  5FV2 V;  1BND A;  1B98 A;  2GYR A;  3RJR A;  1MKK A;  2B0U A;  2C7W A;  5BQC A;  5HI4 A;  1E9J A;  2FJH V;  1RV6 V;  3SEK B;  1WWW V;  2VWE A;  4QCI C;  3MJG A;  3HH2 A;  4KV5 A;  4QAF C;  5HHX A;  1KLC A;  1TZH V;  2TGI A;  1M4U L;  1B8K A;  2QCW A;  1FLT V;  1HCF A;  4UI2 B;  5HK5 E;  4LXS J;  2QJB A;  1TGK A;  1AGQ A;  2ASK A;  1M4U A;  2QJA A;  5BQ8 B;  3JVF A;  1ES7 A;  2XAC A;  1BET A;  2PJY A;  1S4Y B;  2IFG E;  4XPJ A;  4MPL A;  3KFD A;  1REU A;  4UI0 A;  4EAX A;  1ZKZ A;  1QFW B;  3EVS B;  1FL7 B;  1HCN A;  1HCN B;  3BK3 A;  3B4V A;  1JPY A;  1QTY R;  4AY9 B;  4BV4 L;  4ZBN A;  4UI1 A;  2VPF A;  4X1J A;  2VXS A;  1NYU B;  2QR0 C;  3S1K V;  1KAT W;  1AOC A;  2R52 A;  2ARV A;  3E07 A;  2KD3 A;  1TZI V;  4GLS E;  1NYS B;  5HK5 A;  1KLA A;  1B8M B;  4HQX A;  5F3B C;  1BTG A;  4WPB A;  2GNN A;  4MID A;  1XWD B;  1HD4 A;  5BQ8 A;  2X1W A;  1TGJ A;  4KZN A;  5BPU A;  3BDY V;  1HRP A;  1HRP B;  1SG1 A;  3MJK A;  5F3H I;  2FJG V;  2X1X E;  1QFW A;  5BQB A;  3QTK A;  2H62 A;  1FL7 A;  1MJV A;  2QJ9 A;  4AY9 A;  4HR9 A;  3S1B V;  1WQ9 A;  1WQ9 B;  2GYZ A;  5JZ7 A;  1VPP V;  1DZ7 A;  1TFG A; 
#chains in the Genus database with same CATH homology
 5FV1 V;  2GOO A;  4EFV A;  5HI5 A;  3BMP A;  1FZV A;  2P6A A;  4QHU C;  1B8M A;  2BHK A;  2QCQ A;  5E4G A;  1WQ8 A;  5HHD A;  4FAO A;  4UHY A;  1XWD A;  5HI3 A;  5HHV A;  3FUB B;  4GLN E;  5HHC A;  4MQW B;  2R53 A;  3V2A A;  2V5E B;  1BND B;  1MKG A;  1LX5 A;  1BMP A;  4HSA A;  4KXZ A;  1KTZ A;  4HQU A;  5BQE A;  5BQE B;  2ARP A;  4EDX V;  4N1D A;  1NT3 A;  4LXR J;  3QB4 A;  3IJ2 A;  1LXI A;  3EO1 C;  5BQ8 D;  1SGF B;  4YCI C;  1REW A;  2XV7 A;  1CZ8 V;  2GH0 C;  3V6B A;  1VPF A;  4ZFF C;  1BJ1 V;  4EDW V;  2H64 A;  1PDG A;  4UHZ A;  4YCG C;  4EC7 A;  5AEJ A;  3P9W A;  3BUK A;  4MQW A;  1WAQ A;  5FV2 V;  1BND A;  1B98 A;  2GYR A;  3RJR A;  1MKK A;  2B0U A;  2C7W A;  5BQC A;  5HI4 A;  1E9J A;  2FJH V;  1RV6 V;  3SEK B;  1WWW V;  2VWE A;  4QCI C;  3MJG A;  3HH2 A;  4KV5 A;  4QAF C;  5HHX A;  1KLC A;  1TZH V;  2TGI A;  1M4U L;  1B8K A;  2QCW A;  1FLT V;  1HCF A;  4UI2 B;  5HK5 E;  4LXS J;  2QJB A;  1TGK A;  1AGQ A;  2ASK A;  1M4U A;  2QJA A;  5BQ8 B;  3JVF A;  1ES7 A;  2XAC A;  1BET A;  2PJY A;  1S4Y B;  2IFG E;  4XPJ A;  4MPL A;  3KFD A;  1REU A;  4UI0 A;  4EAX A;  1ZKZ A;  1QFW B;  3EVS B;  1FL7 B;  1HCN A;  1HCN B;  3BK3 A;  3B4V A;  1JPY A;  1QTY R;  4AY9 B;  4BV4 L;  4ZBN A;  4UI1 A;  2VPF A;  4X1J A;  2VXS A;  1NYU B;  2QR0 C;  3S1K V;  1KAT W;  1AOC A;  2R52 A;  2ARV A;  3E07 A;  2KD3 A;  1TZI V;  4GLS E;  1NYS B;  5HK5 A;  1KLA A;  1B8M B;  4HQX A;  5F3B C;  1BTG A;  4WPB A;  2GNN A;  4MID A;  1XWD B;  1HD4 A;  5BQ8 A;  2X1W A;  1TGJ A;  4KZN A;  5BPU A;  3BDY V;  1HRP A;  1HRP B;  1SG1 A;  3MJK A;  5F3H I;  2FJG V;  2X1X E;  1QFW A;  5BQB A;  3QTK A;  2H62 A;  1FL7 A;  1MJV A;  2QJ9 A;  4AY9 A;  4HR9 A;  3S1B V;  1WQ9 A;  1WQ9 B;  2GYZ A;  5JZ7 A;  1VPP V;  1DZ7 A;  1TFG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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