The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
11
|
sequence length |
108
|
structure length |
94
|
Chain Sequence |
VMVNLNIHNNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRFRLEKILVSVGCTCVTPIVH
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.
pubmed doi rcsb |
| molecule keywords |
Interleukin-17A
|
| molecule tags |
Immune system/inhibitor
|
| source organism |
Homo sapiens
|
| total genus |
11
|
| structure length |
94
|
| sequence length |
108
|
| chains with identical sequence |
B
|
| ec nomenclature | |
| pdb deposition date | 2016-01-11 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF06083 | IL17 | Interleukin-17 |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | Ribbon | Cystine Knot Cytokines, subunit B | Cystine-knot cytokines |
#chains in the Genus database with same CATH superfamily 1LXI A; 3HH2 A; 3IJ2 A; 3SEK B; 2X1X E; 1TZI V; 1HCN B; 2X1W A; 2H62 A; 5FV1 V; 4QAF C; 5HI5 A; 3V2A A; 1WQ9 A; 1FZV A; 2ASK A; 4EDX V; 3KFD A; 1KTZ A; 1BND B; 2ARP A; 5BQC A; 2QJA A; 2QCQ A; 4QHU C; 5HHD A; 1TFG A; 2QR0 C; 1NYU B; 2P6A A; 2GYZ A; 3BUK A; 2B0U A; 4KXZ A; 4YCI C; 5BQE B; 5HHC A; 4HSA A; 4EFV A; 1B8M B; 4EDW V; 1KLC A; 2H64 A; 1QFW B; 1BET A; 2XAC A; 2PJY A; 3BDY V; 5F3B C; 1WWW V; 2GOO A; 1KAT W; 5BQB A; 4QCI C; 2C7W A; 1HCN A; 4HQU A; 2XV7 A; 1AGQ A; 2VXS A; 3FUB B; 5HHX A; 3MJG A; 1SGF B; 3EO1 C; 1HCF A; 2VWE A; 4HR9 A; 1M4U A; 2FJH V; 1NYS B; 1BND A; 2BHK A; 1MJV A; 5HI3 A; 4MPL A; 4MQW B; 1BTG A; 2TGI A; 2GH0 C; 4UI1 A; 5JZ7 A; 3BK3 A; 4FAO A; 1HD4 A; 1MKG A; 1HRP B; 1FL7 B; 5HK5 E; 4UHZ A; 1ES7 A; 5HK5 A; 1CZ8 V; 2QCW A; 5BQE A; 1B8M A; 5F3H I; 3S1K V; 4HQX A; 1ZKZ A; 3B4V A; 4MID A; 3RJR A; 2ARV A; 1QFW A; 5FV2 V; 4LXR J; 2QJB A; 2FJG V; 5AEJ A; 1JPY A; 4WPB A; 1B8K A; 3S1B V; 4YCG C; 4AY9 B; 4GLS E; 1XWD B; 5BQ8 B; 1LX5 A; 1MKK A; 1TGJ A; 1PDG A; 4KV5 A; 3V6B A; 4MQW A; 1FLT V; 1VPP V; 1TZH V; 2GYR A; 4EAX A; 1B98 A; 5E4G A; 1VPF A; 1BMP A; 1BJ1 V; 1S4Y B; 1HRP A; 4N1D A; 1E9J A; 1FL7 A; 3JVF A; 5BQ8 D; 2GNN A; 3QTK A; 2VPF A; 1RV6 V; 4X1J A; 5HHV A; 5HI4 A; 4ZBN A; 3QB4 A; 4EC7 A; 2R53 A; 2KD3 A; 4UI0 A; 1KLA A; 4ZFF C; 1WQ9 B; 4UHY A; 5BPU A; 4XPJ A; 4GLN E; 1M4U L; 2V5E B; 4AY9 A; 3MJK A; 4UI2 B; 3P9W A; 1WQ8 A; 4KZN A; 1XWD A; 1AOC A; 5BQ8 A; 1REW A; 1NT3 A; 1WAQ A; 1QTY R; 1REU A; 3E07 A; 4BV4 L; 3BMP A; 2R52 A; 2IFG E; 1DZ7 A; 3EVS B; 2QJ9 A; 1TGK A; 4LXS J; 1SG1 A; #chains in the Genus database with same CATH topology 1LXI A; 3HH2 A; 3IJ2 A; 3SEK B; 2X1X E; 1TZI V; 1HCN B; 2X1W A; 2H62 A; 5FV1 V; 4QAF C; 5HI5 A; 3V2A A; 1WQ9 A; 1FZV A; 2ASK A; 4EDX V; 3KFD A; 1KTZ A; 1BND B; 2ARP A; 5BQC A; 2QJA A; 2QCQ A; 4QHU C; 5HHD A; 1TFG A; 2QR0 C; 1NYU B; 2P6A A; 2GYZ A; 3BUK A; 2B0U A; 4KXZ A; 4YCI C; 5BQE B; 5HHC A; 4HSA A; 4EFV A; 1B8M B; 4EDW V; 1KLC A; 2H64 A; 1QFW B; 1BET A; 2XAC A; 2PJY A; 3BDY V; 5F3B C; 1WWW V; 2GOO A; 1KAT W; 5BQB A; 4QCI C; 2C7W A; 1HCN A; 4HQU A; 2XV7 A; 1AGQ A; 2VXS A; 3FUB B; 5HHX A; 3MJG A; 1SGF B; 3EO1 C; 1HCF A; 2VWE A; 4HR9 A; 1M4U A; 2FJH V; 1NYS B; 1BND A; 2BHK A; 1MJV A; 5HI3 A; 4MPL A; 4MQW B; 1BTG A; 2TGI A; 2GH0 C; 4UI1 A; 5JZ7 A; 3BK3 A; 4FAO A; 1HD4 A; 1MKG A; 1HRP B; 1FL7 B; 5HK5 E; 4UHZ A; 1ES7 A; 5HK5 A; 1CZ8 V; 2QCW A; 5BQE A; 1B8M A; 5F3H I; 3S1K V; 4HQX A; 1ZKZ A; 3B4V A; 4MID A; 3RJR A; 2ARV A; 1QFW A; 5FV2 V; 4LXR J; 2QJB A; 2FJG V; 5AEJ A; 1JPY A; 4WPB A; 1B8K A; 3S1B V; 4YCG C; 4AY9 B; 4GLS E; 1XWD B; 5BQ8 B; 1LX5 A; 1MKK A; 1TGJ A; 1PDG A; 4KV5 A; 3V6B A; 4MQW A; 1FLT V; 1VPP V; 1TZH V; 2GYR A; 4EAX A; 1B98 A; 5E4G A; 1VPF A; 1BMP A; 1BJ1 V; 1S4Y B; 1HRP A; 4N1D A; 1E9J A; 1FL7 A; 3JVF A; 5BQ8 D; 2GNN A; 3QTK A; 2VPF A; 1RV6 V; 4X1J A; 5HHV A; 5HI4 A; 4ZBN A; 3QB4 A; 4EC7 A; 2R53 A; 2KD3 A; 4UI0 A; 1KLA A; 4ZFF C; 1WQ9 B; 4UHY A; 5BPU A; 4XPJ A; 4GLN E; 1M4U L; 2V5E B; 4AY9 A; 3MJK A; 4UI2 B; 3P9W A; 1WQ8 A; 4KZN A; 1XWD A; 1AOC A; 5BQ8 A; 1REW A; 1NT3 A; 1WAQ A; 1QTY R; 1REU A; 3E07 A; 4BV4 L; 3BMP A; 2R52 A; 2IFG E; 1DZ7 A; 3EVS B; 2QJ9 A; 1TGK A; 4LXS J; 1SG1 A; #chains in the Genus database with same CATH homology 1LXI A; 3HH2 A; 3IJ2 A; 3SEK B; 2X1X E; 1TZI V; 1HCN B; 2X1W A; 2H62 A; 5FV1 V; 4QAF C; 5HI5 A; 3V2A A; 1WQ9 A; 1FZV A; 2ASK A; 4EDX V; 3KFD A; 1KTZ A; 1BND B; 2ARP A; 5BQC A; 2QJA A; 2QCQ A; 4QHU C; 5HHD A; 1TFG A; 2QR0 C; 1NYU B; 2P6A A; 2GYZ A; 3BUK A; 2B0U A; 4KXZ A; 4YCI C; 5BQE B; 5HHC A; 4HSA A; 4EFV A; 1B8M B; 4EDW V; 1KLC A; 2H64 A; 1QFW B; 1BET A; 2XAC A; 2PJY A; 3BDY V; 5F3B C; 1WWW V; 2GOO A; 1KAT W; 5BQB A; 4QCI C; 2C7W A; 1HCN A; 4HQU A; 2XV7 A; 1AGQ A; 2VXS A; 3FUB B; 5HHX A; 3MJG A; 1SGF B; 3EO1 C; 1HCF A; 2VWE A; 4HR9 A; 1M4U A; 2FJH V; 1NYS B; 1BND A; 2BHK A; 1MJV A; 5HI3 A; 4MPL A; 4MQW B; 1BTG A; 2TGI A; 2GH0 C; 4UI1 A; 5JZ7 A; 3BK3 A; 4FAO A; 1HD4 A; 1MKG A; 1HRP B; 1FL7 B; 5HK5 E; 4UHZ A; 1ES7 A; 5HK5 A; 1CZ8 V; 2QCW A; 5BQE A; 1B8M A; 5F3H I; 3S1K V; 4HQX A; 1ZKZ A; 3B4V A; 4MID A; 3RJR A; 2ARV A; 1QFW A; 5FV2 V; 4LXR J; 2QJB A; 2FJG V; 5AEJ A; 1JPY A; 4WPB A; 1B8K A; 3S1B V; 4YCG C; 4AY9 B; 4GLS E; 1XWD B; 5BQ8 B; 1LX5 A; 1MKK A; 1TGJ A; 1PDG A; 4KV5 A; 3V6B A; 4MQW A; 1FLT V; 1VPP V; 1TZH V; 2GYR A; 4EAX A; 1B98 A; 5E4G A; 1VPF A; 1BMP A; 1BJ1 V; 1S4Y B; 1HRP A; 4N1D A; 1E9J A; 1FL7 A; 3JVF A; 5BQ8 D; 2GNN A; 3QTK A; 2VPF A; 1RV6 V; 4X1J A; 5HHV A; 5HI4 A; 4ZBN A; 3QB4 A; 4EC7 A; 2R53 A; 2KD3 A; 4UI0 A; 1KLA A; 4ZFF C; 1WQ9 B; 4UHY A; 5BPU A; 4XPJ A; 4GLN E; 1M4U L; 2V5E B; 4AY9 A; 3MJK A; 4UI2 B; 3P9W A; 1WQ8 A; 4KZN A; 1XWD A; 1AOC A; 5BQ8 A; 1REW A; 1NT3 A; 1WAQ A; 1QTY R; 1REU A; 3E07 A; 4BV4 L; 3BMP A; 2R52 A; 2IFG E; 1DZ7 A; 3EVS B; 2QJ9 A; 1TGK A; 4LXS J; 1SG1 A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
