1GK1A

Structure-based prediction of modifications in glutarylamidase to allow single-step enzymatic production of 7-aminocephalosporanic acid from cephalosporin c
Total Genus 52

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
153
structure length
153
Chain Sequence
QAPIAAYKPRSNEILWDGYGVPHIYGVDAPSAFYGYGWAQARSHGDNILRLYGEARGKGAEYWGPDYEQTTVWLLTNGVPERAQQWYAQQSPDFRANLDAFAAGINAYAQQNPDDISPEVRQVLPVSGADVVAHAHRLMNFLYVASPGRTLGE
2040608010012014014012010080604020
01020304050Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYAH1 (36-63)S2 (28-32)AH5 (99-118)AH6 (135-148)3H2 (120-122)AH2 (65-70)TVIII1 (150-153)AH3 (75-84)3H3 (125-130)TI1 (24-27)AH4 (86-96)TIV3 (148-151)TIV1 (33-36)3H1 (72-74)TIV2 (130-133)S1 (20-24)Updating...
connected with : NaN
publication title Structure-Based Prediction of Modifications in Glutarylamidase to Allow Single-Step Enzymatic Production of 7-Aminocephalosporanic Acid from Cephalosporin C.
pubmed doi rcsb
molecule tags Hydrolase
source organism Pseudomonas sp.
molecule keywords CEPHALOSPORIN ACYLASE
total genus 52
structure length 153
sequence length 153
chains with identical sequence C
ec nomenclature ec 3.5.1.93: Glutaryl-7-aminocephalosporanic-acid acylase.
pdb deposition date 2001-08-07
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.439.10 Mainly Alpha Orthogonal Bundle Penicillin Amidohydrolase; domain 1 Penicillin Amidohydrolase, domain 1 1gk1A00
4HSRA 4PELA 4YF9A 3SRAA 4K2FA 4M1JA 1E3AA 1H2GA 1CP9A 1FXVA 2AE3A 3K3WA 1AJPA 1PNMA 4E57A 2AE5A 1AJQA 1OR0A 2ADVA 4YFBA 1K5SA 1GM7A 4WKSA 1GK9A 4BTHA 1KECA 2WYCA 2AE4A 1KEHA 4HSTA 3SRBA 1GM9A 2WYDA 4K2GA 1AI6A 3S8RA 1AI5A 1AI4A 2WYEA 4WKVA 4E56A 1JW0A 1JX9A 2WYBA 1PNKA 3JTQA 1GK1A 1GM8A 3L91A 3ML0A 4WKTA 1AI7A 1GK0A 1K7DA 4PEMA 3L94A 4YFAA 1AJNA 3JTRA 4WKUA 3SRCA 4E55A 1FM2A 1JVZA 1K5QA 1GKFA 1GHDA 1FXHA 1PNLA
chains in the Genus database with same CATH superfamily
4HSRA 4PELA 4YF9A 3SRAA 4K2FA 4M1JA 1E3AA 1H2GA 1CP9A 1FXVA 2AE3A 3K3WA 1AJPA 1PNMA 4BWCA 2AE5A 4E57A 1AJQA 1OR0A 2ADVA 4YFBA 1K5SA 1GM7A 4WKSA 1GK9A 4BTHA 1KECA 2WYCA 2AE4A 1KEHA 4HSTA 3FGRA 3FGTA 3SRBA 1GM9A 2WYDA 4K2GA 1AI6A 3S8RA 1AI5A 1AI4A 2WYEA 4WKVA 4E56A 1JW0A 1JX9A 2WYBA 1PNKA 3JTQA 1GK1A 1GM8A 3L91A 3ML0A 4WKTA 1AI7A 1GK0A 1K7DA 4PEMA 3L94A 4YFAA 1AJNA 3JTRA 4WKUA 3SRCA 4E55A 1FM2A 1JVZA 1K5QA 1GKFA 1GHDA 1FXHA 1PNLA
chains in the Genus database with same CATH topology
4HSRA 4PELA 4YF9A 3SRAA 4K2FA 4M1JA 1E3AA 1H2GA 1CP9A 1FXVA 2AE3A 3K3WA 1AJPA 1PNMA 4E57A 2AE5A 1AJQA 1OR0A 2ADVA 4YFBA 1K5SA 1GM7A 4WKSA 1GK9A 4BTHA 1KECA 2WYCA 2AE4A 1KEHA 4HSTA 3SRBA 1GM9A 2WYDA 4K2GA 1AI6A 3S8RA 1AI5A 1AI4A 2WYEA 4WKVA 4E56A 1JW0A 1JX9A 2WYBA 1PNKA 3JTQA 1GK1A 1GM8A 3L91A 3ML0A 4WKTA 1AI7A 1GK0A 1K7DA 4PEMA 3L94A 4YFAA 1AJNA 3JTRA 4WKUA 3SRCA 4E55A 1FM2A 1JVZA 1K5QA 1GKFA 1GHDA 1FXHA 1PNLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HSR A;  4PEL A;  4YF9 A;  3SRA A;  4K2F A;  4M1J A;  1E3A A;  1H2G A;  1CP9 A;  1FXV A;  2AE3 A;  3K3W A;  1AJP A;  1PNM A;  4E57 A;  2AE5 A;  1AJQ A;  1OR0 A;  2ADV A;  4YFB A;  1K5S A;  1GM7 A;  4WKS A;  1GK9 A;  4BTH A;  1KEC A;  2WYC A;  2AE4 A;  1KEH A;  4HST A;  3SRB A;  1GM9 A;  2WYD A;  4K2G A;  1AI6 A;  3S8R A;  1AI5 A;  1AI4 A;  2WYE A;  4WKV A;  4E56 A;  1JW0 A;  1JX9 A;  2WYB A;  1PNK A;  3JTQ A;  1GK1 A;  1GM8 A;  3L91 A;  3ML0 A;  4WKT A;  1AI7 A;  1GK0 A;  1K7D A;  4PEM A;  3L94 A;  4YFA A;  1AJN A;  3JTR A;  4WKU A;  3SRC A;  4E55 A;  1FM2 A;  1JVZ A;  1K5Q A;  1GKF A;  1GHD A;  1FXH A;  1PNL A; 
#chains in the Genus database with same CATH topology
 4HSR A;  4PEL A;  4YF9 A;  3SRA A;  4K2F A;  4M1J A;  1E3A A;  1H2G A;  1CP9 A;  1FXV A;  2AE3 A;  3K3W A;  1AJP A;  1PNM A;  4BWC A;  2AE5 A;  4E57 A;  1AJQ A;  1OR0 A;  2ADV A;  4YFB A;  1K5S A;  1GM7 A;  4WKS A;  1GK9 A;  4BTH A;  1KEC A;  2WYC A;  2AE4 A;  1KEH A;  4HST A;  3FGR A;  3FGT A;  3SRB A;  1GM9 A;  2WYD A;  4K2G A;  1AI6 A;  3S8R A;  1AI5 A;  1AI4 A;  2WYE A;  4WKV A;  4E56 A;  1JW0 A;  1JX9 A;  2WYB A;  1PNK A;  3JTQ A;  1GK1 A;  1GM8 A;  3L91 A;  3ML0 A;  4WKT A;  1AI7 A;  1GK0 A;  1K7D A;  4PEM A;  3L94 A;  4YFA A;  1AJN A;  3JTR A;  4WKU A;  3SRC A;  4E55 A;  1FM2 A;  1JVZ A;  1K5Q A;  1GKF A;  1GHD A;  1FXH A;  1PNL A; 
#chains in the Genus database with same CATH homology
 4HSR A;  4PEL A;  4YF9 A;  3SRA A;  4K2F A;  4M1J A;  1E3A A;  1H2G A;  1CP9 A;  1FXV A;  2AE3 A;  3K3W A;  1AJP A;  1PNM A;  4E57 A;  2AE5 A;  1AJQ A;  1OR0 A;  2ADV A;  4YFB A;  1K5S A;  1GM7 A;  4WKS A;  1GK9 A;  4BTH A;  1KEC A;  2WYC A;  2AE4 A;  1KEH A;  4HST A;  3SRB A;  1GM9 A;  2WYD A;  4K2G A;  1AI6 A;  3S8R A;  1AI5 A;  1AI4 A;  2WYE A;  4WKV A;  4E56 A;  1JW0 A;  1JX9 A;  2WYB A;  1PNK A;  3JTQ A;  1GK1 A;  1GM8 A;  3L91 A;  3ML0 A;  4WKT A;  1AI7 A;  1GK0 A;  1K7D A;  4PEM A;  3L94 A;  4YFA A;  1AJN A;  3JTR A;  4WKU A;  3SRC A;  4E55 A;  1FM2 A;  1JVZ A;  1K5Q A;  1GKF A;  1GHD A;  1FXH A;  1PNL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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