4LABA

Crystal structure of the catalytic domain of rlub
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
187
structure length
187
Chain Sequence
QICRVLAYYKPEGELCTRNDPEGRPTVFDRLPKLRGARWIAVGRLDVNTCGLLLFTTDGELANRLMHPSREVEREYAVRVFGQVDDAKLRDLSRGVQLEDGPAAFKTIKFSGGEGINQWYNVTLTEGRNREVRRLWEAVGVQVSRLIRVRYGDIPLPKGLPRGGWTELDLAQTNYLRELVELPPETS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
pubmed doi rcsb
molecule tags Rna binding protein
source organism Escherichia coli
molecule keywords Ribosomal large subunit pseudouridine synthase B
total genus 48
structure length 187
sequence length 187
ec nomenclature ec 5.4.99.22: 23S rRNA pseudouridine(2605) synthase.
pdb deposition date 2013-06-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00849 PseudoU_synth_2 RNA pseudouridylate synthase
A PF01479 S4 S4 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.2350.10 Alpha Beta 2-Layer Sandwich Pseudouridine synthase Pseudouridine synthase 4labA00
3UAIA 3LWPA 3U28A 4LABA 2RFKA 2AB4A 3LWVA 1SGVA 3HJYA 2HVYA 3LWOA 1QYUA 1R3FA 2EY4A 1KSLA 1ZE2A 2I82A 3MQKA 1V9FA 3LWRA 1PRZA 1ZE1A 3DH3A 1K8WA 3HAXA 3LWQA 1V9KA 1KSVA 1XPIA 1ZL3A 4LGTA 2AUSA 3HJWA 2APOA 1KSKA 1R3EA 2ISTA
chains in the Genus database with same CATH superfamily
1Z2ZA 3UAIA 3LWPA 3U28A 4LABA 1SZWA 2AB4A 2RFKA 3LWVA 1SGVA 3HJYA 2HVYA 3LWOA 1QYUA 1R3FA 2EY4A 1KSLA 1ZE2A 2I82A 3MQKA 1V9FA 3LWRA 1PRZA 1ZE1A 3DH3A 1K8WA 3HAXA 3LWQA 1SI7A 1V9KA 1KSVA 1SB7A 1XPIA 1ZL3A 4LGTA 2AUSA 3HJWA 2APOA 1KSKA 1R3EA 2ISTA
chains in the Genus database with same CATH topology
1Z2ZA 3UAIA 3LWPA 3U28A 4LABA 1SZWA 2AB4A 2RFKA 3LWVA 1SGVA 3HJYA 2HVYA 3LWOA 1QYUA 1R3FA 2EY4A 1KSLA 1ZE2A 2I82A 3MQKA 1V9FA 3LWRA 1PRZA 1ZE1A 3DH3A 1K8WA 3HAXA 3LWQA 1SI7A 1V9KA 1KSVA 1SB7A 1XPIA 1ZL3A 4LGTA 2AUSA 3HJWA 2APOA 1KSKA 1R3EA 2ISTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UAI A;  3LWP A;  3U28 A;  4LAB A;  2RFK A;  2AB4 A;  3LWV A;  1SGV A;  3HJY A;  2HVY A;  3LWO A;  1QYU A;  1R3F A;  2EY4 A;  1KSL A;  1ZE2 A;  2I82 A;  3MQK A;  1V9F A;  3LWR A;  1PRZ A;  1ZE1 A;  3DH3 A;  1K8W A;  3HAX A;  3LWQ A;  1V9K A;  1KSV A;  1XPI A;  1ZL3 A;  4LGT A;  2AUS A;  3HJW A;  2APO A;  1KSK A;  1R3E A;  2IST A; 
#chains in the Genus database with same CATH topology
 1Z2Z A;  3UAI A;  3LWP A;  3U28 A;  4LAB A;  1SZW A;  2AB4 A;  2RFK A;  3LWV A;  1SGV A;  3HJY A;  2HVY A;  3LWO A;  1QYU A;  1R3F A;  2EY4 A;  1KSL A;  1ZE2 A;  2I82 A;  3MQK A;  1V9F A;  3LWR A;  1PRZ A;  1ZE1 A;  3DH3 A;  1K8W A;  3HAX A;  3LWQ A;  1SI7 A;  1V9K A;  1KSV A;  1SB7 A;  1XPI A;  1ZL3 A;  4LGT A;  2AUS A;  3HJW A;  2APO A;  1KSK A;  1R3E A;  2IST A; 
#chains in the Genus database with same CATH homology
 1Z2Z A;  3UAI A;  3LWP A;  3U28 A;  4LAB A;  1SZW A;  2AB4 A;  2RFK A;  3LWV A;  1SGV A;  3HJY A;  2HVY A;  3LWO A;  1QYU A;  1R3F A;  2EY4 A;  1KSL A;  1ZE2 A;  2I82 A;  3MQK A;  1V9F A;  3LWR A;  1PRZ A;  1ZE1 A;  3DH3 A;  1K8W A;  3HAX A;  3LWQ A;  1SI7 A;  1V9K A;  1KSV A;  1SB7 A;  1XPI A;  1ZL3 A;  4LGT A;  2AUS A;  3HJW A;  2APO A;  1KSK A;  1R3E A;  2IST A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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