4LABA

Crystal structure of the catalytic domain of rlub
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
187
structure length
187
Chain Sequence
QICRVLAYYKPEGELCTRNDPEGRPTVFDRLPKLRGARWIAVGRLDVNTCGLLLFTTDGELANRLMHPSREVEREYAVRVFGQVDDAKLRDLSRGVQLEDGPAAFKTIKFSGGEGINQWYNVTLTEGRNREVRRLWEAVGVQVSRLIRVRYGDIPLPKGLPRGGWTELDLAQTNYLRELVELPPETS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
pubmed doi rcsb
molecule tags Rna binding protein
source organism Escherichia coli
molecule keywords Ribosomal large subunit pseudouridine synthase B
total genus 48
structure length 187
sequence length 187
ec nomenclature ec 5.4.99.22: 23S rRNA pseudouridine(2605) synthase.
pdb deposition date 2013-06-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00849 PseudoU_synth_2 RNA pseudouridylate synthase
A PF01479 S4 S4 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.2350.10 Alpha Beta 2-Layer Sandwich Pseudouridine synthase Pseudouridine synthase 4labA00
1ZL3A 1KSLA 1QYUA 3MQKA 3HJWA 1XPIA 1V9KA 1KSKA 1R3FA 2ISTA 3LWOA 2APOA 2I82A 1PRZA 2HVYA 1K8WA 1ZE2A 3HJYA 3UAIA 2AUSA 1ZE1A 1V9FA 4LGTA 3LWVA 3LWPA 3U28A 1R3EA 3LWRA 4LABA 1KSVA 3LWQA 2RFKA 3DH3A 2EY4A 1SGVA 3HAXA 2AB4A
chains in the Genus database with same CATH superfamily
1ZL3A 1KSLA 1QYUA 3MQKA 3HJWA 1XPIA 1V9KA 1KSKA 1R3FA 1Z2ZA 2ISTA 3LWOA 2APOA 2I82A 1PRZA 1SB7A 2HVYA 1K8WA 1ZE2A 3HJYA 3UAIA 2AUSA 1ZE1A 1V9FA 1SZWA 4LGTA 3LWVA 3LWPA 3U28A 1R3EA 1SI7A 3LWRA 4LABA 1KSVA 3LWQA 2RFKA 3DH3A 2EY4A 1SGVA 3HAXA 2AB4A
chains in the Genus database with same CATH topology
1ZL3A 1KSLA 1QYUA 3MQKA 3HJWA 1XPIA 1V9KA 1KSKA 1R3FA 1Z2ZA 2ISTA 3LWOA 2APOA 2I82A 1PRZA 1SB7A 2HVYA 1K8WA 1ZE2A 3HJYA 3UAIA 2AUSA 1ZE1A 1V9FA 1SZWA 4LGTA 3LWVA 3LWPA 3U28A 1R3EA 1SI7A 3LWRA 4LABA 1KSVA 3LWQA 2RFKA 3DH3A 2EY4A 1SGVA 3HAXA 2AB4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZL3 A;  1KSL A;  1QYU A;  3MQK A;  3HJW A;  1XPI A;  1V9K A;  1KSK A;  1R3F A;  2IST A;  3LWO A;  2APO A;  2I82 A;  1PRZ A;  2HVY A;  1K8W A;  1ZE2 A;  3HJY A;  3UAI A;  2AUS A;  1ZE1 A;  1V9F A;  4LGT A;  3LWV A;  3LWP A;  3U28 A;  1R3E A;  3LWR A;  4LAB A;  1KSV A;  3LWQ A;  2RFK A;  3DH3 A;  2EY4 A;  1SGV A;  3HAX A;  2AB4 A; 
#chains in the Genus database with same CATH topology
 1ZL3 A;  1KSL A;  1QYU A;  3MQK A;  3HJW A;  1XPI A;  1V9K A;  1KSK A;  1R3F A;  1Z2Z A;  2IST A;  3LWO A;  2APO A;  2I82 A;  1PRZ A;  1SB7 A;  2HVY A;  1K8W A;  1ZE2 A;  3HJY A;  3UAI A;  2AUS A;  1ZE1 A;  1V9F A;  1SZW A;  4LGT A;  3LWV A;  3LWP A;  3U28 A;  1R3E A;  1SI7 A;  3LWR A;  4LAB A;  1KSV A;  3LWQ A;  2RFK A;  3DH3 A;  2EY4 A;  1SGV A;  3HAX A;  2AB4 A; 
#chains in the Genus database with same CATH homology
 1ZL3 A;  1KSL A;  1QYU A;  3MQK A;  3HJW A;  1XPI A;  1V9K A;  1KSK A;  1R3F A;  1Z2Z A;  2IST A;  3LWO A;  2APO A;  2I82 A;  1PRZ A;  1SB7 A;  2HVY A;  1K8W A;  1ZE2 A;  3HJY A;  3UAI A;  2AUS A;  1ZE1 A;  1V9F A;  1SZW A;  4LGT A;  3LWV A;  3LWP A;  3U28 A;  1R3E A;  1SI7 A;  3LWR A;  4LAB A;  1KSV A;  3LWQ A;  2RFK A;  3DH3 A;  2EY4 A;  1SGV A;  3HAX A;  2AB4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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