1ZE2A

Conformational change of pseudouridine 55 synthase upon its association with rna substrate
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
308
structure length
300
Chain Sequence
MKHGILVAYKPKGPTSHDVVDEVRKKLKTRKVGHGGTLDPFACGVLIIGVNQGTRILEFYKDLKKVYWVKMRLGLITETFDITGEVVEERECNVTEEEIREAIFSFVGEYDQVPPAYSAKKYKGERLYKLAREGKIINLPPKRVKIFKIWDVNIEGRDVSFRVEVSPGTYIRSLCMDIGYKLGCGATAVELVRESVGPHTIEESLNVFEAAPEEIENRIIPLEKCLEWLPRVVVHQESTKMILNGSQIHLEMLKEWDGFKKGEVVRVFNEEGRLLALAEAERNSSFRQERVLTLRKVFQT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase/rna
molecule keywords 5'-R(*GP*GP*CP*CP*AP*CP*GP*GP*UP*(FHU)P*CP*GP*AP*AP*UP*CP*CP
publication title Conformational change of pseudouridine 55 synthase upon its association with RNA substrate
pubmed doi rcsb
source organism Thermotoga maritima
total genus 75
structure length 300
sequence length 308
chains with identical sequence B
ec nomenclature ec 5.4.99.25: tRNA pseudouridine(55) synthase.
pdb deposition date 2005-04-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01472 PUA PUA domain
A PF01509 TruB_N TruB family pseudouridylate synthase (N terminal domain)
A PF16198 TruB_C_2 tRNA pseudouridylate synthase B C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.130.10 Mainly Beta Roll Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 PUA domain 1ze2A02
3.30.2350.10 Alpha Beta 2-Layer Sandwich Pseudouridine synthase Pseudouridine synthase 1ze2A01
2AB4A 2APOA 1J2BA 2EY4A 3LWVA 1XPIA 1SGVA 3C0KA 3LDFA 4LGTA 1ZE2A 3HJWA 2ISTA 2CWWA 3LWPA 3DH3A 2P38A 2I82A 4LABA 3VSEA 1WXXA 2CX1A 2J5VA 3HAXA 2AS0A 3MQKA 3UAIA 2Q07A 1WXWA 2CX0A 1IQ8A 3HJYA 1Q7HA 1ZL3A 1IT7A 2HVYA 2AUSA 1T5YA 3D79A 1SQWA 2RFKA 1PRZA 1R3FA 1R3EA 1ZE1A 1KSLA 3U28A 2J5TA 1KSVA 1V9FA 2B78A 4Q1TA 3LWQA 3LWRA 1K8WA 1QYUA 3LWOA 1KSKA 1ZS7A 1V9KA 1IT8A 4DMGA
chains in the Genus database with same CATH superfamily
2APOA 1J2BA 4LGTA 3M65A 1WK2A 4LABA 3VSEA 2AS0A 3UAIA 3LJCA 3HJYA 1Q7HA 1ZL3A 1ZBOA 1KSLA 3U28A 1SZWA 3M6XA 1QYUA 1V9FA 4DMGA 3M6VA 3LWPA 3M6WA 2Z0TA 3MQKA 2Q07A 1WXWA 1IQ8A 3M4XA 1T5YA 3D79A 1SQWA 2J5TA 1KSVA 3LWRA 1K8WA 1Z2ZA 2AB4A 3LWVA 1XPIA 3LDFA 1ZE2A 3HJWA 3DH3A 2P38A 2I82A 2J5VA 3ZV0C 2E5OA 2FRXA 1IT7A 4CI2B 2RFKA 1SB7A 1ZE1A 1UOYA 1S04A 4TZ4C 4CI3B 4CI1B 1KSKA 1IT8A 2EY4A 1SGVA 3C0KA 1XNEA 1SI7A 2ISTA 2CWWA 2KKUA 3M6UA 1WXXA 2CX1A 3HAXA 2CX0A 2HVYA 2DP9A 2AUSA 1TE7A 1PRZA 1R3FA 1R3EA 3IUWA 2B78A 4Q1TA 3LWQA 3LWOA 2ANEA 1ZS7A 1V9KA
chains in the Genus database with same CATH topology
2AB4A 2APOA 1J2BA 2EY4A 3LWVA 1XPIA 1SGVA 3C0KA 3LDFA 1SI7A 4LGTA 1ZE2A 3HJWA 2ISTA 2CWWA 3LWPA 3DH3A 2P38A 2I82A 4LABA 3VSEA 1WXXA 2CX1A 2J5VA 3HAXA 2AS0A 3MQKA 3UAIA 2Q07A 1WXWA 2CX0A 1IQ8A 3HJYA 1Q7HA 1ZL3A 1IT7A 2HVYA 2AUSA 1T5YA 3D79A 1SQWA 2RFKA 1PRZA 1R3FA 1R3EA 1SB7A 1ZE1A 1KSLA 3U28A 2J5TA 1KSVA 1V9FA 2B78A 4Q1TA 3LWQA 1SZWA 1K8WA 3LWRA 1Z2ZA 1QYUA 3LWOA 1KSKA 1ZS7A 1V9KA 1IT8A 4DMGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2AB4 A;  2APO A;  1J2B A;  2EY4 A;  3LWV A;  1XPI A;  1SGV A;  3C0K A;  3LDF A;  4LGT A;  1ZE2 A;  3HJW A;  2IST A;  2CWW A;  3LWP A;  3DH3 A;  2P38 A;  2I82 A;  4LAB A;  3VSE A;  1WXX A;  2CX1 A;  2J5V A;  3HAX A;  2AS0 A;  3MQK A;  3UAI A;  2Q07 A;  1WXW A;  2CX0 A;  1IQ8 A;  3HJY A;  1Q7H A;  1ZL3 A;  1IT7 A;  2HVY A;  2AUS A;  1T5Y A;  3D79 A;  1SQW A;  2RFK A;  1PRZ A;  1R3F A;  1R3E A;  1ZE1 A;  1KSL A;  3U28 A;  2J5T A;  1KSV A;  1V9F A;  2B78 A;  4Q1T A;  3LWQ A;  3LWR A;  1K8W A;  1QYU A;  3LWO A;  1KSK A;  1ZS7 A;  1V9K A;  1IT8 A;  4DMG A; 
#chains in the Genus database with same CATH topology
 2APO A;  1J2B A;  4LGT A;  3M65 A;  1WK2 A;  4LAB A;  3VSE A;  2AS0 A;  3UAI A;  3LJC A;  3HJY A;  1Q7H A;  1ZL3 A;  1ZBO A;  1KSL A;  3U28 A;  1SZW A;  3M6X A;  1QYU A;  1V9F A;  4DMG A;  3M6V A;  3LWP A;  3M6W A;  2Z0T A;  3MQK A;  2Q07 A;  1WXW A;  1IQ8 A;  3M4X A;  1T5Y A;  3D79 A;  1SQW A;  2J5T A;  1KSV A;  3LWR A;  1K8W A;  1Z2Z A;  2AB4 A;  3LWV A;  1XPI A;  3LDF A;  1ZE2 A;  3HJW A;  3DH3 A;  2P38 A;  2I82 A;  2J5V A;  3ZV0 C;  2E5O A;  2FRX A;  1IT7 A;  4CI2 B;  2RFK A;  1SB7 A;  1ZE1 A;  1UOY A;  1S04 A;  4TZ4 C;  4CI3 B;  4CI1 B;  1KSK A;  1IT8 A;  2EY4 A;  1SGV A;  3C0K A;  1XNE A;  1SI7 A;  2IST A;  2CWW A;  2KKU A;  3M6U A;  1WXX A;  2CX1 A;  3HAX A;  2CX0 A;  2HVY A;  2DP9 A;  2AUS A;  1TE7 A;  1PRZ A;  1R3F A;  1R3E A;  3IUW A;  2B78 A;  4Q1T A;  3LWQ A;  3LWO A;  2ANE A;  1ZS7 A;  1V9K A; 
#chains in the Genus database with same CATH homology
 2AB4 A;  2APO A;  1J2B A;  2EY4 A;  3LWV A;  1XPI A;  1SGV A;  3C0K A;  3LDF A;  1SI7 A;  4LGT A;  1ZE2 A;  3HJW A;  2IST A;  2CWW A;  3LWP A;  3DH3 A;  2P38 A;  2I82 A;  4LAB A;  3VSE A;  1WXX A;  2CX1 A;  2J5V A;  3HAX A;  2AS0 A;  3MQK A;  3UAI A;  2Q07 A;  1WXW A;  2CX0 A;  1IQ8 A;  3HJY A;  1Q7H A;  1ZL3 A;  1IT7 A;  2HVY A;  2AUS A;  1T5Y A;  3D79 A;  1SQW A;  2RFK A;  1PRZ A;  1R3F A;  1R3E A;  1SB7 A;  1ZE1 A;  1KSL A;  3U28 A;  2J5T A;  1KSV A;  1V9F A;  2B78 A;  4Q1T A;  3LWQ A;  1SZW A;  1K8W A;  3LWR A;  1Z2Z A;  1QYU A;  3LWO A;  1KSK A;  1ZS7 A;  1V9K A;  1IT8 A;  4DMG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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