3DH3A

Crystal structure of rluf in complex with a 22 nucleotide rna substrate
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
240
structure length
240
Chain Sequence
DSSVRLNKYISESGICSRREADRYIEQGNVFLNGKRATIGDQVKPGDVVKVNGQLIEPREAEDLVLIALNKPVGIVSTTEDGERDNIVDFVNHSKRVFPIGRLDKDSQGLIFLTNHGDLVNKILRAGNDHEKEYLVTVDKPITEEFIRGMSAGVPILGTVTKKCKVKKEAPFVFRITLVQGLNRQIRRMCEHFGYEVKKLERTRIMNVSLSGIPLGEWRDLTDDELIDLFKLIENSSSEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome.
pubmed doi rcsb
molecule tags Isomerase/rna
source organism Escherichia coli
molecule keywords Ribosomal large subunit pseudouridine synthase F
total genus 60
structure length 240
sequence length 240
chains with identical sequence B, C, D
ec nomenclature ec 5.4.99.21: 23S rRNA pseudouridine(2604) synthase.
pdb deposition date 2008-06-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00849 PseudoU_synth_2 RNA pseudouridylate synthase
A PF01479 S4 S4 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.290.10 Alpha Beta Roll Structural Genomics Hypothetical 15.5 Kd Protein In mrcA-pckA Intergenic Region; Chain A RNA-binding S4 domain 3dh3A01
3.30.2350.10 Alpha Beta 2-Layer Sandwich Pseudouridine synthase Pseudouridine synthase 3dh3A02
4LGTA 1N36D 1XNRD 2UUCD 2KTLA 2JANA 1FKAD 1IBMD 4X62D 4JI1D 3T1HD 3HJWA 1HNXD 4DUZD 1SGVA 4X66D 4NXND 4NXMD 2AB4A 1N33D 4DV3D 4DR2D 4GKJD 4DV7D 2UXDD 2UUAD 4YHHD 3HP7A 1HR0D 3LWOA 2VQED 4B3MD 4LF6D 2F4VD 1JH3A 1VIOA 1C06A 5LMND 4DUYD 4JI3D 4JV5D 1KSVA 1XNQD 1XPIA 3T1YD 4X65D 1KSKA 4LFBD 1K8WA 4JI8D 2VQFD 4JI6D 1ZE2A 3HAXA 1J5ED 2UXBD 4LF8D 4B3TD 1N34D 1IBLD 4LF7D 4DV0D 4B3SD 4JI2D 4GKKD 2ISTA 4LABA 4AQYD 1HNWD 4JI5D 4LFCD 1N32D 4B3RD 4OUDA 2HHHD 2UXCD 1HNZD 1FJGD 4KHPD 1PRZA 2AUSA 3OTOD 4DR7D 5BR8D 4DR6D 4JI7D 3HJYA 4DR5D 1XMQD 1V9FA 4DV5D 3KBGA 4DV1D 1H3EA 2APOA 3LWPA 2UU9D 4LF4D 4LF5D 1QYUA 4LFAD 3U28A 2ZM6D 4DV6D 3UAIA 2I82A 4JYAD 1ZE1A 4X64D 3MQKA 1V9KA 1IBKD 4OX9D 4LF9D 4K0KD 4DV2D 3LWVA 1KSLA 4DV4D 4DR4D 1I94D 5IWAD 2RFKA 4JI4D 1DM9A 3LWQA 2E5LD 2HVYA 4DR1D 2K6PA 5LMUD 4YY3D 4DR3D 1H3FA 1R3EA 2EY4A 1ZL3A 2UUBD 1P9KA 1R3FA 3LWRA 3DH3A 1C05A 1XMOD 4JI0D
chains in the Genus database with same CATH superfamily
4II3A 5FLXE 4LGTA 3J80E 3ONGA 1N36D 5LL6S 1XNRD 2UUCD 2KTLA 2JANA 1FKAD 1IBMD 4X62D 4JI1D 3T1HD 3HJWA 1HNXD 4DUZD 1SGVA 3ONHA 4X66D 4NXND 4NXMD 5FQ2B 2AB4A 1N33D 4DV3D 4DR2D 5KNLA 4GKJD 4DV7D 2UXDD 2UUAD 4YHHD 4II2A 3KYDB 3HP7A 1HR0D 3LWOA 2VQED 1Y8RB 4B3MD 4LF6D 2F4VD 1JH3A 1VIOA 1C06A 4W5VB 5LMND 4DUYD 4JI3D 1KSVA 1XNQD 4JV5D 1XPIA 3T1YD 4X65D 1KSKA 4LFBD 1K8WA 4JI8D 2VQFD 4JI6D 1ZE2A 3HAXA 1J5ED 2UXBD 4LF8D 4B3TD 1N34D 1IBLD 4LF7D 4DV0D 4B3SD 4JI2D 4GKKD 2ISTA 2ZTBA 4LABA 4AQYD 1HNWD 4JI5D 4LFCD 1N32D 4B3RD 4OUDA 2HHHD 2UXCD 1HNZD 1FJGD 4KHPD 1PRZA 2AUSA 5A2QE 3OTOD 4DR7D 5BR8D 2LQ7A 4DR6D 4JI7D 3HJYA 4DR5D 1XMQD 1V9FA 4DV5D 3KBGA 4DV1D 1H3EA 2APOA 3LWPA 2UU9D 4LF4D 4LF5D 3CMMA 3JAME 1QYUA 4LFAD 3U28A 1SI7A 2ZM6D 4DV6D 1Y8XB 3UAIA 4NNJA 2I82A 4JYAD 1ZE1A 2I1SA 4X64D 3MQKA 1SB7A 1V9KA 1IBKD 4OX9D 3J7AF 4LF9D 4K0KD 4DV2D 5IT9E 3LWVA 1KSLA 4DV4D 4DR4D 1I94D 1Z2ZA 5IWAD 1SZWA 2RFKA 4JI4D 1DM9A 3LWQA 1Y8QB 3KYCB 2E5LD 2HVYA 4DR1D 2K6PA 3FN1A 5LMUD 4YY3D 4DR3D 1H3FA 1R3EA 2EY4A 3J81E 1ZL3A 2UUBD 1P9KA 2NVUB 1R3FA 3LWRA 3DH3A 1C05A 1XMOD 4JI0D
chains in the Genus database with same CATH topology
4LGTA 1N36D 1XNRD 2UUCD 2KTLA 2JANA 1FKAD 1IBMD 4X62D 4JI1D 3T1HD 3HJWA 1HNXD 4DUZD 1SGVA 4X66D 4NXND 4NXMD 2AB4A 1N33D 4DV3D 4DR2D 4GKJD 4DV7D 2UXDD 2UUAD 4YHHD 3HP7A 1HR0D 3LWOA 2VQED 4B3MD 4LF6D 2F4VD 1JH3A 1VIOA 1C06A 5LMND 4DUYD 4JI3D 4JV5D 1KSVA 1XNQD 1XPIA 3T1YD 4X65D 1KSKA 4LFBD 1K8WA 4JI8D 2VQFD 4JI6D 1ZE2A 3HAXA 1J5ED 2UXBD 4LF8D 4B3TD 1N34D 1IBLD 4LF7D 4DV0D 4B3SD 4JI2D 4GKKD 2ISTA 4LABA 4AQYD 1HNWD 4JI5D 4LFCD 1N32D 4B3RD 4OUDA 2HHHD 2UXCD 1HNZD 1FJGD 4KHPD 1PRZA 2AUSA 3OTOD 4DR7D 5BR8D 4DR6D 4JI7D 3HJYA 4DR5D 1XMQD 1V9FA 4DV5D 3KBGA 4DV1D 1H3EA 2APOA 3LWPA 2UU9D 4LF4D 4LF5D 1QYUA 4LFAD 3U28A 1SI7A 2ZM6D 4DV6D 3UAIA 2I82A 4JYAD 1ZE1A 4X64D 3MQKA 1SB7A 1V9KA 1IBKD 4OX9D 4LF9D 4K0KD 4DV2D 3LWVA 1KSLA 4DV4D 4DR4D 1I94D 1Z2ZA 5IWAD 1SZWA 2RFKA 4JI4D 1DM9A 3LWQA 2E5LD 2HVYA 4DR1D 2K6PA 5LMUD 4YY3D 4DR3D 1H3FA 1R3EA 2EY4A 1ZL3A 2UUBD 1P9KA 1R3FA 3LWRA 3DH3A 1C05A 1XMOD 4JI0D
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LGT A;  1N36 D;  1XNR D;  2UUC D;  2KTL A;  2JAN A;  1FKA D;  1IBM D;  4X62 D;  4JI1 D;  3T1H D;  3HJW A;  1HNX D;  4DUZ D;  1SGV A;  4X66 D;  4NXN D;  4NXM D;  2AB4 A;  1N33 D;  4DV3 D;  4DR2 D;  4GKJ D;  4DV7 D;  2UXD D;  2UUA D;  4YHH D;  3HP7 A;  1HR0 D;  3LWO A;  2VQE D;  4B3M D;  4LF6 D;  2F4V D;  1JH3 A;  1VIO A;  1C06 A;  5LMN D;  4DUY D;  4JI3 D;  4JV5 D;  1KSV A;  1XNQ D;  1XPI A;  3T1Y D;  4X65 D;  1KSK A;  4LFB D;  1K8W A;  4JI8 D;  2VQF D;  4JI6 D;  1ZE2 A;  3HAX A;  1J5E D;  2UXB D;  4LF8 D;  4B3T D;  1N34 D;  1IBL D;  4LF7 D;  4DV0 D;  4B3S D;  4JI2 D;  4GKK D;  2IST A;  4LAB A;  4AQY D;  1HNW D;  4JI5 D;  4LFC D;  1N32 D;  4B3R D;  4OUD A;  2HHH D;  2UXC D;  1HNZ D;  1FJG D;  4KHP D;  1PRZ A;  2AUS A;  3OTO D;  4DR7 D;  5BR8 D;  4DR6 D;  4JI7 D;  3HJY A;  4DR5 D;  1XMQ D;  1V9F A;  4DV5 D;  3KBG A;  4DV1 D;  1H3E A;  2APO A;  3LWP A;  2UU9 D;  4LF4 D;  4LF5 D;  1QYU A;  4LFA D;  3U28 A;  2ZM6 D;  4DV6 D;  3UAI A;  2I82 A;  4JYA D;  1ZE1 A;  4X64 D;  3MQK A;  1V9K A;  1IBK D;  4OX9 D;  4LF9 D;  4K0K D;  4DV2 D;  3LWV A;  1KSL A;  4DV4 D;  4DR4 D;  1I94 D;  5IWA D;  2RFK A;  4JI4 D;  1DM9 A;  3LWQ A;  2E5L D;  2HVY A;  4DR1 D;  2K6P A;  5LMU D;  4YY3 D;  4DR3 D;  1H3F A;  1R3E A;  2EY4 A;  1ZL3 A;  2UUB D;  1P9K A;  1R3F A;  3LWR A;  3DH3 A;  1C05 A;  1XMO D;  4JI0 D; 
#chains in the Genus database with same CATH topology
 4II3 A;  5FLX E;  4LGT A;  3J80 E;  3ONG A;  1N36 D;  5LL6 S;  1XNR D;  2UUC D;  2KTL A;  2JAN A;  1FKA D;  1IBM D;  4X62 D;  4JI1 D;  3T1H D;  3HJW A;  1HNX D;  4DUZ D;  1SGV A;  3ONH A;  4X66 D;  4NXN D;  4NXM D;  5FQ2 B;  2AB4 A;  1N33 D;  4DV3 D;  4DR2 D;  5KNL A;  4GKJ D;  4DV7 D;  2UXD D;  2UUA D;  4YHH D;  4II2 A;  3KYD B;  3HP7 A;  1HR0 D;  3LWO A;  2VQE D;  1Y8R B;  4B3M D;  4LF6 D;  2F4V D;  1JH3 A;  1VIO A;  1C06 A;  4W5V B;  5LMN D;  4DUY D;  4JI3 D;  1KSV A;  1XNQ D;  4JV5 D;  1XPI A;  3T1Y D;  4X65 D;  1KSK A;  4LFB D;  1K8W A;  4JI8 D;  2VQF D;  4JI6 D;  1ZE2 A;  3HAX A;  1J5E D;  2UXB D;  4LF8 D;  4B3T D;  1N34 D;  1IBL D;  4LF7 D;  4DV0 D;  4B3S D;  4JI2 D;  4GKK D;  2IST A;  2ZTB A;  4LAB A;  4AQY D;  1HNW D;  4JI5 D;  4LFC D;  1N32 D;  4B3R D;  4OUD A;  2HHH D;  2UXC D;  1HNZ D;  1FJG D;  4KHP D;  1PRZ A;  2AUS A;  5A2Q E;  3OTO D;  4DR7 D;  5BR8 D;  2LQ7 A;  4DR6 D;  4JI7 D;  3HJY A;  4DR5 D;  1XMQ D;  1V9F A;  4DV5 D;  3KBG A;  4DV1 D;  1H3E A;  2APO A;  3LWP A;  2UU9 D;  4LF4 D;  4LF5 D;  3CMM A;  3JAM E;  1QYU A;  4LFA D;  3U28 A;  1SI7 A;  2ZM6 D;  4DV6 D;  1Y8X B;  3UAI A;  4NNJ A;  2I82 A;  4JYA D;  1ZE1 A;  2I1S A;  4X64 D;  3MQK A;  1SB7 A;  1V9K A;  1IBK D;  4OX9 D;  3J7A F;  4LF9 D;  4K0K D;  4DV2 D;  5IT9 E;  3LWV A;  1KSL A;  4DV4 D;  4DR4 D;  1I94 D;  1Z2Z A;  5IWA D;  1SZW A;  2RFK A;  4JI4 D;  1DM9 A;  3LWQ A;  1Y8Q B;  3KYC B;  2E5L D;  2HVY A;  4DR1 D;  2K6P A;  3FN1 A;  5LMU D;  4YY3 D;  4DR3 D;  1H3F A;  1R3E A;  2EY4 A;  3J81 E;  1ZL3 A;  2UUB D;  1P9K A;  2NVU B;  1R3F A;  3LWR A;  3DH3 A;  1C05 A;  1XMO D;  4JI0 D; 
#chains in the Genus database with same CATH homology
 4LGT A;  1N36 D;  1XNR D;  2UUC D;  2KTL A;  2JAN A;  1FKA D;  1IBM D;  4X62 D;  4JI1 D;  3T1H D;  3HJW A;  1HNX D;  4DUZ D;  1SGV A;  4X66 D;  4NXN D;  4NXM D;  2AB4 A;  1N33 D;  4DV3 D;  4DR2 D;  4GKJ D;  4DV7 D;  2UXD D;  2UUA D;  4YHH D;  3HP7 A;  1HR0 D;  3LWO A;  2VQE D;  4B3M D;  4LF6 D;  2F4V D;  1JH3 A;  1VIO A;  1C06 A;  5LMN D;  4DUY D;  4JI3 D;  4JV5 D;  1KSV A;  1XNQ D;  1XPI A;  3T1Y D;  4X65 D;  1KSK A;  4LFB D;  1K8W A;  4JI8 D;  2VQF D;  4JI6 D;  1ZE2 A;  3HAX A;  1J5E D;  2UXB D;  4LF8 D;  4B3T D;  1N34 D;  1IBL D;  4LF7 D;  4DV0 D;  4B3S D;  4JI2 D;  4GKK D;  2IST A;  4LAB A;  4AQY D;  1HNW D;  4JI5 D;  4LFC D;  1N32 D;  4B3R D;  4OUD A;  2HHH D;  2UXC D;  1HNZ D;  1FJG D;  4KHP D;  1PRZ A;  2AUS A;  3OTO D;  4DR7 D;  5BR8 D;  4DR6 D;  4JI7 D;  3HJY A;  4DR5 D;  1XMQ D;  1V9F A;  4DV5 D;  3KBG A;  4DV1 D;  1H3E A;  2APO A;  3LWP A;  2UU9 D;  4LF4 D;  4LF5 D;  1QYU A;  4LFA D;  3U28 A;  1SI7 A;  2ZM6 D;  4DV6 D;  3UAI A;  2I82 A;  4JYA D;  1ZE1 A;  4X64 D;  3MQK A;  1SB7 A;  1V9K A;  1IBK D;  4OX9 D;  4LF9 D;  4K0K D;  4DV2 D;  3LWV A;  1KSL A;  4DV4 D;  4DR4 D;  1I94 D;  1Z2Z A;  5IWA D;  1SZW A;  2RFK A;  4JI4 D;  1DM9 A;  3LWQ A;  2E5L D;  2HVY A;  4DR1 D;  2K6P A;  5LMU D;  4YY3 D;  4DR3 D;  1H3F A;  1R3E A;  2EY4 A;  1ZL3 A;  2UUB D;  1P9K A;  1R3F A;  3LWR A;  3DH3 A;  1C05 A;  1XMO D;  4JI0 D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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