1C25A

Human cdc25a catalytic domain
Total Genus 55
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
161
structure length
161
Chain Sequence
MLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords CDC25A
total genus 55
structure length 161
sequence length 161
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 1998-04-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 1c25A00
5LAOA 1H4KX 2MOIA 1URHA 3ILMA 5HPAA 2J6PA 1QXNA 2K0ZA 3K9RA 2VSWA 2IFVA 1GN0A 2HHGA 3HZUA 3ICSA 1YS0A 2GWFA 3ICTA 2EG4B 3OP3A 1HZMA 3FNJA 5HBOA 1UARA 5HBLA 3FOJA 3ICRA 1OKGA 3G5JA 2ORAA 1TQ1A 3O3WA 1RHSA 5HBQA 1YT8A 2MOLA 4WH9A 1BOIA 3UTNX 2FSXA 1DP2A 3FS5A 2A2KA 5HBPA 1CWTA 3OLHA 1CWSA 1WV9A 3P3AA 1BOHA 1VEEA 3AAYA 3GK5A 3IPPA 2UZQA 2IFDA 3AAXA 1YMKA 1E0CA 1RHDA 1T3KA 1YMDA 4F67A 3IWHA 3HIXA 1ORBA 3TP9A 4WH7A 1WHBA 3R2UA 1YMLA 3NTAA 3IPOA 1QB0A 3I3UA 2JTRA 3NHVA 2EG3A 5LAMA 2MRMA 2DCQA 2EG4A 4OCGA 2WLRA 3NTDA 3I2VA 2WLXA 3MZZA 1H4MX 3D1PA 1YM9A 1GMXA 1CWRA 2OUCA 1C25A 3FLHA 3F4AA 3NT6A 2JTQA 3HWIA 2JTSA 3TG3A 3TG1B 2KL3A 4JGTA
chains in the Genus database with same CATH superfamily
5LAOA 1H4KX 2MOIA 1URHA 3ILMA 5HPAA 2J6PA 1QXNA 2K0ZA 3K9RA 2VSWA 2IFVA 1GN0A 2HHGA 3HZUA 3ICSA 1YS0A 2GWFA 3ICTA 2EG4B 3OP3A 1HZMA 3FNJA 5HBOA 1UARA 5HBLA 3FOJA 3ICRA 1OKGA 3G5JA 2ORAA 1TQ1A 3O3WA 1RHSA 5HBQA 1YT8A 2MOLA 4WH9A 1BOIA 3UTNX 2FSXA 1DP2A 3FS5A 2A2KA 5HBPA 1CWTA 3OLHA 1CWSA 1WV9A 3P3AA 1BOHA 1VEEA 3AAYA 3GK5A 3IPPA 2UZQA 2IFDA 3AAXA 1YMKA 1E0CA 1RHDA 1T3KA 1YMDA 4F67A 3IWHA 3HIXA 1ORBA 3TP9A 4WH7A 1WHBA 3R2UA 1YMLA 3NTAA 3IPOA 1QB0A 3I3UA 2JTRA 3NHVA 2EG3A 5LAMA 2MRMA 2DCQA 2EG4A 4OCGA 2WLRA 2Q82A 3NTDA 3I2VA 2WLXA 3MZZA 1H4MX 3D1PA 1YM9A 1GMXA 1CWRA 2OUCA 1C25A 3FLHA 3F4AA 3NT6A 2JTQA 3HWIA 2JTSA 3TG3A 3TG1B 2KL3A 4JGTA
chains in the Genus database with same CATH topology
5LAOA 1H4KX 2MOIA 1URHA 3ILMA 5HPAA 2J6PA 1QXNA 2K0ZA 3K9RA 2VSWA 2IFVA 1GN0A 2HHGA 3HZUA 3ICSA 1YS0A 2GWFA 3ICTA 2EG4B 3OP3A 1HZMA 3FNJA 5HBOA 1UARA 5HBLA 3FOJA 3ICRA 1OKGA 3G5JA 2ORAA 1TQ1A 3O3WA 1RHSA 5HBQA 1YT8A 2MOLA 4WH9A 1BOIA 3UTNX 2FSXA 1DP2A 3FS5A 2A2KA 5HBPA 1CWTA 3OLHA 1CWSA 1WV9A 3P3AA 1BOHA 1VEEA 3AAYA 3GK5A 3IPPA 2UZQA 2IFDA 3AAXA 1YMKA 1E0CA 1RHDA 1T3KA 1YMDA 4F67A 3IWHA 3HIXA 1ORBA 3TP9A 4WH7A 1WHBA 3R2UA 1YMLA 3NTAA 3IPOA 1QB0A 3I3UA 2JTRA 3NHVA 2EG3A 5LAMA 2MRMA 2DCQA 2EG4A 4OCGA 2WLRA 3NTDA 3I2VA 2WLXA 3MZZA 1H4MX 3D1PA 1YM9A 1GMXA 1CWRA 2OUCA 1C25A 3FLHA 3F4AA 3NT6A 2JTQA 3HWIA 2JTSA 3TG3A 3TG1B 2KL3A 4JGTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LAO A;  1H4K X;  2MOI A;  1URH A;  3ILM A;  5HPA A;  2J6P A;  1QXN A;  2K0Z A;  3K9R A;  2VSW A;  2IFV A;  1GN0 A;  2HHG A;  3HZU A;  3ICS A;  1YS0 A;  2GWF A;  3ICT A;  2EG4 B;  3OP3 A;  1HZM A;  3FNJ A;  5HBO A;  1UAR A;  5HBL A;  3FOJ A;  3ICR A;  1OKG A;  3G5J A;  2ORA A;  1TQ1 A;  3O3W A;  1RHS A;  5HBQ A;  1YT8 A;  2MOL A;  4WH9 A;  1BOI A;  3UTN X;  2FSX A;  1DP2 A;  3FS5 A;  2A2K A;  5HBP A;  1CWT A;  3OLH A;  1CWS A;  1WV9 A;  3P3A A;  1BOH A;  1VEE A;  3AAY A;  3GK5 A;  3IPP A;  2UZQ A;  2IFD A;  3AAX A;  1YMK A;  1E0C A;  1RHD A;  1T3K A;  1YMD A;  4F67 A;  3IWH A;  3HIX A;  1ORB A;  3TP9 A;  4WH7 A;  1WHB A;  3R2U A;  1YML A;  3NTA A;  3IPO A;  1QB0 A;  3I3U A;  2JTR A;  3NHV A;  2EG3 A;  5LAM A;  2MRM A;  2DCQ A;  2EG4 A;  4OCG A;  2WLR A;  3NTD A;  3I2V A;  2WLX A;  3MZZ A;  1H4M X;  3D1P A;  1YM9 A;  1GMX A;  1CWR A;  2OUC A;  1C25 A;  3FLH A;  3F4A A;  3NT6 A;  2JTQ A;  3HWI A;  2JTS A;  3TG3 A;  3TG1 B;  2KL3 A;  4JGT A; 
#chains in the Genus database with same CATH topology
 5LAO A;  1H4K X;  2MOI A;  1URH A;  3ILM A;  5HPA A;  2J6P A;  1QXN A;  2K0Z A;  3K9R A;  2VSW A;  2IFV A;  1GN0 A;  2HHG A;  3HZU A;  3ICS A;  1YS0 A;  2GWF A;  3ICT A;  2EG4 B;  3OP3 A;  1HZM A;  3FNJ A;  5HBO A;  1UAR A;  5HBL A;  3FOJ A;  3ICR A;  1OKG A;  3G5J A;  2ORA A;  1TQ1 A;  3O3W A;  1RHS A;  5HBQ A;  1YT8 A;  2MOL A;  4WH9 A;  1BOI A;  3UTN X;  2FSX A;  1DP2 A;  3FS5 A;  2A2K A;  5HBP A;  1CWT A;  3OLH A;  1CWS A;  1WV9 A;  3P3A A;  1BOH A;  1VEE A;  3AAY A;  3GK5 A;  3IPP A;  2UZQ A;  2IFD A;  3AAX A;  1YMK A;  1E0C A;  1RHD A;  1T3K A;  1YMD A;  4F67 A;  3IWH A;  3HIX A;  1ORB A;  3TP9 A;  4WH7 A;  1WHB A;  3R2U A;  1YML A;  3NTA A;  3IPO A;  1QB0 A;  3I3U A;  2JTR A;  3NHV A;  2EG3 A;  5LAM A;  2MRM A;  2DCQ A;  2EG4 A;  4OCG A;  2WLR A;  2Q82 A;  3NTD A;  3I2V A;  2WLX A;  3MZZ A;  1H4M X;  3D1P A;  1YM9 A;  1GMX A;  1CWR A;  2OUC A;  1C25 A;  3FLH A;  3F4A A;  3NT6 A;  2JTQ A;  3HWI A;  2JTS A;  3TG3 A;  3TG1 B;  2KL3 A;  4JGT A; 
#chains in the Genus database with same CATH homology
 5LAO A;  1H4K X;  2MOI A;  1URH A;  3ILM A;  5HPA A;  2J6P A;  1QXN A;  2K0Z A;  3K9R A;  2VSW A;  2IFV A;  1GN0 A;  2HHG A;  3HZU A;  3ICS A;  1YS0 A;  2GWF A;  3ICT A;  2EG4 B;  3OP3 A;  1HZM A;  3FNJ A;  5HBO A;  1UAR A;  5HBL A;  3FOJ A;  3ICR A;  1OKG A;  3G5J A;  2ORA A;  1TQ1 A;  3O3W A;  1RHS A;  5HBQ A;  1YT8 A;  2MOL A;  4WH9 A;  1BOI A;  3UTN X;  2FSX A;  1DP2 A;  3FS5 A;  2A2K A;  5HBP A;  1CWT A;  3OLH A;  1CWS A;  1WV9 A;  3P3A A;  1BOH A;  1VEE A;  3AAY A;  3GK5 A;  3IPP A;  2UZQ A;  2IFD A;  3AAX A;  1YMK A;  1E0C A;  1RHD A;  1T3K A;  1YMD A;  4F67 A;  3IWH A;  3HIX A;  1ORB A;  3TP9 A;  4WH7 A;  1WHB A;  3R2U A;  1YML A;  3NTA A;  3IPO A;  1QB0 A;  3I3U A;  2JTR A;  3NHV A;  2EG3 A;  5LAM A;  2MRM A;  2DCQ A;  2EG4 A;  4OCG A;  2WLR A;  3NTD A;  3I2V A;  2WLX A;  3MZZ A;  1H4M X;  3D1P A;  1YM9 A;  1GMX A;  1CWR A;  2OUC A;  1C25 A;  3FLH A;  3F4A A;  3NT6 A;  2JTQ A;  3HWI A;  2JTS A;  3TG3 A;  3TG1 B;  2KL3 A;  4JGT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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