1C25A

Human cdc25a catalytic domain
Total Genus 55
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
161
structure length
161
Chain Sequence
MLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords CDC25A
total genus 55
structure length 161
sequence length 161
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 1998-04-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 1c25A00
3NT6A 1RHDA 2OUCA 1UARA 1QXNA 3TG3A 1YMKA 1ORBA 4OCGA 2DCQA 3HZUA 3IWHA 1BOIA 2A2KA 3ICTA 3P3AA 1YMDA 3OLHA 3MZZA 1DP2A 3ILMA 3FNJA 3ICSA 3D1PA 1GN0A 2J6PA 2JTQA 2WLRA 2MOIA 2MRMA 2IFVA 2MOLA 3I3UA 3IPPA 3O3WA 1WV9A 4F67A 3GK5A 1YS0A 1E0CA 1CWSA 1YMLA 2GWFA 3FOJA 3NTDA 4WH7A 1T3KA 1H4MX 1GMXA 3ICRA 3NHVA 3OP3A 2HHGA 2JTSA 2EG4A 2VSWA 1URHA 3HIXA 3NTAA 2EG4B 4WH9A 2KL3A 1RHSA 1TQ1A 1C25A 2IFDA 2FSXA 1VEEA 1H4KX 3HWIA 3R2UA 3TP9A 1BOHA 2JTRA 5LAOA 2K0ZA 2EG3A 5HBQA 4JGTA 3F4AA 1OKGA 5HPAA 1YM9A 3IPOA 1YT8A 1HZMA 1QB0A 5HBPA 3AAYA 3TG1B 3FLHA 3FS5A 5LAMA 3G5JA 5HBLA 2WLXA 3UTNX 1WHBA 1CWRA 2ORAA 3I2VA 5HBOA 1CWTA 3AAXA 3K9RA 2UZQA
chains in the Genus database with same CATH superfamily
3NT6A 1RHDA 2OUCA 1UARA 1QXNA 3TG3A 1YMKA 1ORBA 4OCGA 2DCQA 3HZUA 3IWHA 1BOIA 2A2KA 3ICTA 3P3AA 1YMDA 3OLHA 3MZZA 1DP2A 3ILMA 3FNJA 3ICSA 3D1PA 1GN0A 2J6PA 2JTQA 2WLRA 2MOIA 2MRMA 2IFVA 2MOLA 3I3UA 3IPPA 3O3WA 1WV9A 4F67A 3GK5A 1YS0A 1E0CA 1CWSA 1YMLA 2GWFA 3FOJA 3NTDA 4WH7A 1T3KA 1H4MX 1GMXA 3ICRA 3NHVA 3OP3A 2HHGA 2JTSA 2EG4A 2VSWA 1URHA 3HIXA 3NTAA 2EG4B 4WH9A 2KL3A 1RHSA 1TQ1A 1C25A 2IFDA 2FSXA 1VEEA 1H4KX 3HWIA 3R2UA 3TP9A 1BOHA 2JTRA 5LAOA 2K0ZA 2EG3A 5HBQA 4JGTA 3F4AA 1OKGA 5HPAA 1YM9A 3IPOA 1YT8A 1HZMA 1QB0A 5HBPA 3AAYA 3TG1B 3FLHA 3FS5A 5LAMA 3G5JA 5HBLA 2WLXA 3UTNX 1WHBA 1CWRA 2ORAA 3I2VA 5HBOA 2Q82A 1CWTA 3AAXA 3K9RA 2UZQA
chains in the Genus database with same CATH topology
3NT6A 1RHDA 2OUCA 1UARA 1QXNA 3TG3A 1YMKA 1ORBA 4OCGA 2DCQA 3HZUA 3IWHA 1BOIA 2A2KA 3ICTA 3P3AA 1YMDA 3OLHA 3MZZA 1DP2A 3ILMA 3FNJA 3ICSA 3D1PA 1GN0A 2J6PA 2JTQA 2WLRA 2MOIA 2MRMA 2IFVA 2MOLA 3I3UA 3IPPA 3O3WA 1WV9A 4F67A 3GK5A 1YS0A 1E0CA 1CWSA 1YMLA 2GWFA 3FOJA 3NTDA 4WH7A 1T3KA 1H4MX 1GMXA 3ICRA 3NHVA 3OP3A 2HHGA 2JTSA 2EG4A 2VSWA 1URHA 3HIXA 3NTAA 2EG4B 4WH9A 2KL3A 1RHSA 1TQ1A 1C25A 2IFDA 2FSXA 1VEEA 1H4KX 3HWIA 3R2UA 3TP9A 1BOHA 2JTRA 5LAOA 2K0ZA 2EG3A 5HBQA 4JGTA 3F4AA 1OKGA 5HPAA 1YM9A 3IPOA 1YT8A 1HZMA 1QB0A 5HBPA 3AAYA 3TG1B 3FLHA 3FS5A 5LAMA 3G5JA 5HBLA 2WLXA 3UTNX 1WHBA 1CWRA 2ORAA 3I2VA 5HBOA 1CWTA 3AAXA 3K9RA 2UZQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NT6 A;  1RHD A;  2OUC A;  1UAR A;  1QXN A;  3TG3 A;  1YMK A;  1ORB A;  4OCG A;  2DCQ A;  3HZU A;  3IWH A;  1BOI A;  2A2K A;  3ICT A;  3P3A A;  1YMD A;  3OLH A;  3MZZ A;  1DP2 A;  3ILM A;  3FNJ A;  3ICS A;  3D1P A;  1GN0 A;  2J6P A;  2JTQ A;  2WLR A;  2MOI A;  2MRM A;  2IFV A;  2MOL A;  3I3U A;  3IPP A;  3O3W A;  1WV9 A;  4F67 A;  3GK5 A;  1YS0 A;  1E0C A;  1CWS A;  1YML A;  2GWF A;  3FOJ A;  3NTD A;  4WH7 A;  1T3K A;  1H4M X;  1GMX A;  3ICR A;  3NHV A;  3OP3 A;  2HHG A;  2JTS A;  2EG4 A;  2VSW A;  1URH A;  3HIX A;  3NTA A;  2EG4 B;  4WH9 A;  2KL3 A;  1RHS A;  1TQ1 A;  1C25 A;  2IFD A;  2FSX A;  1VEE A;  1H4K X;  3HWI A;  3R2U A;  3TP9 A;  1BOH A;  2JTR A;  5LAO A;  2K0Z A;  2EG3 A;  5HBQ A;  4JGT A;  3F4A A;  1OKG A;  5HPA A;  1YM9 A;  3IPO A;  1YT8 A;  1HZM A;  1QB0 A;  5HBP A;  3AAY A;  3TG1 B;  3FLH A;  3FS5 A;  5LAM A;  3G5J A;  5HBL A;  2WLX A;  3UTN X;  1WHB A;  1CWR A;  2ORA A;  3I2V A;  5HBO A;  1CWT A;  3AAX A;  3K9R A;  2UZQ A; 
#chains in the Genus database with same CATH topology
 3NT6 A;  1RHD A;  2OUC A;  1UAR A;  1QXN A;  3TG3 A;  1YMK A;  1ORB A;  4OCG A;  2DCQ A;  3HZU A;  3IWH A;  1BOI A;  2A2K A;  3ICT A;  3P3A A;  1YMD A;  3OLH A;  3MZZ A;  1DP2 A;  3ILM A;  3FNJ A;  3ICS A;  3D1P A;  1GN0 A;  2J6P A;  2JTQ A;  2WLR A;  2MOI A;  2MRM A;  2IFV A;  2MOL A;  3I3U A;  3IPP A;  3O3W A;  1WV9 A;  4F67 A;  3GK5 A;  1YS0 A;  1E0C A;  1CWS A;  1YML A;  2GWF A;  3FOJ A;  3NTD A;  4WH7 A;  1T3K A;  1H4M X;  1GMX A;  3ICR A;  3NHV A;  3OP3 A;  2HHG A;  2JTS A;  2EG4 A;  2VSW A;  1URH A;  3HIX A;  3NTA A;  2EG4 B;  4WH9 A;  2KL3 A;  1RHS A;  1TQ1 A;  1C25 A;  2IFD A;  2FSX A;  1VEE A;  1H4K X;  3HWI A;  3R2U A;  3TP9 A;  1BOH A;  2JTR A;  5LAO A;  2K0Z A;  2EG3 A;  5HBQ A;  4JGT A;  3F4A A;  1OKG A;  5HPA A;  1YM9 A;  3IPO A;  1YT8 A;  1HZM A;  1QB0 A;  5HBP A;  3AAY A;  3TG1 B;  3FLH A;  3FS5 A;  5LAM A;  3G5J A;  5HBL A;  2WLX A;  3UTN X;  1WHB A;  1CWR A;  2ORA A;  3I2V A;  5HBO A;  2Q82 A;  1CWT A;  3AAX A;  3K9R A;  2UZQ A; 
#chains in the Genus database with same CATH homology
 3NT6 A;  1RHD A;  2OUC A;  1UAR A;  1QXN A;  3TG3 A;  1YMK A;  1ORB A;  4OCG A;  2DCQ A;  3HZU A;  3IWH A;  1BOI A;  2A2K A;  3ICT A;  3P3A A;  1YMD A;  3OLH A;  3MZZ A;  1DP2 A;  3ILM A;  3FNJ A;  3ICS A;  3D1P A;  1GN0 A;  2J6P A;  2JTQ A;  2WLR A;  2MOI A;  2MRM A;  2IFV A;  2MOL A;  3I3U A;  3IPP A;  3O3W A;  1WV9 A;  4F67 A;  3GK5 A;  1YS0 A;  1E0C A;  1CWS A;  1YML A;  2GWF A;  3FOJ A;  3NTD A;  4WH7 A;  1T3K A;  1H4M X;  1GMX A;  3ICR A;  3NHV A;  3OP3 A;  2HHG A;  2JTS A;  2EG4 A;  2VSW A;  1URH A;  3HIX A;  3NTA A;  2EG4 B;  4WH9 A;  2KL3 A;  1RHS A;  1TQ1 A;  1C25 A;  2IFD A;  2FSX A;  1VEE A;  1H4K X;  3HWI A;  3R2U A;  3TP9 A;  1BOH A;  2JTR A;  5LAO A;  2K0Z A;  2EG3 A;  5HBQ A;  4JGT A;  3F4A A;  1OKG A;  5HPA A;  1YM9 A;  3IPO A;  1YT8 A;  1HZM A;  1QB0 A;  5HBP A;  3AAY A;  3TG1 B;  3FLH A;  3FS5 A;  5LAM A;  3G5J A;  5HBL A;  2WLX A;  3UTN X;  1WHB A;  1CWR A;  2ORA A;  3I2V A;  5HBO A;  1CWT A;  3AAX A;  3K9R A;  2UZQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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