1HZMA

Structure of erk2 binding domain of mapk phosphatase mkp-3: structural insights into mkp-3 activation by erk2
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
154
structure length
154
Chain Sequence
MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESLLGLLLKKLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
publication title Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2.
pubmed doi rcsb
source organism Homo sapiens
total genus 23
structure length 154
sequence length 154
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2001-01-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 1hzmA00
1YM9A 1YS0A 3HWIA 3NTDA 4JGTA 3MZZA 2EG3A 2IFVA 3TG1B 3O3WA 2MOLA 3UTNX 3TG3A 2DCQA 3FLHA 4WH9A 1E0CA 2J6PA 1BOIA 1ORBA 5LAOA 2WLRA 1VEEA 1DP2A 1CWSA 2EG4A 5HBOA 3FS5A 3ICTA 3D1PA 1CWTA 5HBQA 1WV9A 3I2VA 3K9RA 3AAYA 2IFDA 3OP3A 3ICRA 2ORAA 1YT8A 3TP9A 3GK5A 2VSWA 1QB0A 2JTRA 2K0ZA 3NHVA 5HPAA 3FNJA 1CWRA 1GN0A 1QXNA 4F67A 2JTQA 1GMXA 3G5JA 3F4AA 1H4KX 3NTAA 2EG4B 3ICSA 3R2UA 1RHDA 4WH7A 2WLXA 1TQ1A 1H4MX 1C25A 3AAXA 2A2KA 3P3AA 3OLHA 2OUCA 2GWFA 3I3UA 1RHSA 1OKGA 3IPOA 3ILMA 2MRMA 4OCGA 1YMLA 1URHA 3HZUA 3IPPA 3HIXA 1T3KA 1BOHA 1UARA 2KL3A 1WHBA 5HBLA 1YMDA 3FOJA 3NT6A 3IWHA 2MOIA 5HBPA 1HZMA 5LAMA 1YMKA 2UZQA 2HHGA 2FSXA 2JTSA
chains in the Genus database with same CATH superfamily
1YM9A 1YS0A 3HWIA 3NTDA 4JGTA 3MZZA 2EG3A 2IFVA 3TG1B 3O3WA 2MOLA 3UTNX 3TG3A 2DCQA 3FLHA 4WH9A 1E0CA 2J6PA 1BOIA 1ORBA 5LAOA 2WLRA 1VEEA 1DP2A 1CWSA 2EG4A 5HBOA 3FS5A 3ICTA 3D1PA 1CWTA 5HBQA 1WV9A 3I2VA 3K9RA 3AAYA 2IFDA 3OP3A 3ICRA 2ORAA 1YT8A 3TP9A 2Q82A 3GK5A 2VSWA 1QB0A 2JTRA 2K0ZA 3NHVA 5HPAA 3FNJA 1CWRA 1GN0A 1QXNA 4F67A 2JTQA 1GMXA 3G5JA 3F4AA 1H4KX 3NTAA 2EG4B 3ICSA 3R2UA 1RHDA 4WH7A 2WLXA 1TQ1A 1H4MX 1C25A 3AAXA 2A2KA 3P3AA 3OLHA 2OUCA 2GWFA 3I3UA 1RHSA 1OKGA 3IPOA 3ILMA 2MRMA 4OCGA 1YMLA 1URHA 3HZUA 3IPPA 3HIXA 1T3KA 1BOHA 1UARA 2KL3A 1WHBA 5HBLA 1YMDA 3FOJA 3NT6A 3IWHA 2MOIA 5HBPA 1HZMA 5LAMA 1YMKA 2UZQA 2HHGA 2FSXA 2JTSA
chains in the Genus database with same CATH topology
1YM9A 1YS0A 3HWIA 3NTDA 4JGTA 3MZZA 2EG3A 2IFVA 3TG1B 3O3WA 2MOLA 3UTNX 3TG3A 2DCQA 3FLHA 4WH9A 1E0CA 2J6PA 1BOIA 1ORBA 5LAOA 2WLRA 1VEEA 1DP2A 1CWSA 2EG4A 5HBOA 3FS5A 3ICTA 3D1PA 1CWTA 5HBQA 1WV9A 3I2VA 3K9RA 3AAYA 2IFDA 3OP3A 3ICRA 2ORAA 1YT8A 3TP9A 3GK5A 2VSWA 1QB0A 2JTRA 2K0ZA 3NHVA 5HPAA 3FNJA 1CWRA 1GN0A 1QXNA 4F67A 2JTQA 1GMXA 3G5JA 3F4AA 1H4KX 3NTAA 2EG4B 3ICSA 3R2UA 1RHDA 4WH7A 2WLXA 1TQ1A 1H4MX 1C25A 3AAXA 2A2KA 3P3AA 3OLHA 2OUCA 2GWFA 3I3UA 1RHSA 1OKGA 3IPOA 3ILMA 2MRMA 4OCGA 1YMLA 1URHA 3HZUA 3IPPA 3HIXA 1T3KA 1BOHA 1UARA 2KL3A 1WHBA 5HBLA 1YMDA 3FOJA 3NT6A 3IWHA 2MOIA 5HBPA 1HZMA 5LAMA 1YMKA 2UZQA 2HHGA 2FSXA 2JTSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YM9 A;  1YS0 A;  3HWI A;  3NTD A;  4JGT A;  3MZZ A;  2EG3 A;  2IFV A;  3TG1 B;  3O3W A;  2MOL A;  3UTN X;  3TG3 A;  2DCQ A;  3FLH A;  4WH9 A;  1E0C A;  2J6P A;  1BOI A;  1ORB A;  5LAO A;  2WLR A;  1VEE A;  1DP2 A;  1CWS A;  2EG4 A;  5HBO A;  3FS5 A;  3ICT A;  3D1P A;  1CWT A;  5HBQ A;  1WV9 A;  3I2V A;  3K9R A;  3AAY A;  2IFD A;  3OP3 A;  3ICR A;  2ORA A;  1YT8 A;  3TP9 A;  3GK5 A;  2VSW A;  1QB0 A;  2JTR A;  2K0Z A;  3NHV A;  5HPA A;  3FNJ A;  1CWR A;  1GN0 A;  1QXN A;  4F67 A;  2JTQ A;  1GMX A;  3G5J A;  3F4A A;  1H4K X;  3NTA A;  2EG4 B;  3ICS A;  3R2U A;  1RHD A;  4WH7 A;  2WLX A;  1TQ1 A;  1H4M X;  1C25 A;  3AAX A;  2A2K A;  3P3A A;  3OLH A;  2OUC A;  2GWF A;  3I3U A;  1RHS A;  1OKG A;  3IPO A;  3ILM A;  2MRM A;  4OCG A;  1YML A;  1URH A;  3HZU A;  3IPP A;  3HIX A;  1T3K A;  1BOH A;  1UAR A;  2KL3 A;  1WHB A;  5HBL A;  1YMD A;  3FOJ A;  3NT6 A;  3IWH A;  2MOI A;  5HBP A;  1HZM A;  5LAM A;  1YMK A;  2UZQ A;  2HHG A;  2FSX A;  2JTS A; 
#chains in the Genus database with same CATH topology
 1YM9 A;  1YS0 A;  3HWI A;  3NTD A;  4JGT A;  3MZZ A;  2EG3 A;  2IFV A;  3TG1 B;  3O3W A;  2MOL A;  3UTN X;  3TG3 A;  2DCQ A;  3FLH A;  4WH9 A;  1E0C A;  2J6P A;  1BOI A;  1ORB A;  5LAO A;  2WLR A;  1VEE A;  1DP2 A;  1CWS A;  2EG4 A;  5HBO A;  3FS5 A;  3ICT A;  3D1P A;  1CWT A;  5HBQ A;  1WV9 A;  3I2V A;  3K9R A;  3AAY A;  2IFD A;  3OP3 A;  3ICR A;  2ORA A;  1YT8 A;  3TP9 A;  2Q82 A;  3GK5 A;  2VSW A;  1QB0 A;  2JTR A;  2K0Z A;  3NHV A;  5HPA A;  3FNJ A;  1CWR A;  1GN0 A;  1QXN A;  4F67 A;  2JTQ A;  1GMX A;  3G5J A;  3F4A A;  1H4K X;  3NTA A;  2EG4 B;  3ICS A;  3R2U A;  1RHD A;  4WH7 A;  2WLX A;  1TQ1 A;  1H4M X;  1C25 A;  3AAX A;  2A2K A;  3P3A A;  3OLH A;  2OUC A;  2GWF A;  3I3U A;  1RHS A;  1OKG A;  3IPO A;  3ILM A;  2MRM A;  4OCG A;  1YML A;  1URH A;  3HZU A;  3IPP A;  3HIX A;  1T3K A;  1BOH A;  1UAR A;  2KL3 A;  1WHB A;  5HBL A;  1YMD A;  3FOJ A;  3NT6 A;  3IWH A;  2MOI A;  5HBP A;  1HZM A;  5LAM A;  1YMK A;  2UZQ A;  2HHG A;  2FSX A;  2JTS A; 
#chains in the Genus database with same CATH homology
 1YM9 A;  1YS0 A;  3HWI A;  3NTD A;  4JGT A;  3MZZ A;  2EG3 A;  2IFV A;  3TG1 B;  3O3W A;  2MOL A;  3UTN X;  3TG3 A;  2DCQ A;  3FLH A;  4WH9 A;  1E0C A;  2J6P A;  1BOI A;  1ORB A;  5LAO A;  2WLR A;  1VEE A;  1DP2 A;  1CWS A;  2EG4 A;  5HBO A;  3FS5 A;  3ICT A;  3D1P A;  1CWT A;  5HBQ A;  1WV9 A;  3I2V A;  3K9R A;  3AAY A;  2IFD A;  3OP3 A;  3ICR A;  2ORA A;  1YT8 A;  3TP9 A;  3GK5 A;  2VSW A;  1QB0 A;  2JTR A;  2K0Z A;  3NHV A;  5HPA A;  3FNJ A;  1CWR A;  1GN0 A;  1QXN A;  4F67 A;  2JTQ A;  1GMX A;  3G5J A;  3F4A A;  1H4K X;  3NTA A;  2EG4 B;  3ICS A;  3R2U A;  1RHD A;  4WH7 A;  2WLX A;  1TQ1 A;  1H4M X;  1C25 A;  3AAX A;  2A2K A;  3P3A A;  3OLH A;  2OUC A;  2GWF A;  3I3U A;  1RHS A;  1OKG A;  3IPO A;  3ILM A;  2MRM A;  4OCG A;  1YML A;  1URH A;  3HZU A;  3IPP A;  3HIX A;  1T3K A;  1BOH A;  1UAR A;  2KL3 A;  1WHB A;  5HBL A;  1YMD A;  3FOJ A;  3NT6 A;  3IWH A;  2MOI A;  5HBP A;  1HZM A;  5LAM A;  1YMK A;  2UZQ A;  2HHG A;  2FSX A;  2JTS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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