1CWRA

Human cdc25b catalytic domain without ion in catalytic site
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
177
structure length
177
Chain Sequence
DHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords PROTEIN (M-PHASE INDUCER PHOSPHATASE 2 (CDC25B))
total genus 60
structure length 177
sequence length 177
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 1999-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 1cwrA00
2IFDA 3FOJA 3I3UA 5HPAA 1VEEA 2UZQA 1QB0A 1UARA 1YMDA 3HIXA 1WHBA 2JTQA 2FSXA 2J6PA 1URHA 1ORBA 4WH7A 3FLHA 2MOLA 2HHGA 3TG1B 2JTSA 5LAMA 1BOHA 1GN0A 1YM9A 1YMKA 2EG3A 3AAYA 2EG4B 3HZUA 2DCQA 4F67A 3P3AA 3UTNX 2VSWA 3OLHA 4OCGA 3NTAA 1HZMA 2WLXA 2KL3A 3FS5A 3G5JA 1H4MX 1YMLA 3IPOA 3NTDA 5HBQA 4JGTA 1OKGA 2GWFA 3IPPA 3O3WA 5HBPA 1CWTA 1DP2A 2K0ZA 1GMXA 3D1PA 1H4KX 1C25A 3GK5A 2MRMA 5HBOA 1TQ1A 3I2VA 2ORAA 3TP9A 3AAXA 3NHVA 2IFVA 1RHSA 1YS0A 3OP3A 3F4AA 1BOIA 1CWRA 2OUCA 1T3KA 2EG4A 3R2UA 3ICSA 1QXNA 3FNJA 1YT8A 1WV9A 3TG3A 2JTRA 3IWHA 5HBLA 5LAOA 3NT6A 4WH9A 2MOIA 2A2KA 3ICTA 3ILMA 2WLRA 3ICRA 3HWIA 3MZZA 1CWSA 1RHDA 3K9RA 1E0CA
chains in the Genus database with same CATH superfamily
2IFDA 3FOJA 3I3UA 5HPAA 1VEEA 2UZQA 1QB0A 1UARA 1YMDA 3HIXA 1WHBA 2JTQA 2FSXA 2J6PA 1URHA 1ORBA 4WH7A 3FLHA 2MOLA 2HHGA 3TG1B 2JTSA 5LAMA 1BOHA 1GN0A 1YM9A 1YMKA 2EG3A 3AAYA 2EG4B 3HZUA 2DCQA 4F67A 3P3AA 3UTNX 2VSWA 2Q82A 3OLHA 4OCGA 3NTAA 1HZMA 2WLXA 2KL3A 3FS5A 3G5JA 1H4MX 1YMLA 3IPOA 3NTDA 5HBQA 4JGTA 1OKGA 2GWFA 3IPPA 3O3WA 5HBPA 1CWTA 1DP2A 2K0ZA 1GMXA 3D1PA 1H4KX 1C25A 3GK5A 2MRMA 5HBOA 1TQ1A 3I2VA 2ORAA 3TP9A 3AAXA 3NHVA 2IFVA 1RHSA 1YS0A 3OP3A 3F4AA 1BOIA 1CWRA 2OUCA 1T3KA 2EG4A 3R2UA 3ICSA 1QXNA 3FNJA 1YT8A 1WV9A 3TG3A 2JTRA 3IWHA 5HBLA 5LAOA 3NT6A 4WH9A 2MOIA 2A2KA 3ICTA 3ILMA 2WLRA 3ICRA 3HWIA 3MZZA 1CWSA 1RHDA 3K9RA 1E0CA
chains in the Genus database with same CATH topology
2IFDA 3FOJA 3I3UA 5HPAA 1VEEA 2UZQA 1QB0A 1UARA 1YMDA 3HIXA 1WHBA 2JTQA 2FSXA 2J6PA 1URHA 1ORBA 4WH7A 3FLHA 2MOLA 2HHGA 3TG1B 2JTSA 5LAMA 1BOHA 1GN0A 1YM9A 1YMKA 2EG3A 3AAYA 2EG4B 3HZUA 2DCQA 4F67A 3P3AA 3UTNX 2VSWA 3OLHA 4OCGA 3NTAA 1HZMA 2WLXA 2KL3A 3FS5A 3G5JA 1H4MX 1YMLA 3IPOA 3NTDA 5HBQA 4JGTA 1OKGA 2GWFA 3IPPA 3O3WA 5HBPA 1CWTA 1DP2A 2K0ZA 1GMXA 3D1PA 1H4KX 1C25A 3GK5A 2MRMA 5HBOA 1TQ1A 3I2VA 2ORAA 3TP9A 3AAXA 3NHVA 2IFVA 1RHSA 1YS0A 3OP3A 3F4AA 1BOIA 1CWRA 2OUCA 1T3KA 2EG4A 3R2UA 3ICSA 1QXNA 3FNJA 1YT8A 1WV9A 3TG3A 2JTRA 3IWHA 5HBLA 5LAOA 3NT6A 4WH9A 2MOIA 2A2KA 3ICTA 3ILMA 2WLRA 3ICRA 3HWIA 3MZZA 1CWSA 1RHDA 3K9RA 1E0CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2IFD A;  3FOJ A;  3I3U A;  5HPA A;  1VEE A;  2UZQ A;  1QB0 A;  1UAR A;  1YMD A;  3HIX A;  1WHB A;  2JTQ A;  2FSX A;  2J6P A;  1URH A;  1ORB A;  4WH7 A;  3FLH A;  2MOL A;  2HHG A;  3TG1 B;  2JTS A;  5LAM A;  1BOH A;  1GN0 A;  1YM9 A;  1YMK A;  2EG3 A;  3AAY A;  2EG4 B;  3HZU A;  2DCQ A;  4F67 A;  3P3A A;  3UTN X;  2VSW A;  3OLH A;  4OCG A;  3NTA A;  1HZM A;  2WLX A;  2KL3 A;  3FS5 A;  3G5J A;  1H4M X;  1YML A;  3IPO A;  3NTD A;  5HBQ A;  4JGT A;  1OKG A;  2GWF A;  3IPP A;  3O3W A;  5HBP A;  1CWT A;  1DP2 A;  2K0Z A;  1GMX A;  3D1P A;  1H4K X;  1C25 A;  3GK5 A;  2MRM A;  5HBO A;  1TQ1 A;  3I2V A;  2ORA A;  3TP9 A;  3AAX A;  3NHV A;  2IFV A;  1RHS A;  1YS0 A;  3OP3 A;  3F4A A;  1BOI A;  1CWR A;  2OUC A;  1T3K A;  2EG4 A;  3R2U A;  3ICS A;  1QXN A;  3FNJ A;  1YT8 A;  1WV9 A;  3TG3 A;  2JTR A;  3IWH A;  5HBL A;  5LAO A;  3NT6 A;  4WH9 A;  2MOI A;  2A2K A;  3ICT A;  3ILM A;  2WLR A;  3ICR A;  3HWI A;  3MZZ A;  1CWS A;  1RHD A;  3K9R A;  1E0C A; 
#chains in the Genus database with same CATH topology
 2IFD A;  3FOJ A;  3I3U A;  5HPA A;  1VEE A;  2UZQ A;  1QB0 A;  1UAR A;  1YMD A;  3HIX A;  1WHB A;  2JTQ A;  2FSX A;  2J6P A;  1URH A;  1ORB A;  4WH7 A;  3FLH A;  2MOL A;  2HHG A;  3TG1 B;  2JTS A;  5LAM A;  1BOH A;  1GN0 A;  1YM9 A;  1YMK A;  2EG3 A;  3AAY A;  2EG4 B;  3HZU A;  2DCQ A;  4F67 A;  3P3A A;  3UTN X;  2VSW A;  2Q82 A;  3OLH A;  4OCG A;  3NTA A;  1HZM A;  2WLX A;  2KL3 A;  3FS5 A;  3G5J A;  1H4M X;  1YML A;  3IPO A;  3NTD A;  5HBQ A;  4JGT A;  1OKG A;  2GWF A;  3IPP A;  3O3W A;  5HBP A;  1CWT A;  1DP2 A;  2K0Z A;  1GMX A;  3D1P A;  1H4K X;  1C25 A;  3GK5 A;  2MRM A;  5HBO A;  1TQ1 A;  3I2V A;  2ORA A;  3TP9 A;  3AAX A;  3NHV A;  2IFV A;  1RHS A;  1YS0 A;  3OP3 A;  3F4A A;  1BOI A;  1CWR A;  2OUC A;  1T3K A;  2EG4 A;  3R2U A;  3ICS A;  1QXN A;  3FNJ A;  1YT8 A;  1WV9 A;  3TG3 A;  2JTR A;  3IWH A;  5HBL A;  5LAO A;  3NT6 A;  4WH9 A;  2MOI A;  2A2K A;  3ICT A;  3ILM A;  2WLR A;  3ICR A;  3HWI A;  3MZZ A;  1CWS A;  1RHD A;  3K9R A;  1E0C A; 
#chains in the Genus database with same CATH homology
 2IFD A;  3FOJ A;  3I3U A;  5HPA A;  1VEE A;  2UZQ A;  1QB0 A;  1UAR A;  1YMD A;  3HIX A;  1WHB A;  2JTQ A;  2FSX A;  2J6P A;  1URH A;  1ORB A;  4WH7 A;  3FLH A;  2MOL A;  2HHG A;  3TG1 B;  2JTS A;  5LAM A;  1BOH A;  1GN0 A;  1YM9 A;  1YMK A;  2EG3 A;  3AAY A;  2EG4 B;  3HZU A;  2DCQ A;  4F67 A;  3P3A A;  3UTN X;  2VSW A;  3OLH A;  4OCG A;  3NTA A;  1HZM A;  2WLX A;  2KL3 A;  3FS5 A;  3G5J A;  1H4M X;  1YML A;  3IPO A;  3NTD A;  5HBQ A;  4JGT A;  1OKG A;  2GWF A;  3IPP A;  3O3W A;  5HBP A;  1CWT A;  1DP2 A;  2K0Z A;  1GMX A;  3D1P A;  1H4K X;  1C25 A;  3GK5 A;  2MRM A;  5HBO A;  1TQ1 A;  3I2V A;  2ORA A;  3TP9 A;  3AAX A;  3NHV A;  2IFV A;  1RHS A;  1YS0 A;  3OP3 A;  3F4A A;  1BOI A;  1CWR A;  2OUC A;  1T3K A;  2EG4 A;  3R2U A;  3ICS A;  1QXN A;  3FNJ A;  1YT8 A;  1WV9 A;  3TG3 A;  2JTR A;  3IWH A;  5HBL A;  5LAO A;  3NT6 A;  4WH9 A;  2MOI A;  2A2K A;  3ICT A;  3ILM A;  2WLR A;  3ICR A;  3HWI A;  3MZZ A;  1CWS A;  1RHD A;  3K9R A;  1E0C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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