1CWSA

Human cdc25b catalytic domain with tungstate
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
178
structure length
178
Chain Sequence
SDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle.
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords CDC25 B-TYPE TYROSINE PHOSPHATASE
total genus 59
structure length 178
sequence length 178
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 1999-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 1cwsA00
3IPOA 2WLXA 1QXNA 2HHGA 3HWIA 3ICRA 2DCQA 3I3UA 2OUCA 2EG3A 5HBLA 1BOHA 1DP2A 5HBPA 3NT6A 3OLHA 5LAOA 1YT8A 3FS5A 1CWSA 1CWTA 5HBOA 3FOJA 2WLRA 2J6PA 2JTQA 1CWRA 3G5JA 2UZQA 1UARA 2GWFA 2MOIA 3NTAA 4OCGA 2VSWA 4WH7A 2IFVA 3HZUA 3O3WA 1URHA 3D1PA 3IWHA 2MRMA 3NHVA 1WV9A 2IFDA 3TG1B 1C25A 3HIXA 3UTNX 2A2KA 3GK5A 3OP3A 2JTSA 3ICSA 3FLHA 1RHSA 1WHBA 3R2UA 1VEEA 1OKGA 1T3KA 2K0ZA 3FNJA 1ORBA 1E0CA 3I2VA 1YMLA 1GN0A 2EG4B 4JGTA 1YMDA 1GMXA 1TQ1A 1HZMA 5LAMA 2JTRA 1RHDA 2EG4A 3IPPA 1YM9A 3TP9A 4WH9A 3MZZA 3ICTA 2FSXA 1YMKA 2KL3A 3K9RA 3F4AA 1QB0A 5HBQA 4F67A 3AAXA 2ORAA 3NTDA 1BOIA 5HPAA 1H4KX 3P3AA 3AAYA 1H4MX 3TG3A 2MOLA 1YS0A 3ILMA
chains in the Genus database with same CATH superfamily
3IPOA 2WLXA 1QXNA 2HHGA 3HWIA 3ICRA 2DCQA 3I3UA 2OUCA 2EG3A 5HBLA 1BOHA 1DP2A 5HBPA 3NT6A 3OLHA 5LAOA 1YT8A 3FS5A 1CWSA 1CWTA 5HBOA 3FOJA 2WLRA 2J6PA 2JTQA 1CWRA 3G5JA 2UZQA 1UARA 2Q82A 2GWFA 2MOIA 3NTAA 4OCGA 2VSWA 4WH7A 2IFVA 3HZUA 3O3WA 1URHA 3D1PA 3IWHA 2MRMA 3NHVA 1WV9A 2IFDA 3TG1B 1C25A 3HIXA 3UTNX 2A2KA 3GK5A 3OP3A 2JTSA 3ICSA 3FLHA 1RHSA 1WHBA 3R2UA 1VEEA 1OKGA 1T3KA 2K0ZA 3FNJA 1ORBA 1E0CA 3I2VA 1YMLA 1GN0A 2EG4B 4JGTA 1YMDA 1GMXA 1TQ1A 1HZMA 5LAMA 2JTRA 1RHDA 2EG4A 3IPPA 1YM9A 3TP9A 4WH9A 3MZZA 3ICTA 2FSXA 1YMKA 2KL3A 3K9RA 3F4AA 1QB0A 5HBQA 4F67A 3AAXA 2ORAA 3NTDA 1BOIA 5HPAA 1H4KX 3P3AA 3AAYA 1H4MX 3TG3A 2MOLA 1YS0A 3ILMA
chains in the Genus database with same CATH topology
3IPOA 2WLXA 1QXNA 2HHGA 3HWIA 3ICRA 2DCQA 3I3UA 2OUCA 2EG3A 5HBLA 1BOHA 1DP2A 5HBPA 3NT6A 3OLHA 5LAOA 1YT8A 3FS5A 1CWSA 1CWTA 5HBOA 3FOJA 2WLRA 2J6PA 2JTQA 1CWRA 3G5JA 2UZQA 1UARA 2GWFA 2MOIA 3NTAA 4OCGA 2VSWA 4WH7A 2IFVA 3HZUA 3O3WA 1URHA 3D1PA 3IWHA 2MRMA 3NHVA 1WV9A 2IFDA 3TG1B 1C25A 3HIXA 3UTNX 2A2KA 3GK5A 3OP3A 2JTSA 3ICSA 3FLHA 1RHSA 1WHBA 3R2UA 1VEEA 1OKGA 1T3KA 2K0ZA 3FNJA 1ORBA 1E0CA 3I2VA 1YMLA 1GN0A 2EG4B 4JGTA 1YMDA 1GMXA 1TQ1A 1HZMA 5LAMA 2JTRA 1RHDA 2EG4A 3IPPA 1YM9A 3TP9A 4WH9A 3MZZA 3ICTA 2FSXA 1YMKA 2KL3A 3K9RA 3F4AA 1QB0A 5HBQA 4F67A 3AAXA 2ORAA 3NTDA 1BOIA 5HPAA 1H4KX 3P3AA 3AAYA 1H4MX 3TG3A 2MOLA 1YS0A 3ILMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IPO A;  2WLX A;  1QXN A;  2HHG A;  3HWI A;  3ICR A;  2DCQ A;  3I3U A;  2OUC A;  2EG3 A;  5HBL A;  1BOH A;  1DP2 A;  5HBP A;  3NT6 A;  3OLH A;  5LAO A;  1YT8 A;  3FS5 A;  1CWS A;  1CWT A;  5HBO A;  3FOJ A;  2WLR A;  2J6P A;  2JTQ A;  1CWR A;  3G5J A;  2UZQ A;  1UAR A;  2GWF A;  2MOI A;  3NTA A;  4OCG A;  2VSW A;  4WH7 A;  2IFV A;  3HZU A;  3O3W A;  1URH A;  3D1P A;  3IWH A;  2MRM A;  3NHV A;  1WV9 A;  2IFD A;  3TG1 B;  1C25 A;  3HIX A;  3UTN X;  2A2K A;  3GK5 A;  3OP3 A;  2JTS A;  3ICS A;  3FLH A;  1RHS A;  1WHB A;  3R2U A;  1VEE A;  1OKG A;  1T3K A;  2K0Z A;  3FNJ A;  1ORB A;  1E0C A;  3I2V A;  1YML A;  1GN0 A;  2EG4 B;  4JGT A;  1YMD A;  1GMX A;  1TQ1 A;  1HZM A;  5LAM A;  2JTR A;  1RHD A;  2EG4 A;  3IPP A;  1YM9 A;  3TP9 A;  4WH9 A;  3MZZ A;  3ICT A;  2FSX A;  1YMK A;  2KL3 A;  3K9R A;  3F4A A;  1QB0 A;  5HBQ A;  4F67 A;  3AAX A;  2ORA A;  3NTD A;  1BOI A;  5HPA A;  1H4K X;  3P3A A;  3AAY A;  1H4M X;  3TG3 A;  2MOL A;  1YS0 A;  3ILM A; 
#chains in the Genus database with same CATH topology
 3IPO A;  2WLX A;  1QXN A;  2HHG A;  3HWI A;  3ICR A;  2DCQ A;  3I3U A;  2OUC A;  2EG3 A;  5HBL A;  1BOH A;  1DP2 A;  5HBP A;  3NT6 A;  3OLH A;  5LAO A;  1YT8 A;  3FS5 A;  1CWS A;  1CWT A;  5HBO A;  3FOJ A;  2WLR A;  2J6P A;  2JTQ A;  1CWR A;  3G5J A;  2UZQ A;  1UAR A;  2Q82 A;  2GWF A;  2MOI A;  3NTA A;  4OCG A;  2VSW A;  4WH7 A;  2IFV A;  3HZU A;  3O3W A;  1URH A;  3D1P A;  3IWH A;  2MRM A;  3NHV A;  1WV9 A;  2IFD A;  3TG1 B;  1C25 A;  3HIX A;  3UTN X;  2A2K A;  3GK5 A;  3OP3 A;  2JTS A;  3ICS A;  3FLH A;  1RHS A;  1WHB A;  3R2U A;  1VEE A;  1OKG A;  1T3K A;  2K0Z A;  3FNJ A;  1ORB A;  1E0C A;  3I2V A;  1YML A;  1GN0 A;  2EG4 B;  4JGT A;  1YMD A;  1GMX A;  1TQ1 A;  1HZM A;  5LAM A;  2JTR A;  1RHD A;  2EG4 A;  3IPP A;  1YM9 A;  3TP9 A;  4WH9 A;  3MZZ A;  3ICT A;  2FSX A;  1YMK A;  2KL3 A;  3K9R A;  3F4A A;  1QB0 A;  5HBQ A;  4F67 A;  3AAX A;  2ORA A;  3NTD A;  1BOI A;  5HPA A;  1H4K X;  3P3A A;  3AAY A;  1H4M X;  3TG3 A;  2MOL A;  1YS0 A;  3ILM A; 
#chains in the Genus database with same CATH homology
 3IPO A;  2WLX A;  1QXN A;  2HHG A;  3HWI A;  3ICR A;  2DCQ A;  3I3U A;  2OUC A;  2EG3 A;  5HBL A;  1BOH A;  1DP2 A;  5HBP A;  3NT6 A;  3OLH A;  5LAO A;  1YT8 A;  3FS5 A;  1CWS A;  1CWT A;  5HBO A;  3FOJ A;  2WLR A;  2J6P A;  2JTQ A;  1CWR A;  3G5J A;  2UZQ A;  1UAR A;  2GWF A;  2MOI A;  3NTA A;  4OCG A;  2VSW A;  4WH7 A;  2IFV A;  3HZU A;  3O3W A;  1URH A;  3D1P A;  3IWH A;  2MRM A;  3NHV A;  1WV9 A;  2IFD A;  3TG1 B;  1C25 A;  3HIX A;  3UTN X;  2A2K A;  3GK5 A;  3OP3 A;  2JTS A;  3ICS A;  3FLH A;  1RHS A;  1WHB A;  3R2U A;  1VEE A;  1OKG A;  1T3K A;  2K0Z A;  3FNJ A;  1ORB A;  1E0C A;  3I2V A;  1YML A;  1GN0 A;  2EG4 B;  4JGT A;  1YMD A;  1GMX A;  1TQ1 A;  1HZM A;  5LAM A;  2JTR A;  1RHD A;  2EG4 A;  3IPP A;  1YM9 A;  3TP9 A;  4WH9 A;  3MZZ A;  3ICT A;  2FSX A;  1YMK A;  2KL3 A;  3K9R A;  3F4A A;  1QB0 A;  5HBQ A;  4F67 A;  3AAX A;  2ORA A;  3NTD A;  1BOI A;  5HPA A;  1H4K X;  3P3A A;  3AAY A;  1H4M X;  3TG3 A;  2MOL A;  1YS0 A;  3ILM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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