1CWSA

Human cdc25b catalytic domain with tungstate
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
178
structure length
178
Chain Sequence
SDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle.
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords CDC25 B-TYPE TYROSINE PHOSPHATASE
total genus 59
structure length 178
sequence length 178
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 1999-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 1cwsA00
3IPPA 4OCGA 1CWSA 2DCQA 3OP3A 2IFVA 3ILMA 4WH7A 3AAXA 1QB0A 4F67A 1WHBA 3IWHA 1OKGA 1H4MX 1DP2A 1BOIA 4WH9A 1RHSA 3NHVA 2MOLA 2EG4A 3O3WA 2UZQA 3TG1B 2JTQA 1URHA 3ICTA 2JTSA 2VSWA 3K9RA 1RHDA 3IPOA 1YMKA 2WLXA 1GN0A 3GK5A 3TP9A 2EG4B 3HWIA 1QXNA 3I2VA 2EG3A 3MZZA 1YT8A 2GWFA 3ICSA 5HPAA 1TQ1A 1YM9A 4JGTA 1BOHA 2JTRA 3P3AA 2A2KA 3NTAA 1H4KX 3G5JA 2HHGA 3D1PA 5LAOA 3NTDA 3R2UA 3TG3A 5HBQA 5HBLA 2KL3A 3FNJA 2ORAA 1VEEA 3HZUA 1WV9A 2IFDA 1UARA 2K0ZA 2MOIA 2MRMA 5HBPA 2OUCA 3FLHA 1T3KA 3AAYA 3HIXA 3I3UA 1YMDA 1YS0A 5LAMA 1E0CA 1C25A 1HZMA 2WLRA 1CWRA 1CWTA 1YMLA 5HBOA 3NT6A 3FS5A 3UTNX 1ORBA 1GMXA 3ICRA 2J6PA 3OLHA 2FSXA 3F4AA 3FOJA
chains in the Genus database with same CATH superfamily
3IPPA 4OCGA 1CWSA 2DCQA 3OP3A 2IFVA 3ILMA 4WH7A 3AAXA 1QB0A 4F67A 1WHBA 3IWHA 1OKGA 1H4MX 1DP2A 1BOIA 2Q82A 4WH9A 1RHSA 3NHVA 2MOLA 2EG4A 3O3WA 2UZQA 3TG1B 2JTQA 1URHA 3ICTA 2JTSA 2VSWA 3K9RA 1RHDA 3IPOA 1YMKA 2WLXA 1GN0A 3GK5A 3TP9A 2EG4B 3HWIA 1QXNA 3I2VA 2EG3A 3MZZA 1YT8A 2GWFA 3ICSA 5HPAA 1TQ1A 1YM9A 4JGTA 1BOHA 2JTRA 3P3AA 2A2KA 3NTAA 1H4KX 3G5JA 2HHGA 3D1PA 5LAOA 3NTDA 3R2UA 3TG3A 5HBQA 5HBLA 2KL3A 3FNJA 2ORAA 1VEEA 3HZUA 1WV9A 2IFDA 1UARA 2K0ZA 2MOIA 2MRMA 5HBPA 2OUCA 3FLHA 1T3KA 3AAYA 3HIXA 3I3UA 1YMDA 1YS0A 5LAMA 1E0CA 1C25A 1HZMA 2WLRA 1CWRA 1CWTA 1YMLA 5HBOA 3NT6A 3FS5A 3UTNX 1ORBA 1GMXA 3ICRA 2J6PA 3OLHA 2FSXA 3F4AA 3FOJA
chains in the Genus database with same CATH topology
3IPPA 4OCGA 1CWSA 2DCQA 3OP3A 2IFVA 3ILMA 4WH7A 3AAXA 1QB0A 4F67A 1WHBA 3IWHA 1OKGA 1H4MX 1DP2A 1BOIA 4WH9A 1RHSA 3NHVA 2MOLA 2EG4A 3O3WA 2UZQA 3TG1B 2JTQA 1URHA 3ICTA 2JTSA 2VSWA 3K9RA 1RHDA 3IPOA 1YMKA 2WLXA 1GN0A 3GK5A 3TP9A 2EG4B 3HWIA 1QXNA 3I2VA 2EG3A 3MZZA 1YT8A 2GWFA 3ICSA 5HPAA 1TQ1A 1YM9A 4JGTA 1BOHA 2JTRA 3P3AA 2A2KA 3NTAA 1H4KX 3G5JA 2HHGA 3D1PA 5LAOA 3NTDA 3R2UA 3TG3A 5HBQA 5HBLA 2KL3A 3FNJA 2ORAA 1VEEA 3HZUA 1WV9A 2IFDA 1UARA 2K0ZA 2MOIA 2MRMA 5HBPA 2OUCA 3FLHA 1T3KA 3AAYA 3HIXA 3I3UA 1YMDA 1YS0A 5LAMA 1E0CA 1C25A 1HZMA 2WLRA 1CWRA 1CWTA 1YMLA 5HBOA 3NT6A 3FS5A 3UTNX 1ORBA 1GMXA 3ICRA 2J6PA 3OLHA 2FSXA 3F4AA 3FOJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IPP A;  4OCG A;  1CWS A;  2DCQ A;  3OP3 A;  2IFV A;  3ILM A;  4WH7 A;  3AAX A;  1QB0 A;  4F67 A;  1WHB A;  3IWH A;  1OKG A;  1H4M X;  1DP2 A;  1BOI A;  4WH9 A;  1RHS A;  3NHV A;  2MOL A;  2EG4 A;  3O3W A;  2UZQ A;  3TG1 B;  2JTQ A;  1URH A;  3ICT A;  2JTS A;  2VSW A;  3K9R A;  1RHD A;  3IPO A;  1YMK A;  2WLX A;  1GN0 A;  3GK5 A;  3TP9 A;  2EG4 B;  3HWI A;  1QXN A;  3I2V A;  2EG3 A;  3MZZ A;  1YT8 A;  2GWF A;  3ICS A;  5HPA A;  1TQ1 A;  1YM9 A;  4JGT A;  1BOH A;  2JTR A;  3P3A A;  2A2K A;  3NTA A;  1H4K X;  3G5J A;  2HHG A;  3D1P A;  5LAO A;  3NTD A;  3R2U A;  3TG3 A;  5HBQ A;  5HBL A;  2KL3 A;  3FNJ A;  2ORA A;  1VEE A;  3HZU A;  1WV9 A;  2IFD A;  1UAR A;  2K0Z A;  2MOI A;  2MRM A;  5HBP A;  2OUC A;  3FLH A;  1T3K A;  3AAY A;  3HIX A;  3I3U A;  1YMD A;  1YS0 A;  5LAM A;  1E0C A;  1C25 A;  1HZM A;  2WLR A;  1CWR A;  1CWT A;  1YML A;  5HBO A;  3NT6 A;  3FS5 A;  3UTN X;  1ORB A;  1GMX A;  3ICR A;  2J6P A;  3OLH A;  2FSX A;  3F4A A;  3FOJ A; 
#chains in the Genus database with same CATH topology
 3IPP A;  4OCG A;  1CWS A;  2DCQ A;  3OP3 A;  2IFV A;  3ILM A;  4WH7 A;  3AAX A;  1QB0 A;  4F67 A;  1WHB A;  3IWH A;  1OKG A;  1H4M X;  1DP2 A;  1BOI A;  2Q82 A;  4WH9 A;  1RHS A;  3NHV A;  2MOL A;  2EG4 A;  3O3W A;  2UZQ A;  3TG1 B;  2JTQ A;  1URH A;  3ICT A;  2JTS A;  2VSW A;  3K9R A;  1RHD A;  3IPO A;  1YMK A;  2WLX A;  1GN0 A;  3GK5 A;  3TP9 A;  2EG4 B;  3HWI A;  1QXN A;  3I2V A;  2EG3 A;  3MZZ A;  1YT8 A;  2GWF A;  3ICS A;  5HPA A;  1TQ1 A;  1YM9 A;  4JGT A;  1BOH A;  2JTR A;  3P3A A;  2A2K A;  3NTA A;  1H4K X;  3G5J A;  2HHG A;  3D1P A;  5LAO A;  3NTD A;  3R2U A;  3TG3 A;  5HBQ A;  5HBL A;  2KL3 A;  3FNJ A;  2ORA A;  1VEE A;  3HZU A;  1WV9 A;  2IFD A;  1UAR A;  2K0Z A;  2MOI A;  2MRM A;  5HBP A;  2OUC A;  3FLH A;  1T3K A;  3AAY A;  3HIX A;  3I3U A;  1YMD A;  1YS0 A;  5LAM A;  1E0C A;  1C25 A;  1HZM A;  2WLR A;  1CWR A;  1CWT A;  1YML A;  5HBO A;  3NT6 A;  3FS5 A;  3UTN X;  1ORB A;  1GMX A;  3ICR A;  2J6P A;  3OLH A;  2FSX A;  3F4A A;  3FOJ A; 
#chains in the Genus database with same CATH homology
 3IPP A;  4OCG A;  1CWS A;  2DCQ A;  3OP3 A;  2IFV A;  3ILM A;  4WH7 A;  3AAX A;  1QB0 A;  4F67 A;  1WHB A;  3IWH A;  1OKG A;  1H4M X;  1DP2 A;  1BOI A;  4WH9 A;  1RHS A;  3NHV A;  2MOL A;  2EG4 A;  3O3W A;  2UZQ A;  3TG1 B;  2JTQ A;  1URH A;  3ICT A;  2JTS A;  2VSW A;  3K9R A;  1RHD A;  3IPO A;  1YMK A;  2WLX A;  1GN0 A;  3GK5 A;  3TP9 A;  2EG4 B;  3HWI A;  1QXN A;  3I2V A;  2EG3 A;  3MZZ A;  1YT8 A;  2GWF A;  3ICS A;  5HPA A;  1TQ1 A;  1YM9 A;  4JGT A;  1BOH A;  2JTR A;  3P3A A;  2A2K A;  3NTA A;  1H4K X;  3G5J A;  2HHG A;  3D1P A;  5LAO A;  3NTD A;  3R2U A;  3TG3 A;  5HBQ A;  5HBL A;  2KL3 A;  3FNJ A;  2ORA A;  1VEE A;  3HZU A;  1WV9 A;  2IFD A;  1UAR A;  2K0Z A;  2MOI A;  2MRM A;  5HBP A;  2OUC A;  3FLH A;  1T3K A;  3AAY A;  3HIX A;  3I3U A;  1YMD A;  1YS0 A;  5LAM A;  1E0C A;  1C25 A;  1HZM A;  2WLR A;  1CWR A;  1CWT A;  1YML A;  5HBO A;  3NT6 A;  3FS5 A;  3UTN X;  1ORB A;  1GMX A;  3ICR A;  2J6P A;  3OLH A;  2FSX A;  3F4A A;  3FOJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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