1FS1B

Insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
133
structure length
116
Chain Sequence
PSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDPVPLPNVNAAILKKVIQWCTHHKDDPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
pubmed doi rcsb
molecule tags Ligase
source organism Homo sapiens
molecule keywords CYCLIN A/CDK2-ASSOCIATED P19
total genus 44
structure length 116
sequence length 133
chains with identical sequence D
ec nomenclature
pdb deposition date 2000-09-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF03931 Skp1_POZ Skp1 family, tetramerisation domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.710.10 Alpha Beta 2-Layer Sandwich Potassium Channel Kv1.1; Chain A Potassium Channel Kv1.1; Chain A 1fs1B00
2P1PA 5JH5B 3C6PA 3C6NA 3DCGB 3OGLA 4W9HH 2FNJC 1EOFA 4W9EB 4JTAB 2E32B 3OHVA 4B95B 4UIJA 3C6OA 5BXDA 5H7HA 3L2OA 2P1MA 3ZUNB 5EUPA 4ZOUA 4W9CB 2ASTA 4W9JB 2IHCA 2NN2A 4APFA 2VPKA 2E31B 4W9DB 2OVQA 2JZ3C 1EOEA 4AJYC 3M52A 2OVRA 1R29A 4CXJA 1DSXA 4B9KE 1HV2A 4BGCA 3GA1A 3OGMA 3ZRFB 3OHUA 1R2BA 3WSOB 3DRZA 3M4TA 5BO4C 2YY9A 4W9LB 5BXHA 4BKSB 4U77A 2IF5A 2ASSA 2I2RA 5A15A 1BUOA 3ZTDB 4CRHA 1LDKD 3V7DA 4JTDB 3LNMB 4U2MA 3KVTA 1CS3A 3FKCA 1FS1B 1P22B 4EOZA 2P1QA 1QDWA 4AWJB 5BXBA 5DAFA 1EODA 4J8ZA 1EXBE 3M8VA 4U2NA 4W9FB 3E4UA 4I6JC 1NN7A 4N9F5 1T1DA 4W9HB 3ZNGB 3BIMA 4CXIA 5FTAA 4UYIA 5HYWB 2Z8HA 1LQBB 3ZRCB 3I3NA 1NEXA 3OGKA 2Q81A 3ZTCB 4W9IB 5A6RA 1S1GA 2VKPA 5IBKA 4W9GB 2MA9C 5HZGC 1FQVB 2IZVC 5DADA 1A68A 2P1NA 4HXIA 4B9KB 4AP2A 4W9KB 2NZ0B 2PPIA 2P1OA 4JGHC 3B84A 4WQOC 1R28A 3HVEB 1QDVA 1VCBB 4CP3A 3LBZA 1LM8C 3HU6A 2OVPA 5LLIB 1FS2B 3HQIA 5H7GA 4CXTA 3ZKJB 3MKSA 3HVEA 3LUTB 2R9RB 4BKTB 3HTMA 2C9WC 2A79B 3M5BA 4JTCB
chains in the Genus database with same CATH superfamily
2P1PA 5JH5B 3C6PA 3C6NA 3DCGB 3OGLA 4W9HH 2FNJC 1EOFA 4W9EB 4JTAB 2E32B 3OHVA 4B95B 4UIJA 3C6OA 5BXDA 5H7HA 3L2OA 2P1MA 3ZUNB 5EUPA 4ZOUA 3DRYA 4W9CB 2ASTA 4W9JB 3DRXA 2IHCA 4ZGCA 2NN2A 4APFA 2VPKA 2E31B 4W9DB 2OVQA 2JZ3C 1EOEA 4AJYC 3M52A 2OVRA 1R29A 4CXJA 1DSXA 4B9KE 1HV2A 4BGCA 3GA1A 3OGMA 3ZRFB 3OHUA 1R2BA 3WSOB 3DRZA 3M4TA 5BO4C 2YY9A 4W9LB 5BXHA 4BKSB 4U77A 2IF5A 2ASSA 2I2RA 5A15A 1BUOA 3ZTDB 4CRHA 1LDKD 3V7DA 4JTDB 3LNMB 4U2MA 3KVTA 1CS3A 3FKCA 1FS1B 1P22B 4EOZA 2P1QA 4YY8A 1QDWA 4AWJB 5BXBA 5DAFA 1EODA 4J8ZA 1EXBE 3M8VA 4U2NA 4W9FB 3E4UA 4I6JC 1NN7A 4N9F5 1T1DA 4W9HB 3ZNGB 3BIMA 4CXIA 5FTAA 4UYIA 5HYWB 2Z8HA 1LQBB 3ZRCB 3I3NA 1NEXA 3OGKA 2Q81A 3ZTCB 4W9IB 5A6RA 1S1GA 2VKPA 5IBKA 4W9GB 2MA9C 5HZGC 1FQVB 2IZVC 5DADA 1A68A 2P1NA 4HXIA 4B9KB 4AP2A 4W9KB 2NZ0B 2PPIA 2P1OA 4JGHC 3B84A 4WQOC 1R28A 3HVEB 1QDVA 1VCBB 4CP3A 3LBZA 1LM8C 3HU6A 2OVPA 5LLIB 1FS2B 3HQIA 5H7GA 4CXTA 3ZKJB 3MKSA 3HVEA 3LUTB 2R9RB 4BKTB 3HTMA 2C9WC 2A79B 3M5BA 4JTCB
chains in the Genus database with same CATH topology
2P1PA 5JH5B 3C6PA 3C6NA 3DCGB 3OGLA 4W9HH 2FNJC 1EOFA 4W9EB 4JTAB 2E32B 3OHVA 4B95B 4UIJA 3C6OA 5BXDA 5H7HA 3L2OA 2P1MA 3ZUNB 5EUPA 4ZOUA 3DRYA 4W9CB 2ASTA 4W9JB 3DRXA 2IHCA 4ZGCA 2NN2A 4APFA 2VPKA 2E31B 4W9DB 2OVQA 2JZ3C 1EOEA 4AJYC 3M52A 2OVRA 1R29A 4CXJA 1DSXA 4B9KE 1HV2A 4BGCA 3GA1A 3OGMA 3ZRFB 3OHUA 1R2BA 3WSOB 3DRZA 3M4TA 5BO4C 2YY9A 4W9LB 5BXHA 4BKSB 4U77A 2IF5A 2ASSA 2I2RA 5A15A 1BUOA 3ZTDB 4CRHA 1LDKD 3V7DA 4JTDB 3LNMB 4U2MA 3KVTA 1CS3A 3FKCA 1FS1B 1P22B 4EOZA 2P1QA 4YY8A 1QDWA 4AWJB 5BXBA 5DAFA 1EODA 4J8ZA 1EXBE 3M8VA 4U2NA 4W9FB 3E4UA 4I6JC 1NN7A 4N9F5 1T1DA 4W9HB 3ZNGB 3BIMA 4CXIA 5FTAA 4UYIA 5HYWB 2Z8HA 1LQBB 3ZRCB 3I3NA 1NEXA 3OGKA 2Q81A 3ZTCB 4W9IB 5A6RA 1S1GA 2VKPA 5IBKA 4W9GB 2MA9C 5HZGC 1FQVB 2IZVC 5DADA 1A68A 2P1NA 4HXIA 4B9KB 4AP2A 4W9KB 2NZ0B 2PPIA 2P1OA 4JGHC 3B84A 4WQOC 1R28A 3HVEB 1QDVA 1VCBB 4CP3A 3LBZA 1LM8C 3HU6A 2OVPA 5LLIB 1FS2B 3HQIA 5H7GA 4CXTA 3ZKJB 3MKSA 3HVEA 3LUTB 2R9RB 4BKTB 3HTMA 2C9WC 2A79B 3M5BA 4JTCB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2P1P A;  5JH5 B;  3C6P A;  3C6N A;  3DCG B;  3OGL A;  4W9H H;  2FNJ C;  1EOF A;  4W9E B;  4JTA B;  2E32 B;  3OHV A;  4B95 B;  4UIJ A;  3C6O A;  5BXD A;  5H7H A;  3L2O A;  2P1M A;  3ZUN B;  5EUP A;  4ZOU A;  4W9C B;  2AST A;  4W9J B;  2IHC A;  2NN2 A;  4APF A;  2VPK A;  2E31 B;  4W9D B;  2OVQ A;  2JZ3 C;  1EOE A;  4AJY C;  3M52 A;  2OVR A;  1R29 A;  4CXJ A;  1DSX A;  4B9K E;  1HV2 A;  4BGC A;  3GA1 A;  3OGM A;  3ZRF B;  3OHU A;  1R2B A;  3WSO B;  3DRZ A;  3M4T A;  5BO4 C;  2YY9 A;  4W9L B;  5BXH A;  4BKS B;  4U77 A;  2IF5 A;  2ASS A;  2I2R A;  5A15 A;  1BUO A;  3ZTD B;  4CRH A;  1LDK D;  3V7D A;  4JTD B;  3LNM B;  4U2M A;  3KVT A;  1CS3 A;  3FKC A;  1FS1 B;  1P22 B;  4EOZ A;  2P1Q A;  1QDW A;  4AWJ B;  5BXB A;  5DAF A;  1EOD A;  4J8Z A;  1EXB E;  3M8V A;  4U2N A;  4W9F B;  3E4U A;  4I6J C;  1NN7 A;  4N9F 5;  1T1D A;  4W9H B;  3ZNG B;  3BIM A;  4CXI A;  5FTA A;  4UYI A;  5HYW B;  2Z8H A;  1LQB B;  3ZRC B;  3I3N A;  1NEX A;  3OGK A;  2Q81 A;  3ZTC B;  4W9I B;  5A6R A;  1S1G A;  2VKP A;  5IBK A;  4W9G B;  2MA9 C;  5HZG C;  1FQV B;  2IZV C;  5DAD A;  1A68 A;  2P1N A;  4HXI A;  4B9K B;  4AP2 A;  4W9K B;  2NZ0 B;  2PPI A;  2P1O A;  4JGH C;  3B84 A;  4WQO C;  1R28 A;  3HVE B;  1QDV A;  1VCB B;  4CP3 A;  3LBZ A;  1LM8 C;  3HU6 A;  2OVP A;  5LLI B;  1FS2 B;  3HQI A;  5H7G A;  4CXT A;  3ZKJ B;  3MKS A;  3HVE A;  3LUT B;  2R9R B;  4BKT B;  3HTM A;  2C9W C;  2A79 B;  3M5B A;  4JTC B; 
#chains in the Genus database with same CATH topology
 2P1P A;  5JH5 B;  3C6P A;  3C6N A;  3DCG B;  3OGL A;  4W9H H;  2FNJ C;  1EOF A;  4W9E B;  4JTA B;  2E32 B;  3OHV A;  4B95 B;  4UIJ A;  3C6O A;  5BXD A;  5H7H A;  3L2O A;  2P1M A;  3ZUN B;  5EUP A;  4ZOU A;  3DRY A;  4W9C B;  2AST A;  4W9J B;  3DRX A;  2IHC A;  4ZGC A;  2NN2 A;  4APF A;  2VPK A;  2E31 B;  4W9D B;  2OVQ A;  2JZ3 C;  1EOE A;  4AJY C;  3M52 A;  2OVR A;  1R29 A;  4CXJ A;  1DSX A;  4B9K E;  1HV2 A;  4BGC A;  3GA1 A;  3OGM A;  3ZRF B;  3OHU A;  1R2B A;  3WSO B;  3DRZ A;  3M4T A;  5BO4 C;  2YY9 A;  4W9L B;  5BXH A;  4BKS B;  4U77 A;  2IF5 A;  2ASS A;  2I2R A;  5A15 A;  1BUO A;  3ZTD B;  4CRH A;  1LDK D;  3V7D A;  4JTD B;  3LNM B;  4U2M A;  3KVT A;  1CS3 A;  3FKC A;  1FS1 B;  1P22 B;  4EOZ A;  2P1Q A;  4YY8 A;  1QDW A;  4AWJ B;  5BXB A;  5DAF A;  1EOD A;  4J8Z A;  1EXB E;  3M8V A;  4U2N A;  4W9F B;  3E4U A;  4I6J C;  1NN7 A;  4N9F 5;  1T1D A;  4W9H B;  3ZNG B;  3BIM A;  4CXI A;  5FTA A;  4UYI A;  5HYW B;  2Z8H A;  1LQB B;  3ZRC B;  3I3N A;  1NEX A;  3OGK A;  2Q81 A;  3ZTC B;  4W9I B;  5A6R A;  1S1G A;  2VKP A;  5IBK A;  4W9G B;  2MA9 C;  5HZG C;  1FQV B;  2IZV C;  5DAD A;  1A68 A;  2P1N A;  4HXI A;  4B9K B;  4AP2 A;  4W9K B;  2NZ0 B;  2PPI A;  2P1O A;  4JGH C;  3B84 A;  4WQO C;  1R28 A;  3HVE B;  1QDV A;  1VCB B;  4CP3 A;  3LBZ A;  1LM8 C;  3HU6 A;  2OVP A;  5LLI B;  1FS2 B;  3HQI A;  5H7G A;  4CXT A;  3ZKJ B;  3MKS A;  3HVE A;  3LUT B;  2R9R B;  4BKT B;  3HTM A;  2C9W C;  2A79 B;  3M5B A;  4JTC B; 
#chains in the Genus database with same CATH homology
 2P1P A;  5JH5 B;  3C6P A;  3C6N A;  3DCG B;  3OGL A;  4W9H H;  2FNJ C;  1EOF A;  4W9E B;  4JTA B;  2E32 B;  3OHV A;  4B95 B;  4UIJ A;  3C6O A;  5BXD A;  5H7H A;  3L2O A;  2P1M A;  3ZUN B;  5EUP A;  4ZOU A;  3DRY A;  4W9C B;  2AST A;  4W9J B;  3DRX A;  2IHC A;  4ZGC A;  2NN2 A;  4APF A;  2VPK A;  2E31 B;  4W9D B;  2OVQ A;  2JZ3 C;  1EOE A;  4AJY C;  3M52 A;  2OVR A;  1R29 A;  4CXJ A;  1DSX A;  4B9K E;  1HV2 A;  4BGC A;  3GA1 A;  3OGM A;  3ZRF B;  3OHU A;  1R2B A;  3WSO B;  3DRZ A;  3M4T A;  5BO4 C;  2YY9 A;  4W9L B;  5BXH A;  4BKS B;  4U77 A;  2IF5 A;  2ASS A;  2I2R A;  5A15 A;  1BUO A;  3ZTD B;  4CRH A;  1LDK D;  3V7D A;  4JTD B;  3LNM B;  4U2M A;  3KVT A;  1CS3 A;  3FKC A;  1FS1 B;  1P22 B;  4EOZ A;  2P1Q A;  4YY8 A;  1QDW A;  4AWJ B;  5BXB A;  5DAF A;  1EOD A;  4J8Z A;  1EXB E;  3M8V A;  4U2N A;  4W9F B;  3E4U A;  4I6J C;  1NN7 A;  4N9F 5;  1T1D A;  4W9H B;  3ZNG B;  3BIM A;  4CXI A;  5FTA A;  4UYI A;  5HYW B;  2Z8H A;  1LQB B;  3ZRC B;  3I3N A;  1NEX A;  3OGK A;  2Q81 A;  3ZTC B;  4W9I B;  5A6R A;  1S1G A;  2VKP A;  5IBK A;  4W9G B;  2MA9 C;  5HZG C;  1FQV B;  2IZV C;  5DAD A;  1A68 A;  2P1N A;  4HXI A;  4B9K B;  4AP2 A;  4W9K B;  2NZ0 B;  2PPI A;  2P1O A;  4JGH C;  3B84 A;  4WQO C;  1R28 A;  3HVE B;  1QDV A;  1VCB B;  4CP3 A;  3LBZ A;  1LM8 C;  3HU6 A;  2OVP A;  5LLI B;  1FS2 B;  3HQI A;  5H7G A;  4CXT A;  3ZKJ B;  3MKS A;  3HVE A;  3LUT B;  2R9R B;  4BKT B;  3HTM A;  2C9W C;  2A79 B;  3M5B A;  4JTC B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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