1FWMA

Crystal structure of the thymidylate synthase r166q mutant
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
263
structure length
263
Chain Sequence
KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQQSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
source organism Escherichia coli
publication title Crystal structures of thymidylate synthase mutant R166Q: Structural basis for the nearly complete loss of catalytic activity.
pubmed doi rcsb
molecule keywords THYMIDYLATE SYNTHASE
total genus 83
structure length 263
sequence length 263
chains with identical sequence B
ec nomenclature ec 2.1.1.45: Thymidylate synthase.
pdb deposition date 2000-09-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00303 Thymidylat_synt Thymidylate synthase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase; Chain A Thymidylate synthase/dCMP hydroxymethylase domain 1fwmA00
1TVWA 3HJ3A 3IX6A 4FQSA 1J3KC 1BP6A 1EVFA 1VZEA 1QQQA 4KYAA 1BKPA 1HW4A 1B02A 4ISKA 4XSDA 4FGTA 5FCTA 5H38A 1FWMA 1DNAA 1TSYA 1NJCA 1TDBA 1NJBA 2RD8B 3BYXA 5J7WA 1FFLA 1BO8A 3UM6A 4Q0DA 1F4DA 3UWLA 1TSMA 4XSEA 1LCBA 5H39A 2RDAA 1BQ2A 3EBUA 4FOGA 1TSXA 1TSNA 1EV5A 2G8XA 3NRRA 2A9WA 1HZWA 1VZAA 1BQ1A 1QZFA 2ONBA 3GH0A 4IRRA 1BSPA 3DL6A 1BJGA 3BFIA 1ZPRA 2H2QA 4KY8A 1JMFA 1VZCA 1JMIA 2KCEA 4G6WX 4ISWA 1B5EA 4KPWA 4EILA 1NJEA 3K2HA 4O1XA 3C0AA 4UP1A 1AOBA 3TMSA 4TMSA 1F4CA 3OB7A 1TSDA 4E5OA 1TDAA 2TDMA 3EHIX 5HS3A 4DP3A 3B9HA 1F28A 1TSVA 1AIQA 3EJLA 1JUJA 1BO7A 3IHIA 1SEJA 1BKOA 3BNZA 1TYSA 1KZJA 1B5DA 4GEVA 1JU6A 4E28A 1TISA 4FOXA 4H0RA 3EAWX 1CI7A 1VZBA 3CL9A 4Q0EA 3INVA 4O7UA 2TSCA 1NCEA 1TDCA 1I00A 1JG0A 1NJDA 3BHLA 3HBBA 4EZ8A 2FTQA 3QG2A 1VZDA 4H1IA 2G8DA 4KY4A 1AN5A 3UM5A 1F4FA 1TDUA 1TSZA 1EV8A 1RTSA 1TSLA 1BIDA 4KNZA 2VETA 3DL5A 2BBQA 4EINA 1HW3A 1TJSA 1AXWA 4PSGA 4DPHA 3BHRA 3IROA 1TLSA 2RD8A 3CLBA 4IQQA 1KZIA 4O1XD 5H3AA 1F4BA 3KJRA 2AAZA 2OIPA 3H9KA 3QGTA 1JMGA 1JUTA 1TVVA 3KJSA 1JTUA 3N5EB 4GYHA 1LCAA 1KCEA 5BY6A 3KGBA 3DG8C 2G86A 4DQ1A 3HB8A 1SYNA 1BSFA 3ED7A 3BGXA 2G8AA 4DPDA 1YPVA 4G2OX 1F4EA 2VF0A 3EGYX 3N5EA 3UWLB 4IQBA 1DDUA 1TVUA 1B49A 4ECKA 4JEFA 1HVYA 3GH2X 3N5GA 5WRNA 3DGAC 3B5BA 4XSCA 2TSRA 4H0UA 3IJZA 3C06A 3IRNA 4O1UA 4LRRA 1TSWA 1LCEA 1TLCA 1J3JC 3IK0A 4F2VA 2FTNA 4FOAA 3UM8A 1BPJA 3EF9A 3QJ7A 1JMHA 1EVGA 2G89A 2TDDA 3IK1A 4EB4A 3EDWX 3GG5A 1TRGA 3BZ0A 4GD7A 1BDUA 3I3RA 1F4GA 2FTOX 3IRMA 1AJMA 1J3IC 1JTQA 1BP0A 3JSUA 3V8HA 1THYA 1NJAA
chains in the Genus database with same CATH superfamily
1TVWA 3HJ3A 3IX6A 4FQSA 1J3KC 1BP6A 1EVFA 1VZEA 1QQQA 4KYAA 1BKPA 1HW4A 1B02A 4ISKA 4XSDA 4FGTA 5FCTA 5H38A 1FWMA 1DNAA 1TSYA 1NJCA 1TDBA 1NJBA 2RD8B 3BYXA 5J7WA 1FFLA 1BO8A 3UM6A 4Q0DA 1F4DA 3UWLA 1TSMA 4XSEA 1LCBA 5H39A 2RDAA 1BQ2A 3EBUA 4FOGA 1TSXA 1TSNA 1EV5A 2G8XA 3NRRA 2A9WA 1HZWA 1VZAA 1BQ1A 1QZFA 2ONBA 3GH0A 4IRRA 1BSPA 3DL6A 1BJGA 3BFIA 1ZPRA 2H2QA 4KY8A 1JMFA 1VZCA 1JMIA 2KCEA 4G6WX 4ISWA 1B5EA 4KPWA 4EILA 1NJEA 3K2HA 4O1XA 3C0AA 4UP1A 1AOBA 3TMSA 4TMSA 1F4CA 3OB7A 1TSDA 4E5OA 1TDAA 2TDMA 3EHIX 5HS3A 4DP3A 3B9HA 1F28A 1TSVA 1AIQA 3EJLA 1JUJA 1BO7A 3IHIA 1SEJA 1BKOA 3BNZA 1TYSA 1KZJA 1B5DA 4GEVA 1JU6A 4E28A 1TISA 4FOXA 4H0RA 3EAWX 1CI7A 1VZBA 3CL9A 4Q0EA 3INVA 4O7UA 2TSCA 1NCEA 1TDCA 1I00A 1JG0A 1NJDA 3BHLA 3HBBA 4EZ8A 2FTQA 3QG2A 1VZDA 4H1IA 2G8DA 4KY4A 1AN5A 3UM5A 1F4FA 1TDUA 1TSZA 1EV8A 1RTSA 1TSLA 1BIDA 4KNZA 2VETA 3DL5A 2BBQA 4EINA 1HW3A 1TJSA 1AXWA 4PSGA 4DPHA 3BHRA 3IROA 1TLSA 2RD8A 3CLBA 4IQQA 1KZIA 4O1XD 5H3AA 1F4BA 3KJRA 2AAZA 2OIPA 3H9KA 3QGTA 1JMGA 1JUTA 1TVVA 3KJSA 1JTUA 3N5EB 4GYHA 1LCAA 1KCEA 5BY6A 3KGBA 3DG8C 2G86A 4DQ1A 3HB8A 1SYNA 1BSFA 3ED7A 3BGXA 2G8AA 4DPDA 1YPVA 4G2OX 1F4EA 2VF0A 3EGYX 3N5EA 3UWLB 4IQBA 1DDUA 1TVUA 1B49A 4ECKA 4JEFA 1HVYA 3GH2X 3N5GA 5WRNA 3DGAC 3B5BA 4XSCA 2TSRA 4H0UA 3IJZA 3C06A 3IRNA 4O1UA 4LRRA 1TSWA 1LCEA 1TLCA 1J3JC 3IK0A 4F2VA 2FTNA 4FOAA 3UM8A 1BPJA 3EF9A 3QJ7A 1JMHA 1EVGA 2G89A 2TDDA 3IK1A 4EB4A 3EDWX 3GG5A 1TRGA 3BZ0A 4GD7A 1BDUA 3I3RA 1F4GA 2FTOX 3IRMA 1AJMA 1J3IC 1JTQA 1BP0A 3JSUA 3V8HA 1THYA 1NJAA
chains in the Genus database with same CATH topology
1TVWA 3HJ3A 3IX6A 4FQSA 1J3KC 1BP6A 1EVFA 1VZEA 1QQQA 4KYAA 1BKPA 1HW4A 1B02A 4ISKA 4XSDA 4FGTA 5FCTA 5H38A 1FWMA 1DNAA 1TSYA 1NJCA 1TDBA 1NJBA 2RD8B 3BYXA 5J7WA 1FFLA 1BO8A 3UM6A 4Q0DA 1F4DA 3UWLA 1TSMA 4XSEA 1LCBA 5H39A 2RDAA 1BQ2A 3EBUA 4FOGA 1TSXA 1TSNA 1EV5A 2G8XA 3NRRA 2A9WA 1HZWA 1VZAA 1BQ1A 1QZFA 2ONBA 3GH0A 4IRRA 1BSPA 3DL6A 1BJGA 3BFIA 1ZPRA 2H2QA 4KY8A 1JMFA 1VZCA 1JMIA 2KCEA 4G6WX 4ISWA 1B5EA 4KPWA 4EILA 1NJEA 3K2HA 4O1XA 3C0AA 4UP1A 1AOBA 3TMSA 4TMSA 1F4CA 3OB7A 1TSDA 4E5OA 1TDAA 2TDMA 3EHIX 5HS3A 4DP3A 3B9HA 1F28A 1TSVA 1AIQA 3EJLA 1JUJA 1BO7A 3IHIA 1SEJA 1BKOA 3BNZA 1TYSA 1KZJA 1B5DA 4GEVA 1JU6A 4E28A 1TISA 4FOXA 4H0RA 3EAWX 1CI7A 1VZBA 3CL9A 4Q0EA 3INVA 4O7UA 2TSCA 1NCEA 1TDCA 1I00A 1JG0A 1NJDA 3BHLA 3HBBA 4EZ8A 2FTQA 3QG2A 1VZDA 4H1IA 2G8DA 4KY4A 1AN5A 3UM5A 1F4FA 1TDUA 1TSZA 1EV8A 1RTSA 1TSLA 1BIDA 4KNZA 2VETA 3DL5A 2BBQA 4EINA 1HW3A 1TJSA 1AXWA 4PSGA 4DPHA 3BHRA 3IROA 1TLSA 2RD8A 3CLBA 4IQQA 1KZIA 4O1XD 5H3AA 1F4BA 3KJRA 2AAZA 2OIPA 3H9KA 3QGTA 1JMGA 1JUTA 1TVVA 3KJSA 1JTUA 3N5EB 4GYHA 1LCAA 1KCEA 5BY6A 3KGBA 3DG8C 2G86A 4DQ1A 3HB8A 1SYNA 1BSFA 3ED7A 3BGXA 2G8AA 4DPDA 1YPVA 4G2OX 1F4EA 2VF0A 3EGYX 3N5EA 3UWLB 4IQBA 1DDUA 1TVUA 1B49A 4ECKA 4JEFA 1HVYA 3GH2X 3N5GA 5WRNA 3DGAC 3B5BA 4XSCA 2TSRA 4H0UA 3IJZA 3C06A 3IRNA 4O1UA 4LRRA 1TSWA 1LCEA 1TLCA 1J3JC 3IK0A 4F2VA 2FTNA 4FOAA 3UM8A 1BPJA 3EF9A 3QJ7A 1JMHA 1EVGA 2G89A 2TDDA 3IK1A 4EB4A 3EDWX 3GG5A 1TRGA 3BZ0A 4GD7A 1BDUA 3I3RA 1F4GA 2FTOX 3IRMA 1AJMA 1J3IC 1JTQA 1BP0A 3JSUA 3V8HA 1THYA 1NJAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TVW A;  3HJ3 A;  3IX6 A;  4FQS A;  1J3K C;  1BP6 A;  1EVF A;  1VZE A;  1QQQ A;  4KYA A;  1BKP A;  1HW4 A;  1B02 A;  4ISK A;  4XSD A;  4FGT A;  5FCT A;  5H38 A;  1FWM A;  1DNA A;  1TSY A;  1NJC A;  1TDB A;  1NJB A;  2RD8 B;  3BYX A;  5J7W A;  1FFL A;  1BO8 A;  3UM6 A;  4Q0D A;  1F4D A;  3UWL A;  1TSM A;  4XSE A;  1LCB A;  5H39 A;  2RDA A;  1BQ2 A;  3EBU A;  4FOG A;  1TSX A;  1TSN A;  1EV5 A;  2G8X A;  3NRR A;  2A9W A;  1HZW A;  1VZA A;  1BQ1 A;  1QZF A;  2ONB A;  3GH0 A;  4IRR A;  1BSP A;  3DL6 A;  1BJG A;  3BFI A;  1ZPR A;  2H2Q A;  4KY8 A;  1JMF A;  1VZC A;  1JMI A;  2KCE A;  4G6W X;  4ISW A;  1B5E A;  4KPW A;  4EIL A;  1NJE A;  3K2H A;  4O1X A;  3C0A A;  4UP1 A;  1AOB A;  3TMS A;  4TMS A;  1F4C A;  3OB7 A;  1TSD A;  4E5O A;  1TDA A;  2TDM A;  3EHI X;  5HS3 A;  4DP3 A;  3B9H A;  1F28 A;  1TSV A;  1AIQ A;  3EJL A;  1JUJ A;  1BO7 A;  3IHI A;  1SEJ A;  1BKO A;  3BNZ A;  1TYS A;  1KZJ A;  1B5D A;  4GEV A;  1JU6 A;  4E28 A;  1TIS A;  4FOX A;  4H0R A;  3EAW X;  1CI7 A;  1VZB A;  3CL9 A;  4Q0E A;  3INV A;  4O7U A;  2TSC A;  1NCE A;  1TDC A;  1I00 A;  1JG0 A;  1NJD A;  3BHL A;  3HBB A;  4EZ8 A;  2FTQ A;  3QG2 A;  1VZD A;  4H1I A;  2G8D A;  4KY4 A;  1AN5 A;  3UM5 A;  1F4F A;  1TDU A;  1TSZ A;  1EV8 A;  1RTS A;  1TSL A;  1BID A;  4KNZ A;  2VET A;  3DL5 A;  2BBQ A;  4EIN A;  1HW3 A;  1TJS A;  1AXW A;  4PSG A;  4DPH A;  3BHR A;  3IRO A;  1TLS A;  2RD8 A;  3CLB A;  4IQQ A;  1KZI A;  4O1X D;  5H3A A;  1F4B A;  3KJR A;  2AAZ A;  2OIP A;  3H9K A;  3QGT A;  1JMG A;  1JUT A;  1TVV A;  3KJS A;  1JTU A;  3N5E B;  4GYH A;  1LCA A;  1KCE A;  5BY6 A;  3KGB A;  3DG8 C;  2G86 A;  4DQ1 A;  3HB8 A;  1SYN A;  1BSF A;  3ED7 A;  3BGX A;  2G8A A;  4DPD A;  1YPV A;  4G2O X;  1F4E A;  2VF0 A;  3EGY X;  3N5E A;  3UWL B;  4IQB A;  1DDU A;  1TVU A;  1B49 A;  4ECK A;  4JEF A;  1HVY A;  3GH2 X;  3N5G A;  5WRN A;  3DGA C;  3B5B A;  4XSC A;  2TSR A;  4H0U A;  3IJZ A;  3C06 A;  3IRN A;  4O1U A;  4LRR A;  1TSW A;  1LCE A;  1TLC A;  1J3J C;  3IK0 A;  4F2V A;  2FTN A;  4FOA A;  3UM8 A;  1BPJ A;  3EF9 A;  3QJ7 A;  1JMH A;  1EVG A;  2G89 A;  2TDD A;  3IK1 A;  4EB4 A;  3EDW X;  3GG5 A;  1TRG A;  3BZ0 A;  4GD7 A;  1BDU A;  3I3R A;  1F4G A;  2FTO X;  3IRM A;  1AJM A;  1J3I C;  1JTQ A;  1BP0 A;  3JSU A;  3V8H A;  1THY A;  1NJA A; 
#chains in the Genus database with same CATH topology
 1TVW A;  3HJ3 A;  3IX6 A;  4FQS A;  1J3K C;  1BP6 A;  1EVF A;  1VZE A;  1QQQ A;  4KYA A;  1BKP A;  1HW4 A;  1B02 A;  4ISK A;  4XSD A;  4FGT A;  5FCT A;  5H38 A;  1FWM A;  1DNA A;  1TSY A;  1NJC A;  1TDB A;  1NJB A;  2RD8 B;  3BYX A;  5J7W A;  1FFL A;  1BO8 A;  3UM6 A;  4Q0D A;  1F4D A;  3UWL A;  1TSM A;  4XSE A;  1LCB A;  5H39 A;  2RDA A;  1BQ2 A;  3EBU A;  4FOG A;  1TSX A;  1TSN A;  1EV5 A;  2G8X A;  3NRR A;  2A9W A;  1HZW A;  1VZA A;  1BQ1 A;  1QZF A;  2ONB A;  3GH0 A;  4IRR A;  1BSP A;  3DL6 A;  1BJG A;  3BFI A;  1ZPR A;  2H2Q A;  4KY8 A;  1JMF A;  1VZC A;  1JMI A;  2KCE A;  4G6W X;  4ISW A;  1B5E A;  4KPW A;  4EIL A;  1NJE A;  3K2H A;  4O1X A;  3C0A A;  4UP1 A;  1AOB A;  3TMS A;  4TMS A;  1F4C A;  3OB7 A;  1TSD A;  4E5O A;  1TDA A;  2TDM A;  3EHI X;  5HS3 A;  4DP3 A;  3B9H A;  1F28 A;  1TSV A;  1AIQ A;  3EJL A;  1JUJ A;  1BO7 A;  3IHI A;  1SEJ A;  1BKO A;  3BNZ A;  1TYS A;  1KZJ A;  1B5D A;  4GEV A;  1JU6 A;  4E28 A;  1TIS A;  4FOX A;  4H0R A;  3EAW X;  1CI7 A;  1VZB A;  3CL9 A;  4Q0E A;  3INV A;  4O7U A;  2TSC A;  1NCE A;  1TDC A;  1I00 A;  1JG0 A;  1NJD A;  3BHL A;  3HBB A;  4EZ8 A;  2FTQ A;  3QG2 A;  1VZD A;  4H1I A;  2G8D A;  4KY4 A;  1AN5 A;  3UM5 A;  1F4F A;  1TDU A;  1TSZ A;  1EV8 A;  1RTS A;  1TSL A;  1BID A;  4KNZ A;  2VET A;  3DL5 A;  2BBQ A;  4EIN A;  1HW3 A;  1TJS A;  1AXW A;  4PSG A;  4DPH A;  3BHR A;  3IRO A;  1TLS A;  2RD8 A;  3CLB A;  4IQQ A;  1KZI A;  4O1X D;  5H3A A;  1F4B A;  3KJR A;  2AAZ A;  2OIP A;  3H9K A;  3QGT A;  1JMG A;  1JUT A;  1TVV A;  3KJS A;  1JTU A;  3N5E B;  4GYH A;  1LCA A;  1KCE A;  5BY6 A;  3KGB A;  3DG8 C;  2G86 A;  4DQ1 A;  3HB8 A;  1SYN A;  1BSF A;  3ED7 A;  3BGX A;  2G8A A;  4DPD A;  1YPV A;  4G2O X;  1F4E A;  2VF0 A;  3EGY X;  3N5E A;  3UWL B;  4IQB A;  1DDU A;  1TVU A;  1B49 A;  4ECK A;  4JEF A;  1HVY A;  3GH2 X;  3N5G A;  5WRN A;  3DGA C;  3B5B A;  4XSC A;  2TSR A;  4H0U A;  3IJZ A;  3C06 A;  3IRN A;  4O1U A;  4LRR A;  1TSW A;  1LCE A;  1TLC A;  1J3J C;  3IK0 A;  4F2V A;  2FTN A;  4FOA A;  3UM8 A;  1BPJ A;  3EF9 A;  3QJ7 A;  1JMH A;  1EVG A;  2G89 A;  2TDD A;  3IK1 A;  4EB4 A;  3EDW X;  3GG5 A;  1TRG A;  3BZ0 A;  4GD7 A;  1BDU A;  3I3R A;  1F4G A;  2FTO X;  3IRM A;  1AJM A;  1J3I C;  1JTQ A;  1BP0 A;  3JSU A;  3V8H A;  1THY A;  1NJA A; 
#chains in the Genus database with same CATH homology
 1TVW A;  3HJ3 A;  3IX6 A;  4FQS A;  1J3K C;  1BP6 A;  1EVF A;  1VZE A;  1QQQ A;  4KYA A;  1BKP A;  1HW4 A;  1B02 A;  4ISK A;  4XSD A;  4FGT A;  5FCT A;  5H38 A;  1FWM A;  1DNA A;  1TSY A;  1NJC A;  1TDB A;  1NJB A;  2RD8 B;  3BYX A;  5J7W A;  1FFL A;  1BO8 A;  3UM6 A;  4Q0D A;  1F4D A;  3UWL A;  1TSM A;  4XSE A;  1LCB A;  5H39 A;  2RDA A;  1BQ2 A;  3EBU A;  4FOG A;  1TSX A;  1TSN A;  1EV5 A;  2G8X A;  3NRR A;  2A9W A;  1HZW A;  1VZA A;  1BQ1 A;  1QZF A;  2ONB A;  3GH0 A;  4IRR A;  1BSP A;  3DL6 A;  1BJG A;  3BFI A;  1ZPR A;  2H2Q A;  4KY8 A;  1JMF A;  1VZC A;  1JMI A;  2KCE A;  4G6W X;  4ISW A;  1B5E A;  4KPW A;  4EIL A;  1NJE A;  3K2H A;  4O1X A;  3C0A A;  4UP1 A;  1AOB A;  3TMS A;  4TMS A;  1F4C A;  3OB7 A;  1TSD A;  4E5O A;  1TDA A;  2TDM A;  3EHI X;  5HS3 A;  4DP3 A;  3B9H A;  1F28 A;  1TSV A;  1AIQ A;  3EJL A;  1JUJ A;  1BO7 A;  3IHI A;  1SEJ A;  1BKO A;  3BNZ A;  1TYS A;  1KZJ A;  1B5D A;  4GEV A;  1JU6 A;  4E28 A;  1TIS A;  4FOX A;  4H0R A;  3EAW X;  1CI7 A;  1VZB A;  3CL9 A;  4Q0E A;  3INV A;  4O7U A;  2TSC A;  1NCE A;  1TDC A;  1I00 A;  1JG0 A;  1NJD A;  3BHL A;  3HBB A;  4EZ8 A;  2FTQ A;  3QG2 A;  1VZD A;  4H1I A;  2G8D A;  4KY4 A;  1AN5 A;  3UM5 A;  1F4F A;  1TDU A;  1TSZ A;  1EV8 A;  1RTS A;  1TSL A;  1BID A;  4KNZ A;  2VET A;  3DL5 A;  2BBQ A;  4EIN A;  1HW3 A;  1TJS A;  1AXW A;  4PSG A;  4DPH A;  3BHR A;  3IRO A;  1TLS A;  2RD8 A;  3CLB A;  4IQQ A;  1KZI A;  4O1X D;  5H3A A;  1F4B A;  3KJR A;  2AAZ A;  2OIP A;  3H9K A;  3QGT A;  1JMG A;  1JUT A;  1TVV A;  3KJS A;  1JTU A;  3N5E B;  4GYH A;  1LCA A;  1KCE A;  5BY6 A;  3KGB A;  3DG8 C;  2G86 A;  4DQ1 A;  3HB8 A;  1SYN A;  1BSF A;  3ED7 A;  3BGX A;  2G8A A;  4DPD A;  1YPV A;  4G2O X;  1F4E A;  2VF0 A;  3EGY X;  3N5E A;  3UWL B;  4IQB A;  1DDU A;  1TVU A;  1B49 A;  4ECK A;  4JEF A;  1HVY A;  3GH2 X;  3N5G A;  5WRN A;  3DGA C;  3B5B A;  4XSC A;  2TSR A;  4H0U A;  3IJZ A;  3C06 A;  3IRN A;  4O1U A;  4LRR A;  1TSW A;  1LCE A;  1TLC A;  1J3J C;  3IK0 A;  4F2V A;  2FTN A;  4FOA A;  3UM8 A;  1BPJ A;  3EF9 A;  3QJ7 A;  1JMH A;  1EVG A;  2G89 A;  2TDD A;  3IK1 A;  4EB4 A;  3EDW X;  3GG5 A;  1TRG A;  3BZ0 A;  4GD7 A;  1BDU A;  3I3R A;  1F4G A;  2FTO X;  3IRM A;  1AJM A;  1J3I C;  1JTQ A;  1BP0 A;  3JSU A;  3V8H A;  1THY A;  1NJA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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