1HZMA

Structure of erk2 binding domain of mapk phosphatase mkp-3: structural insights into mkp-3 activation by erk2
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
154
structure length
154
Chain Sequence
MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESLLGLLLKKLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
total genus 23
structure length 154
sequence length 154
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2001-01-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 1hzmA00
2JTSA 4WH9A 3TG3A 1UARA 3F4AA 3IPOA 3I2VA 1GN0A 3NTAA 1H4KX 1YMLA 2DCQA 2HHGA 2UZQA 4F67A 3FNJA 3GK5A 3AAXA 2IFDA 1TQ1A 5HPAA 1DP2A 1CWSA 1BOHA 4JGTA 1QXNA 2IFVA 5LAMA 3FS5A 2MRMA 2A2KA 4WH7A 3ILMA 3R2UA 3G5JA 3IWHA 1QB0A 1YM9A 3K9RA 1YS0A 1URHA 3HZUA 1RHDA 3AAYA 3HIXA 1BOIA 4OCGA 2GWFA 3D1PA 1WHBA 5HBOA 5HBQA 1C25A 1YMDA 3I3UA 2K0ZA 3ICTA 5LAOA 3NTDA 1YT8A 1VEEA 3MZZA 2FSXA 3NT6A 1WV9A 1E0CA 1GMXA 1T3KA 3O3WA 3FOJA 2J6PA 2JTRA 1CWTA 2EG3A 1H4MX 2ORAA 3OLHA 2MOLA 3TP9A 3ICSA 1HZMA 2EG4A 3FLHA 1CWRA 2WLXA 3HWIA 3NHVA 3TG1B 3UTNX 3P3AA 3ICRA 1YMKA 2JTQA 2EG4B 3IPPA 1OKGA 5HBPA 1ORBA 2WLRA 5HBLA 2MOIA 2OUCA 1RHSA 2VSWA 2KL3A 3OP3A
chains in the Genus database with same CATH superfamily
2JTSA 4WH9A 3TG3A 1UARA 3F4AA 3IPOA 3I2VA 1GN0A 3NTAA 1H4KX 1YMLA 2DCQA 2HHGA 2UZQA 4F67A 3FNJA 3GK5A 3AAXA 2IFDA 1TQ1A 5HPAA 1DP2A 1CWSA 1BOHA 4JGTA 1QXNA 2IFVA 5LAMA 3FS5A 2MRMA 2A2KA 4WH7A 3ILMA 3R2UA 3G5JA 3IWHA 1QB0A 1YM9A 3K9RA 1YS0A 1URHA 3HZUA 1RHDA 3AAYA 3HIXA 1BOIA 4OCGA 2GWFA 3D1PA 1WHBA 5HBOA 5HBQA 1C25A 1YMDA 3I3UA 2Q82A 2K0ZA 3ICTA 5LAOA 3NTDA 1YT8A 1VEEA 3MZZA 2FSXA 3NT6A 1WV9A 1E0CA 1GMXA 1T3KA 3O3WA 3FOJA 2J6PA 2JTRA 1CWTA 2EG3A 1H4MX 2ORAA 3OLHA 2MOLA 3TP9A 3ICSA 1HZMA 2EG4A 3FLHA 1CWRA 2WLXA 3HWIA 3NHVA 3TG1B 3UTNX 3P3AA 3ICRA 1YMKA 2JTQA 2EG4B 3IPPA 1OKGA 5HBPA 1ORBA 2WLRA 5HBLA 2MOIA 2OUCA 1RHSA 2VSWA 2KL3A 3OP3A
chains in the Genus database with same CATH topology
2JTSA 4WH9A 3TG3A 1UARA 3F4AA 3IPOA 3I2VA 1GN0A 3NTAA 1H4KX 1YMLA 2DCQA 2HHGA 2UZQA 4F67A 3FNJA 3GK5A 3AAXA 2IFDA 1TQ1A 5HPAA 1DP2A 1CWSA 1BOHA 4JGTA 1QXNA 2IFVA 5LAMA 3FS5A 2MRMA 2A2KA 4WH7A 3ILMA 3R2UA 3G5JA 3IWHA 1QB0A 1YM9A 3K9RA 1YS0A 1URHA 3HZUA 1RHDA 3AAYA 3HIXA 1BOIA 4OCGA 2GWFA 3D1PA 1WHBA 5HBOA 5HBQA 1C25A 1YMDA 3I3UA 2K0ZA 3ICTA 5LAOA 3NTDA 1YT8A 1VEEA 3MZZA 2FSXA 3NT6A 1WV9A 1E0CA 1GMXA 1T3KA 3O3WA 3FOJA 2J6PA 2JTRA 1CWTA 2EG3A 1H4MX 2ORAA 3OLHA 2MOLA 3TP9A 3ICSA 1HZMA 2EG4A 3FLHA 1CWRA 2WLXA 3HWIA 3NHVA 3TG1B 3UTNX 3P3AA 3ICRA 1YMKA 2JTQA 2EG4B 3IPPA 1OKGA 5HBPA 1ORBA 2WLRA 5HBLA 2MOIA 2OUCA 1RHSA 2VSWA 2KL3A 3OP3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JTS A;  4WH9 A;  3TG3 A;  1UAR A;  3F4A A;  3IPO A;  3I2V A;  1GN0 A;  3NTA A;  1H4K X;  1YML A;  2DCQ A;  2HHG A;  2UZQ A;  4F67 A;  3FNJ A;  3GK5 A;  3AAX A;  2IFD A;  1TQ1 A;  5HPA A;  1DP2 A;  1CWS A;  1BOH A;  4JGT A;  1QXN A;  2IFV A;  5LAM A;  3FS5 A;  2MRM A;  2A2K A;  4WH7 A;  3ILM A;  3R2U A;  3G5J A;  3IWH A;  1QB0 A;  1YM9 A;  3K9R A;  1YS0 A;  1URH A;  3HZU A;  1RHD A;  3AAY A;  3HIX A;  1BOI A;  4OCG A;  2GWF A;  3D1P A;  1WHB A;  5HBO A;  5HBQ A;  1C25 A;  1YMD A;  3I3U A;  2K0Z A;  3ICT A;  5LAO A;  3NTD A;  1YT8 A;  1VEE A;  3MZZ A;  2FSX A;  3NT6 A;  1WV9 A;  1E0C A;  1GMX A;  1T3K A;  3O3W A;  3FOJ A;  2J6P A;  2JTR A;  1CWT A;  2EG3 A;  1H4M X;  2ORA A;  3OLH A;  2MOL A;  3TP9 A;  3ICS A;  1HZM A;  2EG4 A;  3FLH A;  1CWR A;  2WLX A;  3HWI A;  3NHV A;  3TG1 B;  3UTN X;  3P3A A;  3ICR A;  1YMK A;  2JTQ A;  2EG4 B;  3IPP A;  1OKG A;  5HBP A;  1ORB A;  2WLR A;  5HBL A;  2MOI A;  2OUC A;  1RHS A;  2VSW A;  2KL3 A;  3OP3 A; 
#chains in the Genus database with same CATH topology
 2JTS A;  4WH9 A;  3TG3 A;  1UAR A;  3F4A A;  3IPO A;  3I2V A;  1GN0 A;  3NTA A;  1H4K X;  1YML A;  2DCQ A;  2HHG A;  2UZQ A;  4F67 A;  3FNJ A;  3GK5 A;  3AAX A;  2IFD A;  1TQ1 A;  5HPA A;  1DP2 A;  1CWS A;  1BOH A;  4JGT A;  1QXN A;  2IFV A;  5LAM A;  3FS5 A;  2MRM A;  2A2K A;  4WH7 A;  3ILM A;  3R2U A;  3G5J A;  3IWH A;  1QB0 A;  1YM9 A;  3K9R A;  1YS0 A;  1URH A;  3HZU A;  1RHD A;  3AAY A;  3HIX A;  1BOI A;  4OCG A;  2GWF A;  3D1P A;  1WHB A;  5HBO A;  5HBQ A;  1C25 A;  1YMD A;  3I3U A;  2Q82 A;  2K0Z A;  3ICT A;  5LAO A;  3NTD A;  1YT8 A;  1VEE A;  3MZZ A;  2FSX A;  3NT6 A;  1WV9 A;  1E0C A;  1GMX A;  1T3K A;  3O3W A;  3FOJ A;  2J6P A;  2JTR A;  1CWT A;  2EG3 A;  1H4M X;  2ORA A;  3OLH A;  2MOL A;  3TP9 A;  3ICS A;  1HZM A;  2EG4 A;  3FLH A;  1CWR A;  2WLX A;  3HWI A;  3NHV A;  3TG1 B;  3UTN X;  3P3A A;  3ICR A;  1YMK A;  2JTQ A;  2EG4 B;  3IPP A;  1OKG A;  5HBP A;  1ORB A;  2WLR A;  5HBL A;  2MOI A;  2OUC A;  1RHS A;  2VSW A;  2KL3 A;  3OP3 A; 
#chains in the Genus database with same CATH homology
 2JTS A;  4WH9 A;  3TG3 A;  1UAR A;  3F4A A;  3IPO A;  3I2V A;  1GN0 A;  3NTA A;  1H4K X;  1YML A;  2DCQ A;  2HHG A;  2UZQ A;  4F67 A;  3FNJ A;  3GK5 A;  3AAX A;  2IFD A;  1TQ1 A;  5HPA A;  1DP2 A;  1CWS A;  1BOH A;  4JGT A;  1QXN A;  2IFV A;  5LAM A;  3FS5 A;  2MRM A;  2A2K A;  4WH7 A;  3ILM A;  3R2U A;  3G5J A;  3IWH A;  1QB0 A;  1YM9 A;  3K9R A;  1YS0 A;  1URH A;  3HZU A;  1RHD A;  3AAY A;  3HIX A;  1BOI A;  4OCG A;  2GWF A;  3D1P A;  1WHB A;  5HBO A;  5HBQ A;  1C25 A;  1YMD A;  3I3U A;  2K0Z A;  3ICT A;  5LAO A;  3NTD A;  1YT8 A;  1VEE A;  3MZZ A;  2FSX A;  3NT6 A;  1WV9 A;  1E0C A;  1GMX A;  1T3K A;  3O3W A;  3FOJ A;  2J6P A;  2JTR A;  1CWT A;  2EG3 A;  1H4M X;  2ORA A;  3OLH A;  2MOL A;  3TP9 A;  3ICS A;  1HZM A;  2EG4 A;  3FLH A;  1CWR A;  2WLX A;  3HWI A;  3NHV A;  3TG1 B;  3UTN X;  3P3A A;  3ICR A;  1YMK A;  2JTQ A;  2EG4 B;  3IPP A;  1OKG A;  5HBP A;  1ORB A;  2WLR A;  5HBL A;  2MOI A;  2OUC A;  1RHS A;  2VSW A;  2KL3 A;  3OP3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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