The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
83
|
sequence length |
286
|
structure length |
286
|
Chain Sequence |
HGELQYLGQIQHILRCGVEKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.
pubmed doi rcsb |
| molecule tags |
Transferase
|
| source organism |
Homo sapiens
|
| molecule keywords |
THYMIDYLATE SYNTHASE
|
| total genus |
83
|
| structure length |
286
|
| sequence length |
286
|
| chains with identical sequence |
B, C, D
|
| ec nomenclature |
ec
2.1.1.45: Thymidylate synthase. |
| pdb deposition date | 2001-08-24 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00303 | Thymidylat_synt | Thymidylate synthase |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase; Chain A | Thymidylate synthase/dCMP hydroxymethylase domain |
#chains in the Genus database with same CATH superfamily 4KNZ A; 1BQ1 A; 3BHR A; 1HZW A; 5H3A A; 1HVY A; 1CI7 A; 1DNA A; 1JMF A; 3DL5 A; 3IHI A; 1J3I C; 4H0U A; 1VZC A; 4DQ1 A; 3BZ0 A; 4JEF A; 4F2V A; 3EJL A; 4EIL A; 1F4C A; 1LCB A; 2BBQ A; 1NJB A; 3INV A; 1TJS A; 1F4E A; 4XSD A; 1TRG A; 4FGT A; 1DDU A; 1BO8 A; 1TVU A; 2TSC A; 1JG0 A; 1JUT A; 3DL6 A; 1TSX A; 2VET A; 4KYA A; 4EZ8 A; 3EF9 A; 1BSP A; 1VZB A; 1BID A; 1F4B A; 1HW3 A; 1VZA A; 4PSG A; 3HJ3 A; 3KJR A; 4H0R A; 2TDD A; 3UM8 A; 5J7W A; 1YPV A; 2FTO X; 2FTQ A; 4FOG A; 4IRR A; 1KZI A; 1TYS A; 3C06 A; 4TMS A; 5FCT A; 1AOB A; 1ZPR A; 2G8A A; 4UP1 A; 2G8D A; 3KGB A; 3QG2 A; 1TDU A; 1KZJ A; 1JTQ A; 3GH2 X; 2A9W A; 2TDM A; 1EV8 A; 1TSY A; 3HBB A; 4O1U A; 3TMS A; 2ONB A; 2G8X A; 3GH0 A; 3C0A A; 3N5G A; 1NJA A; 3IRM A; 3N5E A; 3UWL A; 4DPD A; 1SEJ A; 1TSV A; 3QGT A; 3UM5 A; 4EIN A; 1I00 A; 1JU6 A; 2G89 A; 1TLC A; 1VZD A; 4DP3 A; 1BPJ A; 3EDW X; 1TLS A; 2RD8 A; 5WRN A; 1TVW A; 4FOX A; 1JUJ A; 1KCE A; 3IK0 A; 3K2H A; 3BFI A; 1HW4 A; 4KY8 A; 2H2Q A; 1BSF A; 2TSR A; 2RDA A; 4Q0E A; 1TSD A; 1J3K C; 1EVG A; 1RTS A; 1QQQ A; 4Q0D A; 1THY A; 2OIP A; 1BP0 A; 1TSN A; 1TSZ A; 1J3J C; 3CL9 A; 3BGX A; 1F4F A; 3BYX A; 1F4G A; 4XSE A; 3BHL A; 3UM6 A; 3IJZ A; 1B49 A; 1TSM A; 3DGA C; 1NCE A; 3IX6 A; 1BKO A; 4G6W X; 1TSW A; 4E5O A; 1B5D A; 3IK1 A; 3KJS A; 4KY4 A; 1NJD A; 2VF0 A; 1JMI A; 5H39 A; 1AXW A; 3EGY X; 4DPH A; 4LRR A; 3B5B A; 3BNZ A; 4ISK A; 1F28 A; 3CLB A; 3EBU A; 1JMH A; 4G2O X; 1JMG A; 5BY6 A; 4ISW A; 1BDU A; 2G86 A; 3DG8 C; 1BKP A; 3ED7 A; 3I3R A; 1B02 A; 3IRN A; 4GEV A; 4KPW A; 4H1I A; 3H9K A; 1B5E A; 3N5E B; 3UWL B; 3IRO A; 4ECK A; 4FOA A; 1VZE A; 1LCE A; 1NJE A; 1QZF A; 1TSL A; 1TVV A; 2RD8 B; 3JSU A; 3QJ7 A; 1FFL A; 3OB7 A; 1JTU A; 4EB4 A; 4E28 A; 3B9H A; 1NJC A; 4O1X A; 3EAW X; 1EV5 A; 1BP6 A; 1BQ2 A; 1SYN A; 1TIS A; 1AN5 A; 1FWM A; 3EHI X; 5HS3 A; 1BJG A; 4O1X D; 2AAZ A; 2FTN A; 3NRR A; 4IQQ A; 2KCE A; 3V8H A; 4GYH A; 1BO7 A; 1AJM A; 1F4D A; 1LCA A; 4IQB A; 4GD7 A; 3GG5 A; 4FQS A; 4XSC A; 1EVF A; 1AIQ A; 1TDB A; 4O7U A; 1TDC A; 1TDA A; 3HB8 A; 5H38 A; #chains in the Genus database with same CATH topology 4KNZ A; 1BQ1 A; 3BHR A; 1HZW A; 5H3A A; 1HVY A; 1CI7 A; 1DNA A; 1JMF A; 3DL5 A; 3IHI A; 1J3I C; 4H0U A; 1VZC A; 4DQ1 A; 3BZ0 A; 4JEF A; 4F2V A; 3EJL A; 4EIL A; 1F4C A; 1LCB A; 2BBQ A; 1NJB A; 3INV A; 1TJS A; 1F4E A; 4XSD A; 1TRG A; 4FGT A; 1DDU A; 1BO8 A; 1TVU A; 2TSC A; 1JG0 A; 1JUT A; 3DL6 A; 1TSX A; 2VET A; 4KYA A; 4EZ8 A; 3EF9 A; 1BSP A; 1VZB A; 1BID A; 1F4B A; 1HW3 A; 1VZA A; 4PSG A; 3HJ3 A; 3KJR A; 4H0R A; 2TDD A; 3UM8 A; 5J7W A; 1YPV A; 2FTO X; 2FTQ A; 4FOG A; 4IRR A; 1KZI A; 1TYS A; 3C06 A; 4TMS A; 5FCT A; 1AOB A; 1ZPR A; 2G8A A; 4UP1 A; 2G8D A; 3KGB A; 3QG2 A; 1TDU A; 1KZJ A; 1JTQ A; 3GH2 X; 2A9W A; 2TDM A; 1EV8 A; 1TSY A; 3HBB A; 4O1U A; 3TMS A; 2ONB A; 2G8X A; 3GH0 A; 3C0A A; 3N5G A; 1NJA A; 3IRM A; 3N5E A; 3UWL A; 4DPD A; 1SEJ A; 1TSV A; 3QGT A; 3UM5 A; 4EIN A; 1I00 A; 1JU6 A; 2G89 A; 1TLC A; 1VZD A; 4DP3 A; 1BPJ A; 3EDW X; 1TLS A; 2RD8 A; 5WRN A; 1TVW A; 4FOX A; 1JUJ A; 1KCE A; 3IK0 A; 3K2H A; 3BFI A; 1HW4 A; 4KY8 A; 2H2Q A; 1BSF A; 2TSR A; 2RDA A; 4Q0E A; 1TSD A; 1J3K C; 1EVG A; 1RTS A; 1QQQ A; 4Q0D A; 1THY A; 2OIP A; 1BP0 A; 1TSN A; 1TSZ A; 1J3J C; 3CL9 A; 3BGX A; 1F4F A; 3BYX A; 1F4G A; 4XSE A; 3BHL A; 3UM6 A; 3IJZ A; 1B49 A; 1TSM A; 3DGA C; 1NCE A; 3IX6 A; 1BKO A; 4G6W X; 1TSW A; 4E5O A; 1B5D A; 3IK1 A; 3KJS A; 4KY4 A; 1NJD A; 2VF0 A; 1JMI A; 5H39 A; 1AXW A; 3EGY X; 4DPH A; 4LRR A; 3B5B A; 3BNZ A; 4ISK A; 1F28 A; 3CLB A; 3EBU A; 1JMH A; 4G2O X; 1JMG A; 5BY6 A; 4ISW A; 1BDU A; 2G86 A; 3DG8 C; 1BKP A; 3ED7 A; 3I3R A; 1B02 A; 3IRN A; 4GEV A; 4KPW A; 4H1I A; 3H9K A; 1B5E A; 3N5E B; 3UWL B; 3IRO A; 4ECK A; 4FOA A; 1VZE A; 1LCE A; 1NJE A; 1QZF A; 1TSL A; 1TVV A; 2RD8 B; 3JSU A; 3QJ7 A; 1FFL A; 3OB7 A; 1JTU A; 4EB4 A; 4E28 A; 3B9H A; 1NJC A; 4O1X A; 3EAW X; 1EV5 A; 1BP6 A; 1BQ2 A; 1SYN A; 1TIS A; 1AN5 A; 1FWM A; 3EHI X; 5HS3 A; 1BJG A; 4O1X D; 2AAZ A; 2FTN A; 3NRR A; 4IQQ A; 2KCE A; 3V8H A; 4GYH A; 1BO7 A; 1AJM A; 1F4D A; 1LCA A; 4IQB A; 4GD7 A; 3GG5 A; 4FQS A; 4XSC A; 1EVF A; 1AIQ A; 1TDB A; 4O7U A; 1TDC A; 1TDA A; 3HB8 A; 5H38 A; #chains in the Genus database with same CATH homology 4KNZ A; 1BQ1 A; 3BHR A; 1HZW A; 5H3A A; 1HVY A; 1CI7 A; 1DNA A; 1JMF A; 3DL5 A; 3IHI A; 1J3I C; 4H0U A; 1VZC A; 4DQ1 A; 3BZ0 A; 4JEF A; 4F2V A; 3EJL A; 4EIL A; 1F4C A; 1LCB A; 2BBQ A; 1NJB A; 3INV A; 1TJS A; 1F4E A; 4XSD A; 1TRG A; 4FGT A; 1DDU A; 1BO8 A; 1TVU A; 2TSC A; 1JG0 A; 1JUT A; 3DL6 A; 1TSX A; 2VET A; 4KYA A; 4EZ8 A; 3EF9 A; 1BSP A; 1VZB A; 1BID A; 1F4B A; 1HW3 A; 1VZA A; 4PSG A; 3HJ3 A; 3KJR A; 4H0R A; 2TDD A; 3UM8 A; 5J7W A; 1YPV A; 2FTO X; 2FTQ A; 4FOG A; 4IRR A; 1KZI A; 1TYS A; 3C06 A; 4TMS A; 5FCT A; 1AOB A; 1ZPR A; 2G8A A; 4UP1 A; 2G8D A; 3KGB A; 3QG2 A; 1TDU A; 1KZJ A; 1JTQ A; 3GH2 X; 2A9W A; 2TDM A; 1EV8 A; 1TSY A; 3HBB A; 4O1U A; 3TMS A; 2ONB A; 2G8X A; 3GH0 A; 3C0A A; 3N5G A; 1NJA A; 3IRM A; 3N5E A; 3UWL A; 4DPD A; 1SEJ A; 1TSV A; 3QGT A; 3UM5 A; 4EIN A; 1I00 A; 1JU6 A; 2G89 A; 1TLC A; 1VZD A; 4DP3 A; 1BPJ A; 3EDW X; 1TLS A; 2RD8 A; 5WRN A; 1TVW A; 4FOX A; 1JUJ A; 1KCE A; 3IK0 A; 3K2H A; 3BFI A; 1HW4 A; 4KY8 A; 2H2Q A; 1BSF A; 2TSR A; 2RDA A; 4Q0E A; 1TSD A; 1J3K C; 1EVG A; 1RTS A; 1QQQ A; 4Q0D A; 1THY A; 2OIP A; 1BP0 A; 1TSN A; 1TSZ A; 1J3J C; 3CL9 A; 3BGX A; 1F4F A; 3BYX A; 1F4G A; 4XSE A; 3BHL A; 3UM6 A; 3IJZ A; 1B49 A; 1TSM A; 3DGA C; 1NCE A; 3IX6 A; 1BKO A; 4G6W X; 1TSW A; 4E5O A; 1B5D A; 3IK1 A; 3KJS A; 4KY4 A; 1NJD A; 2VF0 A; 1JMI A; 5H39 A; 1AXW A; 3EGY X; 4DPH A; 4LRR A; 3B5B A; 3BNZ A; 4ISK A; 1F28 A; 3CLB A; 3EBU A; 1JMH A; 4G2O X; 1JMG A; 5BY6 A; 4ISW A; 1BDU A; 2G86 A; 3DG8 C; 1BKP A; 3ED7 A; 3I3R A; 1B02 A; 3IRN A; 4GEV A; 4KPW A; 4H1I A; 3H9K A; 1B5E A; 3N5E B; 3UWL B; 3IRO A; 4ECK A; 4FOA A; 1VZE A; 1LCE A; 1NJE A; 1QZF A; 1TSL A; 1TVV A; 2RD8 B; 3JSU A; 3QJ7 A; 1FFL A; 3OB7 A; 1JTU A; 4EB4 A; 4E28 A; 3B9H A; 1NJC A; 4O1X A; 3EAW X; 1EV5 A; 1BP6 A; 1BQ2 A; 1SYN A; 1TIS A; 1AN5 A; 1FWM A; 3EHI X; 5HS3 A; 1BJG A; 4O1X D; 2AAZ A; 2FTN A; 3NRR A; 4IQQ A; 2KCE A; 3V8H A; 4GYH A; 1BO7 A; 1AJM A; 1F4D A; 1LCA A; 4IQB A; 4GD7 A; 3GG5 A; 4FQS A; 4XSC A; 1EVF A; 1AIQ A; 1TDB A; 4O7U A; 1TDC A; 1TDA A; 3HB8 A; 5H38 A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
