1QB0A

Human cdc25b catalytic domain
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
177
structure length
177
Chain Sequence
DHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords PROTEIN (M-PHASE INDUCER PHOSPHATASE 2 (CDC25B))
total genus 61
structure length 177
sequence length 177
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 1999-04-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 1qb0A00
3AAXA 1YMLA 3FNJA 3I3UA 5HPAA 1ORBA 1YT8A 5LAMA 3GK5A 3I2VA 2ORAA 1HZMA 1OKGA 3ICTA 3NHVA 2UZQA 1RHSA 1TQ1A 1E0CA 3HZUA 3MZZA 3HIXA 1VEEA 1WHBA 3K9RA 1WV9A 3D1PA 2GWFA 5LAOA 1DP2A 2MOLA 2WLRA 3OLHA 1BOHA 3FOJA 1YMDA 2HHGA 3ILMA 2VSWA 2DCQA 3NTAA 1YS0A 1CWTA 2A2KA 1QB0A 2EG3A 3TP9A 1C25A 4WH9A 3OP3A 1H4KX 3IWHA 2MOIA 3FLHA 4JGTA 3UTNX 1CWSA 1GMXA 1RHDA 2IFVA 3R2UA 1YM9A 3FS5A 3F4AA 3O3WA 1T3KA 4OCGA 2IFDA 2JTSA 5HBOA 3NT6A 1BOIA 2K0ZA 2FSXA 2JTRA 5HBLA 2J6PA 3TG3A 3AAYA 2WLXA 1URHA 1YMKA 2MRMA 5HBPA 2JTQA 2EG4A 3TG1B 4F67A 1GN0A 3ICSA 2KL3A 3IPOA 3ICRA 2EG4B 1QXNA 3HWIA 3G5JA 3P3AA 1CWRA 1UARA 2OUCA 5HBQA 3IPPA 3NTDA 4WH7A 1H4MX
chains in the Genus database with same CATH superfamily
3AAXA 1YMLA 3FNJA 3I3UA 5HPAA 1ORBA 1YT8A 5LAMA 3GK5A 3I2VA 2ORAA 1HZMA 1OKGA 3ICTA 3NHVA 2UZQA 1RHSA 1TQ1A 1E0CA 3HZUA 3MZZA 3HIXA 1VEEA 1WHBA 3K9RA 1WV9A 3D1PA 2GWFA 5LAOA 1DP2A 2MOLA 2WLRA 3OLHA 1BOHA 3FOJA 1YMDA 2HHGA 3ILMA 2VSWA 2DCQA 3NTAA 1YS0A 1CWTA 2A2KA 1QB0A 2EG3A 3TP9A 1C25A 4WH9A 3OP3A 1H4KX 3IWHA 2MOIA 3FLHA 4JGTA 3UTNX 1CWSA 1GMXA 1RHDA 2IFVA 3R2UA 1YM9A 3FS5A 3F4AA 3O3WA 1T3KA 4OCGA 2IFDA 2JTSA 5HBOA 3NT6A 1BOIA 2K0ZA 2FSXA 2JTRA 5HBLA 2J6PA 3TG3A 3AAYA 2WLXA 1URHA 1YMKA 2MRMA 5HBPA 2JTQA 2EG4A 3TG1B 4F67A 1GN0A 3ICSA 2KL3A 3IPOA 3ICRA 2EG4B 1QXNA 3HWIA 3G5JA 2Q82A 3P3AA 1CWRA 1UARA 2OUCA 5HBQA 3IPPA 3NTDA 4WH7A 1H4MX
chains in the Genus database with same CATH topology
3AAXA 1YMLA 3FNJA 3I3UA 5HPAA 1ORBA 1YT8A 5LAMA 3GK5A 3I2VA 2ORAA 1HZMA 1OKGA 3ICTA 3NHVA 2UZQA 1RHSA 1TQ1A 1E0CA 3HZUA 3MZZA 3HIXA 1VEEA 1WHBA 3K9RA 1WV9A 3D1PA 2GWFA 5LAOA 1DP2A 2MOLA 2WLRA 3OLHA 1BOHA 3FOJA 1YMDA 2HHGA 3ILMA 2VSWA 2DCQA 3NTAA 1YS0A 1CWTA 2A2KA 1QB0A 2EG3A 3TP9A 1C25A 4WH9A 3OP3A 1H4KX 3IWHA 2MOIA 3FLHA 4JGTA 3UTNX 1CWSA 1GMXA 1RHDA 2IFVA 3R2UA 1YM9A 3FS5A 3F4AA 3O3WA 1T3KA 4OCGA 2IFDA 2JTSA 5HBOA 3NT6A 1BOIA 2K0ZA 2FSXA 2JTRA 5HBLA 2J6PA 3TG3A 3AAYA 2WLXA 1URHA 1YMKA 2MRMA 5HBPA 2JTQA 2EG4A 3TG1B 4F67A 1GN0A 3ICSA 2KL3A 3IPOA 3ICRA 2EG4B 1QXNA 3HWIA 3G5JA 3P3AA 1CWRA 1UARA 2OUCA 5HBQA 3IPPA 3NTDA 4WH7A 1H4MX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3AAX A;  1YML A;  3FNJ A;  3I3U A;  5HPA A;  1ORB A;  1YT8 A;  5LAM A;  3GK5 A;  3I2V A;  2ORA A;  1HZM A;  1OKG A;  3ICT A;  3NHV A;  2UZQ A;  1RHS A;  1TQ1 A;  1E0C A;  3HZU A;  3MZZ A;  3HIX A;  1VEE A;  1WHB A;  3K9R A;  1WV9 A;  3D1P A;  2GWF A;  5LAO A;  1DP2 A;  2MOL A;  2WLR A;  3OLH A;  1BOH A;  3FOJ A;  1YMD A;  2HHG A;  3ILM A;  2VSW A;  2DCQ A;  3NTA A;  1YS0 A;  1CWT A;  2A2K A;  1QB0 A;  2EG3 A;  3TP9 A;  1C25 A;  4WH9 A;  3OP3 A;  1H4K X;  3IWH A;  2MOI A;  3FLH A;  4JGT A;  3UTN X;  1CWS A;  1GMX A;  1RHD A;  2IFV A;  3R2U A;  1YM9 A;  3FS5 A;  3F4A A;  3O3W A;  1T3K A;  4OCG A;  2IFD A;  2JTS A;  5HBO A;  3NT6 A;  1BOI A;  2K0Z A;  2FSX A;  2JTR A;  5HBL A;  2J6P A;  3TG3 A;  3AAY A;  2WLX A;  1URH A;  1YMK A;  2MRM A;  5HBP A;  2JTQ A;  2EG4 A;  3TG1 B;  4F67 A;  1GN0 A;  3ICS A;  2KL3 A;  3IPO A;  3ICR A;  2EG4 B;  1QXN A;  3HWI A;  3G5J A;  3P3A A;  1CWR A;  1UAR A;  2OUC A;  5HBQ A;  3IPP A;  3NTD A;  4WH7 A;  1H4M X; 
#chains in the Genus database with same CATH topology
 3AAX A;  1YML A;  3FNJ A;  3I3U A;  5HPA A;  1ORB A;  1YT8 A;  5LAM A;  3GK5 A;  3I2V A;  2ORA A;  1HZM A;  1OKG A;  3ICT A;  3NHV A;  2UZQ A;  1RHS A;  1TQ1 A;  1E0C A;  3HZU A;  3MZZ A;  3HIX A;  1VEE A;  1WHB A;  3K9R A;  1WV9 A;  3D1P A;  2GWF A;  5LAO A;  1DP2 A;  2MOL A;  2WLR A;  3OLH A;  1BOH A;  3FOJ A;  1YMD A;  2HHG A;  3ILM A;  2VSW A;  2DCQ A;  3NTA A;  1YS0 A;  1CWT A;  2A2K A;  1QB0 A;  2EG3 A;  3TP9 A;  1C25 A;  4WH9 A;  3OP3 A;  1H4K X;  3IWH A;  2MOI A;  3FLH A;  4JGT A;  3UTN X;  1CWS A;  1GMX A;  1RHD A;  2IFV A;  3R2U A;  1YM9 A;  3FS5 A;  3F4A A;  3O3W A;  1T3K A;  4OCG A;  2IFD A;  2JTS A;  5HBO A;  3NT6 A;  1BOI A;  2K0Z A;  2FSX A;  2JTR A;  5HBL A;  2J6P A;  3TG3 A;  3AAY A;  2WLX A;  1URH A;  1YMK A;  2MRM A;  5HBP A;  2JTQ A;  2EG4 A;  3TG1 B;  4F67 A;  1GN0 A;  3ICS A;  2KL3 A;  3IPO A;  3ICR A;  2EG4 B;  1QXN A;  3HWI A;  3G5J A;  2Q82 A;  3P3A A;  1CWR A;  1UAR A;  2OUC A;  5HBQ A;  3IPP A;  3NTD A;  4WH7 A;  1H4M X; 
#chains in the Genus database with same CATH homology
 3AAX A;  1YML A;  3FNJ A;  3I3U A;  5HPA A;  1ORB A;  1YT8 A;  5LAM A;  3GK5 A;  3I2V A;  2ORA A;  1HZM A;  1OKG A;  3ICT A;  3NHV A;  2UZQ A;  1RHS A;  1TQ1 A;  1E0C A;  3HZU A;  3MZZ A;  3HIX A;  1VEE A;  1WHB A;  3K9R A;  1WV9 A;  3D1P A;  2GWF A;  5LAO A;  1DP2 A;  2MOL A;  2WLR A;  3OLH A;  1BOH A;  3FOJ A;  1YMD A;  2HHG A;  3ILM A;  2VSW A;  2DCQ A;  3NTA A;  1YS0 A;  1CWT A;  2A2K A;  1QB0 A;  2EG3 A;  3TP9 A;  1C25 A;  4WH9 A;  3OP3 A;  1H4K X;  3IWH A;  2MOI A;  3FLH A;  4JGT A;  3UTN X;  1CWS A;  1GMX A;  1RHD A;  2IFV A;  3R2U A;  1YM9 A;  3FS5 A;  3F4A A;  3O3W A;  1T3K A;  4OCG A;  2IFD A;  2JTS A;  5HBO A;  3NT6 A;  1BOI A;  2K0Z A;  2FSX A;  2JTR A;  5HBL A;  2J6P A;  3TG3 A;  3AAY A;  2WLX A;  1URH A;  1YMK A;  2MRM A;  5HBP A;  2JTQ A;  2EG4 A;  3TG1 B;  4F67 A;  1GN0 A;  3ICS A;  2KL3 A;  3IPO A;  3ICR A;  2EG4 B;  1QXN A;  3HWI A;  3G5J A;  3P3A A;  1CWR A;  1UAR A;  2OUC A;  5HBQ A;  3IPP A;  3NTD A;  4WH7 A;  1H4M X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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