1QB0A

Human cdc25b catalytic domain
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
177
structure length
177
Chain Sequence
DHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
source organism Homo sapiens
publication title Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle.
pubmed doi rcsb
molecule keywords PROTEIN (M-PHASE INDUCER PHOSPHATASE 2 (CDC25B))
total genus 61
structure length 177
sequence length 177
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 1999-04-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 1qb0A00
2FSXA 2HHGA 2GWFA 1URHA 3HWIA 2DCQA 2WLRA 3TP9A 3O3WA 1CWRA 2JTSA 1HZMA 1OKGA 2UZQA 3F4AA 1QB0A 3NTDA 1C25A 1BOHA 3AAYA 3G5JA 1T3KA 1H4MX 2VSWA 2EG4B 1CWSA 5HPAA 1RHSA 1YMDA 2MOLA 1YT8A 2MRMA 3K9RA 3NT6A 1ORBA 2IFVA 3FLHA 4OCGA 2MOIA 2J6PA 1TQ1A 1GMXA 1YS0A 1QXNA 1GN0A 5LAMA 3ILMA 3TG3A 1YMKA 1VEEA 3GK5A 1YM9A 1DP2A 3AAXA 3NHVA 1WV9A 2IFDA 3UTNX 1BOIA 2A2KA 3IWHA 5HBPA 1CWTA 3OP3A 1RHDA 2EG3A 4F67A 3I2VA 5HBLA 1WHBA 2WLXA 5HBOA 3IPPA 3ICTA 2JTQA 3HZUA 3TG1B 3MZZA 5LAOA 3FS5A 3IPOA 3FOJA 1YMLA 3FNJA 1E0CA 3I3UA 2ORAA 2OUCA 3NTAA 5HBQA 3P3AA 3ICSA 2K0ZA 1UARA 4JGTA 2KL3A 1H4KX 3OLHA 3HIXA 2EG4A 3D1PA 4WH9A 4WH7A 3ICRA 3R2UA 2JTRA
chains in the Genus database with same CATH superfamily
2FSXA 2HHGA 2GWFA 1URHA 3HWIA 2DCQA 2WLRA 3TP9A 3O3WA 1CWRA 2JTSA 1HZMA 1OKGA 2UZQA 3F4AA 1QB0A 3NTDA 1C25A 1BOHA 3AAYA 3G5JA 1T3KA 1H4MX 2VSWA 2EG4B 1CWSA 5HPAA 1RHSA 1YMDA 2MOLA 1YT8A 2MRMA 3K9RA 3NT6A 1ORBA 2IFVA 3FLHA 4OCGA 2MOIA 2J6PA 1TQ1A 1GMXA 1YS0A 1QXNA 1GN0A 5LAMA 3ILMA 3TG3A 1YMKA 1VEEA 3GK5A 1YM9A 1DP2A 3AAXA 3NHVA 1WV9A 2IFDA 3UTNX 1BOIA 2A2KA 3IWHA 5HBPA 1CWTA 3OP3A 1RHDA 2EG3A 4F67A 2Q82A 3I2VA 5HBLA 1WHBA 2WLXA 5HBOA 3IPPA 3ICTA 2JTQA 3HZUA 3TG1B 3MZZA 5LAOA 3FS5A 3IPOA 3FOJA 1YMLA 3FNJA 1E0CA 3I3UA 2ORAA 2OUCA 3NTAA 5HBQA 3P3AA 3ICSA 2K0ZA 1UARA 4JGTA 2KL3A 1H4KX 3OLHA 3HIXA 2EG4A 3D1PA 4WH9A 4WH7A 3ICRA 3R2UA 2JTRA
chains in the Genus database with same CATH topology
2FSXA 2HHGA 2GWFA 1URHA 3HWIA 2DCQA 2WLRA 3TP9A 3O3WA 1CWRA 2JTSA 1HZMA 1OKGA 2UZQA 3F4AA 1QB0A 3NTDA 1C25A 1BOHA 3AAYA 3G5JA 1T3KA 1H4MX 2VSWA 2EG4B 1CWSA 5HPAA 1RHSA 1YMDA 2MOLA 1YT8A 2MRMA 3K9RA 3NT6A 1ORBA 2IFVA 3FLHA 4OCGA 2MOIA 2J6PA 1TQ1A 1GMXA 1YS0A 1QXNA 1GN0A 5LAMA 3ILMA 3TG3A 1YMKA 1VEEA 3GK5A 1YM9A 1DP2A 3AAXA 3NHVA 1WV9A 2IFDA 3UTNX 1BOIA 2A2KA 3IWHA 5HBPA 1CWTA 3OP3A 1RHDA 2EG3A 4F67A 3I2VA 5HBLA 1WHBA 2WLXA 5HBOA 3IPPA 3ICTA 2JTQA 3HZUA 3TG1B 3MZZA 5LAOA 3FS5A 3IPOA 3FOJA 1YMLA 3FNJA 1E0CA 3I3UA 2ORAA 2OUCA 3NTAA 5HBQA 3P3AA 3ICSA 2K0ZA 1UARA 4JGTA 2KL3A 1H4KX 3OLHA 3HIXA 2EG4A 3D1PA 4WH9A 4WH7A 3ICRA 3R2UA 2JTRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FSX A;  2HHG A;  2GWF A;  1URH A;  3HWI A;  2DCQ A;  2WLR A;  3TP9 A;  3O3W A;  1CWR A;  2JTS A;  1HZM A;  1OKG A;  2UZQ A;  3F4A A;  1QB0 A;  3NTD A;  1C25 A;  1BOH A;  3AAY A;  3G5J A;  1T3K A;  1H4M X;  2VSW A;  2EG4 B;  1CWS A;  5HPA A;  1RHS A;  1YMD A;  2MOL A;  1YT8 A;  2MRM A;  3K9R A;  3NT6 A;  1ORB A;  2IFV A;  3FLH A;  4OCG A;  2MOI A;  2J6P A;  1TQ1 A;  1GMX A;  1YS0 A;  1QXN A;  1GN0 A;  5LAM A;  3ILM A;  3TG3 A;  1YMK A;  1VEE A;  3GK5 A;  1YM9 A;  1DP2 A;  3AAX A;  3NHV A;  1WV9 A;  2IFD A;  3UTN X;  1BOI A;  2A2K A;  3IWH A;  5HBP A;  1CWT A;  3OP3 A;  1RHD A;  2EG3 A;  4F67 A;  3I2V A;  5HBL A;  1WHB A;  2WLX A;  5HBO A;  3IPP A;  3ICT A;  2JTQ A;  3HZU A;  3TG1 B;  3MZZ A;  5LAO A;  3FS5 A;  3IPO A;  3FOJ A;  1YML A;  3FNJ A;  1E0C A;  3I3U A;  2ORA A;  2OUC A;  3NTA A;  5HBQ A;  3P3A A;  3ICS A;  2K0Z A;  1UAR A;  4JGT A;  2KL3 A;  1H4K X;  3OLH A;  3HIX A;  2EG4 A;  3D1P A;  4WH9 A;  4WH7 A;  3ICR A;  3R2U A;  2JTR A; 
#chains in the Genus database with same CATH topology
 2FSX A;  2HHG A;  2GWF A;  1URH A;  3HWI A;  2DCQ A;  2WLR A;  3TP9 A;  3O3W A;  1CWR A;  2JTS A;  1HZM A;  1OKG A;  2UZQ A;  3F4A A;  1QB0 A;  3NTD A;  1C25 A;  1BOH A;  3AAY A;  3G5J A;  1T3K A;  1H4M X;  2VSW A;  2EG4 B;  1CWS A;  5HPA A;  1RHS A;  1YMD A;  2MOL A;  1YT8 A;  2MRM A;  3K9R A;  3NT6 A;  1ORB A;  2IFV A;  3FLH A;  4OCG A;  2MOI A;  2J6P A;  1TQ1 A;  1GMX A;  1YS0 A;  1QXN A;  1GN0 A;  5LAM A;  3ILM A;  3TG3 A;  1YMK A;  1VEE A;  3GK5 A;  1YM9 A;  1DP2 A;  3AAX A;  3NHV A;  1WV9 A;  2IFD A;  3UTN X;  1BOI A;  2A2K A;  3IWH A;  5HBP A;  1CWT A;  3OP3 A;  1RHD A;  2EG3 A;  4F67 A;  2Q82 A;  3I2V A;  5HBL A;  1WHB A;  2WLX A;  5HBO A;  3IPP A;  3ICT A;  2JTQ A;  3HZU A;  3TG1 B;  3MZZ A;  5LAO A;  3FS5 A;  3IPO A;  3FOJ A;  1YML A;  3FNJ A;  1E0C A;  3I3U A;  2ORA A;  2OUC A;  3NTA A;  5HBQ A;  3P3A A;  3ICS A;  2K0Z A;  1UAR A;  4JGT A;  2KL3 A;  1H4K X;  3OLH A;  3HIX A;  2EG4 A;  3D1P A;  4WH9 A;  4WH7 A;  3ICR A;  3R2U A;  2JTR A; 
#chains in the Genus database with same CATH homology
 2FSX A;  2HHG A;  2GWF A;  1URH A;  3HWI A;  2DCQ A;  2WLR A;  3TP9 A;  3O3W A;  1CWR A;  2JTS A;  1HZM A;  1OKG A;  2UZQ A;  3F4A A;  1QB0 A;  3NTD A;  1C25 A;  1BOH A;  3AAY A;  3G5J A;  1T3K A;  1H4M X;  2VSW A;  2EG4 B;  1CWS A;  5HPA A;  1RHS A;  1YMD A;  2MOL A;  1YT8 A;  2MRM A;  3K9R A;  3NT6 A;  1ORB A;  2IFV A;  3FLH A;  4OCG A;  2MOI A;  2J6P A;  1TQ1 A;  1GMX A;  1YS0 A;  1QXN A;  1GN0 A;  5LAM A;  3ILM A;  3TG3 A;  1YMK A;  1VEE A;  3GK5 A;  1YM9 A;  1DP2 A;  3AAX A;  3NHV A;  1WV9 A;  2IFD A;  3UTN X;  1BOI A;  2A2K A;  3IWH A;  5HBP A;  1CWT A;  3OP3 A;  1RHD A;  2EG3 A;  4F67 A;  3I2V A;  5HBL A;  1WHB A;  2WLX A;  5HBO A;  3IPP A;  3ICT A;  2JTQ A;  3HZU A;  3TG1 B;  3MZZ A;  5LAO A;  3FS5 A;  3IPO A;  3FOJ A;  1YML A;  3FNJ A;  1E0C A;  3I3U A;  2ORA A;  2OUC A;  3NTA A;  5HBQ A;  3P3A A;  3ICS A;  2K0Z A;  1UAR A;  4JGT A;  2KL3 A;  1H4K X;  3OLH A;  3HIX A;  2EG4 A;  3D1P A;  4WH9 A;  4WH7 A;  3ICR A;  3R2U A;  2JTR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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