1YMLA

Crystal structure of the cdc25b phosphatase catalytic domain with the active site cysteine in the sulfenic form
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
175
structure length
170
Chain Sequence
MELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPKRVILIFHEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Mechanism of Oxidative Regulation of the Phosphatase Cdc25B via an Intramolecular Disulfide Bond
pubmed doi rcsb
molecule tags Hydrolase, cell cycle
source organism Homo sapiens
molecule keywords M-phase inducer phosphatase 2
total genus 62
structure length 170
sequence length 175
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2005-01-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 1ymlA00
3TG1B 4OCGA 3AAYA 2WLRA 1GN0A 2UZQA 3IPOA 2IFDA 1YS0A 1URHA 2FSXA 2JTSA 2VSWA 5HBLA 3F4AA 4JGTA 1TQ1A 3TG3A 3HZUA 1BOIA 3HIXA 3FS5A 3ILMA 1H4KX 4WH9A 3P3AA 2HHGA 3GK5A 5LAOA 3NTDA 3ICSA 2MOIA 1YM9A 2MOLA 4F67A 3K9RA 3TP9A 3I3UA 2GWFA 5HBPA 2EG3A 2WLXA 3FNJA 1E0CA 3OP3A 1HZMA 1YT8A 1CWSA 3ICRA 2OUCA 2EG4A 1H4MX 3I2VA 3D1PA 2A2KA 1YMLA 5HPAA 3O3WA 1YMKA 1VEEA 1QB0A 2KL3A 2J6PA 1OKGA 2ORAA 3AAXA 1T3KA 1QXNA 3FOJA 3FLHA 1BOHA 1UARA 3NHVA 1YMDA 2DCQA 5HBQA 1WHBA 1DP2A 1C25A 3MZZA 5LAMA 3HWIA 3OLHA 1WV9A 2IFVA 1RHSA 2JTQA 2JTRA 1RHDA 2EG4B 4WH7A 3IWHA 3NT6A 1GMXA 3UTNX 3IPPA 5HBOA 3G5JA 1ORBA 3ICTA 1CWRA 3NTAA 2K0ZA 1CWTA 3R2UA 2MRMA
chains in the Genus database with same CATH superfamily
3TG1B 4OCGA 3AAYA 2Q82A 2WLRA 1GN0A 2UZQA 3IPOA 2IFDA 1YS0A 1URHA 2FSXA 2JTSA 2VSWA 5HBLA 3F4AA 4JGTA 1TQ1A 3TG3A 3HZUA 1BOIA 3HIXA 3FS5A 3ILMA 1H4KX 4WH9A 3P3AA 2HHGA 3GK5A 5LAOA 3NTDA 3ICSA 2MOIA 1YM9A 2MOLA 4F67A 3K9RA 3TP9A 3I3UA 2GWFA 5HBPA 2EG3A 2WLXA 3FNJA 1E0CA 3OP3A 1HZMA 1YT8A 1CWSA 3ICRA 2OUCA 2EG4A 1H4MX 3I2VA 3D1PA 2A2KA 1YMLA 5HPAA 3O3WA 1YMKA 1VEEA 1QB0A 2KL3A 2J6PA 1OKGA 2ORAA 3AAXA 1T3KA 1QXNA 3FOJA 3FLHA 1BOHA 1UARA 3NHVA 1YMDA 2DCQA 5HBQA 1WHBA 1DP2A 1C25A 3MZZA 5LAMA 3HWIA 3OLHA 1WV9A 2IFVA 1RHSA 2JTQA 2JTRA 1RHDA 2EG4B 4WH7A 3IWHA 3NT6A 1GMXA 3UTNX 3IPPA 5HBOA 3G5JA 1ORBA 3ICTA 1CWRA 3NTAA 2K0ZA 1CWTA 3R2UA 2MRMA
chains in the Genus database with same CATH topology
3TG1B 4OCGA 3AAYA 2WLRA 1GN0A 2UZQA 3IPOA 2IFDA 1YS0A 1URHA 2FSXA 2JTSA 2VSWA 5HBLA 3F4AA 4JGTA 1TQ1A 3TG3A 3HZUA 1BOIA 3HIXA 3FS5A 3ILMA 1H4KX 4WH9A 3P3AA 2HHGA 3GK5A 5LAOA 3NTDA 3ICSA 2MOIA 1YM9A 2MOLA 4F67A 3K9RA 3TP9A 3I3UA 2GWFA 5HBPA 2EG3A 2WLXA 3FNJA 1E0CA 3OP3A 1HZMA 1YT8A 1CWSA 3ICRA 2OUCA 2EG4A 1H4MX 3I2VA 3D1PA 2A2KA 1YMLA 5HPAA 3O3WA 1YMKA 1VEEA 1QB0A 2KL3A 2J6PA 1OKGA 2ORAA 3AAXA 1T3KA 1QXNA 3FOJA 3FLHA 1BOHA 1UARA 3NHVA 1YMDA 2DCQA 5HBQA 1WHBA 1DP2A 1C25A 3MZZA 5LAMA 3HWIA 3OLHA 1WV9A 2IFVA 1RHSA 2JTQA 2JTRA 1RHDA 2EG4B 4WH7A 3IWHA 3NT6A 1GMXA 3UTNX 3IPPA 5HBOA 3G5JA 1ORBA 3ICTA 1CWRA 3NTAA 2K0ZA 1CWTA 3R2UA 2MRMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TG1 B;  4OCG A;  3AAY A;  2WLR A;  1GN0 A;  2UZQ A;  3IPO A;  2IFD A;  1YS0 A;  1URH A;  2FSX A;  2JTS A;  2VSW A;  5HBL A;  3F4A A;  4JGT A;  1TQ1 A;  3TG3 A;  3HZU A;  1BOI A;  3HIX A;  3FS5 A;  3ILM A;  1H4K X;  4WH9 A;  3P3A A;  2HHG A;  3GK5 A;  5LAO A;  3NTD A;  3ICS A;  2MOI A;  1YM9 A;  2MOL A;  4F67 A;  3K9R A;  3TP9 A;  3I3U A;  2GWF A;  5HBP A;  2EG3 A;  2WLX A;  3FNJ A;  1E0C A;  3OP3 A;  1HZM A;  1YT8 A;  1CWS A;  3ICR A;  2OUC A;  2EG4 A;  1H4M X;  3I2V A;  3D1P A;  2A2K A;  1YML A;  5HPA A;  3O3W A;  1YMK A;  1VEE A;  1QB0 A;  2KL3 A;  2J6P A;  1OKG A;  2ORA A;  3AAX A;  1T3K A;  1QXN A;  3FOJ A;  3FLH A;  1BOH A;  1UAR A;  3NHV A;  1YMD A;  2DCQ A;  5HBQ A;  1WHB A;  1DP2 A;  1C25 A;  3MZZ A;  5LAM A;  3HWI A;  3OLH A;  1WV9 A;  2IFV A;  1RHS A;  2JTQ A;  2JTR A;  1RHD A;  2EG4 B;  4WH7 A;  3IWH A;  3NT6 A;  1GMX A;  3UTN X;  3IPP A;  5HBO A;  3G5J A;  1ORB A;  3ICT A;  1CWR A;  3NTA A;  2K0Z A;  1CWT A;  3R2U A;  2MRM A; 
#chains in the Genus database with same CATH topology
 3TG1 B;  4OCG A;  3AAY A;  2Q82 A;  2WLR A;  1GN0 A;  2UZQ A;  3IPO A;  2IFD A;  1YS0 A;  1URH A;  2FSX A;  2JTS A;  2VSW A;  5HBL A;  3F4A A;  4JGT A;  1TQ1 A;  3TG3 A;  3HZU A;  1BOI A;  3HIX A;  3FS5 A;  3ILM A;  1H4K X;  4WH9 A;  3P3A A;  2HHG A;  3GK5 A;  5LAO A;  3NTD A;  3ICS A;  2MOI A;  1YM9 A;  2MOL A;  4F67 A;  3K9R A;  3TP9 A;  3I3U A;  2GWF A;  5HBP A;  2EG3 A;  2WLX A;  3FNJ A;  1E0C A;  3OP3 A;  1HZM A;  1YT8 A;  1CWS A;  3ICR A;  2OUC A;  2EG4 A;  1H4M X;  3I2V A;  3D1P A;  2A2K A;  1YML A;  5HPA A;  3O3W A;  1YMK A;  1VEE A;  1QB0 A;  2KL3 A;  2J6P A;  1OKG A;  2ORA A;  3AAX A;  1T3K A;  1QXN A;  3FOJ A;  3FLH A;  1BOH A;  1UAR A;  3NHV A;  1YMD A;  2DCQ A;  5HBQ A;  1WHB A;  1DP2 A;  1C25 A;  3MZZ A;  5LAM A;  3HWI A;  3OLH A;  1WV9 A;  2IFV A;  1RHS A;  2JTQ A;  2JTR A;  1RHD A;  2EG4 B;  4WH7 A;  3IWH A;  3NT6 A;  1GMX A;  3UTN X;  3IPP A;  5HBO A;  3G5J A;  1ORB A;  3ICT A;  1CWR A;  3NTA A;  2K0Z A;  1CWT A;  3R2U A;  2MRM A; 
#chains in the Genus database with same CATH homology
 3TG1 B;  4OCG A;  3AAY A;  2WLR A;  1GN0 A;  2UZQ A;  3IPO A;  2IFD A;  1YS0 A;  1URH A;  2FSX A;  2JTS A;  2VSW A;  5HBL A;  3F4A A;  4JGT A;  1TQ1 A;  3TG3 A;  3HZU A;  1BOI A;  3HIX A;  3FS5 A;  3ILM A;  1H4K X;  4WH9 A;  3P3A A;  2HHG A;  3GK5 A;  5LAO A;  3NTD A;  3ICS A;  2MOI A;  1YM9 A;  2MOL A;  4F67 A;  3K9R A;  3TP9 A;  3I3U A;  2GWF A;  5HBP A;  2EG3 A;  2WLX A;  3FNJ A;  1E0C A;  3OP3 A;  1HZM A;  1YT8 A;  1CWS A;  3ICR A;  2OUC A;  2EG4 A;  1H4M X;  3I2V A;  3D1P A;  2A2K A;  1YML A;  5HPA A;  3O3W A;  1YMK A;  1VEE A;  1QB0 A;  2KL3 A;  2J6P A;  1OKG A;  2ORA A;  3AAX A;  1T3K A;  1QXN A;  3FOJ A;  3FLH A;  1BOH A;  1UAR A;  3NHV A;  1YMD A;  2DCQ A;  5HBQ A;  1WHB A;  1DP2 A;  1C25 A;  3MZZ A;  5LAM A;  3HWI A;  3OLH A;  1WV9 A;  2IFV A;  1RHS A;  2JTQ A;  2JTR A;  1RHD A;  2EG4 B;  4WH7 A;  3IWH A;  3NT6 A;  1GMX A;  3UTN X;  3IPP A;  5HBO A;  3G5J A;  1ORB A;  3ICT A;  1CWR A;  3NTA A;  2K0Z A;  1CWT A;  3R2U A;  2MRM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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