1YS0A

Crystal structure of the cdc25b phosphatase catalytic domain with the active site cysteine in the disulfide form
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
175
structure length
171
Chain Sequence
MELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase, cell cycle
source organism Homo sapiens
publication title Structural Mechanism of Oxidative Regulation of the Phosphatase Cdc25B via an Intramolecular Disulfide Bond
pubmed doi rcsb
molecule keywords M-phase inducer phosphatase 2
total genus 57
structure length 171
sequence length 175
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2005-02-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 1ys0A00
1DP2A 3HZUA 5HBQA 3TG1B 1OKGA 5HBLA 2EG3A 3FLHA 2IFVA 1YS0A 1QXNA 1YMDA 1H4KX 5HBOA 2EG4B 3I3UA 2WLXA 1QB0A 2GWFA 1YMLA 1RHDA 3NT6A 3ICRA 3IPPA 1H4MX 2MOLA 2EG4A 3P3AA 3ICTA 3HWIA 3AAXA 5LAOA 1TQ1A 2MOIA 1YT8A 3NTDA 2K0ZA 2MRMA 3FOJA 3IPOA 3ICSA 1CWSA 1GN0A 2WLRA 3OP3A 2A2KA 1CWRA 3NTAA 2JTQA 1ORBA 2J6PA 4F67A 1GMXA 4WH7A 3FS5A 1RHSA 3K9RA 2HHGA 5HBPA 1HZMA 3TP9A 3ILMA 3OLHA 3IWHA 1BOIA 1T3KA 5HPAA 2OUCA 3AAYA 3I2VA 2DCQA 2JTRA 3R2UA 3F4AA 1YMKA 3HIXA 1C25A 3G5JA 2KL3A 3NHVA 1UARA 3GK5A 3UTNX 2JTSA 1WHBA 1WV9A 1BOHA 1URHA 2IFDA 2FSXA 3O3WA 1CWTA 5LAMA 2ORAA 2UZQA 4WH9A 3TG3A 1YM9A 3FNJA 4JGTA 3MZZA 3D1PA 2VSWA 1VEEA 4OCGA 1E0CA
chains in the Genus database with same CATH superfamily
1DP2A 3HZUA 5HBQA 3TG1B 1OKGA 5HBLA 2EG3A 3FLHA 2IFVA 1YS0A 1QXNA 1YMDA 1H4KX 5HBOA 2EG4B 3I3UA 2WLXA 1QB0A 2GWFA 1YMLA 1RHDA 3NT6A 3ICRA 3IPPA 1H4MX 2MOLA 2EG4A 3P3AA 3ICTA 3HWIA 3AAXA 5LAOA 1TQ1A 2Q82A 2MOIA 1YT8A 3NTDA 2K0ZA 2MRMA 3FOJA 3IPOA 3ICSA 1CWSA 1GN0A 2WLRA 3OP3A 2A2KA 1CWRA 3NTAA 2JTQA 1ORBA 2J6PA 4F67A 1GMXA 4WH7A 3FS5A 1RHSA 3K9RA 2HHGA 5HBPA 1HZMA 3TP9A 3ILMA 3OLHA 3IWHA 1BOIA 1T3KA 5HPAA 2OUCA 3AAYA 3I2VA 2DCQA 2JTRA 3R2UA 3F4AA 1YMKA 3HIXA 1C25A 3G5JA 2KL3A 3NHVA 1UARA 3GK5A 3UTNX 2JTSA 1WHBA 1WV9A 1BOHA 1URHA 2IFDA 2FSXA 3O3WA 1CWTA 5LAMA 2ORAA 2UZQA 4WH9A 3TG3A 1YM9A 3FNJA 4JGTA 3MZZA 3D1PA 2VSWA 1VEEA 4OCGA 1E0CA
chains in the Genus database with same CATH topology
1DP2A 3HZUA 5HBQA 3TG1B 1OKGA 5HBLA 2EG3A 3FLHA 2IFVA 1YS0A 1QXNA 1YMDA 1H4KX 5HBOA 2EG4B 3I3UA 2WLXA 1QB0A 2GWFA 1YMLA 1RHDA 3NT6A 3ICRA 3IPPA 1H4MX 2MOLA 2EG4A 3P3AA 3ICTA 3HWIA 3AAXA 5LAOA 1TQ1A 2MOIA 1YT8A 3NTDA 2K0ZA 2MRMA 3FOJA 3IPOA 3ICSA 1CWSA 1GN0A 2WLRA 3OP3A 2A2KA 1CWRA 3NTAA 2JTQA 1ORBA 2J6PA 4F67A 1GMXA 4WH7A 3FS5A 1RHSA 3K9RA 2HHGA 5HBPA 1HZMA 3TP9A 3ILMA 3OLHA 3IWHA 1BOIA 1T3KA 5HPAA 2OUCA 3AAYA 3I2VA 2DCQA 2JTRA 3R2UA 3F4AA 1YMKA 3HIXA 1C25A 3G5JA 2KL3A 3NHVA 1UARA 3GK5A 3UTNX 2JTSA 1WHBA 1WV9A 1BOHA 1URHA 2IFDA 2FSXA 3O3WA 1CWTA 5LAMA 2ORAA 2UZQA 4WH9A 3TG3A 1YM9A 3FNJA 4JGTA 3MZZA 3D1PA 2VSWA 1VEEA 4OCGA 1E0CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DP2 A;  3HZU A;  5HBQ A;  3TG1 B;  1OKG A;  5HBL A;  2EG3 A;  3FLH A;  2IFV A;  1YS0 A;  1QXN A;  1YMD A;  1H4K X;  5HBO A;  2EG4 B;  3I3U A;  2WLX A;  1QB0 A;  2GWF A;  1YML A;  1RHD A;  3NT6 A;  3ICR A;  3IPP A;  1H4M X;  2MOL A;  2EG4 A;  3P3A A;  3ICT A;  3HWI A;  3AAX A;  5LAO A;  1TQ1 A;  2MOI A;  1YT8 A;  3NTD A;  2K0Z A;  2MRM A;  3FOJ A;  3IPO A;  3ICS A;  1CWS A;  1GN0 A;  2WLR A;  3OP3 A;  2A2K A;  1CWR A;  3NTA A;  2JTQ A;  1ORB A;  2J6P A;  4F67 A;  1GMX A;  4WH7 A;  3FS5 A;  1RHS A;  3K9R A;  2HHG A;  5HBP A;  1HZM A;  3TP9 A;  3ILM A;  3OLH A;  3IWH A;  1BOI A;  1T3K A;  5HPA A;  2OUC A;  3AAY A;  3I2V A;  2DCQ A;  2JTR A;  3R2U A;  3F4A A;  1YMK A;  3HIX A;  1C25 A;  3G5J A;  2KL3 A;  3NHV A;  1UAR A;  3GK5 A;  3UTN X;  2JTS A;  1WHB A;  1WV9 A;  1BOH A;  1URH A;  2IFD A;  2FSX A;  3O3W A;  1CWT A;  5LAM A;  2ORA A;  2UZQ A;  4WH9 A;  3TG3 A;  1YM9 A;  3FNJ A;  4JGT A;  3MZZ A;  3D1P A;  2VSW A;  1VEE A;  4OCG A;  1E0C A; 
#chains in the Genus database with same CATH topology
 1DP2 A;  3HZU A;  5HBQ A;  3TG1 B;  1OKG A;  5HBL A;  2EG3 A;  3FLH A;  2IFV A;  1YS0 A;  1QXN A;  1YMD A;  1H4K X;  5HBO A;  2EG4 B;  3I3U A;  2WLX A;  1QB0 A;  2GWF A;  1YML A;  1RHD A;  3NT6 A;  3ICR A;  3IPP A;  1H4M X;  2MOL A;  2EG4 A;  3P3A A;  3ICT A;  3HWI A;  3AAX A;  5LAO A;  1TQ1 A;  2Q82 A;  2MOI A;  1YT8 A;  3NTD A;  2K0Z A;  2MRM A;  3FOJ A;  3IPO A;  3ICS A;  1CWS A;  1GN0 A;  2WLR A;  3OP3 A;  2A2K A;  1CWR A;  3NTA A;  2JTQ A;  1ORB A;  2J6P A;  4F67 A;  1GMX A;  4WH7 A;  3FS5 A;  1RHS A;  3K9R A;  2HHG A;  5HBP A;  1HZM A;  3TP9 A;  3ILM A;  3OLH A;  3IWH A;  1BOI A;  1T3K A;  5HPA A;  2OUC A;  3AAY A;  3I2V A;  2DCQ A;  2JTR A;  3R2U A;  3F4A A;  1YMK A;  3HIX A;  1C25 A;  3G5J A;  2KL3 A;  3NHV A;  1UAR A;  3GK5 A;  3UTN X;  2JTS A;  1WHB A;  1WV9 A;  1BOH A;  1URH A;  2IFD A;  2FSX A;  3O3W A;  1CWT A;  5LAM A;  2ORA A;  2UZQ A;  4WH9 A;  3TG3 A;  1YM9 A;  3FNJ A;  4JGT A;  3MZZ A;  3D1P A;  2VSW A;  1VEE A;  4OCG A;  1E0C A; 
#chains in the Genus database with same CATH homology
 1DP2 A;  3HZU A;  5HBQ A;  3TG1 B;  1OKG A;  5HBL A;  2EG3 A;  3FLH A;  2IFV A;  1YS0 A;  1QXN A;  1YMD A;  1H4K X;  5HBO A;  2EG4 B;  3I3U A;  2WLX A;  1QB0 A;  2GWF A;  1YML A;  1RHD A;  3NT6 A;  3ICR A;  3IPP A;  1H4M X;  2MOL A;  2EG4 A;  3P3A A;  3ICT A;  3HWI A;  3AAX A;  5LAO A;  1TQ1 A;  2MOI A;  1YT8 A;  3NTD A;  2K0Z A;  2MRM A;  3FOJ A;  3IPO A;  3ICS A;  1CWS A;  1GN0 A;  2WLR A;  3OP3 A;  2A2K A;  1CWR A;  3NTA A;  2JTQ A;  1ORB A;  2J6P A;  4F67 A;  1GMX A;  4WH7 A;  3FS5 A;  1RHS A;  3K9R A;  2HHG A;  5HBP A;  1HZM A;  3TP9 A;  3ILM A;  3OLH A;  3IWH A;  1BOI A;  1T3K A;  5HPA A;  2OUC A;  3AAY A;  3I2V A;  2DCQ A;  2JTR A;  3R2U A;  3F4A A;  1YMK A;  3HIX A;  1C25 A;  3G5J A;  2KL3 A;  3NHV A;  1UAR A;  3GK5 A;  3UTN X;  2JTS A;  1WHB A;  1WV9 A;  1BOH A;  1URH A;  2IFD A;  2FSX A;  3O3W A;  1CWT A;  5LAM A;  2ORA A;  2UZQ A;  4WH9 A;  3TG3 A;  1YM9 A;  3FNJ A;  4JGT A;  3MZZ A;  3D1P A;  2VSW A;  1VEE A;  4OCG A;  1E0C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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