1YS0A

Crystal structure of the cdc25b phosphatase catalytic domain with the active site cysteine in the disulfide form
Total Genus 57
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
175
structure length
171
Chain Sequence
MELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSW
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Mechanism of Oxidative Regulation of the Phosphatase Cdc25B via an Intramolecular Disulfide Bond
pubmed doi rcsb
molecule tags Hydrolase, cell cycle
source organism Homo sapiens
molecule keywords M-phase inducer phosphatase 2
total genus 57
structure length 171
sequence length 175
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2005-02-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 1ys0A00
1C25A 4WH7A 1WHBA 1CWSA 2JTSA 1CWTA 3F4AA 3TG1B 3IWHA 2MOIA 1ORBA 1QXNA 2WLRA 2IFDA 5LAOA 1GN0A 1YMKA 3ICTA 1OKGA 2EG4A 1WV9A 1YM9A 2MOLA 3MZZA 3AAYA 3R2UA 3NT6A 3NTAA 2KL3A 2WLXA 1RHDA 1DP2A 1VEEA 1YS0A 2MRMA 1YMDA 3ILMA 2JTRA 2EG4B 1RHSA 3FS5A 1UARA 1TQ1A 2VSWA 5HBQA 2JTQA 2ORAA 5HBLA 5HPAA 1URHA 2HHGA 3HZUA 2DCQA 4WH9A 3FLHA 3FNJA 1H4MX 2OUCA 2J6PA 3HIXA 3AAXA 3G5JA 1BOIA 3K9RA 3I2VA 1T3KA 2FSXA 3TP9A 3IPPA 2IFVA 1HZMA 4JGTA 1E0CA 3GK5A 2EG3A 4F67A 1QB0A 3I3UA 3ICSA 1H4KX 3OLHA 1YT8A 4OCGA 5LAMA 3ICRA 3TG3A 1BOHA 3IPOA 2UZQA 2K0ZA 3NHVA 5HBOA 1YMLA 2A2KA 1CWRA 3NTDA 3FOJA 3HWIA 3P3AA 3UTNX 3D1PA 1GMXA 3O3WA 3OP3A 5HBPA 2GWFA
chains in the Genus database with same CATH superfamily
1C25A 4WH7A 1WHBA 1CWSA 2JTSA 1CWTA 3F4AA 3TG1B 3IWHA 2MOIA 1ORBA 1QXNA 2WLRA 2IFDA 5LAOA 1GN0A 1YMKA 3ICTA 1OKGA 2EG4A 1WV9A 1YM9A 2MOLA 3MZZA 3AAYA 3R2UA 3NT6A 3NTAA 2KL3A 2WLXA 1RHDA 1DP2A 1VEEA 1YS0A 2MRMA 1YMDA 3ILMA 2JTRA 2EG4B 1RHSA 3FS5A 1UARA 1TQ1A 2VSWA 5HBQA 2JTQA 2ORAA 5HBLA 5HPAA 1URHA 2HHGA 3HZUA 2DCQA 4WH9A 3FLHA 3FNJA 1H4MX 2OUCA 2J6PA 3HIXA 3AAXA 3G5JA 1BOIA 3K9RA 3I2VA 1T3KA 2FSXA 3TP9A 3IPPA 2IFVA 1HZMA 4JGTA 1E0CA 3GK5A 2EG3A 4F67A 1QB0A 3I3UA 3ICSA 1H4KX 3OLHA 1YT8A 4OCGA 5LAMA 3ICRA 3TG3A 1BOHA 3IPOA 2UZQA 2K0ZA 3NHVA 5HBOA 1YMLA 2A2KA 1CWRA 3NTDA 3FOJA 3HWIA 3P3AA 3UTNX 3D1PA 1GMXA 2Q82A 3O3WA 3OP3A 5HBPA 2GWFA
chains in the Genus database with same CATH topology
1C25A 4WH7A 1WHBA 1CWSA 2JTSA 1CWTA 3F4AA 3TG1B 3IWHA 2MOIA 1ORBA 1QXNA 2WLRA 2IFDA 5LAOA 1GN0A 1YMKA 3ICTA 1OKGA 2EG4A 1WV9A 1YM9A 2MOLA 3MZZA 3AAYA 3R2UA 3NT6A 3NTAA 2KL3A 2WLXA 1RHDA 1DP2A 1VEEA 1YS0A 2MRMA 1YMDA 3ILMA 2JTRA 2EG4B 1RHSA 3FS5A 1UARA 1TQ1A 2VSWA 5HBQA 2JTQA 2ORAA 5HBLA 5HPAA 1URHA 2HHGA 3HZUA 2DCQA 4WH9A 3FLHA 3FNJA 1H4MX 2OUCA 2J6PA 3HIXA 3AAXA 3G5JA 1BOIA 3K9RA 3I2VA 1T3KA 2FSXA 3TP9A 3IPPA 2IFVA 1HZMA 4JGTA 1E0CA 3GK5A 2EG3A 4F67A 1QB0A 3I3UA 3ICSA 1H4KX 3OLHA 1YT8A 4OCGA 5LAMA 3ICRA 3TG3A 1BOHA 3IPOA 2UZQA 2K0ZA 3NHVA 5HBOA 1YMLA 2A2KA 1CWRA 3NTDA 3FOJA 3HWIA 3P3AA 3UTNX 3D1PA 1GMXA 3O3WA 3OP3A 5HBPA 2GWFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C25 A;  4WH7 A;  1WHB A;  1CWS A;  2JTS A;  1CWT A;  3F4A A;  3TG1 B;  3IWH A;  2MOI A;  1ORB A;  1QXN A;  2WLR A;  2IFD A;  5LAO A;  1GN0 A;  1YMK A;  3ICT A;  1OKG A;  2EG4 A;  1WV9 A;  1YM9 A;  2MOL A;  3MZZ A;  3AAY A;  3R2U A;  3NT6 A;  3NTA A;  2KL3 A;  2WLX A;  1RHD A;  1DP2 A;  1VEE A;  1YS0 A;  2MRM A;  1YMD A;  3ILM A;  2JTR A;  2EG4 B;  1RHS A;  3FS5 A;  1UAR A;  1TQ1 A;  2VSW A;  5HBQ A;  2JTQ A;  2ORA A;  5HBL A;  5HPA A;  1URH A;  2HHG A;  3HZU A;  2DCQ A;  4WH9 A;  3FLH A;  3FNJ A;  1H4M X;  2OUC A;  2J6P A;  3HIX A;  3AAX A;  3G5J A;  1BOI A;  3K9R A;  3I2V A;  1T3K A;  2FSX A;  3TP9 A;  3IPP A;  2IFV A;  1HZM A;  4JGT A;  1E0C A;  3GK5 A;  2EG3 A;  4F67 A;  1QB0 A;  3I3U A;  3ICS A;  1H4K X;  3OLH A;  1YT8 A;  4OCG A;  5LAM A;  3ICR A;  3TG3 A;  1BOH A;  3IPO A;  2UZQ A;  2K0Z A;  3NHV A;  5HBO A;  1YML A;  2A2K A;  1CWR A;  3NTD A;  3FOJ A;  3HWI A;  3P3A A;  3UTN X;  3D1P A;  1GMX A;  3O3W A;  3OP3 A;  5HBP A;  2GWF A; 
#chains in the Genus database with same CATH topology
 1C25 A;  4WH7 A;  1WHB A;  1CWS A;  2JTS A;  1CWT A;  3F4A A;  3TG1 B;  3IWH A;  2MOI A;  1ORB A;  1QXN A;  2WLR A;  2IFD A;  5LAO A;  1GN0 A;  1YMK A;  3ICT A;  1OKG A;  2EG4 A;  1WV9 A;  1YM9 A;  2MOL A;  3MZZ A;  3AAY A;  3R2U A;  3NT6 A;  3NTA A;  2KL3 A;  2WLX A;  1RHD A;  1DP2 A;  1VEE A;  1YS0 A;  2MRM A;  1YMD A;  3ILM A;  2JTR A;  2EG4 B;  1RHS A;  3FS5 A;  1UAR A;  1TQ1 A;  2VSW A;  5HBQ A;  2JTQ A;  2ORA A;  5HBL A;  5HPA A;  1URH A;  2HHG A;  3HZU A;  2DCQ A;  4WH9 A;  3FLH A;  3FNJ A;  1H4M X;  2OUC A;  2J6P A;  3HIX A;  3AAX A;  3G5J A;  1BOI A;  3K9R A;  3I2V A;  1T3K A;  2FSX A;  3TP9 A;  3IPP A;  2IFV A;  1HZM A;  4JGT A;  1E0C A;  3GK5 A;  2EG3 A;  4F67 A;  1QB0 A;  3I3U A;  3ICS A;  1H4K X;  3OLH A;  1YT8 A;  4OCG A;  5LAM A;  3ICR A;  3TG3 A;  1BOH A;  3IPO A;  2UZQ A;  2K0Z A;  3NHV A;  5HBO A;  1YML A;  2A2K A;  1CWR A;  3NTD A;  3FOJ A;  3HWI A;  3P3A A;  3UTN X;  3D1P A;  1GMX A;  2Q82 A;  3O3W A;  3OP3 A;  5HBP A;  2GWF A; 
#chains in the Genus database with same CATH homology
 1C25 A;  4WH7 A;  1WHB A;  1CWS A;  2JTS A;  1CWT A;  3F4A A;  3TG1 B;  3IWH A;  2MOI A;  1ORB A;  1QXN A;  2WLR A;  2IFD A;  5LAO A;  1GN0 A;  1YMK A;  3ICT A;  1OKG A;  2EG4 A;  1WV9 A;  1YM9 A;  2MOL A;  3MZZ A;  3AAY A;  3R2U A;  3NT6 A;  3NTA A;  2KL3 A;  2WLX A;  1RHD A;  1DP2 A;  1VEE A;  1YS0 A;  2MRM A;  1YMD A;  3ILM A;  2JTR A;  2EG4 B;  1RHS A;  3FS5 A;  1UAR A;  1TQ1 A;  2VSW A;  5HBQ A;  2JTQ A;  2ORA A;  5HBL A;  5HPA A;  1URH A;  2HHG A;  3HZU A;  2DCQ A;  4WH9 A;  3FLH A;  3FNJ A;  1H4M X;  2OUC A;  2J6P A;  3HIX A;  3AAX A;  3G5J A;  1BOI A;  3K9R A;  3I2V A;  1T3K A;  2FSX A;  3TP9 A;  3IPP A;  2IFV A;  1HZM A;  4JGT A;  1E0C A;  3GK5 A;  2EG3 A;  4F67 A;  1QB0 A;  3I3U A;  3ICS A;  1H4K X;  3OLH A;  1YT8 A;  4OCG A;  5LAM A;  3ICR A;  3TG3 A;  1BOH A;  3IPO A;  2UZQ A;  2K0Z A;  3NHV A;  5HBO A;  1YML A;  2A2K A;  1CWR A;  3NTD A;  3FOJ A;  3HWI A;  3P3A A;  3UTN X;  3D1P A;  1GMX A;  3O3W A;  3OP3 A;  5HBP A;  2GWF A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...