1HZMA

Structure of erk2 binding domain of mapk phosphatase mkp-3: structural insights into mkp-3 activation by erk2
Total Genus 23
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
154
structure length
154
Chain Sequence
MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESLLGLLLKKLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
total genus 23
structure length 154
sequence length 154
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2001-01-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 1hzmA00
2ORAA 3IPPA 2EG3A 3IPOA 2EG4B 3FNJA 2FSXA 3D1PA 3FS5A 5HBPA 1T3KA 1RHDA 1WV9A 1YMDA 2VSWA 3FOJA 2JTSA 3AAXA 4OCGA 3HWIA 1VEEA 3IWHA 2IFDA 3TP9A 5LAMA 3GK5A 1CWRA 2MOIA 3O3WA 3ILMA 1YMLA 1GMXA 1DP2A 1GN0A 1YMKA 3OP3A 1H4KX 3OLHA 4WH7A 1RHSA 2J6PA 1HZMA 3K9RA 1YT8A 2EG4A 3ICTA 3I2VA 2A2KA 2HHGA 1UARA 3UTNX 3NHVA 3ICRA 2MOLA 3TG3A 3TG1B 1URHA 1YS0A 3MZZA 2JTQA 2GWFA 1WHBA 5HBQA 3F4AA 2MRMA 1OKGA 2DCQA 2JTRA 2WLRA 3NTAA 3I3UA 2KL3A 5HPAA 1CWSA 1BOHA 1CWTA 2IFVA 1YM9A 3R2UA 1C25A 2OUCA 5HBOA 5LAOA 5HBLA 3HIXA 3NTDA 1E0CA 4WH9A 3ICSA 1BOIA 3G5JA 1QB0A 2UZQA 1TQ1A 3AAYA 1QXNA 2WLXA 4JGTA 3P3AA 1H4MX 3NT6A 1ORBA 4F67A 3HZUA 3FLHA 2K0ZA
chains in the Genus database with same CATH superfamily
2ORAA 3IPPA 2EG3A 3IPOA 2EG4B 3FNJA 2FSXA 3D1PA 3FS5A 5HBPA 1T3KA 1RHDA 1WV9A 1YMDA 2VSWA 3FOJA 2JTSA 3AAXA 4OCGA 3HWIA 1VEEA 3IWHA 2IFDA 3TP9A 5LAMA 3GK5A 1CWRA 2MOIA 3O3WA 3ILMA 1YMLA 1GMXA 1DP2A 1GN0A 1YMKA 3OP3A 1H4KX 3OLHA 4WH7A 1RHSA 2J6PA 1HZMA 3K9RA 1YT8A 2EG4A 3ICTA 3I2VA 2A2KA 2HHGA 1UARA 3UTNX 3NHVA 3ICRA 2MOLA 3TG3A 3TG1B 1URHA 1YS0A 3MZZA 2JTQA 2GWFA 1WHBA 5HBQA 3F4AA 2MRMA 1OKGA 2DCQA 2JTRA 2WLRA 3NTAA 3I3UA 2KL3A 5HPAA 1CWSA 1BOHA 1CWTA 2IFVA 1YM9A 3R2UA 1C25A 2OUCA 5HBOA 5LAOA 5HBLA 3HIXA 3NTDA 1E0CA 4WH9A 3ICSA 1BOIA 3G5JA 1QB0A 2UZQA 1TQ1A 3AAYA 1QXNA 2WLXA 4JGTA 3P3AA 1H4MX 3NT6A 1ORBA 4F67A 3HZUA 3FLHA 2Q82A 2K0ZA
chains in the Genus database with same CATH topology
2ORAA 3IPPA 2EG3A 3IPOA 2EG4B 3FNJA 2FSXA 3D1PA 3FS5A 5HBPA 1T3KA 1RHDA 1WV9A 1YMDA 2VSWA 3FOJA 2JTSA 3AAXA 4OCGA 3HWIA 1VEEA 3IWHA 2IFDA 3TP9A 5LAMA 3GK5A 1CWRA 2MOIA 3O3WA 3ILMA 1YMLA 1GMXA 1DP2A 1GN0A 1YMKA 3OP3A 1H4KX 3OLHA 4WH7A 1RHSA 2J6PA 1HZMA 3K9RA 1YT8A 2EG4A 3ICTA 3I2VA 2A2KA 2HHGA 1UARA 3UTNX 3NHVA 3ICRA 2MOLA 3TG3A 3TG1B 1URHA 1YS0A 3MZZA 2JTQA 2GWFA 1WHBA 5HBQA 3F4AA 2MRMA 1OKGA 2DCQA 2JTRA 2WLRA 3NTAA 3I3UA 2KL3A 5HPAA 1CWSA 1BOHA 1CWTA 2IFVA 1YM9A 3R2UA 1C25A 2OUCA 5HBOA 5LAOA 5HBLA 3HIXA 3NTDA 1E0CA 4WH9A 3ICSA 1BOIA 3G5JA 1QB0A 2UZQA 1TQ1A 3AAYA 1QXNA 2WLXA 4JGTA 3P3AA 1H4MX 3NT6A 1ORBA 4F67A 3HZUA 3FLHA 2K0ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ORA A;  3IPP A;  2EG3 A;  3IPO A;  2EG4 B;  3FNJ A;  2FSX A;  3D1P A;  3FS5 A;  5HBP A;  1T3K A;  1RHD A;  1WV9 A;  1YMD A;  2VSW A;  3FOJ A;  2JTS A;  3AAX A;  4OCG A;  3HWI A;  1VEE A;  3IWH A;  2IFD A;  3TP9 A;  5LAM A;  3GK5 A;  1CWR A;  2MOI A;  3O3W A;  3ILM A;  1YML A;  1GMX A;  1DP2 A;  1GN0 A;  1YMK A;  3OP3 A;  1H4K X;  3OLH A;  4WH7 A;  1RHS A;  2J6P A;  1HZM A;  3K9R A;  1YT8 A;  2EG4 A;  3ICT A;  3I2V A;  2A2K A;  2HHG A;  1UAR A;  3UTN X;  3NHV A;  3ICR A;  2MOL A;  3TG3 A;  3TG1 B;  1URH A;  1YS0 A;  3MZZ A;  2JTQ A;  2GWF A;  1WHB A;  5HBQ A;  3F4A A;  2MRM A;  1OKG A;  2DCQ A;  2JTR A;  2WLR A;  3NTA A;  3I3U A;  2KL3 A;  5HPA A;  1CWS A;  1BOH A;  1CWT A;  2IFV A;  1YM9 A;  3R2U A;  1C25 A;  2OUC A;  5HBO A;  5LAO A;  5HBL A;  3HIX A;  3NTD A;  1E0C A;  4WH9 A;  3ICS A;  1BOI A;  3G5J A;  1QB0 A;  2UZQ A;  1TQ1 A;  3AAY A;  1QXN A;  2WLX A;  4JGT A;  3P3A A;  1H4M X;  3NT6 A;  1ORB A;  4F67 A;  3HZU A;  3FLH A;  2K0Z A; 
#chains in the Genus database with same CATH topology
 2ORA A;  3IPP A;  2EG3 A;  3IPO A;  2EG4 B;  3FNJ A;  2FSX A;  3D1P A;  3FS5 A;  5HBP A;  1T3K A;  1RHD A;  1WV9 A;  1YMD A;  2VSW A;  3FOJ A;  2JTS A;  3AAX A;  4OCG A;  3HWI A;  1VEE A;  3IWH A;  2IFD A;  3TP9 A;  5LAM A;  3GK5 A;  1CWR A;  2MOI A;  3O3W A;  3ILM A;  1YML A;  1GMX A;  1DP2 A;  1GN0 A;  1YMK A;  3OP3 A;  1H4K X;  3OLH A;  4WH7 A;  1RHS A;  2J6P A;  1HZM A;  3K9R A;  1YT8 A;  2EG4 A;  3ICT A;  3I2V A;  2A2K A;  2HHG A;  1UAR A;  3UTN X;  3NHV A;  3ICR A;  2MOL A;  3TG3 A;  3TG1 B;  1URH A;  1YS0 A;  3MZZ A;  2JTQ A;  2GWF A;  1WHB A;  5HBQ A;  3F4A A;  2MRM A;  1OKG A;  2DCQ A;  2JTR A;  2WLR A;  3NTA A;  3I3U A;  2KL3 A;  5HPA A;  1CWS A;  1BOH A;  1CWT A;  2IFV A;  1YM9 A;  3R2U A;  1C25 A;  2OUC A;  5HBO A;  5LAO A;  5HBL A;  3HIX A;  3NTD A;  1E0C A;  4WH9 A;  3ICS A;  1BOI A;  3G5J A;  1QB0 A;  2UZQ A;  1TQ1 A;  3AAY A;  1QXN A;  2WLX A;  4JGT A;  3P3A A;  1H4M X;  3NT6 A;  1ORB A;  4F67 A;  3HZU A;  3FLH A;  2Q82 A;  2K0Z A; 
#chains in the Genus database with same CATH homology
 2ORA A;  3IPP A;  2EG3 A;  3IPO A;  2EG4 B;  3FNJ A;  2FSX A;  3D1P A;  3FS5 A;  5HBP A;  1T3K A;  1RHD A;  1WV9 A;  1YMD A;  2VSW A;  3FOJ A;  2JTS A;  3AAX A;  4OCG A;  3HWI A;  1VEE A;  3IWH A;  2IFD A;  3TP9 A;  5LAM A;  3GK5 A;  1CWR A;  2MOI A;  3O3W A;  3ILM A;  1YML A;  1GMX A;  1DP2 A;  1GN0 A;  1YMK A;  3OP3 A;  1H4K X;  3OLH A;  4WH7 A;  1RHS A;  2J6P A;  1HZM A;  3K9R A;  1YT8 A;  2EG4 A;  3ICT A;  3I2V A;  2A2K A;  2HHG A;  1UAR A;  3UTN X;  3NHV A;  3ICR A;  2MOL A;  3TG3 A;  3TG1 B;  1URH A;  1YS0 A;  3MZZ A;  2JTQ A;  2GWF A;  1WHB A;  5HBQ A;  3F4A A;  2MRM A;  1OKG A;  2DCQ A;  2JTR A;  2WLR A;  3NTA A;  3I3U A;  2KL3 A;  5HPA A;  1CWS A;  1BOH A;  1CWT A;  2IFV A;  1YM9 A;  3R2U A;  1C25 A;  2OUC A;  5HBO A;  5LAO A;  5HBL A;  3HIX A;  3NTD A;  1E0C A;  4WH9 A;  3ICS A;  1BOI A;  3G5J A;  1QB0 A;  2UZQ A;  1TQ1 A;  3AAY A;  1QXN A;  2WLX A;  4JGT A;  3P3A A;  1H4M X;  3NT6 A;  1ORB A;  4F67 A;  3HZU A;  3FLH A;  2K0Z A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...