2A2KA

Crystal structure of an active site mutant, c473s, of cdc25b phosphatase catalytic domain
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
175
structure length
171
Chain Sequence
MELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPKRVILIFHSEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Experimental Validation of the Docking Orientation of Cdc25 with Its Cdk2-CycA Protein Substrate.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords M-phase inducer phosphatase 2
total genus 62
structure length 171
sequence length 175
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2005-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 2a2kA00
3NTAA 1TQ1A 3R2UA 1RHDA 5LAMA 2KL3A 1H4MX 2FSXA 1QB0A 1CWRA 3ILMA 2MOLA 2EG3A 3GK5A 3FLHA 1RHSA 2VSWA 3ICRA 3MZZA 4WH7A 1YS0A 3NT6A 1WV9A 1HZMA 3O3WA 1DP2A 1VEEA 3TG3A 2HHGA 3ICTA 1UARA 2MOIA 2JTQA 1GN0A 1YMKA 2GWFA 2WLRA 1YM9A 2A2KA 2ORAA 1CWTA 1YMLA 3HIXA 3I3UA 3AAYA 3FOJA 4OCGA 2WLXA 4JGTA 2IFDA 3HZUA 1BOHA 1GMXA 1OKGA 1URHA 5HPAA 1ORBA 4F67A 3NHVA 5HBQA 1BOIA 2JTRA 1CWSA 1YMDA 1T3KA 4WH9A 5HBPA 3IWHA 3TG1B 3I2VA 2EG4A 5HBLA 1WHBA 3F4AA 3OLHA 5HBOA 1C25A 3ICSA 3K9RA 2MRMA 2EG4B 3NTDA 3OP3A 1E0CA 2JTSA 2DCQA 2IFVA 5LAOA 2K0ZA 3AAXA 3IPOA 3UTNX 3TP9A 1QXNA 1H4KX 1YT8A 3FNJA 3HWIA 3D1PA 2J6PA 3IPPA 2UZQA 3P3AA 2OUCA 3FS5A 3G5JA
chains in the Genus database with same CATH superfamily
3NTAA 1TQ1A 3R2UA 1RHDA 5LAMA 2KL3A 1H4MX 2FSXA 1QB0A 1CWRA 3ILMA 2MOLA 2EG3A 3GK5A 3FLHA 1RHSA 2VSWA 3ICRA 3MZZA 4WH7A 1YS0A 3NT6A 1WV9A 1HZMA 3O3WA 1DP2A 1VEEA 3TG3A 2HHGA 3ICTA 1UARA 2MOIA 2JTQA 1GN0A 1YMKA 2GWFA 2WLRA 2Q82A 1YM9A 2A2KA 2ORAA 1CWTA 1YMLA 3HIXA 3I3UA 3AAYA 3FOJA 4OCGA 2WLXA 4JGTA 2IFDA 3HZUA 1BOHA 1GMXA 1OKGA 1URHA 5HPAA 1ORBA 4F67A 3NHVA 5HBQA 1BOIA 2JTRA 1CWSA 1YMDA 1T3KA 4WH9A 5HBPA 3IWHA 3TG1B 3I2VA 2EG4A 5HBLA 1WHBA 3F4AA 3OLHA 5HBOA 1C25A 3ICSA 3K9RA 2MRMA 2EG4B 3NTDA 3OP3A 1E0CA 2JTSA 2DCQA 2IFVA 5LAOA 2K0ZA 3AAXA 3IPOA 3UTNX 3TP9A 1QXNA 1H4KX 1YT8A 3FNJA 3HWIA 3D1PA 2J6PA 3IPPA 2UZQA 3P3AA 2OUCA 3FS5A 3G5JA
chains in the Genus database with same CATH topology
3NTAA 1TQ1A 3R2UA 1RHDA 5LAMA 2KL3A 1H4MX 2FSXA 1QB0A 1CWRA 3ILMA 2MOLA 2EG3A 3GK5A 3FLHA 1RHSA 2VSWA 3ICRA 3MZZA 4WH7A 1YS0A 3NT6A 1WV9A 1HZMA 3O3WA 1DP2A 1VEEA 3TG3A 2HHGA 3ICTA 1UARA 2MOIA 2JTQA 1GN0A 1YMKA 2GWFA 2WLRA 1YM9A 2A2KA 2ORAA 1CWTA 1YMLA 3HIXA 3I3UA 3AAYA 3FOJA 4OCGA 2WLXA 4JGTA 2IFDA 3HZUA 1BOHA 1GMXA 1OKGA 1URHA 5HPAA 1ORBA 4F67A 3NHVA 5HBQA 1BOIA 2JTRA 1CWSA 1YMDA 1T3KA 4WH9A 5HBPA 3IWHA 3TG1B 3I2VA 2EG4A 5HBLA 1WHBA 3F4AA 3OLHA 5HBOA 1C25A 3ICSA 3K9RA 2MRMA 2EG4B 3NTDA 3OP3A 1E0CA 2JTSA 2DCQA 2IFVA 5LAOA 2K0ZA 3AAXA 3IPOA 3UTNX 3TP9A 1QXNA 1H4KX 1YT8A 3FNJA 3HWIA 3D1PA 2J6PA 3IPPA 2UZQA 3P3AA 2OUCA 3FS5A 3G5JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NTA A;  1TQ1 A;  3R2U A;  1RHD A;  5LAM A;  2KL3 A;  1H4M X;  2FSX A;  1QB0 A;  1CWR A;  3ILM A;  2MOL A;  2EG3 A;  3GK5 A;  3FLH A;  1RHS A;  2VSW A;  3ICR A;  3MZZ A;  4WH7 A;  1YS0 A;  3NT6 A;  1WV9 A;  1HZM A;  3O3W A;  1DP2 A;  1VEE A;  3TG3 A;  2HHG A;  3ICT A;  1UAR A;  2MOI A;  2JTQ A;  1GN0 A;  1YMK A;  2GWF A;  2WLR A;  1YM9 A;  2A2K A;  2ORA A;  1CWT A;  1YML A;  3HIX A;  3I3U A;  3AAY A;  3FOJ A;  4OCG A;  2WLX A;  4JGT A;  2IFD A;  3HZU A;  1BOH A;  1GMX A;  1OKG A;  1URH A;  5HPA A;  1ORB A;  4F67 A;  3NHV A;  5HBQ A;  1BOI A;  2JTR A;  1CWS A;  1YMD A;  1T3K A;  4WH9 A;  5HBP A;  3IWH A;  3TG1 B;  3I2V A;  2EG4 A;  5HBL A;  1WHB A;  3F4A A;  3OLH A;  5HBO A;  1C25 A;  3ICS A;  3K9R A;  2MRM A;  2EG4 B;  3NTD A;  3OP3 A;  1E0C A;  2JTS A;  2DCQ A;  2IFV A;  5LAO A;  2K0Z A;  3AAX A;  3IPO A;  3UTN X;  3TP9 A;  1QXN A;  1H4K X;  1YT8 A;  3FNJ A;  3HWI A;  3D1P A;  2J6P A;  3IPP A;  2UZQ A;  3P3A A;  2OUC A;  3FS5 A;  3G5J A; 
#chains in the Genus database with same CATH topology
 3NTA A;  1TQ1 A;  3R2U A;  1RHD A;  5LAM A;  2KL3 A;  1H4M X;  2FSX A;  1QB0 A;  1CWR A;  3ILM A;  2MOL A;  2EG3 A;  3GK5 A;  3FLH A;  1RHS A;  2VSW A;  3ICR A;  3MZZ A;  4WH7 A;  1YS0 A;  3NT6 A;  1WV9 A;  1HZM A;  3O3W A;  1DP2 A;  1VEE A;  3TG3 A;  2HHG A;  3ICT A;  1UAR A;  2MOI A;  2JTQ A;  1GN0 A;  1YMK A;  2GWF A;  2WLR A;  2Q82 A;  1YM9 A;  2A2K A;  2ORA A;  1CWT A;  1YML A;  3HIX A;  3I3U A;  3AAY A;  3FOJ A;  4OCG A;  2WLX A;  4JGT A;  2IFD A;  3HZU A;  1BOH A;  1GMX A;  1OKG A;  1URH A;  5HPA A;  1ORB A;  4F67 A;  3NHV A;  5HBQ A;  1BOI A;  2JTR A;  1CWS A;  1YMD A;  1T3K A;  4WH9 A;  5HBP A;  3IWH A;  3TG1 B;  3I2V A;  2EG4 A;  5HBL A;  1WHB A;  3F4A A;  3OLH A;  5HBO A;  1C25 A;  3ICS A;  3K9R A;  2MRM A;  2EG4 B;  3NTD A;  3OP3 A;  1E0C A;  2JTS A;  2DCQ A;  2IFV A;  5LAO A;  2K0Z A;  3AAX A;  3IPO A;  3UTN X;  3TP9 A;  1QXN A;  1H4K X;  1YT8 A;  3FNJ A;  3HWI A;  3D1P A;  2J6P A;  3IPP A;  2UZQ A;  3P3A A;  2OUC A;  3FS5 A;  3G5J A; 
#chains in the Genus database with same CATH homology
 3NTA A;  1TQ1 A;  3R2U A;  1RHD A;  5LAM A;  2KL3 A;  1H4M X;  2FSX A;  1QB0 A;  1CWR A;  3ILM A;  2MOL A;  2EG3 A;  3GK5 A;  3FLH A;  1RHS A;  2VSW A;  3ICR A;  3MZZ A;  4WH7 A;  1YS0 A;  3NT6 A;  1WV9 A;  1HZM A;  3O3W A;  1DP2 A;  1VEE A;  3TG3 A;  2HHG A;  3ICT A;  1UAR A;  2MOI A;  2JTQ A;  1GN0 A;  1YMK A;  2GWF A;  2WLR A;  1YM9 A;  2A2K A;  2ORA A;  1CWT A;  1YML A;  3HIX A;  3I3U A;  3AAY A;  3FOJ A;  4OCG A;  2WLX A;  4JGT A;  2IFD A;  3HZU A;  1BOH A;  1GMX A;  1OKG A;  1URH A;  5HPA A;  1ORB A;  4F67 A;  3NHV A;  5HBQ A;  1BOI A;  2JTR A;  1CWS A;  1YMD A;  1T3K A;  4WH9 A;  5HBP A;  3IWH A;  3TG1 B;  3I2V A;  2EG4 A;  5HBL A;  1WHB A;  3F4A A;  3OLH A;  5HBO A;  1C25 A;  3ICS A;  3K9R A;  2MRM A;  2EG4 B;  3NTD A;  3OP3 A;  1E0C A;  2JTS A;  2DCQ A;  2IFV A;  5LAO A;  2K0Z A;  3AAX A;  3IPO A;  3UTN X;  3TP9 A;  1QXN A;  1H4K X;  1YT8 A;  3FNJ A;  3HWI A;  3D1P A;  2J6P A;  3IPP A;  2UZQ A;  3P3A A;  2OUC A;  3FS5 A;  3G5J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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