2AR5A

Crystal structure of the mammalian c2alpha-pi3 kinase px-domain
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
117
structure length
117
Chain Sequence
MDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHGSHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ligand-binding specificity of PI3Kinase C2alpha PX domain.
rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Phosphoinositide 3-kinase
total genus 27
structure length 117
sequence length 117
ec nomenclature ec 2.7.1.154: Phosphatidylinositol-4-phosphate 3-kinase.
pdb deposition date 2005-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00787 PX PX domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1520.10 Alpha Beta 2-Layer Sandwich PX Domain Phox-like domain 2ar5A00
2I4KA 3P0CA 2CZOA 3HPBA 2V14A 4AZ9A 4P2IA 3IQ2A 2AR5A 2RAIA 3DYTA 4PZGA 1O7KA 2WWEA 1KQ6A 2RAJA 2V6VA 3LUIA 4HASA 1XTEA 2DYBA 4ON3A 2ETTA 2REAA 4PQOA 4P2JA 4IKBB 2L73A 1KMDA 3FOGA 2RAKA 2REDA 1H6HA 4BGJA 1GD5A 4OXWA 4IKBA 1XTNA 4IKDA 2CSKA 2IWLX 3HPCX 4PQPA 1OCSA 4AKVA 1OCUA 2YPSA
chains in the Genus database with same CATH superfamily
2I4KA 3P0CA 2CZOA 3HPBA 2V14A 4AZ9A 4P2IA 3IQ2A 2AR5A 2RAIA 3DYTA 4PZGA 1O7KA 2WWEA 1KQ6A 2RAJA 2V6VA 3LUIA 4HASA 1XTEA 2DYBA 4ON3A 2ETTA 2REAA 4PQOA 4P2JA 4IKBB 2L73A 1KMDA 3FOGA 2RAKA 2REDA 1H6HA 4BGJA 1GD5A 4OXWA 4IKBA 1XTNA 4IKDA 2CSKA 2IWLX 3HPCX 4PQPA 1OCSA 4AKVA 1OCUA 2YPSA
chains in the Genus database with same CATH topology
2I4KA 3P0CA 2CZOA 3HPBA 2V14A 4AZ9A 4P2IA 3IQ2A 2AR5A 2RAIA 3DYTA 4PZGA 1O7KA 2WWEA 1KQ6A 2RAJA 2V6VA 3LUIA 4HASA 1XTEA 2DYBA 4ON3A 2ETTA 2REAA 4PQOA 4P2JA 4IKBB 2L73A 1KMDA 3FOGA 2RAKA 2REDA 1H6HA 4BGJA 1GD5A 4OXWA 4IKBA 1XTNA 4IKDA 2CSKA 2IWLX 3HPCX 4PQPA 1OCSA 4AKVA 1OCUA 2YPSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2I4K A;  3P0C A;  2CZO A;  3HPB A;  2V14 A;  4AZ9 A;  4P2I A;  3IQ2 A;  2AR5 A;  2RAI A;  3DYT A;  4PZG A;  1O7K A;  2WWE A;  1KQ6 A;  2RAJ A;  2V6V A;  3LUI A;  4HAS A;  1XTE A;  2DYB A;  4ON3 A;  2ETT A;  2REA A;  4PQO A;  4P2J A;  4IKB B;  2L73 A;  1KMD A;  3FOG A;  2RAK A;  2RED A;  1H6H A;  4BGJ A;  1GD5 A;  4OXW A;  4IKB A;  1XTN A;  4IKD A;  2CSK A;  2IWL X;  3HPC X;  4PQP A;  1OCS A;  4AKV A;  1OCU A;  2YPS A; 
#chains in the Genus database with same CATH topology
 2I4K A;  3P0C A;  2CZO A;  3HPB A;  2V14 A;  4AZ9 A;  4P2I A;  3IQ2 A;  2AR5 A;  2RAI A;  3DYT A;  4PZG A;  1O7K A;  2WWE A;  1KQ6 A;  2RAJ A;  2V6V A;  3LUI A;  4HAS A;  1XTE A;  2DYB A;  4ON3 A;  2ETT A;  2REA A;  4PQO A;  4P2J A;  4IKB B;  2L73 A;  1KMD A;  3FOG A;  2RAK A;  2RED A;  1H6H A;  4BGJ A;  1GD5 A;  4OXW A;  4IKB A;  1XTN A;  4IKD A;  2CSK A;  2IWL X;  3HPC X;  4PQP A;  1OCS A;  4AKV A;  1OCU A;  2YPS A; 
#chains in the Genus database with same CATH homology
 2I4K A;  3P0C A;  2CZO A;  3HPB A;  2V14 A;  4AZ9 A;  4P2I A;  3IQ2 A;  2AR5 A;  2RAI A;  3DYT A;  4PZG A;  1O7K A;  2WWE A;  1KQ6 A;  2RAJ A;  2V6V A;  3LUI A;  4HAS A;  1XTE A;  2DYB A;  4ON3 A;  2ETT A;  2REA A;  4PQO A;  4P2J A;  4IKB B;  2L73 A;  1KMD A;  3FOG A;  2RAK A;  2RED A;  1H6H A;  4BGJ A;  1GD5 A;  4OXW A;  4IKB A;  1XTN A;  4IKD A;  2CSK A;  2IWL X;  3HPC X;  4PQP A;  1OCS A;  4AKV A;  1OCU A;  2YPS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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