2AR5A

Crystal structure of the mammalian c2alpha-pi3 kinase px-domain
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
117
structure length
117
Chain Sequence
MDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHGSHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ligand-binding specificity of PI3Kinase C2alpha PX domain.
rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Phosphoinositide 3-kinase
total genus 27
structure length 117
sequence length 117
ec nomenclature ec 2.7.1.154: Phosphatidylinositol-4-phosphate 3-kinase.
pdb deposition date 2005-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00787 PX PX domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1520.10 Alpha Beta 2-Layer Sandwich PX Domain Phox-like domain 2ar5A00
3HPBA 4PQPA 4P2IA 1XTEA 2L73A 2REAA 2RAKA 4IKDA 4IKBB 3FOGA 2V6VA 2V14A 1OCUA 4HASA 4BGJA 4ON3A 4PZGA 1KMDA 4OXWA 2REDA 3DYTA 3HPCX 2CZOA 4PQOA 4P2JA 3LUIA 1GD5A 1KQ6A 2CSKA 4AZ9A 1OCSA 2I4KA 2AR5A 2RAIA 1XTNA 2YPSA 2IWLX 3IQ2A 2RAJA 2WWEA 4IKBA 2ETTA 3P0CA 4AKVA 2DYBA 1O7KA 1H6HA
chains in the Genus database with same CATH superfamily
3HPBA 4PQPA 4P2IA 1XTEA 2L73A 2REAA 2RAKA 4IKDA 4IKBB 3FOGA 2V6VA 2V14A 1OCUA 4HASA 4BGJA 4ON3A 4PZGA 1KMDA 4OXWA 2REDA 3DYTA 3HPCX 2CZOA 4PQOA 4P2JA 3LUIA 1GD5A 1KQ6A 2CSKA 4AZ9A 1OCSA 2I4KA 2AR5A 2RAIA 1XTNA 2YPSA 2IWLX 3IQ2A 2RAJA 2WWEA 4IKBA 2ETTA 3P0CA 4AKVA 2DYBA 1O7KA 1H6HA
chains in the Genus database with same CATH topology
3HPBA 4PQPA 4P2IA 1XTEA 2L73A 2REAA 2RAKA 4IKDA 4IKBB 3FOGA 2V6VA 2V14A 1OCUA 4HASA 4BGJA 4ON3A 4PZGA 1KMDA 4OXWA 2REDA 3DYTA 3HPCX 2CZOA 4PQOA 4P2JA 3LUIA 1GD5A 1KQ6A 2CSKA 4AZ9A 1OCSA 2I4KA 2AR5A 2RAIA 1XTNA 2YPSA 2IWLX 3IQ2A 2RAJA 2WWEA 4IKBA 2ETTA 3P0CA 4AKVA 2DYBA 1O7KA 1H6HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HPB A;  4PQP A;  4P2I A;  1XTE A;  2L73 A;  2REA A;  2RAK A;  4IKD A;  4IKB B;  3FOG A;  2V6V A;  2V14 A;  1OCU A;  4HAS A;  4BGJ A;  4ON3 A;  4PZG A;  1KMD A;  4OXW A;  2RED A;  3DYT A;  3HPC X;  2CZO A;  4PQO A;  4P2J A;  3LUI A;  1GD5 A;  1KQ6 A;  2CSK A;  4AZ9 A;  1OCS A;  2I4K A;  2AR5 A;  2RAI A;  1XTN A;  2YPS A;  2IWL X;  3IQ2 A;  2RAJ A;  2WWE A;  4IKB A;  2ETT A;  3P0C A;  4AKV A;  2DYB A;  1O7K A;  1H6H A; 
#chains in the Genus database with same CATH topology
 3HPB A;  4PQP A;  4P2I A;  1XTE A;  2L73 A;  2REA A;  2RAK A;  4IKD A;  4IKB B;  3FOG A;  2V6V A;  2V14 A;  1OCU A;  4HAS A;  4BGJ A;  4ON3 A;  4PZG A;  1KMD A;  4OXW A;  2RED A;  3DYT A;  3HPC X;  2CZO A;  4PQO A;  4P2J A;  3LUI A;  1GD5 A;  1KQ6 A;  2CSK A;  4AZ9 A;  1OCS A;  2I4K A;  2AR5 A;  2RAI A;  1XTN A;  2YPS A;  2IWL X;  3IQ2 A;  2RAJ A;  2WWE A;  4IKB A;  2ETT A;  3P0C A;  4AKV A;  2DYB A;  1O7K A;  1H6H A; 
#chains in the Genus database with same CATH homology
 3HPB A;  4PQP A;  4P2I A;  1XTE A;  2L73 A;  2REA A;  2RAK A;  4IKD A;  4IKB B;  3FOG A;  2V6V A;  2V14 A;  1OCU A;  4HAS A;  4BGJ A;  4ON3 A;  4PZG A;  1KMD A;  4OXW A;  2RED A;  3DYT A;  3HPC X;  2CZO A;  4PQO A;  4P2J A;  3LUI A;  1GD5 A;  1KQ6 A;  2CSK A;  4AZ9 A;  1OCS A;  2I4K A;  2AR5 A;  2RAI A;  1XTN A;  2YPS A;  2IWL X;  3IQ2 A;  2RAJ A;  2WWE A;  4IKB A;  2ETT A;  3P0C A;  4AKV A;  2DYB A;  1O7K A;  1H6H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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