2IFDA

Crystal structure of a remote binding site mutant, r492l, of cdc25b phosphatase catalytic domain
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
175
structure length
175
Chain Sequence
MELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDLAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Kinetic and structural studies of specific protein-protein interactions in substrate catalysis by Cdc25B phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords M-phase inducer phosphatase 2
total genus 62
structure length 175
sequence length 175
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2006-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 2ifdA00
1QXNA 2EG3A 1YM9A 1URHA 3TG3A 1ORBA 3ICTA 2JTSA 3NTDA 1YT8A 1YMLA 4F67A 2JTQA 4JGTA 1YS0A 1QB0A 3P3AA 1HZMA 3GK5A 3MZZA 5LAOA 1WHBA 1BOHA 1H4MX 3NT6A 2JTRA 3I2VA 2IFVA 2EG4B 3OP3A 1RHDA 3HIXA 2MOLA 2MOIA 1RHSA 1TQ1A 2HHGA 2WLXA 3AAYA 3IPPA 3IWHA 1T3KA 3NTAA 2UZQA 1GN0A 2OUCA 3TP9A 1CWRA 5HPAA 3O3WA 1YMDA 2VSWA 3G5JA 3TG1B 4OCGA 4WH7A 3HZUA 2EG4A 2MRMA 1YMKA 3ICRA 4WH9A 2IFDA 3HWIA 5HBPA 2A2KA 2K0ZA 5HBQA 2FSXA 2WLRA 3FOJA 1DP2A 3ILMA 2KL3A 2GWFA 2J6PA 1VEEA 1WV9A 1BOIA 1GMXA 1OKGA 1CWTA 3NHVA 3FLHA 3FNJA 3I3UA 3D1PA 5LAMA 1E0CA 2DCQA 1C25A 3R2UA 5HBOA 3ICSA 3UTNX 3OLHA 3F4AA 1CWSA 3K9RA 3FS5A 3IPOA 1H4KX 5HBLA 1UARA 3AAXA 2ORAA
chains in the Genus database with same CATH superfamily
1QXNA 2EG3A 1YM9A 1URHA 3TG3A 1ORBA 3ICTA 2JTSA 3NTDA 1YT8A 1YMLA 4F67A 2JTQA 4JGTA 1YS0A 1QB0A 3P3AA 1HZMA 3GK5A 3MZZA 5LAOA 1WHBA 1BOHA 1H4MX 3NT6A 2JTRA 3I2VA 2Q82A 2IFVA 2EG4B 3OP3A 1RHDA 3HIXA 2MOLA 2MOIA 1RHSA 1TQ1A 2HHGA 2WLXA 3AAYA 3IPPA 3IWHA 1T3KA 3NTAA 2UZQA 1GN0A 2OUCA 3TP9A 1CWRA 5HPAA 3O3WA 1YMDA 2VSWA 3G5JA 3TG1B 4OCGA 4WH7A 3HZUA 2EG4A 2MRMA 1YMKA 3ICRA 4WH9A 2IFDA 3HWIA 5HBPA 2A2KA 2K0ZA 5HBQA 2FSXA 2WLRA 3FOJA 1DP2A 3ILMA 2KL3A 2GWFA 2J6PA 1VEEA 1WV9A 1BOIA 1GMXA 1OKGA 1CWTA 3NHVA 3FLHA 3FNJA 3I3UA 3D1PA 5LAMA 1E0CA 2DCQA 1C25A 3R2UA 5HBOA 3ICSA 3UTNX 3OLHA 3F4AA 1CWSA 3K9RA 3FS5A 3IPOA 1H4KX 5HBLA 1UARA 3AAXA 2ORAA
chains in the Genus database with same CATH topology
1QXNA 2EG3A 1YM9A 1URHA 3TG3A 1ORBA 3ICTA 2JTSA 3NTDA 1YT8A 1YMLA 4F67A 2JTQA 4JGTA 1YS0A 1QB0A 3P3AA 1HZMA 3GK5A 3MZZA 5LAOA 1WHBA 1BOHA 1H4MX 3NT6A 2JTRA 3I2VA 2IFVA 2EG4B 3OP3A 1RHDA 3HIXA 2MOLA 2MOIA 1RHSA 1TQ1A 2HHGA 2WLXA 3AAYA 3IPPA 3IWHA 1T3KA 3NTAA 2UZQA 1GN0A 2OUCA 3TP9A 1CWRA 5HPAA 3O3WA 1YMDA 2VSWA 3G5JA 3TG1B 4OCGA 4WH7A 3HZUA 2EG4A 2MRMA 1YMKA 3ICRA 4WH9A 2IFDA 3HWIA 5HBPA 2A2KA 2K0ZA 5HBQA 2FSXA 2WLRA 3FOJA 1DP2A 3ILMA 2KL3A 2GWFA 2J6PA 1VEEA 1WV9A 1BOIA 1GMXA 1OKGA 1CWTA 3NHVA 3FLHA 3FNJA 3I3UA 3D1PA 5LAMA 1E0CA 2DCQA 1C25A 3R2UA 5HBOA 3ICSA 3UTNX 3OLHA 3F4AA 1CWSA 3K9RA 3FS5A 3IPOA 1H4KX 5HBLA 1UARA 3AAXA 2ORAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1QXN A;  2EG3 A;  1YM9 A;  1URH A;  3TG3 A;  1ORB A;  3ICT A;  2JTS A;  3NTD A;  1YT8 A;  1YML A;  4F67 A;  2JTQ A;  4JGT A;  1YS0 A;  1QB0 A;  3P3A A;  1HZM A;  3GK5 A;  3MZZ A;  5LAO A;  1WHB A;  1BOH A;  1H4M X;  3NT6 A;  2JTR A;  3I2V A;  2IFV A;  2EG4 B;  3OP3 A;  1RHD A;  3HIX A;  2MOL A;  2MOI A;  1RHS A;  1TQ1 A;  2HHG A;  2WLX A;  3AAY A;  3IPP A;  3IWH A;  1T3K A;  3NTA A;  2UZQ A;  1GN0 A;  2OUC A;  3TP9 A;  1CWR A;  5HPA A;  3O3W A;  1YMD A;  2VSW A;  3G5J A;  3TG1 B;  4OCG A;  4WH7 A;  3HZU A;  2EG4 A;  2MRM A;  1YMK A;  3ICR A;  4WH9 A;  2IFD A;  3HWI A;  5HBP A;  2A2K A;  2K0Z A;  5HBQ A;  2FSX A;  2WLR A;  3FOJ A;  1DP2 A;  3ILM A;  2KL3 A;  2GWF A;  2J6P A;  1VEE A;  1WV9 A;  1BOI A;  1GMX A;  1OKG A;  1CWT A;  3NHV A;  3FLH A;  3FNJ A;  3I3U A;  3D1P A;  5LAM A;  1E0C A;  2DCQ A;  1C25 A;  3R2U A;  5HBO A;  3ICS A;  3UTN X;  3OLH A;  3F4A A;  1CWS A;  3K9R A;  3FS5 A;  3IPO A;  1H4K X;  5HBL A;  1UAR A;  3AAX A;  2ORA A; 
#chains in the Genus database with same CATH topology
 1QXN A;  2EG3 A;  1YM9 A;  1URH A;  3TG3 A;  1ORB A;  3ICT A;  2JTS A;  3NTD A;  1YT8 A;  1YML A;  4F67 A;  2JTQ A;  4JGT A;  1YS0 A;  1QB0 A;  3P3A A;  1HZM A;  3GK5 A;  3MZZ A;  5LAO A;  1WHB A;  1BOH A;  1H4M X;  3NT6 A;  2JTR A;  3I2V A;  2Q82 A;  2IFV A;  2EG4 B;  3OP3 A;  1RHD A;  3HIX A;  2MOL A;  2MOI A;  1RHS A;  1TQ1 A;  2HHG A;  2WLX A;  3AAY A;  3IPP A;  3IWH A;  1T3K A;  3NTA A;  2UZQ A;  1GN0 A;  2OUC A;  3TP9 A;  1CWR A;  5HPA A;  3O3W A;  1YMD A;  2VSW A;  3G5J A;  3TG1 B;  4OCG A;  4WH7 A;  3HZU A;  2EG4 A;  2MRM A;  1YMK A;  3ICR A;  4WH9 A;  2IFD A;  3HWI A;  5HBP A;  2A2K A;  2K0Z A;  5HBQ A;  2FSX A;  2WLR A;  3FOJ A;  1DP2 A;  3ILM A;  2KL3 A;  2GWF A;  2J6P A;  1VEE A;  1WV9 A;  1BOI A;  1GMX A;  1OKG A;  1CWT A;  3NHV A;  3FLH A;  3FNJ A;  3I3U A;  3D1P A;  5LAM A;  1E0C A;  2DCQ A;  1C25 A;  3R2U A;  5HBO A;  3ICS A;  3UTN X;  3OLH A;  3F4A A;  1CWS A;  3K9R A;  3FS5 A;  3IPO A;  1H4K X;  5HBL A;  1UAR A;  3AAX A;  2ORA A; 
#chains in the Genus database with same CATH homology
 1QXN A;  2EG3 A;  1YM9 A;  1URH A;  3TG3 A;  1ORB A;  3ICT A;  2JTS A;  3NTD A;  1YT8 A;  1YML A;  4F67 A;  2JTQ A;  4JGT A;  1YS0 A;  1QB0 A;  3P3A A;  1HZM A;  3GK5 A;  3MZZ A;  5LAO A;  1WHB A;  1BOH A;  1H4M X;  3NT6 A;  2JTR A;  3I2V A;  2IFV A;  2EG4 B;  3OP3 A;  1RHD A;  3HIX A;  2MOL A;  2MOI A;  1RHS A;  1TQ1 A;  2HHG A;  2WLX A;  3AAY A;  3IPP A;  3IWH A;  1T3K A;  3NTA A;  2UZQ A;  1GN0 A;  2OUC A;  3TP9 A;  1CWR A;  5HPA A;  3O3W A;  1YMD A;  2VSW A;  3G5J A;  3TG1 B;  4OCG A;  4WH7 A;  3HZU A;  2EG4 A;  2MRM A;  1YMK A;  3ICR A;  4WH9 A;  2IFD A;  3HWI A;  5HBP A;  2A2K A;  2K0Z A;  5HBQ A;  2FSX A;  2WLR A;  3FOJ A;  1DP2 A;  3ILM A;  2KL3 A;  2GWF A;  2J6P A;  1VEE A;  1WV9 A;  1BOI A;  1GMX A;  1OKG A;  1CWT A;  3NHV A;  3FLH A;  3FNJ A;  3I3U A;  3D1P A;  5LAM A;  1E0C A;  2DCQ A;  1C25 A;  3R2U A;  5HBO A;  3ICS A;  3UTN X;  3OLH A;  3F4A A;  1CWS A;  3K9R A;  3FS5 A;  3IPO A;  1H4K X;  5HBL A;  1UAR A;  3AAX A;  2ORA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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