2IFDA

Crystal structure of a remote binding site mutant, r492l, of cdc25b phosphatase catalytic domain
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
175
structure length
175
Chain Sequence
MELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDLAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Kinetic and structural studies of specific protein-protein interactions in substrate catalysis by Cdc25B phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords M-phase inducer phosphatase 2
total genus 62
structure length 175
sequence length 175
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2006-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 2ifdA00
3HIXA 2IFVA 3IPPA 3OP3A 5LAOA 3O3WA 5HBOA 1GN0A 1OKGA 4F67A 3HWIA 3OLHA 2WLRA 4OCGA 3UTNX 1RHSA 1CWRA 2ORAA 1BOIA 2MRMA 3FS5A 4WH9A 2HHGA 2DCQA 2KL3A 1VEEA 3K9RA 2K0ZA 2OUCA 1E0CA 1H4MX 1ORBA 3HZUA 1UARA 5HBQA 3ICRA 3AAXA 1C25A 1QB0A 3ILMA 3NTDA 3I2VA 1H4KX 1WV9A 5LAMA 3FNJA 2JTQA 2IFDA 1CWSA 1URHA 3NTAA 2EG4A 3P3AA 1YM9A 1YS0A 2MOLA 5HBLA 1CWTA 3G5JA 2JTSA 1YMLA 3AAYA 1WHBA 2GWFA 2MOIA 2UZQA 5HBPA 1YMDA 3ICTA 3TG3A 3IWHA 1YT8A 2VSWA 3ICSA 1YMKA 2FSXA 1DP2A 1T3KA 2JTRA 3FOJA 3NHVA 1QXNA 3MZZA 1RHDA 5HPAA 3FLHA 3NT6A 3TP9A 1HZMA 3GK5A 1GMXA 1TQ1A 3D1PA 2EG3A 3IPOA 3I3UA 2J6PA 3F4AA 3R2UA 3TG1B 2WLXA 1BOHA 2EG4B 2A2KA 4JGTA 4WH7A
chains in the Genus database with same CATH superfamily
3HIXA 2IFVA 3IPPA 3OP3A 5LAOA 3O3WA 5HBOA 1GN0A 1OKGA 4F67A 3HWIA 3OLHA 2WLRA 4OCGA 3UTNX 1RHSA 1CWRA 2ORAA 1BOIA 2MRMA 3FS5A 4WH9A 2HHGA 2DCQA 2KL3A 1VEEA 3K9RA 2K0ZA 2OUCA 1E0CA 1H4MX 1ORBA 3HZUA 1UARA 5HBQA 3ICRA 3AAXA 1C25A 1QB0A 3ILMA 3NTDA 3I2VA 1H4KX 1WV9A 5LAMA 3FNJA 2JTQA 2IFDA 1CWSA 1URHA 3NTAA 2EG4A 3P3AA 1YM9A 1YS0A 2MOLA 5HBLA 1CWTA 3G5JA 2JTSA 1YMLA 3AAYA 1WHBA 2GWFA 2MOIA 2UZQA 5HBPA 1YMDA 3ICTA 3TG3A 3IWHA 1YT8A 2VSWA 3ICSA 1YMKA 2FSXA 1DP2A 1T3KA 2JTRA 3FOJA 3NHVA 1QXNA 3MZZA 1RHDA 5HPAA 3FLHA 3NT6A 3TP9A 1HZMA 3GK5A 1GMXA 1TQ1A 2Q82A 3D1PA 2EG3A 3IPOA 3I3UA 2J6PA 3F4AA 3R2UA 3TG1B 2WLXA 1BOHA 2EG4B 2A2KA 4JGTA 4WH7A
chains in the Genus database with same CATH topology
3HIXA 2IFVA 3IPPA 3OP3A 5LAOA 3O3WA 5HBOA 1GN0A 1OKGA 4F67A 3HWIA 3OLHA 2WLRA 4OCGA 3UTNX 1RHSA 1CWRA 2ORAA 1BOIA 2MRMA 3FS5A 4WH9A 2HHGA 2DCQA 2KL3A 1VEEA 3K9RA 2K0ZA 2OUCA 1E0CA 1H4MX 1ORBA 3HZUA 1UARA 5HBQA 3ICRA 3AAXA 1C25A 1QB0A 3ILMA 3NTDA 3I2VA 1H4KX 1WV9A 5LAMA 3FNJA 2JTQA 2IFDA 1CWSA 1URHA 3NTAA 2EG4A 3P3AA 1YM9A 1YS0A 2MOLA 5HBLA 1CWTA 3G5JA 2JTSA 1YMLA 3AAYA 1WHBA 2GWFA 2MOIA 2UZQA 5HBPA 1YMDA 3ICTA 3TG3A 3IWHA 1YT8A 2VSWA 3ICSA 1YMKA 2FSXA 1DP2A 1T3KA 2JTRA 3FOJA 3NHVA 1QXNA 3MZZA 1RHDA 5HPAA 3FLHA 3NT6A 3TP9A 1HZMA 3GK5A 1GMXA 1TQ1A 3D1PA 2EG3A 3IPOA 3I3UA 2J6PA 3F4AA 3R2UA 3TG1B 2WLXA 1BOHA 2EG4B 2A2KA 4JGTA 4WH7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HIX A;  2IFV A;  3IPP A;  3OP3 A;  5LAO A;  3O3W A;  5HBO A;  1GN0 A;  1OKG A;  4F67 A;  3HWI A;  3OLH A;  2WLR A;  4OCG A;  3UTN X;  1RHS A;  1CWR A;  2ORA A;  1BOI A;  2MRM A;  3FS5 A;  4WH9 A;  2HHG A;  2DCQ A;  2KL3 A;  1VEE A;  3K9R A;  2K0Z A;  2OUC A;  1E0C A;  1H4M X;  1ORB A;  3HZU A;  1UAR A;  5HBQ A;  3ICR A;  3AAX A;  1C25 A;  1QB0 A;  3ILM A;  3NTD A;  3I2V A;  1H4K X;  1WV9 A;  5LAM A;  3FNJ A;  2JTQ A;  2IFD A;  1CWS A;  1URH A;  3NTA A;  2EG4 A;  3P3A A;  1YM9 A;  1YS0 A;  2MOL A;  5HBL A;  1CWT A;  3G5J A;  2JTS A;  1YML A;  3AAY A;  1WHB A;  2GWF A;  2MOI A;  2UZQ A;  5HBP A;  1YMD A;  3ICT A;  3TG3 A;  3IWH A;  1YT8 A;  2VSW A;  3ICS A;  1YMK A;  2FSX A;  1DP2 A;  1T3K A;  2JTR A;  3FOJ A;  3NHV A;  1QXN A;  3MZZ A;  1RHD A;  5HPA A;  3FLH A;  3NT6 A;  3TP9 A;  1HZM A;  3GK5 A;  1GMX A;  1TQ1 A;  3D1P A;  2EG3 A;  3IPO A;  3I3U A;  2J6P A;  3F4A A;  3R2U A;  3TG1 B;  2WLX A;  1BOH A;  2EG4 B;  2A2K A;  4JGT A;  4WH7 A; 
#chains in the Genus database with same CATH topology
 3HIX A;  2IFV A;  3IPP A;  3OP3 A;  5LAO A;  3O3W A;  5HBO A;  1GN0 A;  1OKG A;  4F67 A;  3HWI A;  3OLH A;  2WLR A;  4OCG A;  3UTN X;  1RHS A;  1CWR A;  2ORA A;  1BOI A;  2MRM A;  3FS5 A;  4WH9 A;  2HHG A;  2DCQ A;  2KL3 A;  1VEE A;  3K9R A;  2K0Z A;  2OUC A;  1E0C A;  1H4M X;  1ORB A;  3HZU A;  1UAR A;  5HBQ A;  3ICR A;  3AAX A;  1C25 A;  1QB0 A;  3ILM A;  3NTD A;  3I2V A;  1H4K X;  1WV9 A;  5LAM A;  3FNJ A;  2JTQ A;  2IFD A;  1CWS A;  1URH A;  3NTA A;  2EG4 A;  3P3A A;  1YM9 A;  1YS0 A;  2MOL A;  5HBL A;  1CWT A;  3G5J A;  2JTS A;  1YML A;  3AAY A;  1WHB A;  2GWF A;  2MOI A;  2UZQ A;  5HBP A;  1YMD A;  3ICT A;  3TG3 A;  3IWH A;  1YT8 A;  2VSW A;  3ICS A;  1YMK A;  2FSX A;  1DP2 A;  1T3K A;  2JTR A;  3FOJ A;  3NHV A;  1QXN A;  3MZZ A;  1RHD A;  5HPA A;  3FLH A;  3NT6 A;  3TP9 A;  1HZM A;  3GK5 A;  1GMX A;  1TQ1 A;  2Q82 A;  3D1P A;  2EG3 A;  3IPO A;  3I3U A;  2J6P A;  3F4A A;  3R2U A;  3TG1 B;  2WLX A;  1BOH A;  2EG4 B;  2A2K A;  4JGT A;  4WH7 A; 
#chains in the Genus database with same CATH homology
 3HIX A;  2IFV A;  3IPP A;  3OP3 A;  5LAO A;  3O3W A;  5HBO A;  1GN0 A;  1OKG A;  4F67 A;  3HWI A;  3OLH A;  2WLR A;  4OCG A;  3UTN X;  1RHS A;  1CWR A;  2ORA A;  1BOI A;  2MRM A;  3FS5 A;  4WH9 A;  2HHG A;  2DCQ A;  2KL3 A;  1VEE A;  3K9R A;  2K0Z A;  2OUC A;  1E0C A;  1H4M X;  1ORB A;  3HZU A;  1UAR A;  5HBQ A;  3ICR A;  3AAX A;  1C25 A;  1QB0 A;  3ILM A;  3NTD A;  3I2V A;  1H4K X;  1WV9 A;  5LAM A;  3FNJ A;  2JTQ A;  2IFD A;  1CWS A;  1URH A;  3NTA A;  2EG4 A;  3P3A A;  1YM9 A;  1YS0 A;  2MOL A;  5HBL A;  1CWT A;  3G5J A;  2JTS A;  1YML A;  3AAY A;  1WHB A;  2GWF A;  2MOI A;  2UZQ A;  5HBP A;  1YMD A;  3ICT A;  3TG3 A;  3IWH A;  1YT8 A;  2VSW A;  3ICS A;  1YMK A;  2FSX A;  1DP2 A;  1T3K A;  2JTR A;  3FOJ A;  3NHV A;  1QXN A;  3MZZ A;  1RHD A;  5HPA A;  3FLH A;  3NT6 A;  3TP9 A;  1HZM A;  3GK5 A;  1GMX A;  1TQ1 A;  3D1P A;  2EG3 A;  3IPO A;  3I3U A;  2J6P A;  3F4A A;  3R2U A;  3TG1 B;  2WLX A;  1BOH A;  2EG4 B;  2A2K A;  4JGT A;  4WH7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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