2IFVA

Crystal structure of an active site mutant, c473d, of cdc25b phosphatase catalytic domain
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
175
structure length
175
Chain Sequence
MELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHDEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Kinetic and structural studies of specific protein-protein interactions in substrate catalysis by Cdc25B phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords M-phase inducer phosphatase 2
total genus 62
structure length 175
sequence length 175
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2006-09-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 2ifvA00
1CWSA 3NHVA 1YM9A 1TQ1A 2DCQA 3O3WA 3UTNX 1GMXA 4WH9A 2OUCA 2FSXA 1YMKA 3NTAA 3D1PA 3K9RA 3FLHA 2K0ZA 3NT6A 3IWHA 2KL3A 3FS5A 1BOIA 2MOIA 2WLRA 1T3KA 3FNJA 1VEEA 1QXNA 3ICRA 1ORBA 2IFDA 2ORAA 1YMDA 3GK5A 1UARA 1WV9A 2UZQA 5LAOA 4WH7A 5HBPA 3TG3A 1CWRA 2A2KA 4OCGA 3P3AA 3TG1B 3IPOA 2JTSA 5LAMA 1GN0A 3ICTA 3R2UA 3MZZA 3F4AA 3HWIA 1RHSA 3HIXA 1E0CA 1URHA 2EG4A 3G5JA 5HBLA 3I3UA 3OLHA 5HBOA 2HHGA 3ILMA 1WHBA 3IPPA 1HZMA 3NTDA 3ICSA 3FOJA 2GWFA 1BOHA 2JTQA 2J6PA 5HBQA 4F67A 2MRMA 3TP9A 1H4MX 3AAYA 2VSWA 1H4KX 1YT8A 3OP3A 1OKGA 3AAXA 1DP2A 2WLXA 2EG4B 1YMLA 1QB0A 3HZUA 5HPAA 2EG3A 2MOLA 2IFVA 1CWTA 1RHDA 1YS0A 3I2VA 1C25A 4JGTA 2JTRA
chains in the Genus database with same CATH superfamily
1CWSA 3NHVA 1YM9A 1TQ1A 2Q82A 2DCQA 3O3WA 3UTNX 1GMXA 4WH9A 2OUCA 2FSXA 1YMKA 3NTAA 3D1PA 3K9RA 3FLHA 2K0ZA 3NT6A 3IWHA 2KL3A 3FS5A 1BOIA 2MOIA 2WLRA 1T3KA 3FNJA 1VEEA 1QXNA 3ICRA 1ORBA 2IFDA 2ORAA 1YMDA 3GK5A 1UARA 1WV9A 2UZQA 5LAOA 4WH7A 5HBPA 3TG3A 1CWRA 2A2KA 4OCGA 3P3AA 3TG1B 3IPOA 2JTSA 5LAMA 1GN0A 3ICTA 3R2UA 3MZZA 3F4AA 3HWIA 1RHSA 3HIXA 1E0CA 1URHA 2EG4A 3G5JA 5HBLA 3I3UA 3OLHA 5HBOA 2HHGA 3ILMA 1WHBA 3IPPA 1HZMA 3NTDA 3ICSA 3FOJA 2GWFA 1BOHA 2JTQA 2J6PA 5HBQA 4F67A 2MRMA 3TP9A 1H4MX 3AAYA 2VSWA 1H4KX 1YT8A 3OP3A 1OKGA 3AAXA 1DP2A 2WLXA 2EG4B 1YMLA 1QB0A 3HZUA 5HPAA 2EG3A 2MOLA 2IFVA 1CWTA 1RHDA 1YS0A 3I2VA 1C25A 4JGTA 2JTRA
chains in the Genus database with same CATH topology
1CWSA 3NHVA 1YM9A 1TQ1A 2DCQA 3O3WA 3UTNX 1GMXA 4WH9A 2OUCA 2FSXA 1YMKA 3NTAA 3D1PA 3K9RA 3FLHA 2K0ZA 3NT6A 3IWHA 2KL3A 3FS5A 1BOIA 2MOIA 2WLRA 1T3KA 3FNJA 1VEEA 1QXNA 3ICRA 1ORBA 2IFDA 2ORAA 1YMDA 3GK5A 1UARA 1WV9A 2UZQA 5LAOA 4WH7A 5HBPA 3TG3A 1CWRA 2A2KA 4OCGA 3P3AA 3TG1B 3IPOA 2JTSA 5LAMA 1GN0A 3ICTA 3R2UA 3MZZA 3F4AA 3HWIA 1RHSA 3HIXA 1E0CA 1URHA 2EG4A 3G5JA 5HBLA 3I3UA 3OLHA 5HBOA 2HHGA 3ILMA 1WHBA 3IPPA 1HZMA 3NTDA 3ICSA 3FOJA 2GWFA 1BOHA 2JTQA 2J6PA 5HBQA 4F67A 2MRMA 3TP9A 1H4MX 3AAYA 2VSWA 1H4KX 1YT8A 3OP3A 1OKGA 3AAXA 1DP2A 2WLXA 2EG4B 1YMLA 1QB0A 3HZUA 5HPAA 2EG3A 2MOLA 2IFVA 1CWTA 1RHDA 1YS0A 3I2VA 1C25A 4JGTA 2JTRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1CWS A;  3NHV A;  1YM9 A;  1TQ1 A;  2DCQ A;  3O3W A;  3UTN X;  1GMX A;  4WH9 A;  2OUC A;  2FSX A;  1YMK A;  3NTA A;  3D1P A;  3K9R A;  3FLH A;  2K0Z A;  3NT6 A;  3IWH A;  2KL3 A;  3FS5 A;  1BOI A;  2MOI A;  2WLR A;  1T3K A;  3FNJ A;  1VEE A;  1QXN A;  3ICR A;  1ORB A;  2IFD A;  2ORA A;  1YMD A;  3GK5 A;  1UAR A;  1WV9 A;  2UZQ A;  5LAO A;  4WH7 A;  5HBP A;  3TG3 A;  1CWR A;  2A2K A;  4OCG A;  3P3A A;  3TG1 B;  3IPO A;  2JTS A;  5LAM A;  1GN0 A;  3ICT A;  3R2U A;  3MZZ A;  3F4A A;  3HWI A;  1RHS A;  3HIX A;  1E0C A;  1URH A;  2EG4 A;  3G5J A;  5HBL A;  3I3U A;  3OLH A;  5HBO A;  2HHG A;  3ILM A;  1WHB A;  3IPP A;  1HZM A;  3NTD A;  3ICS A;  3FOJ A;  2GWF A;  1BOH A;  2JTQ A;  2J6P A;  5HBQ A;  4F67 A;  2MRM A;  3TP9 A;  1H4M X;  3AAY A;  2VSW A;  1H4K X;  1YT8 A;  3OP3 A;  1OKG A;  3AAX A;  1DP2 A;  2WLX A;  2EG4 B;  1YML A;  1QB0 A;  3HZU A;  5HPA A;  2EG3 A;  2MOL A;  2IFV A;  1CWT A;  1RHD A;  1YS0 A;  3I2V A;  1C25 A;  4JGT A;  2JTR A; 
#chains in the Genus database with same CATH topology
 1CWS A;  3NHV A;  1YM9 A;  1TQ1 A;  2Q82 A;  2DCQ A;  3O3W A;  3UTN X;  1GMX A;  4WH9 A;  2OUC A;  2FSX A;  1YMK A;  3NTA A;  3D1P A;  3K9R A;  3FLH A;  2K0Z A;  3NT6 A;  3IWH A;  2KL3 A;  3FS5 A;  1BOI A;  2MOI A;  2WLR A;  1T3K A;  3FNJ A;  1VEE A;  1QXN A;  3ICR A;  1ORB A;  2IFD A;  2ORA A;  1YMD A;  3GK5 A;  1UAR A;  1WV9 A;  2UZQ A;  5LAO A;  4WH7 A;  5HBP A;  3TG3 A;  1CWR A;  2A2K A;  4OCG A;  3P3A A;  3TG1 B;  3IPO A;  2JTS A;  5LAM A;  1GN0 A;  3ICT A;  3R2U A;  3MZZ A;  3F4A A;  3HWI A;  1RHS A;  3HIX A;  1E0C A;  1URH A;  2EG4 A;  3G5J A;  5HBL A;  3I3U A;  3OLH A;  5HBO A;  2HHG A;  3ILM A;  1WHB A;  3IPP A;  1HZM A;  3NTD A;  3ICS A;  3FOJ A;  2GWF A;  1BOH A;  2JTQ A;  2J6P A;  5HBQ A;  4F67 A;  2MRM A;  3TP9 A;  1H4M X;  3AAY A;  2VSW A;  1H4K X;  1YT8 A;  3OP3 A;  1OKG A;  3AAX A;  1DP2 A;  2WLX A;  2EG4 B;  1YML A;  1QB0 A;  3HZU A;  5HPA A;  2EG3 A;  2MOL A;  2IFV A;  1CWT A;  1RHD A;  1YS0 A;  3I2V A;  1C25 A;  4JGT A;  2JTR A; 
#chains in the Genus database with same CATH homology
 1CWS A;  3NHV A;  1YM9 A;  1TQ1 A;  2DCQ A;  3O3W A;  3UTN X;  1GMX A;  4WH9 A;  2OUC A;  2FSX A;  1YMK A;  3NTA A;  3D1P A;  3K9R A;  3FLH A;  2K0Z A;  3NT6 A;  3IWH A;  2KL3 A;  3FS5 A;  1BOI A;  2MOI A;  2WLR A;  1T3K A;  3FNJ A;  1VEE A;  1QXN A;  3ICR A;  1ORB A;  2IFD A;  2ORA A;  1YMD A;  3GK5 A;  1UAR A;  1WV9 A;  2UZQ A;  5LAO A;  4WH7 A;  5HBP A;  3TG3 A;  1CWR A;  2A2K A;  4OCG A;  3P3A A;  3TG1 B;  3IPO A;  2JTS A;  5LAM A;  1GN0 A;  3ICT A;  3R2U A;  3MZZ A;  3F4A A;  3HWI A;  1RHS A;  3HIX A;  1E0C A;  1URH A;  2EG4 A;  3G5J A;  5HBL A;  3I3U A;  3OLH A;  5HBO A;  2HHG A;  3ILM A;  1WHB A;  3IPP A;  1HZM A;  3NTD A;  3ICS A;  3FOJ A;  2GWF A;  1BOH A;  2JTQ A;  2J6P A;  5HBQ A;  4F67 A;  2MRM A;  3TP9 A;  1H4M X;  3AAY A;  2VSW A;  1H4K X;  1YT8 A;  3OP3 A;  1OKG A;  3AAX A;  1DP2 A;  2WLX A;  2EG4 B;  1YML A;  1QB0 A;  3HZU A;  5HPA A;  2EG3 A;  2MOL A;  2IFV A;  1CWT A;  1RHD A;  1YS0 A;  3I2V A;  1C25 A;  4JGT A;  2JTR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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