2IWLX

Structure of the px domain of phosphoinositide 3-kinase-c2alpha
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
131
structure length
121
Chain Sequence
LSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural and Membrane Binding Analysis of the Phox Homology Domain of Phosphoinositide 3-Kinase- C2{Alpha}.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords PHOSPHATIDYLINOSITOL-4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINI
total genus 32
structure length 121
sequence length 131
ec nomenclature ec 2.7.1.154: Phosphatidylinositol-4-phosphate 3-kinase.
pdb deposition date 2006-07-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF00787 PX PX domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1520.10 Alpha Beta 2-Layer Sandwich PX Domain Phox-like domain 2iwlX00
2ETTA 2REDA 2YPSA 2AR5A 3DYTA 3P0CA 1GD5A 2CZOA 1OCUA 2L73A 2RAIA 3HPCX 4PZGA 4AKVA 4P2IA 1KQ6A 2IWLX 2WWEA 4PQPA 2I4KA 3LUIA 4HASA 1OCSA 2V14A 3FOGA 4ON3A 4IKDA 2RAJA 1XTEA 2DYBA 2REAA 4OXWA 4IKBB 4P2JA 4BGJA 2CSKA 4AZ9A 1XTNA 2V6VA 1KMDA 1H6HA 3HPBA 4PQOA 3IQ2A 4IKBA 2RAKA 1O7KA
chains in the Genus database with same CATH superfamily
2ETTA 2REDA 2YPSA 2AR5A 3DYTA 3P0CA 1GD5A 2CZOA 1OCUA 2L73A 2RAIA 3HPCX 4PZGA 4AKVA 4P2IA 1KQ6A 2IWLX 2WWEA 4PQPA 2I4KA 3LUIA 4HASA 1OCSA 2V14A 3FOGA 4ON3A 4IKDA 2RAJA 1XTEA 2DYBA 2REAA 4OXWA 4IKBB 4P2JA 4BGJA 2CSKA 4AZ9A 1XTNA 2V6VA 1KMDA 1H6HA 3HPBA 4PQOA 3IQ2A 4IKBA 2RAKA 1O7KA
chains in the Genus database with same CATH topology
2ETTA 2REDA 2YPSA 2AR5A 3DYTA 3P0CA 1GD5A 2CZOA 1OCUA 2L73A 2RAIA 3HPCX 4PZGA 4AKVA 4P2IA 1KQ6A 2IWLX 2WWEA 4PQPA 2I4KA 3LUIA 4HASA 1OCSA 2V14A 3FOGA 4ON3A 4IKDA 2RAJA 1XTEA 2DYBA 2REAA 4OXWA 4IKBB 4P2JA 4BGJA 2CSKA 4AZ9A 1XTNA 2V6VA 1KMDA 1H6HA 3HPBA 4PQOA 3IQ2A 4IKBA 2RAKA 1O7KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ETT A;  2RED A;  2YPS A;  2AR5 A;  3DYT A;  3P0C A;  1GD5 A;  2CZO A;  1OCU A;  2L73 A;  2RAI A;  3HPC X;  4PZG A;  4AKV A;  4P2I A;  1KQ6 A;  2IWL X;  2WWE A;  4PQP A;  2I4K A;  3LUI A;  4HAS A;  1OCS A;  2V14 A;  3FOG A;  4ON3 A;  4IKD A;  2RAJ A;  1XTE A;  2DYB A;  2REA A;  4OXW A;  4IKB B;  4P2J A;  4BGJ A;  2CSK A;  4AZ9 A;  1XTN A;  2V6V A;  1KMD A;  1H6H A;  3HPB A;  4PQO A;  3IQ2 A;  4IKB A;  2RAK A;  1O7K A; 
#chains in the Genus database with same CATH topology
 2ETT A;  2RED A;  2YPS A;  2AR5 A;  3DYT A;  3P0C A;  1GD5 A;  2CZO A;  1OCU A;  2L73 A;  2RAI A;  3HPC X;  4PZG A;  4AKV A;  4P2I A;  1KQ6 A;  2IWL X;  2WWE A;  4PQP A;  2I4K A;  3LUI A;  4HAS A;  1OCS A;  2V14 A;  3FOG A;  4ON3 A;  4IKD A;  2RAJ A;  1XTE A;  2DYB A;  2REA A;  4OXW A;  4IKB B;  4P2J A;  4BGJ A;  2CSK A;  4AZ9 A;  1XTN A;  2V6V A;  1KMD A;  1H6H A;  3HPB A;  4PQO A;  3IQ2 A;  4IKB A;  2RAK A;  1O7K A; 
#chains in the Genus database with same CATH homology
 2ETT A;  2RED A;  2YPS A;  2AR5 A;  3DYT A;  3P0C A;  1GD5 A;  2CZO A;  1OCU A;  2L73 A;  2RAI A;  3HPC X;  4PZG A;  4AKV A;  4P2I A;  1KQ6 A;  2IWL X;  2WWE A;  4PQP A;  2I4K A;  3LUI A;  4HAS A;  1OCS A;  2V14 A;  3FOG A;  4ON3 A;  4IKD A;  2RAJ A;  1XTE A;  2DYB A;  2REA A;  4OXW A;  4IKB B;  4P2J A;  4BGJ A;  2CSK A;  4AZ9 A;  1XTN A;  2V6V A;  1KMD A;  1H6H A;  3HPB A;  4PQO A;  3IQ2 A;  4IKB A;  2RAK A;  1O7K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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