2IWLX

Structure of the px domain of phosphoinositide 3-kinase-c2alpha
Total Genus 32

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
131
structure length
121
Chain Sequence
LSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEK

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
molecule tags Transferase
source organism Homo sapiens
publication title Structural and Membrane Binding Analysis of the Phox Homology Domain of Phosphoinositide 3-Kinase- C2{Alpha}.
pubmed doi rcsb
molecule keywords PHOSPHATIDYLINOSITOL-4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINI
total genus 32
structure length 121
sequence length 131
ec nomenclature ec 2.7.1.154: Phosphatidylinositol-4-phosphate 3-kinase.
pdb deposition date 2006-07-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF00787 PX PX domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1520.10 Alpha Beta 2-Layer Sandwich PX Domain Phox-like domain 2iwlX00
4PQPA 2DYBA 2RAJA 4IKDA 1GD5A 1KQ6A 3HPCX 2RAKA 4P2JA 2V6VA 3IQ2A 4HASA 2REDA 3DYTA 2CSKA 4ON3A 4AKVA 3LUIA 2V14A 4PQOA 1OCSA 2AR5A 4IKBB 1KMDA 2REAA 4P2IA 1XTNA 2YPSA 4OXWA 3P0CA 1OCUA 3HPBA 1O7KA 4PZGA 4IKBA 1H6HA 2L73A 2ETTA 1XTEA 2RAIA 3FOGA 4AZ9A 2WWEA 2I4KA 4BGJA 2IWLX 2CZOA
chains in the Genus database with same CATH superfamily
4PQPA 2DYBA 2RAJA 4IKDA 1GD5A 1KQ6A 3HPCX 2RAKA 4P2JA 2V6VA 3IQ2A 4HASA 2REDA 3DYTA 2CSKA 4ON3A 4AKVA 3LUIA 2V14A 4PQOA 1OCSA 2AR5A 4IKBB 1KMDA 2REAA 4P2IA 1XTNA 2YPSA 4OXWA 3P0CA 1OCUA 3HPBA 1O7KA 4PZGA 4IKBA 1H6HA 2L73A 2ETTA 1XTEA 2RAIA 3FOGA 4AZ9A 2WWEA 2I4KA 4BGJA 2IWLX 2CZOA
chains in the Genus database with same CATH topology
4PQPA 2DYBA 2RAJA 4IKDA 1GD5A 1KQ6A 3HPCX 2RAKA 4P2JA 2V6VA 3IQ2A 4HASA 2REDA 3DYTA 2CSKA 4ON3A 4AKVA 3LUIA 2V14A 4PQOA 1OCSA 2AR5A 4IKBB 1KMDA 2REAA 4P2IA 1XTNA 2YPSA 4OXWA 3P0CA 1OCUA 3HPBA 1O7KA 4PZGA 4IKBA 1H6HA 2L73A 2ETTA 1XTEA 2RAIA 3FOGA 4AZ9A 2WWEA 2I4KA 4BGJA 2IWLX 2CZOA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4PQP A;  2DYB A;  2RAJ A;  4IKD A;  1GD5 A;  1KQ6 A;  3HPC X;  2RAK A;  4P2J A;  2V6V A;  3IQ2 A;  4HAS A;  2RED A;  3DYT A;  2CSK A;  4ON3 A;  4AKV A;  3LUI A;  2V14 A;  4PQO A;  1OCS A;  2AR5 A;  4IKB B;  1KMD A;  2REA A;  4P2I A;  1XTN A;  2YPS A;  4OXW A;  3P0C A;  1OCU A;  3HPB A;  1O7K A;  4PZG A;  4IKB A;  1H6H A;  2L73 A;  2ETT A;  1XTE A;  2RAI A;  3FOG A;  4AZ9 A;  2WWE A;  2I4K A;  4BGJ A;  2IWL X;  2CZO A; 
#chains in the Genus database with same CATH topology
 4PQP A;  2DYB A;  2RAJ A;  4IKD A;  1GD5 A;  1KQ6 A;  3HPC X;  2RAK A;  4P2J A;  2V6V A;  3IQ2 A;  4HAS A;  2RED A;  3DYT A;  2CSK A;  4ON3 A;  4AKV A;  3LUI A;  2V14 A;  4PQO A;  1OCS A;  2AR5 A;  4IKB B;  1KMD A;  2REA A;  4P2I A;  1XTN A;  2YPS A;  4OXW A;  3P0C A;  1OCU A;  3HPB A;  1O7K A;  4PZG A;  4IKB A;  1H6H A;  2L73 A;  2ETT A;  1XTE A;  2RAI A;  3FOG A;  4AZ9 A;  2WWE A;  2I4K A;  4BGJ A;  2IWL X;  2CZO A; 
#chains in the Genus database with same CATH homology
 4PQP A;  2DYB A;  2RAJ A;  4IKD A;  1GD5 A;  1KQ6 A;  3HPC X;  2RAK A;  4P2J A;  2V6V A;  3IQ2 A;  4HAS A;  2RED A;  3DYT A;  2CSK A;  4ON3 A;  4AKV A;  3LUI A;  2V14 A;  4PQO A;  1OCS A;  2AR5 A;  4IKB B;  1KMD A;  2REA A;  4P2I A;  1XTN A;  2YPS A;  4OXW A;  3P0C A;  1OCU A;  3HPB A;  1O7K A;  4PZG A;  4IKB A;  1H6H A;  2L73 A;  2ETT A;  1XTE A;  2RAI A;  3FOG A;  4AZ9 A;  2WWE A;  2I4K A;  4BGJ A;  2IWL X;  2CZO A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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