2OUCA

Crystal structure of the map kinase binding domain of mkp5
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
142
structure length
132
Chain Sequence
KIIYPNDLAKKMTKPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSKE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Dual specificity protein phosphatase 10
total genus 48
structure length 132
sequence length 142
chains with identical sequence B
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2007-02-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 2oucA00
3IPOA 1YM9A 1WHBA 3FOJA 2J6PA 1RHSA 5HBPA 3I2VA 1ORBA 1YMKA 1OKGA 3IPPA 3AAXA 3I3UA 2JTSA 3TP9A 5HBLA 5LAMA 3TG1B 3ILMA 4WH7A 2EG4A 3MZZA 2JTQA 1C25A 3OP3A 2WLRA 1HZMA 5LAOA 5HBQA 2OUCA 3HIXA 1CWRA 3AAYA 1UARA 1TQ1A 2GWFA 2UZQA 3R2UA 1WV9A 2K0ZA 2WLXA 2DCQA 3NHVA 3GK5A 3O3WA 1RHDA 1GMXA 5HPAA 1BOIA 3ICRA 3IWHA 3NT6A 4WH9A 3F4AA 1QXNA 4JGTA 3FS5A 3ICSA 1BOHA 1E0CA 4OCGA 2FSXA 2KL3A 1CWTA 2MOLA 2ORAA 2IFVA 3FLHA 2A2KA 3K9RA 2JTRA 3OLHA 3D1PA 4F67A 1DP2A 2HHGA 1VEEA 2MOIA 3G5JA 3P3AA 1YMLA 3TG3A 2EG3A 3NTDA 3ICTA 3UTNX 1H4KX 3HZUA 1YMDA 1T3KA 2MRMA 3NTAA 3HWIA 1GN0A 3FNJA 5HBOA 1YS0A 2IFDA 1CWSA 2EG4B 1QB0A 2VSWA 1YT8A 1H4MX 1URHA
chains in the Genus database with same CATH superfamily
3IPOA 1YM9A 1WHBA 3FOJA 2J6PA 1RHSA 5HBPA 3I2VA 1ORBA 1YMKA 1OKGA 3IPPA 3AAXA 3I3UA 2JTSA 3TP9A 5HBLA 5LAMA 3TG1B 3ILMA 4WH7A 2EG4A 3MZZA 2JTQA 1C25A 3OP3A 2WLRA 1HZMA 5LAOA 5HBQA 2OUCA 3HIXA 1CWRA 3AAYA 1UARA 1TQ1A 2GWFA 2UZQA 3R2UA 1WV9A 2K0ZA 2WLXA 2DCQA 3NHVA 3GK5A 3O3WA 1RHDA 1GMXA 5HPAA 1BOIA 3ICRA 3IWHA 3NT6A 4WH9A 3F4AA 1QXNA 4JGTA 3FS5A 3ICSA 1BOHA 1E0CA 4OCGA 2FSXA 2KL3A 1CWTA 2MOLA 2ORAA 2IFVA 3FLHA 2A2KA 3K9RA 2JTRA 3OLHA 3D1PA 4F67A 1DP2A 2HHGA 1VEEA 2MOIA 3G5JA 3P3AA 1YMLA 3TG3A 2EG3A 3NTDA 3ICTA 3UTNX 1H4KX 3HZUA 1YMDA 1T3KA 2MRMA 3NTAA 2Q82A 3HWIA 1GN0A 3FNJA 5HBOA 1YS0A 2IFDA 1CWSA 2EG4B 1QB0A 2VSWA 1YT8A 1H4MX 1URHA
chains in the Genus database with same CATH topology
3IPOA 1YM9A 1WHBA 3FOJA 2J6PA 1RHSA 5HBPA 3I2VA 1ORBA 1YMKA 1OKGA 3IPPA 3AAXA 3I3UA 2JTSA 3TP9A 5HBLA 5LAMA 3TG1B 3ILMA 4WH7A 2EG4A 3MZZA 2JTQA 1C25A 3OP3A 2WLRA 1HZMA 5LAOA 5HBQA 2OUCA 3HIXA 1CWRA 3AAYA 1UARA 1TQ1A 2GWFA 2UZQA 3R2UA 1WV9A 2K0ZA 2WLXA 2DCQA 3NHVA 3GK5A 3O3WA 1RHDA 1GMXA 5HPAA 1BOIA 3ICRA 3IWHA 3NT6A 4WH9A 3F4AA 1QXNA 4JGTA 3FS5A 3ICSA 1BOHA 1E0CA 4OCGA 2FSXA 2KL3A 1CWTA 2MOLA 2ORAA 2IFVA 3FLHA 2A2KA 3K9RA 2JTRA 3OLHA 3D1PA 4F67A 1DP2A 2HHGA 1VEEA 2MOIA 3G5JA 3P3AA 1YMLA 3TG3A 2EG3A 3NTDA 3ICTA 3UTNX 1H4KX 3HZUA 1YMDA 1T3KA 2MRMA 3NTAA 3HWIA 1GN0A 3FNJA 5HBOA 1YS0A 2IFDA 1CWSA 2EG4B 1QB0A 2VSWA 1YT8A 1H4MX 1URHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IPO A;  1YM9 A;  1WHB A;  3FOJ A;  2J6P A;  1RHS A;  5HBP A;  3I2V A;  1ORB A;  1YMK A;  1OKG A;  3IPP A;  3AAX A;  3I3U A;  2JTS A;  3TP9 A;  5HBL A;  5LAM A;  3TG1 B;  3ILM A;  4WH7 A;  2EG4 A;  3MZZ A;  2JTQ A;  1C25 A;  3OP3 A;  2WLR A;  1HZM A;  5LAO A;  5HBQ A;  2OUC A;  3HIX A;  1CWR A;  3AAY A;  1UAR A;  1TQ1 A;  2GWF A;  2UZQ A;  3R2U A;  1WV9 A;  2K0Z A;  2WLX A;  2DCQ A;  3NHV A;  3GK5 A;  3O3W A;  1RHD A;  1GMX A;  5HPA A;  1BOI A;  3ICR A;  3IWH A;  3NT6 A;  4WH9 A;  3F4A A;  1QXN A;  4JGT A;  3FS5 A;  3ICS A;  1BOH A;  1E0C A;  4OCG A;  2FSX A;  2KL3 A;  1CWT A;  2MOL A;  2ORA A;  2IFV A;  3FLH A;  2A2K A;  3K9R A;  2JTR A;  3OLH A;  3D1P A;  4F67 A;  1DP2 A;  2HHG A;  1VEE A;  2MOI A;  3G5J A;  3P3A A;  1YML A;  3TG3 A;  2EG3 A;  3NTD A;  3ICT A;  3UTN X;  1H4K X;  3HZU A;  1YMD A;  1T3K A;  2MRM A;  3NTA A;  3HWI A;  1GN0 A;  3FNJ A;  5HBO A;  1YS0 A;  2IFD A;  1CWS A;  2EG4 B;  1QB0 A;  2VSW A;  1YT8 A;  1H4M X;  1URH A; 
#chains in the Genus database with same CATH topology
 3IPO A;  1YM9 A;  1WHB A;  3FOJ A;  2J6P A;  1RHS A;  5HBP A;  3I2V A;  1ORB A;  1YMK A;  1OKG A;  3IPP A;  3AAX A;  3I3U A;  2JTS A;  3TP9 A;  5HBL A;  5LAM A;  3TG1 B;  3ILM A;  4WH7 A;  2EG4 A;  3MZZ A;  2JTQ A;  1C25 A;  3OP3 A;  2WLR A;  1HZM A;  5LAO A;  5HBQ A;  2OUC A;  3HIX A;  1CWR A;  3AAY A;  1UAR A;  1TQ1 A;  2GWF A;  2UZQ A;  3R2U A;  1WV9 A;  2K0Z A;  2WLX A;  2DCQ A;  3NHV A;  3GK5 A;  3O3W A;  1RHD A;  1GMX A;  5HPA A;  1BOI A;  3ICR A;  3IWH A;  3NT6 A;  4WH9 A;  3F4A A;  1QXN A;  4JGT A;  3FS5 A;  3ICS A;  1BOH A;  1E0C A;  4OCG A;  2FSX A;  2KL3 A;  1CWT A;  2MOL A;  2ORA A;  2IFV A;  3FLH A;  2A2K A;  3K9R A;  2JTR A;  3OLH A;  3D1P A;  4F67 A;  1DP2 A;  2HHG A;  1VEE A;  2MOI A;  3G5J A;  3P3A A;  1YML A;  3TG3 A;  2EG3 A;  3NTD A;  3ICT A;  3UTN X;  1H4K X;  3HZU A;  1YMD A;  1T3K A;  2MRM A;  3NTA A;  2Q82 A;  3HWI A;  1GN0 A;  3FNJ A;  5HBO A;  1YS0 A;  2IFD A;  1CWS A;  2EG4 B;  1QB0 A;  2VSW A;  1YT8 A;  1H4M X;  1URH A; 
#chains in the Genus database with same CATH homology
 3IPO A;  1YM9 A;  1WHB A;  3FOJ A;  2J6P A;  1RHS A;  5HBP A;  3I2V A;  1ORB A;  1YMK A;  1OKG A;  3IPP A;  3AAX A;  3I3U A;  2JTS A;  3TP9 A;  5HBL A;  5LAM A;  3TG1 B;  3ILM A;  4WH7 A;  2EG4 A;  3MZZ A;  2JTQ A;  1C25 A;  3OP3 A;  2WLR A;  1HZM A;  5LAO A;  5HBQ A;  2OUC A;  3HIX A;  1CWR A;  3AAY A;  1UAR A;  1TQ1 A;  2GWF A;  2UZQ A;  3R2U A;  1WV9 A;  2K0Z A;  2WLX A;  2DCQ A;  3NHV A;  3GK5 A;  3O3W A;  1RHD A;  1GMX A;  5HPA A;  1BOI A;  3ICR A;  3IWH A;  3NT6 A;  4WH9 A;  3F4A A;  1QXN A;  4JGT A;  3FS5 A;  3ICS A;  1BOH A;  1E0C A;  4OCG A;  2FSX A;  2KL3 A;  1CWT A;  2MOL A;  2ORA A;  2IFV A;  3FLH A;  2A2K A;  3K9R A;  2JTR A;  3OLH A;  3D1P A;  4F67 A;  1DP2 A;  2HHG A;  1VEE A;  2MOI A;  3G5J A;  3P3A A;  1YML A;  3TG3 A;  2EG3 A;  3NTD A;  3ICT A;  3UTN X;  1H4K X;  3HZU A;  1YMD A;  1T3K A;  2MRM A;  3NTA A;  3HWI A;  1GN0 A;  3FNJ A;  5HBO A;  1YS0 A;  2IFD A;  1CWS A;  2EG4 B;  1QB0 A;  2VSW A;  1YT8 A;  1H4M X;  1URH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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