2REAA

Crystal structures of c2alpha-pi3 kinase px-domain domain indicate conformational change associated with ligand binding.
Total Genus 30
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
116
structure length
116
Chain Sequence
DGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHGSHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containi
total genus 30
structure length 116
sequence length 116
ec nomenclature ec 2.7.1.154: Phosphatidylinositol-4-phosphate 3-kinase.
pdb deposition date 2007-09-26
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1520.10 Alpha Beta 2-Layer Sandwich PX Domain Phox-like domain 2reaA00
3IQ2A 1XTEA 4OXWA 3DYTA 4PQOA 2V14A 4IKDA 1KQ6A 2RAKA 1OCSA 1O7KA 3HPCX 2CZOA 2IWLX 2RAJA 4IKBB 4PQPA 3P0CA 3HPBA 2CSKA 1KMDA 1OCUA 2REAA 2YPSA 4ON3A 2RAIA 2ETTA 4PZGA 1H6HA 3LUIA 4BGJA 2REDA 4HASA 4IKBA 2V6VA 3FOGA 4AKVA 2AR5A 4P2IA 4AZ9A 1XTNA 1GD5A 2L73A 2WWEA 2DYBA 4P2JA 2I4KA
chains in the Genus database with same CATH superfamily
3IQ2A 1XTEA 4OXWA 3DYTA 4PQOA 2V14A 4IKDA 1KQ6A 2RAKA 1OCSA 1O7KA 3HPCX 2CZOA 2IWLX 2RAJA 4IKBB 4PQPA 3P0CA 3HPBA 2CSKA 1KMDA 1OCUA 2REAA 2YPSA 4ON3A 2RAIA 2ETTA 4PZGA 1H6HA 3LUIA 4BGJA 2REDA 4HASA 4IKBA 2V6VA 3FOGA 4AKVA 2AR5A 4P2IA 4AZ9A 1XTNA 1GD5A 2L73A 2WWEA 2DYBA 4P2JA 2I4KA
chains in the Genus database with same CATH topology
3IQ2A 1XTEA 4OXWA 3DYTA 4PQOA 2V14A 4IKDA 1KQ6A 2RAKA 1OCSA 1O7KA 3HPCX 2CZOA 2IWLX 2RAJA 4IKBB 4PQPA 3P0CA 3HPBA 2CSKA 1KMDA 1OCUA 2REAA 2YPSA 4ON3A 2RAIA 2ETTA 4PZGA 1H6HA 3LUIA 4BGJA 2REDA 4HASA 4IKBA 2V6VA 3FOGA 4AKVA 2AR5A 4P2IA 4AZ9A 1XTNA 1GD5A 2L73A 2WWEA 2DYBA 4P2JA 2I4KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IQ2 A;  1XTE A;  4OXW A;  3DYT A;  4PQO A;  2V14 A;  4IKD A;  1KQ6 A;  2RAK A;  1OCS A;  1O7K A;  3HPC X;  2CZO A;  2IWL X;  2RAJ A;  4IKB B;  4PQP A;  3P0C A;  3HPB A;  2CSK A;  1KMD A;  1OCU A;  2REA A;  2YPS A;  4ON3 A;  2RAI A;  2ETT A;  4PZG A;  1H6H A;  3LUI A;  4BGJ A;  2RED A;  4HAS A;  4IKB A;  2V6V A;  3FOG A;  4AKV A;  2AR5 A;  4P2I A;  4AZ9 A;  1XTN A;  1GD5 A;  2L73 A;  2WWE A;  2DYB A;  4P2J A;  2I4K A; 
#chains in the Genus database with same CATH topology
 3IQ2 A;  1XTE A;  4OXW A;  3DYT A;  4PQO A;  2V14 A;  4IKD A;  1KQ6 A;  2RAK A;  1OCS A;  1O7K A;  3HPC X;  2CZO A;  2IWL X;  2RAJ A;  4IKB B;  4PQP A;  3P0C A;  3HPB A;  2CSK A;  1KMD A;  1OCU A;  2REA A;  2YPS A;  4ON3 A;  2RAI A;  2ETT A;  4PZG A;  1H6H A;  3LUI A;  4BGJ A;  2RED A;  4HAS A;  4IKB A;  2V6V A;  3FOG A;  4AKV A;  2AR5 A;  4P2I A;  4AZ9 A;  1XTN A;  1GD5 A;  2L73 A;  2WWE A;  2DYB A;  4P2J A;  2I4K A; 
#chains in the Genus database with same CATH homology
 3IQ2 A;  1XTE A;  4OXW A;  3DYT A;  4PQO A;  2V14 A;  4IKD A;  1KQ6 A;  2RAK A;  1OCS A;  1O7K A;  3HPC X;  2CZO A;  2IWL X;  2RAJ A;  4IKB B;  4PQP A;  3P0C A;  3HPB A;  2CSK A;  1KMD A;  1OCU A;  2REA A;  2YPS A;  4ON3 A;  2RAI A;  2ETT A;  4PZG A;  1H6H A;  3LUI A;  4BGJ A;  2RED A;  4HAS A;  4IKB A;  2V6V A;  3FOG A;  4AKV A;  2AR5 A;  4P2I A;  4AZ9 A;  1XTN A;  1GD5 A;  2L73 A;  2WWE A;  2DYB A;  4P2J A;  2I4K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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