2REAA

Crystal structures of c2alpha-pi3 kinase px-domain domain indicate conformational change associated with ligand binding.
Total Genus 30
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
116
structure length
116
Chain Sequence
DGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHGSHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containi
total genus 30
structure length 116
sequence length 116
ec nomenclature ec 2.7.1.154: Phosphatidylinositol-4-phosphate 3-kinase.
pdb deposition date 2007-09-26
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1520.10 Alpha Beta 2-Layer Sandwich PX Domain Phox-like domain 2reaA00
1H6HA 2RAJA 3FOGA 3IQ2A 1XTNA 4IKBB 2AR5A 4OXWA 2V6VA 4P2IA 2I4KA 2ETTA 2IWLX 4IKDA 2YPSA 1XTEA 2L73A 1O7KA 4AZ9A 3LUIA 2RAKA 1KMDA 4AKVA 4PZGA 3P0CA 1OCUA 4HASA 2CZOA 1OCSA 2CSKA 4PQPA 1KQ6A 4PQOA 4BGJA 2REAA 4ON3A 2WWEA 3HPCX 2REDA 2DYBA 4IKBA 2RAIA 3DYTA 1GD5A 3HPBA 2V14A 4P2JA
chains in the Genus database with same CATH superfamily
1H6HA 2RAJA 3FOGA 3IQ2A 1XTNA 4IKBB 2AR5A 4OXWA 2V6VA 4P2IA 2I4KA 2ETTA 2IWLX 4IKDA 2YPSA 1XTEA 2L73A 1O7KA 4AZ9A 3LUIA 2RAKA 1KMDA 4AKVA 4PZGA 3P0CA 1OCUA 4HASA 2CZOA 1OCSA 2CSKA 4PQPA 1KQ6A 4PQOA 4BGJA 2REAA 4ON3A 2WWEA 3HPCX 2REDA 2DYBA 4IKBA 2RAIA 3DYTA 1GD5A 3HPBA 2V14A 4P2JA
chains in the Genus database with same CATH topology
1H6HA 2RAJA 3FOGA 3IQ2A 1XTNA 4IKBB 2AR5A 4OXWA 2V6VA 4P2IA 2I4KA 2ETTA 2IWLX 4IKDA 2YPSA 1XTEA 2L73A 1O7KA 4AZ9A 3LUIA 2RAKA 1KMDA 4AKVA 4PZGA 3P0CA 1OCUA 4HASA 2CZOA 1OCSA 2CSKA 4PQPA 1KQ6A 4PQOA 4BGJA 2REAA 4ON3A 2WWEA 3HPCX 2REDA 2DYBA 4IKBA 2RAIA 3DYTA 1GD5A 3HPBA 2V14A 4P2JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1H6H A;  2RAJ A;  3FOG A;  3IQ2 A;  1XTN A;  4IKB B;  2AR5 A;  4OXW A;  2V6V A;  4P2I A;  2I4K A;  2ETT A;  2IWL X;  4IKD A;  2YPS A;  1XTE A;  2L73 A;  1O7K A;  4AZ9 A;  3LUI A;  2RAK A;  1KMD A;  4AKV A;  4PZG A;  3P0C A;  1OCU A;  4HAS A;  2CZO A;  1OCS A;  2CSK A;  4PQP A;  1KQ6 A;  4PQO A;  4BGJ A;  2REA A;  4ON3 A;  2WWE A;  3HPC X;  2RED A;  2DYB A;  4IKB A;  2RAI A;  3DYT A;  1GD5 A;  3HPB A;  2V14 A;  4P2J A; 
#chains in the Genus database with same CATH topology
 1H6H A;  2RAJ A;  3FOG A;  3IQ2 A;  1XTN A;  4IKB B;  2AR5 A;  4OXW A;  2V6V A;  4P2I A;  2I4K A;  2ETT A;  2IWL X;  4IKD A;  2YPS A;  1XTE A;  2L73 A;  1O7K A;  4AZ9 A;  3LUI A;  2RAK A;  1KMD A;  4AKV A;  4PZG A;  3P0C A;  1OCU A;  4HAS A;  2CZO A;  1OCS A;  2CSK A;  4PQP A;  1KQ6 A;  4PQO A;  4BGJ A;  2REA A;  4ON3 A;  2WWE A;  3HPC X;  2RED A;  2DYB A;  4IKB A;  2RAI A;  3DYT A;  1GD5 A;  3HPB A;  2V14 A;  4P2J A; 
#chains in the Genus database with same CATH homology
 1H6H A;  2RAJ A;  3FOG A;  3IQ2 A;  1XTN A;  4IKB B;  2AR5 A;  4OXW A;  2V6V A;  4P2I A;  2I4K A;  2ETT A;  2IWL X;  4IKD A;  2YPS A;  1XTE A;  2L73 A;  1O7K A;  4AZ9 A;  3LUI A;  2RAK A;  1KMD A;  4AKV A;  4PZG A;  3P0C A;  1OCU A;  4HAS A;  2CZO A;  1OCS A;  2CSK A;  4PQP A;  1KQ6 A;  4PQO A;  4BGJ A;  2REA A;  4ON3 A;  2WWE A;  3HPC X;  2RED A;  2DYB A;  4IKB A;  2RAI A;  3DYT A;  1GD5 A;  3HPB A;  2V14 A;  4P2J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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