2REDA

Crystal structures of c2alpha-pi3 kinase px-domain domain indicate conformational change associated with ligand binding.
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
117
structure length
114
Chain Sequence
MDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHGSHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containi
total genus 27
structure length 114
sequence length 117
ec nomenclature ec 2.7.1.154: Phosphatidylinositol-4-phosphate 3-kinase.
pdb deposition date 2007-09-26
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1520.10 Alpha Beta 2-Layer Sandwich PX Domain Phox-like domain 2redA00
2I4KA 4P2JA 3P0CA 4IKDA 1H6HA 2YPSA 2REAA 2V6VA 4ON3A 4PQPA 3LUIA 1KMDA 4P2IA 2RAIA 1KQ6A 2CSKA 4HASA 4IKBB 2RAKA 2ETTA 2L73A 1OCUA 1XTNA 4PQOA 2REDA 3FOGA 4PZGA 3HPBA 3IQ2A 2AR5A 2DYBA 1OCSA 4AKVA 2IWLX 2V14A 4AZ9A 1GD5A 3HPCX 4OXWA 2RAJA 4IKBA 2WWEA 1XTEA 3DYTA 4BGJA 2CZOA 1O7KA
chains in the Genus database with same CATH superfamily
2I4KA 4P2JA 3P0CA 4IKDA 1H6HA 2YPSA 2REAA 2V6VA 4ON3A 4PQPA 3LUIA 1KMDA 4P2IA 2RAIA 1KQ6A 2CSKA 4HASA 4IKBB 2RAKA 2ETTA 2L73A 1OCUA 1XTNA 4PQOA 2REDA 3FOGA 4PZGA 3HPBA 3IQ2A 2AR5A 2DYBA 1OCSA 4AKVA 2IWLX 2V14A 4AZ9A 1GD5A 3HPCX 4OXWA 2RAJA 4IKBA 2WWEA 1XTEA 3DYTA 4BGJA 2CZOA 1O7KA
chains in the Genus database with same CATH topology
2I4KA 4P2JA 3P0CA 4IKDA 1H6HA 2YPSA 2REAA 2V6VA 4ON3A 4PQPA 3LUIA 1KMDA 4P2IA 2RAIA 1KQ6A 2CSKA 4HASA 4IKBB 2RAKA 2ETTA 2L73A 1OCUA 1XTNA 4PQOA 2REDA 3FOGA 4PZGA 3HPBA 3IQ2A 2AR5A 2DYBA 1OCSA 4AKVA 2IWLX 2V14A 4AZ9A 1GD5A 3HPCX 4OXWA 2RAJA 4IKBA 2WWEA 1XTEA 3DYTA 4BGJA 2CZOA 1O7KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2I4K A;  4P2J A;  3P0C A;  4IKD A;  1H6H A;  2YPS A;  2REA A;  2V6V A;  4ON3 A;  4PQP A;  3LUI A;  1KMD A;  4P2I A;  2RAI A;  1KQ6 A;  2CSK A;  4HAS A;  4IKB B;  2RAK A;  2ETT A;  2L73 A;  1OCU A;  1XTN A;  4PQO A;  2RED A;  3FOG A;  4PZG A;  3HPB A;  3IQ2 A;  2AR5 A;  2DYB A;  1OCS A;  4AKV A;  2IWL X;  2V14 A;  4AZ9 A;  1GD5 A;  3HPC X;  4OXW A;  2RAJ A;  4IKB A;  2WWE A;  1XTE A;  3DYT A;  4BGJ A;  2CZO A;  1O7K A; 
#chains in the Genus database with same CATH topology
 2I4K A;  4P2J A;  3P0C A;  4IKD A;  1H6H A;  2YPS A;  2REA A;  2V6V A;  4ON3 A;  4PQP A;  3LUI A;  1KMD A;  4P2I A;  2RAI A;  1KQ6 A;  2CSK A;  4HAS A;  4IKB B;  2RAK A;  2ETT A;  2L73 A;  1OCU A;  1XTN A;  4PQO A;  2RED A;  3FOG A;  4PZG A;  3HPB A;  3IQ2 A;  2AR5 A;  2DYB A;  1OCS A;  4AKV A;  2IWL X;  2V14 A;  4AZ9 A;  1GD5 A;  3HPC X;  4OXW A;  2RAJ A;  4IKB A;  2WWE A;  1XTE A;  3DYT A;  4BGJ A;  2CZO A;  1O7K A; 
#chains in the Genus database with same CATH homology
 2I4K A;  4P2J A;  3P0C A;  4IKD A;  1H6H A;  2YPS A;  2REA A;  2V6V A;  4ON3 A;  4PQP A;  3LUI A;  1KMD A;  4P2I A;  2RAI A;  1KQ6 A;  2CSK A;  4HAS A;  4IKB B;  2RAK A;  2ETT A;  2L73 A;  1OCU A;  1XTN A;  4PQO A;  2RED A;  3FOG A;  4PZG A;  3HPB A;  3IQ2 A;  2AR5 A;  2DYB A;  1OCS A;  4AKV A;  2IWL X;  2V14 A;  4AZ9 A;  1GD5 A;  3HPC X;  4OXW A;  2RAJ A;  4IKB A;  2WWE A;  1XTE A;  3DYT A;  4BGJ A;  2CZO A;  1O7K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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