2REDA

Crystal structures of c2alpha-pi3 kinase px-domain domain indicate conformational change associated with ligand binding.
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
117
structure length
114
Chain Sequence
MDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHGSHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containi
total genus 27
structure length 114
sequence length 117
ec nomenclature ec 2.7.1.154: Phosphatidylinositol-4-phosphate 3-kinase.
pdb deposition date 2007-09-26
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1520.10 Alpha Beta 2-Layer Sandwich PX Domain Phox-like domain 2redA00
3FOGA 4IKBB 1O7KA 3HPBA 4P2IA 4HASA 1XTNA 2ETTA 2I4KA 4AZ9A 1H6HA 2REDA 1OCSA 2V6VA 4ON3A 1OCUA 4IKDA 2RAJA 4P2JA 4PZGA 2RAIA 1XTEA 2IWLX 4PQPA 4OXWA 1KQ6A 2CSKA 2RAKA 1GD5A 2V14A 3DYTA 2WWEA 2DYBA 2CZOA 2YPSA 3HPCX 4IKBA 4PQOA 4AKVA 2AR5A 2REAA 4BGJA 1KMDA 3P0CA 3LUIA 3IQ2A 2L73A
chains in the Genus database with same CATH superfamily
3FOGA 4IKBB 1O7KA 3HPBA 4P2IA 4HASA 1XTNA 2ETTA 2I4KA 4AZ9A 1H6HA 2REDA 1OCSA 2V6VA 4ON3A 1OCUA 4IKDA 2RAJA 4P2JA 4PZGA 2RAIA 1XTEA 2IWLX 4PQPA 4OXWA 1KQ6A 2CSKA 2RAKA 1GD5A 2V14A 3DYTA 2WWEA 2DYBA 2CZOA 2YPSA 3HPCX 4IKBA 4PQOA 4AKVA 2AR5A 2REAA 4BGJA 1KMDA 3P0CA 3LUIA 3IQ2A 2L73A
chains in the Genus database with same CATH topology
3FOGA 4IKBB 1O7KA 3HPBA 4P2IA 4HASA 1XTNA 2ETTA 2I4KA 4AZ9A 1H6HA 2REDA 1OCSA 2V6VA 4ON3A 1OCUA 4IKDA 2RAJA 4P2JA 4PZGA 2RAIA 1XTEA 2IWLX 4PQPA 4OXWA 1KQ6A 2CSKA 2RAKA 1GD5A 2V14A 3DYTA 2WWEA 2DYBA 2CZOA 2YPSA 3HPCX 4IKBA 4PQOA 4AKVA 2AR5A 2REAA 4BGJA 1KMDA 3P0CA 3LUIA 3IQ2A 2L73A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FOG A;  4IKB B;  1O7K A;  3HPB A;  4P2I A;  4HAS A;  1XTN A;  2ETT A;  2I4K A;  4AZ9 A;  1H6H A;  2RED A;  1OCS A;  2V6V A;  4ON3 A;  1OCU A;  4IKD A;  2RAJ A;  4P2J A;  4PZG A;  2RAI A;  1XTE A;  2IWL X;  4PQP A;  4OXW A;  1KQ6 A;  2CSK A;  2RAK A;  1GD5 A;  2V14 A;  3DYT A;  2WWE A;  2DYB A;  2CZO A;  2YPS A;  3HPC X;  4IKB A;  4PQO A;  4AKV A;  2AR5 A;  2REA A;  4BGJ A;  1KMD A;  3P0C A;  3LUI A;  3IQ2 A;  2L73 A; 
#chains in the Genus database with same CATH topology
 3FOG A;  4IKB B;  1O7K A;  3HPB A;  4P2I A;  4HAS A;  1XTN A;  2ETT A;  2I4K A;  4AZ9 A;  1H6H A;  2RED A;  1OCS A;  2V6V A;  4ON3 A;  1OCU A;  4IKD A;  2RAJ A;  4P2J A;  4PZG A;  2RAI A;  1XTE A;  2IWL X;  4PQP A;  4OXW A;  1KQ6 A;  2CSK A;  2RAK A;  1GD5 A;  2V14 A;  3DYT A;  2WWE A;  2DYB A;  2CZO A;  2YPS A;  3HPC X;  4IKB A;  4PQO A;  4AKV A;  2AR5 A;  2REA A;  4BGJ A;  1KMD A;  3P0C A;  3LUI A;  3IQ2 A;  2L73 A; 
#chains in the Genus database with same CATH homology
 3FOG A;  4IKB B;  1O7K A;  3HPB A;  4P2I A;  4HAS A;  1XTN A;  2ETT A;  2I4K A;  4AZ9 A;  1H6H A;  2RED A;  1OCS A;  2V6V A;  4ON3 A;  1OCU A;  4IKD A;  2RAJ A;  4P2J A;  4PZG A;  2RAI A;  1XTE A;  2IWL X;  4PQP A;  4OXW A;  1KQ6 A;  2CSK A;  2RAK A;  1GD5 A;  2V14 A;  3DYT A;  2WWE A;  2DYB A;  2CZO A;  2YPS A;  3HPC X;  4IKB A;  4PQO A;  4AKV A;  2AR5 A;  2REA A;  4BGJ A;  1KMD A;  3P0C A;  3LUI A;  3IQ2 A;  2L73 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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