2WWE | Genus

Total Genus 35

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	35
sequence length	111
structure length	111
Chain Sequence	NLYFQSMSIERATILGFSKKSSNLYLIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLPEFPHWWHLPFTNSDHRRFRDLNHYMEQILNVSHEVTNSDCVLSFFLSE

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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The Resolver thinks Pdb

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reading 111 atoms

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111 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Transferase
source organism	Homo sapiens
publication title	Crystal Structure of the Phox Homology Domain of Human Phosphoinositide-3-Kinase-C2-Gamma rcsb
molecule keywords	PHOSPHOINOSITIDE-3-KINASE, CLASS 2, GAMMA POLYPEPTIDE
total genus	35
structure length	111
sequence length	111
ec nomenclature	ec 2.7.1.154: Phosphatidylinositol-4-phosphate 3-kinase.
pdb deposition date	2009-10-22

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00787	PX	PX domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.30.1520.10	Alpha Beta	2-Layer Sandwich	PX Domain	Phox-like domain	2wweA01

4IKDA 2REDA 1GD5A 4PQPA 2I4KA 3LUIA 4PQOA 2L73A 1OCSA 4OXWA 4PZGA 2V6VA 3FOGA 2RAJA 2AR5A 2IWLX 4IKBB 1XTEA 1KMDA 2CZOA 1O7KA 3P0CA 2RAKA 1OCUA 4HASA 2V14A 3DYTA 1XTNA 4P2IA 2ETTA 2WWEA 2CSKA 2YPSA 3HPBA 1H6HA 4IKBA 4ON3A 4AZ9A 2RAIA 4AKVA 4BGJA 2REAA 4P2JA 3IQ2A 3HPCX 1KQ6A 2DYBA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 4IKD A;  2RED A;  1GD5 A;  4PQP A;  2I4K A;  3LUI A;  4PQO A;  2L73 A;  1OCS A;  4OXW A;  4PZG A;  2V6V A;  3FOG A;  2RAJ A;  2AR5 A;  2IWL X;  4IKB B;  1XTE A;  1KMD A;  2CZO A;  1O7K A;  3P0C A;  2RAK A;  1OCU A;  4HAS A;  2V14 A;  3DYT A;  1XTN A;  4P2I A;  2ETT A;  2WWE A;  2CSK A;  2YPS A;  3HPB A;  1H6H A;  4IKB A;  4ON3 A;  4AZ9 A;  2RAI A;  4AKV A;  4BGJ A;  2REA A;  4P2J A;  3IQ2 A;  3HPC X;  1KQ6 A;  2DYB A; 
#chains in the Genus database with same CATH topology
 4IKD A;  2RED A;  1GD5 A;  4PQP A;  2I4K A;  3LUI A;  4PQO A;  2L73 A;  1OCS A;  4OXW A;  4PZG A;  2V6V A;  3FOG A;  2RAJ A;  2AR5 A;  2IWL X;  4IKB B;  1XTE A;  1KMD A;  2CZO A;  1O7K A;  3P0C A;  2RAK A;  1OCU A;  4HAS A;  2V14 A;  3DYT A;  1XTN A;  4P2I A;  2ETT A;  2WWE A;  2CSK A;  2YPS A;  3HPB A;  1H6H A;  4IKB A;  4ON3 A;  4AZ9 A;  2RAI A;  4AKV A;  4BGJ A;  2REA A;  4P2J A;  3IQ2 A;  3HPC X;  1KQ6 A;  2DYB A; 
#chains in the Genus database with same CATH homology
 4IKD A;  2RED A;  1GD5 A;  4PQP A;  2I4K A;  3LUI A;  4PQO A;  2L73 A;  1OCS A;  4OXW A;  4PZG A;  2V6V A;  3FOG A;  2RAJ A;  2AR5 A;  2IWL X;  4IKB B;  1XTE A;  1KMD A;  2CZO A;  1O7K A;  3P0C A;  2RAK A;  1OCU A;  4HAS A;  2V14 A;  3DYT A;  1XTN A;  4P2I A;  2ETT A;  2WWE A;  2CSK A;  2YPS A;  3HPB A;  1H6H A;  4IKB A;  4ON3 A;  4AZ9 A;  2RAI A;  4AKV A;  4BGJ A;  2REA A;  4P2J A;  3IQ2 A;  3HPC X;  1KQ6 A;  2DYB A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2WWEA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations