2OUCA

Crystal structure of the map kinase binding domain of mkp5
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
142
structure length
132
Chain Sequence
KIIYPNDLAKKMTKPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSKE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Dual specificity protein phosphatase 10
total genus 48
structure length 132
sequence length 142
chains with identical sequence B
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2007-02-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 2oucA00
2KL3A 1GN0A 1E0CA 5HPAA 1TQ1A 1UARA 3UTNX 4OCGA 3GK5A 3AAYA 5HBPA 1T3KA 1VEEA 3ILMA 2ORAA 1YM9A 4JGTA 3AAXA 2HHGA 2VSWA 1ORBA 1WV9A 1YMLA 2EG4A 3F4AA 3O3WA 2K0ZA 2EG4B 3FOJA 1GMXA 2IFDA 5HBQA 1H4MX 3NTAA 3HZUA 3ICRA 1QB0A 2OUCA 1HZMA 2GWFA 3G5JA 3IPOA 3ICSA 2UZQA 1URHA 2JTRA 3TG1B 3NT6A 3D1PA 3OLHA 5LAMA 3TP9A 1CWSA 3FS5A 3R2UA 1QXNA 1RHDA 1CWTA 2DCQA 2MRMA 3IPPA 3MZZA 1WHBA 2MOLA 4WH9A 3NHVA 3TG3A 2MOIA 2JTQA 2WLXA 1YT8A 1YMKA 3FNJA 3K9RA 1RHSA 3HIXA 2JTSA 2A2KA 3ICTA 2WLRA 5HBOA 2IFVA 3I3UA 1YMDA 1DP2A 3FLHA 1H4KX 5LAOA 3I2VA 1BOIA 1YS0A 2J6PA 2FSXA 4WH7A 2EG3A 3P3AA 3NTDA 3HWIA 1C25A 3OP3A 5HBLA 4F67A 1OKGA 3IWHA 1BOHA 1CWRA
chains in the Genus database with same CATH superfamily
2KL3A 1GN0A 1E0CA 5HPAA 1TQ1A 1UARA 3UTNX 4OCGA 3GK5A 3AAYA 5HBPA 1T3KA 1VEEA 3ILMA 2ORAA 1YM9A 4JGTA 3AAXA 2HHGA 2VSWA 1ORBA 1WV9A 1YMLA 2EG4A 3F4AA 3O3WA 2K0ZA 2EG4B 3FOJA 1GMXA 2IFDA 5HBQA 1H4MX 3NTAA 3HZUA 3ICRA 1QB0A 2OUCA 1HZMA 2GWFA 3G5JA 3IPOA 3ICSA 2UZQA 1URHA 2JTRA 3TG1B 3NT6A 3D1PA 3OLHA 5LAMA 3TP9A 1CWSA 3FS5A 3R2UA 1QXNA 1RHDA 1CWTA 2DCQA 2MRMA 3IPPA 3MZZA 1WHBA 2MOLA 4WH9A 3NHVA 3TG3A 2MOIA 2JTQA 2WLXA 1YT8A 1YMKA 3FNJA 3K9RA 1RHSA 3HIXA 2JTSA 2A2KA 3ICTA 2WLRA 5HBOA 2IFVA 3I3UA 1YMDA 1DP2A 3FLHA 1H4KX 5LAOA 3I2VA 1BOIA 1YS0A 2J6PA 2FSXA 2Q82A 4WH7A 2EG3A 3P3AA 3NTDA 3HWIA 1C25A 3OP3A 5HBLA 4F67A 1OKGA 3IWHA 1BOHA 1CWRA
chains in the Genus database with same CATH topology
2KL3A 1GN0A 1E0CA 5HPAA 1TQ1A 1UARA 3UTNX 4OCGA 3GK5A 3AAYA 5HBPA 1T3KA 1VEEA 3ILMA 2ORAA 1YM9A 4JGTA 3AAXA 2HHGA 2VSWA 1ORBA 1WV9A 1YMLA 2EG4A 3F4AA 3O3WA 2K0ZA 2EG4B 3FOJA 1GMXA 2IFDA 5HBQA 1H4MX 3NTAA 3HZUA 3ICRA 1QB0A 2OUCA 1HZMA 2GWFA 3G5JA 3IPOA 3ICSA 2UZQA 1URHA 2JTRA 3TG1B 3NT6A 3D1PA 3OLHA 5LAMA 3TP9A 1CWSA 3FS5A 3R2UA 1QXNA 1RHDA 1CWTA 2DCQA 2MRMA 3IPPA 3MZZA 1WHBA 2MOLA 4WH9A 3NHVA 3TG3A 2MOIA 2JTQA 2WLXA 1YT8A 1YMKA 3FNJA 3K9RA 1RHSA 3HIXA 2JTSA 2A2KA 3ICTA 2WLRA 5HBOA 2IFVA 3I3UA 1YMDA 1DP2A 3FLHA 1H4KX 5LAOA 3I2VA 1BOIA 1YS0A 2J6PA 2FSXA 4WH7A 2EG3A 3P3AA 3NTDA 3HWIA 1C25A 3OP3A 5HBLA 4F67A 1OKGA 3IWHA 1BOHA 1CWRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KL3 A;  1GN0 A;  1E0C A;  5HPA A;  1TQ1 A;  1UAR A;  3UTN X;  4OCG A;  3GK5 A;  3AAY A;  5HBP A;  1T3K A;  1VEE A;  3ILM A;  2ORA A;  1YM9 A;  4JGT A;  3AAX A;  2HHG A;  2VSW A;  1ORB A;  1WV9 A;  1YML A;  2EG4 A;  3F4A A;  3O3W A;  2K0Z A;  2EG4 B;  3FOJ A;  1GMX A;  2IFD A;  5HBQ A;  1H4M X;  3NTA A;  3HZU A;  3ICR A;  1QB0 A;  2OUC A;  1HZM A;  2GWF A;  3G5J A;  3IPO A;  3ICS A;  2UZQ A;  1URH A;  2JTR A;  3TG1 B;  3NT6 A;  3D1P A;  3OLH A;  5LAM A;  3TP9 A;  1CWS A;  3FS5 A;  3R2U A;  1QXN A;  1RHD A;  1CWT A;  2DCQ A;  2MRM A;  3IPP A;  3MZZ A;  1WHB A;  2MOL A;  4WH9 A;  3NHV A;  3TG3 A;  2MOI A;  2JTQ A;  2WLX A;  1YT8 A;  1YMK A;  3FNJ A;  3K9R A;  1RHS A;  3HIX A;  2JTS A;  2A2K A;  3ICT A;  2WLR A;  5HBO A;  2IFV A;  3I3U A;  1YMD A;  1DP2 A;  3FLH A;  1H4K X;  5LAO A;  3I2V A;  1BOI A;  1YS0 A;  2J6P A;  2FSX A;  4WH7 A;  2EG3 A;  3P3A A;  3NTD A;  3HWI A;  1C25 A;  3OP3 A;  5HBL A;  4F67 A;  1OKG A;  3IWH A;  1BOH A;  1CWR A; 
#chains in the Genus database with same CATH topology
 2KL3 A;  1GN0 A;  1E0C A;  5HPA A;  1TQ1 A;  1UAR A;  3UTN X;  4OCG A;  3GK5 A;  3AAY A;  5HBP A;  1T3K A;  1VEE A;  3ILM A;  2ORA A;  1YM9 A;  4JGT A;  3AAX A;  2HHG A;  2VSW A;  1ORB A;  1WV9 A;  1YML A;  2EG4 A;  3F4A A;  3O3W A;  2K0Z A;  2EG4 B;  3FOJ A;  1GMX A;  2IFD A;  5HBQ A;  1H4M X;  3NTA A;  3HZU A;  3ICR A;  1QB0 A;  2OUC A;  1HZM A;  2GWF A;  3G5J A;  3IPO A;  3ICS A;  2UZQ A;  1URH A;  2JTR A;  3TG1 B;  3NT6 A;  3D1P A;  3OLH A;  5LAM A;  3TP9 A;  1CWS A;  3FS5 A;  3R2U A;  1QXN A;  1RHD A;  1CWT A;  2DCQ A;  2MRM A;  3IPP A;  3MZZ A;  1WHB A;  2MOL A;  4WH9 A;  3NHV A;  3TG3 A;  2MOI A;  2JTQ A;  2WLX A;  1YT8 A;  1YMK A;  3FNJ A;  3K9R A;  1RHS A;  3HIX A;  2JTS A;  2A2K A;  3ICT A;  2WLR A;  5HBO A;  2IFV A;  3I3U A;  1YMD A;  1DP2 A;  3FLH A;  1H4K X;  5LAO A;  3I2V A;  1BOI A;  1YS0 A;  2J6P A;  2FSX A;  2Q82 A;  4WH7 A;  2EG3 A;  3P3A A;  3NTD A;  3HWI A;  1C25 A;  3OP3 A;  5HBL A;  4F67 A;  1OKG A;  3IWH A;  1BOH A;  1CWR A; 
#chains in the Genus database with same CATH homology
 2KL3 A;  1GN0 A;  1E0C A;  5HPA A;  1TQ1 A;  1UAR A;  3UTN X;  4OCG A;  3GK5 A;  3AAY A;  5HBP A;  1T3K A;  1VEE A;  3ILM A;  2ORA A;  1YM9 A;  4JGT A;  3AAX A;  2HHG A;  2VSW A;  1ORB A;  1WV9 A;  1YML A;  2EG4 A;  3F4A A;  3O3W A;  2K0Z A;  2EG4 B;  3FOJ A;  1GMX A;  2IFD A;  5HBQ A;  1H4M X;  3NTA A;  3HZU A;  3ICR A;  1QB0 A;  2OUC A;  1HZM A;  2GWF A;  3G5J A;  3IPO A;  3ICS A;  2UZQ A;  1URH A;  2JTR A;  3TG1 B;  3NT6 A;  3D1P A;  3OLH A;  5LAM A;  3TP9 A;  1CWS A;  3FS5 A;  3R2U A;  1QXN A;  1RHD A;  1CWT A;  2DCQ A;  2MRM A;  3IPP A;  3MZZ A;  1WHB A;  2MOL A;  4WH9 A;  3NHV A;  3TG3 A;  2MOI A;  2JTQ A;  2WLX A;  1YT8 A;  1YMK A;  3FNJ A;  3K9R A;  1RHS A;  3HIX A;  2JTS A;  2A2K A;  3ICT A;  2WLR A;  5HBO A;  2IFV A;  3I3U A;  1YMD A;  1DP2 A;  3FLH A;  1H4K X;  5LAO A;  3I2V A;  1BOI A;  1YS0 A;  2J6P A;  2FSX A;  4WH7 A;  2EG3 A;  3P3A A;  3NTD A;  3HWI A;  1C25 A;  3OP3 A;  5HBL A;  4F67 A;  1OKG A;  3IWH A;  1BOH A;  1CWR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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