3LBZA

Crystal structure of the bcl6 btb domain complexed with the small molecule inhibitor 79-6
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
122
structure length
122
Chain Sequence
SQIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKRNLSVINLDPEINPEGFNILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKAS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo.
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords B-cell lymphoma 6 protein
total genus 42
structure length 122
sequence length 122
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00651 BTB BTB/POZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.710.10 Alpha Beta 2-Layer Sandwich Potassium Channel Kv1.1; Chain A Potassium Channel Kv1.1; Chain A 3lbzA00
5BXBA 1BUOA 3E4UA 3M4TA 3OHVA 3M5BA 4J8ZA 4AWJB 3MKSA 4W9EB 1EODA 4W9KB 3DCGB 3V7DA 3ZTCB 5BXHA 4HXIA 4B95B 4CRHA 4JGHC 1LQBB 1P22B 3BIMA 5H7HA 4U77A 2I2RA 3GA1A 4UIJA 5BXDA 1FS2B 5DADA 3OGLA 4W9DB 3LUTB 3L2OA 2Q81A 4U2NA 4UYIA 2NZ0B 3M52A 2VKPA 3ZUNB 3OHUA 3LBZA 2R9RB 1EXBE 4W9IB 4EOZA 3ZTDB 2OVQA 4AJYC 5BO4C 2E31B 5LLIB 4B9KB 3C6NA 4WQOC 4CXTA 1FQVB 1S1GA 1R2BA 2IHCA 4CXIA 4BGCA 3ZNGB 2PPIA 4W9HB 1NN7A 3C6OA 4W9HH 2P1NA 3HVEA 4BKSB 1VCBB 5IBKA 1R29A 3KVTA 4W9CB 3OGKA 3I3NA 5DAFA 3LNMB 2ASTA 1A68A 5A6RA 2C9WC 2IF5A 3ZRCB 3WSOB 2Z8HA 1QDWA 2E32B 1FS1B 2NN2A 1HV2A 4U2MA 3FKCA 3B84A 4CP3A 5HYWB 2JZ3C 3HQIA 2VPKA 2YY9A 2P1PA 2OVRA 3HTMA 5EUPA 4W9GB 2MA9C 4JTAB 4W9FB 4CXJA 3M8VA 3ZRFB 3HU6A 2P1MA 1T1DA 4ZOUA 2OVPA 3ZKJB 3OGMA 4B9KE 1R28A 2P1OA 5H7GA 3DRZA 1LDKD 1LM8C 5JH5B 5FTAA 2IZVC 5HZGC 4JTDB 1CS3A 4W9LB 5A15A 4W9JB 1DSXA 2FNJC 1EOFA 4BKTB 2P1QA 1NEXA 2ASSA 1QDVA 3HVEB 4I6JC 4APFA 4N9F5 2A79B 1EOEA 4JTCB 4AP2A 3C6PA
chains in the Genus database with same CATH superfamily
5BXBA 1BUOA 3E4UA 3M4TA 3OHVA 3M5BA 4J8ZA 4AWJB 3MKSA 4W9EB 4YY8A 1EODA 4W9KB 3DCGB 3DRYA 3V7DA 3ZTCB 5BXHA 4HXIA 4B95B 4CRHA 4JGHC 1LQBB 1P22B 3BIMA 5H7HA 4U77A 2I2RA 3GA1A 4UIJA 5BXDA 1FS2B 5DADA 3OGLA 4W9DB 3LUTB 3L2OA 2Q81A 4U2NA 4UYIA 2NZ0B 3M52A 2VKPA 3ZUNB 3OHUA 3LBZA 2R9RB 1EXBE 4W9IB 4EOZA 3ZTDB 2OVQA 4AJYC 5BO4C 2E31B 5LLIB 4B9KB 3C6NA 4WQOC 4CXTA 3DRXA 1FQVB 1S1GA 1R2BA 2IHCA 4CXIA 4BGCA 3ZNGB 2PPIA 4W9HB 1NN7A 3C6OA 4W9HH 2P1NA 3HVEA 4BKSB 1VCBB 5IBKA 1R29A 3KVTA 4W9CB 3OGKA 3I3NA 5DAFA 3LNMB 2ASTA 1A68A 5A6RA 2C9WC 2IF5A 3ZRCB 3WSOB 2Z8HA 1QDWA 2E32B 1FS1B 2NN2A 1HV2A 4U2MA 3FKCA 3B84A 4CP3A 5HYWB 2JZ3C 3HQIA 2VPKA 2YY9A 2P1PA 2OVRA 3HTMA 5EUPA 4W9GB 2MA9C 4JTAB 4W9FB 4CXJA 3M8VA 3ZRFB 3HU6A 2P1MA 1T1DA 4ZOUA 2OVPA 3ZKJB 3OGMA 4B9KE 1R28A 2P1OA 5H7GA 3DRZA 1LDKD 1LM8C 5JH5B 5FTAA 2IZVC 5HZGC 4JTDB 1CS3A 4W9LB 5A15A 4W9JB 1DSXA 2FNJC 1EOFA 4BKTB 2P1QA 1NEXA 2ASSA 1QDVA 3HVEB 4ZGCA 4I6JC 4APFA 4N9F5 2A79B 1EOEA 4JTCB 4AP2A 3C6PA
chains in the Genus database with same CATH topology
5BXBA 1BUOA 3E4UA 3M4TA 3OHVA 3M5BA 4J8ZA 4AWJB 3MKSA 4W9EB 4YY8A 1EODA 4W9KB 3DCGB 3DRYA 3V7DA 3ZTCB 5BXHA 4HXIA 4B95B 4CRHA 4JGHC 1LQBB 1P22B 3BIMA 5H7HA 4U77A 2I2RA 3GA1A 4UIJA 5BXDA 1FS2B 5DADA 3OGLA 4W9DB 3LUTB 3L2OA 2Q81A 4U2NA 4UYIA 2NZ0B 3M52A 2VKPA 3ZUNB 3OHUA 3LBZA 2R9RB 1EXBE 4W9IB 4EOZA 3ZTDB 2OVQA 4AJYC 5BO4C 2E31B 5LLIB 4B9KB 3C6NA 4WQOC 4CXTA 3DRXA 1FQVB 1S1GA 1R2BA 2IHCA 4CXIA 4BGCA 3ZNGB 2PPIA 4W9HB 1NN7A 3C6OA 4W9HH 2P1NA 3HVEA 4BKSB 1VCBB 5IBKA 1R29A 3KVTA 4W9CB 3OGKA 3I3NA 5DAFA 3LNMB 2ASTA 1A68A 5A6RA 2C9WC 2IF5A 3ZRCB 3WSOB 2Z8HA 1QDWA 2E32B 1FS1B 2NN2A 1HV2A 4U2MA 3FKCA 3B84A 4CP3A 5HYWB 2JZ3C 3HQIA 2VPKA 2YY9A 2P1PA 2OVRA 3HTMA 5EUPA 4W9GB 2MA9C 4JTAB 4W9FB 4CXJA 3M8VA 3ZRFB 3HU6A 2P1MA 1T1DA 4ZOUA 2OVPA 3ZKJB 3OGMA 4B9KE 1R28A 2P1OA 5H7GA 3DRZA 1LDKD 1LM8C 5JH5B 5FTAA 2IZVC 5HZGC 4JTDB 1CS3A 4W9LB 5A15A 4W9JB 1DSXA 2FNJC 1EOFA 4BKTB 2P1QA 1NEXA 2ASSA 1QDVA 3HVEB 4ZGCA 4I6JC 4APFA 4N9F5 2A79B 1EOEA 4JTCB 4AP2A 3C6PA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5BXB A;  1BUO A;  3E4U A;  3M4T A;  3OHV A;  3M5B A;  4J8Z A;  4AWJ B;  3MKS A;  4W9E B;  1EOD A;  4W9K B;  3DCG B;  3V7D A;  3ZTC B;  5BXH A;  4HXI A;  4B95 B;  4CRH A;  4JGH C;  1LQB B;  1P22 B;  3BIM A;  5H7H A;  4U77 A;  2I2R A;  3GA1 A;  4UIJ A;  5BXD A;  1FS2 B;  5DAD A;  3OGL A;  4W9D B;  3LUT B;  3L2O A;  2Q81 A;  4U2N A;  4UYI A;  2NZ0 B;  3M52 A;  2VKP A;  3ZUN B;  3OHU A;  3LBZ A;  2R9R B;  1EXB E;  4W9I B;  4EOZ A;  3ZTD B;  2OVQ A;  4AJY C;  5BO4 C;  2E31 B;  5LLI B;  4B9K B;  3C6N A;  4WQO C;  4CXT A;  1FQV B;  1S1G A;  1R2B A;  2IHC A;  4CXI A;  4BGC A;  3ZNG B;  2PPI A;  4W9H B;  1NN7 A;  3C6O A;  4W9H H;  2P1N A;  3HVE A;  4BKS B;  1VCB B;  5IBK A;  1R29 A;  3KVT A;  4W9C B;  3OGK A;  3I3N A;  5DAF A;  3LNM B;  2AST A;  1A68 A;  5A6R A;  2C9W C;  2IF5 A;  3ZRC B;  3WSO B;  2Z8H A;  1QDW A;  2E32 B;  1FS1 B;  2NN2 A;  1HV2 A;  4U2M A;  3FKC A;  3B84 A;  4CP3 A;  5HYW B;  2JZ3 C;  3HQI A;  2VPK A;  2YY9 A;  2P1P A;  2OVR A;  3HTM A;  5EUP A;  4W9G B;  2MA9 C;  4JTA B;  4W9F B;  4CXJ A;  3M8V A;  3ZRF B;  3HU6 A;  2P1M A;  1T1D A;  4ZOU A;  2OVP A;  3ZKJ B;  3OGM A;  4B9K E;  1R28 A;  2P1O A;  5H7G A;  3DRZ A;  1LDK D;  1LM8 C;  5JH5 B;  5FTA A;  2IZV C;  5HZG C;  4JTD B;  1CS3 A;  4W9L B;  5A15 A;  4W9J B;  1DSX A;  2FNJ C;  1EOF A;  4BKT B;  2P1Q A;  1NEX A;  2ASS A;  1QDV A;  3HVE B;  4I6J C;  4APF A;  4N9F 5;  2A79 B;  1EOE A;  4JTC B;  4AP2 A;  3C6P A; 
#chains in the Genus database with same CATH topology
 5BXB A;  1BUO A;  3E4U A;  3M4T A;  3OHV A;  3M5B A;  4J8Z A;  4AWJ B;  3MKS A;  4W9E B;  4YY8 A;  1EOD A;  4W9K B;  3DCG B;  3DRY A;  3V7D A;  3ZTC B;  5BXH A;  4HXI A;  4B95 B;  4CRH A;  4JGH C;  1LQB B;  1P22 B;  3BIM A;  5H7H A;  4U77 A;  2I2R A;  3GA1 A;  4UIJ A;  5BXD A;  1FS2 B;  5DAD A;  3OGL A;  4W9D B;  3LUT B;  3L2O A;  2Q81 A;  4U2N A;  4UYI A;  2NZ0 B;  3M52 A;  2VKP A;  3ZUN B;  3OHU A;  3LBZ A;  2R9R B;  1EXB E;  4W9I B;  4EOZ A;  3ZTD B;  2OVQ A;  4AJY C;  5BO4 C;  2E31 B;  5LLI B;  4B9K B;  3C6N A;  4WQO C;  4CXT A;  3DRX A;  1FQV B;  1S1G A;  1R2B A;  2IHC A;  4CXI A;  4BGC A;  3ZNG B;  2PPI A;  4W9H B;  1NN7 A;  3C6O A;  4W9H H;  2P1N A;  3HVE A;  4BKS B;  1VCB B;  5IBK A;  1R29 A;  3KVT A;  4W9C B;  3OGK A;  3I3N A;  5DAF A;  3LNM B;  2AST A;  1A68 A;  5A6R A;  2C9W C;  2IF5 A;  3ZRC B;  3WSO B;  2Z8H A;  1QDW A;  2E32 B;  1FS1 B;  2NN2 A;  1HV2 A;  4U2M A;  3FKC A;  3B84 A;  4CP3 A;  5HYW B;  2JZ3 C;  3HQI A;  2VPK A;  2YY9 A;  2P1P A;  2OVR A;  3HTM A;  5EUP A;  4W9G B;  2MA9 C;  4JTA B;  4W9F B;  4CXJ A;  3M8V A;  3ZRF B;  3HU6 A;  2P1M A;  1T1D A;  4ZOU A;  2OVP A;  3ZKJ B;  3OGM A;  4B9K E;  1R28 A;  2P1O A;  5H7G A;  3DRZ A;  1LDK D;  1LM8 C;  5JH5 B;  5FTA A;  2IZV C;  5HZG C;  4JTD B;  1CS3 A;  4W9L B;  5A15 A;  4W9J B;  1DSX A;  2FNJ C;  1EOF A;  4BKT B;  2P1Q A;  1NEX A;  2ASS A;  1QDV A;  3HVE B;  4ZGC A;  4I6J C;  4APF A;  4N9F 5;  2A79 B;  1EOE A;  4JTC B;  4AP2 A;  3C6P A; 
#chains in the Genus database with same CATH homology
 5BXB A;  1BUO A;  3E4U A;  3M4T A;  3OHV A;  3M5B A;  4J8Z A;  4AWJ B;  3MKS A;  4W9E B;  4YY8 A;  1EOD A;  4W9K B;  3DCG B;  3DRY A;  3V7D A;  3ZTC B;  5BXH A;  4HXI A;  4B95 B;  4CRH A;  4JGH C;  1LQB B;  1P22 B;  3BIM A;  5H7H A;  4U77 A;  2I2R A;  3GA1 A;  4UIJ A;  5BXD A;  1FS2 B;  5DAD A;  3OGL A;  4W9D B;  3LUT B;  3L2O A;  2Q81 A;  4U2N A;  4UYI A;  2NZ0 B;  3M52 A;  2VKP A;  3ZUN B;  3OHU A;  3LBZ A;  2R9R B;  1EXB E;  4W9I B;  4EOZ A;  3ZTD B;  2OVQ A;  4AJY C;  5BO4 C;  2E31 B;  5LLI B;  4B9K B;  3C6N A;  4WQO C;  4CXT A;  3DRX A;  1FQV B;  1S1G A;  1R2B A;  2IHC A;  4CXI A;  4BGC A;  3ZNG B;  2PPI A;  4W9H B;  1NN7 A;  3C6O A;  4W9H H;  2P1N A;  3HVE A;  4BKS B;  1VCB B;  5IBK A;  1R29 A;  3KVT A;  4W9C B;  3OGK A;  3I3N A;  5DAF A;  3LNM B;  2AST A;  1A68 A;  5A6R A;  2C9W C;  2IF5 A;  3ZRC B;  3WSO B;  2Z8H A;  1QDW A;  2E32 B;  1FS1 B;  2NN2 A;  1HV2 A;  4U2M A;  3FKC A;  3B84 A;  4CP3 A;  5HYW B;  2JZ3 C;  3HQI A;  2VPK A;  2YY9 A;  2P1P A;  2OVR A;  3HTM A;  5EUP A;  4W9G B;  2MA9 C;  4JTA B;  4W9F B;  4CXJ A;  3M8V A;  3ZRF B;  3HU6 A;  2P1M A;  1T1D A;  4ZOU A;  2OVP A;  3ZKJ B;  3OGM A;  4B9K E;  1R28 A;  2P1O A;  5H7G A;  3DRZ A;  1LDK D;  1LM8 C;  5JH5 B;  5FTA A;  2IZV C;  5HZG C;  4JTD B;  1CS3 A;  4W9L B;  5A15 A;  4W9J B;  1DSX A;  2FNJ C;  1EOF A;  4BKT B;  2P1Q A;  1NEX A;  2ASS A;  1QDV A;  3HVE B;  4ZGC A;  4I6J C;  4APF A;  4N9F 5;  2A79 B;  1EOE A;  4JTC B;  4AP2 A;  3C6P A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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