3TG1B

Crystal structure of p38alpha in complex with a mapk docking partner
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
140
structure length
130
Chain Sequence
KIIYPNDLAKKMTKPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Distinct Interaction Mode Revealed by the Crystal Structure of the Kinase p38alpha with the MAPK Binding Domain of the Phosphatase MKP5.
pubmed doi rcsb
molecule tags Transferase/hydrolase
source organism Mus musculus
molecule keywords Mitogen-activated protein kinase 14
total genus 35
structure length 130
sequence length 140
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2011-08-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 3tg1B00
3UTNX 2JTRA 2J6PA 2ORAA 2K0ZA 3AAXA 2WLRA 3TG3A 1YMDA 3FLHA 3AAYA 1CWRA 3IPOA 3I3UA 2MOIA 3FNJA 1QB0A 3IWHA 2KL3A 1YS0A 2JTSA 2JTQA 1C25A 1YMLA 2FSXA 2DCQA 1YT8A 3NT6A 1RHSA 3FS5A 3MZZA 1UARA 1VEEA 1YMKA 5HBPA 1ORBA 3F4AA 1TQ1A 3TG1B 4WH9A 1YM9A 4OCGA 1RHDA 3D1PA 2MRMA 1BOHA 3ICTA 5HPAA 4JGTA 1WHBA 2IFVA 4WH7A 2WLXA 3NHVA 3K9RA 1OKGA 1CWTA 1E0CA 2EG4B 5LAOA 1BOIA 3OLHA 1WV9A 3GK5A 3NTDA 3P3AA 3O3WA 2GWFA 2OUCA 1CWSA 3HZUA 3ICSA 3TP9A 5LAMA 2UZQA 5HBQA 2EG4A 3ICRA 1T3KA 3I2VA 2VSWA 2HHGA 3G5JA 1H4MX 1GMXA 3FOJA 3ILMA 5HBOA 3IPPA 1H4KX 2IFDA 3HWIA 3OP3A 3R2UA 2A2KA 1GN0A 1HZMA 1URHA 2MOLA 1QXNA 2EG3A 1DP2A 3HIXA 5HBLA 3NTAA 4F67A
chains in the Genus database with same CATH superfamily
3UTNX 2JTRA 2J6PA 2ORAA 2K0ZA 3AAXA 2WLRA 3TG3A 1YMDA 3FLHA 3AAYA 1CWRA 3IPOA 3I3UA 2MOIA 3FNJA 1QB0A 3IWHA 2KL3A 1YS0A 2JTSA 2JTQA 1C25A 1YMLA 2FSXA 2DCQA 1YT8A 3NT6A 1RHSA 3FS5A 3MZZA 1UARA 1VEEA 1YMKA 5HBPA 1ORBA 3F4AA 1TQ1A 3TG1B 4WH9A 1YM9A 4OCGA 1RHDA 3D1PA 2MRMA 1BOHA 3ICTA 5HPAA 4JGTA 1WHBA 2IFVA 4WH7A 2WLXA 3NHVA 3K9RA 1OKGA 1CWTA 1E0CA 2EG4B 5LAOA 1BOIA 3OLHA 1WV9A 3GK5A 3NTDA 3P3AA 3O3WA 2GWFA 2OUCA 1CWSA 3HZUA 3ICSA 3TP9A 5LAMA 2UZQA 5HBQA 2EG4A 3ICRA 1T3KA 3I2VA 2VSWA 2HHGA 3G5JA 1H4MX 1GMXA 3FOJA 3ILMA 5HBOA 3IPPA 1H4KX 2IFDA 2Q82A 3HWIA 3OP3A 3R2UA 2A2KA 1GN0A 1HZMA 1URHA 2MOLA 1QXNA 2EG3A 1DP2A 3HIXA 5HBLA 3NTAA 4F67A
chains in the Genus database with same CATH topology
3UTNX 2JTRA 2J6PA 2ORAA 2K0ZA 3AAXA 2WLRA 3TG3A 1YMDA 3FLHA 3AAYA 1CWRA 3IPOA 3I3UA 2MOIA 3FNJA 1QB0A 3IWHA 2KL3A 1YS0A 2JTSA 2JTQA 1C25A 1YMLA 2FSXA 2DCQA 1YT8A 3NT6A 1RHSA 3FS5A 3MZZA 1UARA 1VEEA 1YMKA 5HBPA 1ORBA 3F4AA 1TQ1A 3TG1B 4WH9A 1YM9A 4OCGA 1RHDA 3D1PA 2MRMA 1BOHA 3ICTA 5HPAA 4JGTA 1WHBA 2IFVA 4WH7A 2WLXA 3NHVA 3K9RA 1OKGA 1CWTA 1E0CA 2EG4B 5LAOA 1BOIA 3OLHA 1WV9A 3GK5A 3NTDA 3P3AA 3O3WA 2GWFA 2OUCA 1CWSA 3HZUA 3ICSA 3TP9A 5LAMA 2UZQA 5HBQA 2EG4A 3ICRA 1T3KA 3I2VA 2VSWA 2HHGA 3G5JA 1H4MX 1GMXA 3FOJA 3ILMA 5HBOA 3IPPA 1H4KX 2IFDA 3HWIA 3OP3A 3R2UA 2A2KA 1GN0A 1HZMA 1URHA 2MOLA 1QXNA 2EG3A 1DP2A 3HIXA 5HBLA 3NTAA 4F67A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UTN X;  2JTR A;  2J6P A;  2ORA A;  2K0Z A;  3AAX A;  2WLR A;  3TG3 A;  1YMD A;  3FLH A;  3AAY A;  1CWR A;  3IPO A;  3I3U A;  2MOI A;  3FNJ A;  1QB0 A;  3IWH A;  2KL3 A;  1YS0 A;  2JTS A;  2JTQ A;  1C25 A;  1YML A;  2FSX A;  2DCQ A;  1YT8 A;  3NT6 A;  1RHS A;  3FS5 A;  3MZZ A;  1UAR A;  1VEE A;  1YMK A;  5HBP A;  1ORB A;  3F4A A;  1TQ1 A;  3TG1 B;  4WH9 A;  1YM9 A;  4OCG A;  1RHD A;  3D1P A;  2MRM A;  1BOH A;  3ICT A;  5HPA A;  4JGT A;  1WHB A;  2IFV A;  4WH7 A;  2WLX A;  3NHV A;  3K9R A;  1OKG A;  1CWT A;  1E0C A;  2EG4 B;  5LAO A;  1BOI A;  3OLH A;  1WV9 A;  3GK5 A;  3NTD A;  3P3A A;  3O3W A;  2GWF A;  2OUC A;  1CWS A;  3HZU A;  3ICS A;  3TP9 A;  5LAM A;  2UZQ A;  5HBQ A;  2EG4 A;  3ICR A;  1T3K A;  3I2V A;  2VSW A;  2HHG A;  3G5J A;  1H4M X;  1GMX A;  3FOJ A;  3ILM A;  5HBO A;  3IPP A;  1H4K X;  2IFD A;  3HWI A;  3OP3 A;  3R2U A;  2A2K A;  1GN0 A;  1HZM A;  1URH A;  2MOL A;  1QXN A;  2EG3 A;  1DP2 A;  3HIX A;  5HBL A;  3NTA A;  4F67 A; 
#chains in the Genus database with same CATH topology
 3UTN X;  2JTR A;  2J6P A;  2ORA A;  2K0Z A;  3AAX A;  2WLR A;  3TG3 A;  1YMD A;  3FLH A;  3AAY A;  1CWR A;  3IPO A;  3I3U A;  2MOI A;  3FNJ A;  1QB0 A;  3IWH A;  2KL3 A;  1YS0 A;  2JTS A;  2JTQ A;  1C25 A;  1YML A;  2FSX A;  2DCQ A;  1YT8 A;  3NT6 A;  1RHS A;  3FS5 A;  3MZZ A;  1UAR A;  1VEE A;  1YMK A;  5HBP A;  1ORB A;  3F4A A;  1TQ1 A;  3TG1 B;  4WH9 A;  1YM9 A;  4OCG A;  1RHD A;  3D1P A;  2MRM A;  1BOH A;  3ICT A;  5HPA A;  4JGT A;  1WHB A;  2IFV A;  4WH7 A;  2WLX A;  3NHV A;  3K9R A;  1OKG A;  1CWT A;  1E0C A;  2EG4 B;  5LAO A;  1BOI A;  3OLH A;  1WV9 A;  3GK5 A;  3NTD A;  3P3A A;  3O3W A;  2GWF A;  2OUC A;  1CWS A;  3HZU A;  3ICS A;  3TP9 A;  5LAM A;  2UZQ A;  5HBQ A;  2EG4 A;  3ICR A;  1T3K A;  3I2V A;  2VSW A;  2HHG A;  3G5J A;  1H4M X;  1GMX A;  3FOJ A;  3ILM A;  5HBO A;  3IPP A;  1H4K X;  2IFD A;  2Q82 A;  3HWI A;  3OP3 A;  3R2U A;  2A2K A;  1GN0 A;  1HZM A;  1URH A;  2MOL A;  1QXN A;  2EG3 A;  1DP2 A;  3HIX A;  5HBL A;  3NTA A;  4F67 A; 
#chains in the Genus database with same CATH homology
 3UTN X;  2JTR A;  2J6P A;  2ORA A;  2K0Z A;  3AAX A;  2WLR A;  3TG3 A;  1YMD A;  3FLH A;  3AAY A;  1CWR A;  3IPO A;  3I3U A;  2MOI A;  3FNJ A;  1QB0 A;  3IWH A;  2KL3 A;  1YS0 A;  2JTS A;  2JTQ A;  1C25 A;  1YML A;  2FSX A;  2DCQ A;  1YT8 A;  3NT6 A;  1RHS A;  3FS5 A;  3MZZ A;  1UAR A;  1VEE A;  1YMK A;  5HBP A;  1ORB A;  3F4A A;  1TQ1 A;  3TG1 B;  4WH9 A;  1YM9 A;  4OCG A;  1RHD A;  3D1P A;  2MRM A;  1BOH A;  3ICT A;  5HPA A;  4JGT A;  1WHB A;  2IFV A;  4WH7 A;  2WLX A;  3NHV A;  3K9R A;  1OKG A;  1CWT A;  1E0C A;  2EG4 B;  5LAO A;  1BOI A;  3OLH A;  1WV9 A;  3GK5 A;  3NTD A;  3P3A A;  3O3W A;  2GWF A;  2OUC A;  1CWS A;  3HZU A;  3ICS A;  3TP9 A;  5LAM A;  2UZQ A;  5HBQ A;  2EG4 A;  3ICR A;  1T3K A;  3I2V A;  2VSW A;  2HHG A;  3G5J A;  1H4M X;  1GMX A;  3FOJ A;  3ILM A;  5HBO A;  3IPP A;  1H4K X;  2IFD A;  3HWI A;  3OP3 A;  3R2U A;  2A2K A;  1GN0 A;  1HZM A;  1URH A;  2MOL A;  1QXN A;  2EG3 A;  1DP2 A;  3HIX A;  5HBL A;  3NTA A;  4F67 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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