3TG3A

Crystal structure of the mapk binding domain of mkp7
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
131
structure length
128
Chain Sequence
TQIVTERLVALLESGTEKVLLIDSRPFVEYNTSHILEAININCSKLMKRRLQQDKVLITELIQHSAKDIDCSQKVVVYDQSSQDVASLSSDCFLTVLLGKLEKSFNSVHLLAGGFAEFSRCFPGLCEG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Distinct Interaction Mode Revealed by the Crystal Structure of the Kinase p38alpha with the MAPK Binding Domain of the Phosphatase MKP5.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Dual specificity protein phosphatase 16
total genus 43
structure length 128
sequence length 131
chains with identical sequence B, C, D
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2011-08-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 3tg3A00
3IPPA 3I2VA 5HBOA 3OLHA 1WHBA 2K0ZA 3ICTA 1BOHA 2WLRA 5HBPA 2MOIA 3ICSA 1YT8A 1WV9A 3HIXA 3OP3A 5LAOA 3TP9A 3GK5A 3NT6A 1GN0A 5HBLA 1VEEA 1TQ1A 2FSXA 3I3UA 3K9RA 3FNJA 3ICRA 1C25A 2MRMA 1YMDA 1YMLA 3NTAA 5HPAA 2MOLA 3NTDA 2UZQA 4WH9A 2JTRA 2IFDA 3TG1B 1OKGA 2VSWA 3FS5A 3D1PA 2J6PA 1H4MX 3FLHA 5LAMA 1E0CA 1HZMA 1QB0A 3G5JA 4OCGA 1DP2A 1YM9A 3P3AA 1BOIA 2ORAA 1CWRA 2JTQA 1ORBA 3F4AA 1H4KX 4F67A 2KL3A 2EG4B 3AAXA 3HZUA 3ILMA 3UTNX 1RHSA 1T3KA 1YMKA 2WLXA 1YS0A 1QXNA 2GWFA 2EG3A 1URHA 2HHGA 1CWSA 2A2KA 3NHVA 3R2UA 3HWIA 3TG3A 3IWHA 1CWTA 3O3WA 3AAYA 2EG4A 2OUCA 1GMXA 1UARA 4WH7A 2DCQA 5HBQA 2JTSA 3MZZA 4JGTA 3IPOA 3FOJA 2IFVA 1RHDA
chains in the Genus database with same CATH superfamily
3IPPA 3I2VA 5HBOA 3OLHA 1WHBA 2K0ZA 3ICTA 1BOHA 2WLRA 5HBPA 2MOIA 3ICSA 1YT8A 1WV9A 3HIXA 3OP3A 5LAOA 3TP9A 3GK5A 3NT6A 1GN0A 5HBLA 1VEEA 1TQ1A 2FSXA 3I3UA 3K9RA 3FNJA 3ICRA 1C25A 2MRMA 1YMDA 1YMLA 3NTAA 5HPAA 2MOLA 3NTDA 2UZQA 4WH9A 2JTRA 2IFDA 3TG1B 1OKGA 2VSWA 3FS5A 3D1PA 2J6PA 1H4MX 3FLHA 5LAMA 1E0CA 1HZMA 1QB0A 3G5JA 4OCGA 1DP2A 2Q82A 1YM9A 3P3AA 1BOIA 2ORAA 1CWRA 2JTQA 1ORBA 3F4AA 1H4KX 4F67A 2KL3A 2EG4B 3AAXA 3HZUA 3ILMA 3UTNX 1RHSA 1T3KA 1YMKA 2WLXA 1YS0A 1QXNA 2GWFA 2EG3A 1URHA 2HHGA 1CWSA 2A2KA 3NHVA 3R2UA 3HWIA 3TG3A 3IWHA 1CWTA 3O3WA 3AAYA 2EG4A 2OUCA 1GMXA 1UARA 4WH7A 2DCQA 5HBQA 2JTSA 3MZZA 4JGTA 3IPOA 3FOJA 2IFVA 1RHDA
chains in the Genus database with same CATH topology
3IPPA 3I2VA 5HBOA 3OLHA 1WHBA 2K0ZA 3ICTA 1BOHA 2WLRA 5HBPA 2MOIA 3ICSA 1YT8A 1WV9A 3HIXA 3OP3A 5LAOA 3TP9A 3GK5A 3NT6A 1GN0A 5HBLA 1VEEA 1TQ1A 2FSXA 3I3UA 3K9RA 3FNJA 3ICRA 1C25A 2MRMA 1YMDA 1YMLA 3NTAA 5HPAA 2MOLA 3NTDA 2UZQA 4WH9A 2JTRA 2IFDA 3TG1B 1OKGA 2VSWA 3FS5A 3D1PA 2J6PA 1H4MX 3FLHA 5LAMA 1E0CA 1HZMA 1QB0A 3G5JA 4OCGA 1DP2A 1YM9A 3P3AA 1BOIA 2ORAA 1CWRA 2JTQA 1ORBA 3F4AA 1H4KX 4F67A 2KL3A 2EG4B 3AAXA 3HZUA 3ILMA 3UTNX 1RHSA 1T3KA 1YMKA 2WLXA 1YS0A 1QXNA 2GWFA 2EG3A 1URHA 2HHGA 1CWSA 2A2KA 3NHVA 3R2UA 3HWIA 3TG3A 3IWHA 1CWTA 3O3WA 3AAYA 2EG4A 2OUCA 1GMXA 1UARA 4WH7A 2DCQA 5HBQA 2JTSA 3MZZA 4JGTA 3IPOA 3FOJA 2IFVA 1RHDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IPP A;  3I2V A;  5HBO A;  3OLH A;  1WHB A;  2K0Z A;  3ICT A;  1BOH A;  2WLR A;  5HBP A;  2MOI A;  3ICS A;  1YT8 A;  1WV9 A;  3HIX A;  3OP3 A;  5LAO A;  3TP9 A;  3GK5 A;  3NT6 A;  1GN0 A;  5HBL A;  1VEE A;  1TQ1 A;  2FSX A;  3I3U A;  3K9R A;  3FNJ A;  3ICR A;  1C25 A;  2MRM A;  1YMD A;  1YML A;  3NTA A;  5HPA A;  2MOL A;  3NTD A;  2UZQ A;  4WH9 A;  2JTR A;  2IFD A;  3TG1 B;  1OKG A;  2VSW A;  3FS5 A;  3D1P A;  2J6P A;  1H4M X;  3FLH A;  5LAM A;  1E0C A;  1HZM A;  1QB0 A;  3G5J A;  4OCG A;  1DP2 A;  1YM9 A;  3P3A A;  1BOI A;  2ORA A;  1CWR A;  2JTQ A;  1ORB A;  3F4A A;  1H4K X;  4F67 A;  2KL3 A;  2EG4 B;  3AAX A;  3HZU A;  3ILM A;  3UTN X;  1RHS A;  1T3K A;  1YMK A;  2WLX A;  1YS0 A;  1QXN A;  2GWF A;  2EG3 A;  1URH A;  2HHG A;  1CWS A;  2A2K A;  3NHV A;  3R2U A;  3HWI A;  3TG3 A;  3IWH A;  1CWT A;  3O3W A;  3AAY A;  2EG4 A;  2OUC A;  1GMX A;  1UAR A;  4WH7 A;  2DCQ A;  5HBQ A;  2JTS A;  3MZZ A;  4JGT A;  3IPO A;  3FOJ A;  2IFV A;  1RHD A; 
#chains in the Genus database with same CATH topology
 3IPP A;  3I2V A;  5HBO A;  3OLH A;  1WHB A;  2K0Z A;  3ICT A;  1BOH A;  2WLR A;  5HBP A;  2MOI A;  3ICS A;  1YT8 A;  1WV9 A;  3HIX A;  3OP3 A;  5LAO A;  3TP9 A;  3GK5 A;  3NT6 A;  1GN0 A;  5HBL A;  1VEE A;  1TQ1 A;  2FSX A;  3I3U A;  3K9R A;  3FNJ A;  3ICR A;  1C25 A;  2MRM A;  1YMD A;  1YML A;  3NTA A;  5HPA A;  2MOL A;  3NTD A;  2UZQ A;  4WH9 A;  2JTR A;  2IFD A;  3TG1 B;  1OKG A;  2VSW A;  3FS5 A;  3D1P A;  2J6P A;  1H4M X;  3FLH A;  5LAM A;  1E0C A;  1HZM A;  1QB0 A;  3G5J A;  4OCG A;  1DP2 A;  2Q82 A;  1YM9 A;  3P3A A;  1BOI A;  2ORA A;  1CWR A;  2JTQ A;  1ORB A;  3F4A A;  1H4K X;  4F67 A;  2KL3 A;  2EG4 B;  3AAX A;  3HZU A;  3ILM A;  3UTN X;  1RHS A;  1T3K A;  1YMK A;  2WLX A;  1YS0 A;  1QXN A;  2GWF A;  2EG3 A;  1URH A;  2HHG A;  1CWS A;  2A2K A;  3NHV A;  3R2U A;  3HWI A;  3TG3 A;  3IWH A;  1CWT A;  3O3W A;  3AAY A;  2EG4 A;  2OUC A;  1GMX A;  1UAR A;  4WH7 A;  2DCQ A;  5HBQ A;  2JTS A;  3MZZ A;  4JGT A;  3IPO A;  3FOJ A;  2IFV A;  1RHD A; 
#chains in the Genus database with same CATH homology
 3IPP A;  3I2V A;  5HBO A;  3OLH A;  1WHB A;  2K0Z A;  3ICT A;  1BOH A;  2WLR A;  5HBP A;  2MOI A;  3ICS A;  1YT8 A;  1WV9 A;  3HIX A;  3OP3 A;  5LAO A;  3TP9 A;  3GK5 A;  3NT6 A;  1GN0 A;  5HBL A;  1VEE A;  1TQ1 A;  2FSX A;  3I3U A;  3K9R A;  3FNJ A;  3ICR A;  1C25 A;  2MRM A;  1YMD A;  1YML A;  3NTA A;  5HPA A;  2MOL A;  3NTD A;  2UZQ A;  4WH9 A;  2JTR A;  2IFD A;  3TG1 B;  1OKG A;  2VSW A;  3FS5 A;  3D1P A;  2J6P A;  1H4M X;  3FLH A;  5LAM A;  1E0C A;  1HZM A;  1QB0 A;  3G5J A;  4OCG A;  1DP2 A;  1YM9 A;  3P3A A;  1BOI A;  2ORA A;  1CWR A;  2JTQ A;  1ORB A;  3F4A A;  1H4K X;  4F67 A;  2KL3 A;  2EG4 B;  3AAX A;  3HZU A;  3ILM A;  3UTN X;  1RHS A;  1T3K A;  1YMK A;  2WLX A;  1YS0 A;  1QXN A;  2GWF A;  2EG3 A;  1URH A;  2HHG A;  1CWS A;  2A2K A;  3NHV A;  3R2U A;  3HWI A;  3TG3 A;  3IWH A;  1CWT A;  3O3W A;  3AAY A;  2EG4 A;  2OUC A;  1GMX A;  1UAR A;  4WH7 A;  2DCQ A;  5HBQ A;  2JTS A;  3MZZ A;  4JGT A;  3IPO A;  3FOJ A;  2IFV A;  1RHD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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