4B95B

Pvhl-elob-elob-eloc complex_(2s,4r)-1-(2-chlorophenyl)carbonyl-n-[(4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide bound
Total Genus 29

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
96
structure length
87
Chain Sequence
MYVKLISSDGHEFIVKREHALTSGTIKAMLSTNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
S1 (18-22)TI1 (23-26)EMPTYS2 (28-32)AH2 (40-46)AH3 (67-83)S3 (59-61)TIV1 (83-86)AH1 (33-37)Updating...
connected with : NaN
molecule tags Transcription
source organism Homo sapiens
publication title Small-Molecule Inhibitors of the Interaction between the E3 Ligase Vhl and Hif1Alpha
pubmed doi rcsb
molecule keywords TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2
total genus 29
structure length 87
sequence length 96
chains with identical sequence E, H, K
ec nomenclature
pdb deposition date 2012-08-31
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.710.10 Alpha Beta 2-Layer Sandwich Potassium Channel Kv1.1; Chain A Potassium Channel Kv1.1; Chain A 4b95B00
3OGMA 1P22B 5H7HA 4W9EB 3HU6A 5IBKA 1R28A 2JZ3C 4W9FB 1EODA 4WQOC 4CXJA 3HVEA 2P1MA 4W9IB 2P1PA 3DRZA 2P1OA 1T1DA 4U2NA 4AP2A 4B9KB 3I3NA 2Z8HA 3OHUA 2Q81A 1CS3A 5DADA 4U2MA 3ZRFB 2E31B 3M4TA 3HTMA 4JGHC 1A68A 3E4UA 4CRHA 3ZRCB 3LNMB 4HXIA 4I6JC 2R9RB 3DCGB 5BXBA 4AWJB 2NZ0B 3GA1A 4W9CB 1QDVA 3C6NA 1EXBE 2MA9C 1HV2A 1EOFA 3V7DA 1VCBB 4JTDB 2YY9A 2P1NA 2I2RA 2OVRA 4CXIA 4W9HH 4J8ZA 3BIMA 4B9KE 5BO4C 4B95B 4JTAB 1R2BA 2PPIA 1FS2B 4ZOUA 3KVTA 2C9WC 1BUOA 4BKTB 3WSOB 3ZTDB 2IF5A 4BKSB 1DSXA 5EUPA 3ZUNB 2VPKA 3M8VA 4CXTA 4EOZA 4W9JB 3ZNGB 2A79B 5BXDA 4W9HB 3M5BA 2E32B 3C6PA 3LBZA 3FKCA 3LUTB 3M52A 5HZGC 4N9F5 5A15A 3MKSA 1R29A 5HYWB 2VKPA 3C6OA 3OGKA 4UYIA 3L2OA 3OGLA 1NEXA 3OHVA 2OVQA 5FTAA 2NN2A 1QDWA 4UIJA 3HQIA 4U77A 2FNJC 3B84A 2ASSA 5H7GA 1FQVB 4CP3A 4AJYC 2ASTA 4W9DB 4W9LB 5A6RA 5BXHA 1S1GA 2P1QA 5DAFA 4APFA 4W9GB 3ZKJB 3HVEB 1NN7A 2IZVC 4JTCB 4W9KB 1LDKD 3ZTCB 5JH5B 2OVPA 5LLIB 1FS1B 4BGCA 1LM8C 1LQBB 1EOEA 2IHCA
chains in the Genus database with same CATH superfamily
3OGMA 3DRXA 1P22B 5H7HA 4W9EB 3HU6A 5IBKA 1R28A 2JZ3C 4W9FB 1EODA 4YY8A 4WQOC 4CXJA 3HVEA 2P1MA 4W9IB 2P1PA 3DRZA 2P1OA 1T1DA 4U2NA 4AP2A 4B9KB 3I3NA 2Z8HA 3OHUA 2Q81A 1CS3A 5DADA 4U2MA 3ZRFB 2E31B 3M4TA 3HTMA 4JGHC 1A68A 3E4UA 4CRHA 3ZRCB 3LNMB 4HXIA 4I6JC 2R9RB 3DCGB 5BXBA 4AWJB 2NZ0B 3GA1A 4W9CB 1QDVA 3C6NA 1EXBE 2MA9C 1HV2A 1EOFA 3V7DA 1VCBB 4JTDB 2YY9A 2P1NA 2I2RA 2OVRA 4CXIA 3DRYA 4W9HH 4J8ZA 3BIMA 4B9KE 5BO4C 4B95B 4JTAB 1R2BA 2PPIA 1FS2B 4ZOUA 3KVTA 2C9WC 1BUOA 4BKTB 3WSOB 3ZTDB 2IF5A 4BKSB 1DSXA 5EUPA 3ZUNB 2VPKA 3M8VA 4CXTA 4EOZA 4W9JB 3ZNGB 2A79B 5BXDA 4W9HB 3M5BA 2E32B 3C6PA 3LBZA 3FKCA 3LUTB 3M52A 5HZGC 4N9F5 5A15A 3MKSA 1R29A 5HYWB 2VKPA 3C6OA 3OGKA 4UYIA 3L2OA 3OGLA 1NEXA 3OHVA 2OVQA 5FTAA 2NN2A 1QDWA 4ZGCA 4UIJA 3HQIA 4U77A 2FNJC 3B84A 2ASSA 5H7GA 1FQVB 4CP3A 4AJYC 2ASTA 4W9DB 4W9LB 5A6RA 5BXHA 1S1GA 2P1QA 5DAFA 4APFA 4W9GB 3ZKJB 3HVEB 1NN7A 2IZVC 4JTCB 4W9KB 1LDKD 3ZTCB 5JH5B 2OVPA 5LLIB 1FS1B 4BGCA 1LM8C 1LQBB 1EOEA 2IHCA
chains in the Genus database with same CATH topology
3OGMA 3DRXA 1P22B 5H7HA 4W9EB 3HU6A 5IBKA 1R28A 2JZ3C 4W9FB 1EODA 4YY8A 4WQOC 4CXJA 3HVEA 2P1MA 4W9IB 2P1PA 3DRZA 2P1OA 1T1DA 4U2NA 4AP2A 4B9KB 3I3NA 2Z8HA 3OHUA 2Q81A 1CS3A 5DADA 4U2MA 3ZRFB 2E31B 3M4TA 3HTMA 4JGHC 1A68A 3E4UA 4CRHA 3ZRCB 3LNMB 4HXIA 4I6JC 2R9RB 3DCGB 5BXBA 4AWJB 2NZ0B 3GA1A 4W9CB 1QDVA 3C6NA 1EXBE 2MA9C 1HV2A 1EOFA 3V7DA 1VCBB 4JTDB 2YY9A 2P1NA 2I2RA 2OVRA 4CXIA 3DRYA 4W9HH 4J8ZA 3BIMA 4B9KE 5BO4C 4B95B 4JTAB 1R2BA 2PPIA 1FS2B 4ZOUA 3KVTA 2C9WC 1BUOA 4BKTB 3WSOB 3ZTDB 2IF5A 4BKSB 1DSXA 5EUPA 3ZUNB 2VPKA 3M8VA 4CXTA 4EOZA 4W9JB 3ZNGB 2A79B 5BXDA 4W9HB 3M5BA 2E32B 3C6PA 3LBZA 3FKCA 3LUTB 3M52A 5HZGC 4N9F5 5A15A 3MKSA 1R29A 5HYWB 2VKPA 3C6OA 3OGKA 4UYIA 3L2OA 3OGLA 1NEXA 3OHVA 2OVQA 5FTAA 2NN2A 1QDWA 4ZGCA 4UIJA 3HQIA 4U77A 2FNJC 3B84A 2ASSA 5H7GA 1FQVB 4CP3A 4AJYC 2ASTA 4W9DB 4W9LB 5A6RA 5BXHA 1S1GA 2P1QA 5DAFA 4APFA 4W9GB 3ZKJB 3HVEB 1NN7A 2IZVC 4JTCB 4W9KB 1LDKD 3ZTCB 5JH5B 2OVPA 5LLIB 1FS1B 4BGCA 1LM8C 1LQBB 1EOEA 2IHCA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3OGM A;  1P22 B;  5H7H A;  4W9E B;  3HU6 A;  5IBK A;  1R28 A;  2JZ3 C;  4W9F B;  1EOD A;  4WQO C;  4CXJ A;  3HVE A;  2P1M A;  4W9I B;  2P1P A;  3DRZ A;  2P1O A;  1T1D A;  4U2N A;  4AP2 A;  4B9K B;  3I3N A;  2Z8H A;  3OHU A;  2Q81 A;  1CS3 A;  5DAD A;  4U2M A;  3ZRF B;  2E31 B;  3M4T A;  3HTM A;  4JGH C;  1A68 A;  3E4U A;  4CRH A;  3ZRC B;  3LNM B;  4HXI A;  4I6J C;  2R9R B;  3DCG B;  5BXB A;  4AWJ B;  2NZ0 B;  3GA1 A;  4W9C B;  1QDV A;  3C6N A;  1EXB E;  2MA9 C;  1HV2 A;  1EOF A;  3V7D A;  1VCB B;  4JTD B;  2YY9 A;  2P1N A;  2I2R A;  2OVR A;  4CXI A;  4W9H H;  4J8Z A;  3BIM A;  4B9K E;  5BO4 C;  4B95 B;  4JTA B;  1R2B A;  2PPI A;  1FS2 B;  4ZOU A;  3KVT A;  2C9W C;  1BUO A;  4BKT B;  3WSO B;  3ZTD B;  2IF5 A;  4BKS B;  1DSX A;  5EUP A;  3ZUN B;  2VPK A;  3M8V A;  4CXT A;  4EOZ A;  4W9J B;  3ZNG B;  2A79 B;  5BXD A;  4W9H B;  3M5B A;  2E32 B;  3C6P A;  3LBZ A;  3FKC A;  3LUT B;  3M52 A;  5HZG C;  4N9F 5;  5A15 A;  3MKS A;  1R29 A;  5HYW B;  2VKP A;  3C6O A;  3OGK A;  4UYI A;  3L2O A;  3OGL A;  1NEX A;  3OHV A;  2OVQ A;  5FTA A;  2NN2 A;  1QDW A;  4UIJ A;  3HQI A;  4U77 A;  2FNJ C;  3B84 A;  2ASS A;  5H7G A;  1FQV B;  4CP3 A;  4AJY C;  2AST A;  4W9D B;  4W9L B;  5A6R A;  5BXH A;  1S1G A;  2P1Q A;  5DAF A;  4APF A;  4W9G B;  3ZKJ B;  3HVE B;  1NN7 A;  2IZV C;  4JTC B;  4W9K B;  1LDK D;  3ZTC B;  5JH5 B;  2OVP A;  5LLI B;  1FS1 B;  4BGC A;  1LM8 C;  1LQB B;  1EOE A;  2IHC A; 
#chains in the Genus database with same CATH topology
 3OGM A;  3DRX A;  1P22 B;  5H7H A;  4W9E B;  3HU6 A;  5IBK A;  1R28 A;  2JZ3 C;  4W9F B;  1EOD A;  4YY8 A;  4WQO C;  4CXJ A;  3HVE A;  2P1M A;  4W9I B;  2P1P A;  3DRZ A;  2P1O A;  1T1D A;  4U2N A;  4AP2 A;  4B9K B;  3I3N A;  2Z8H A;  3OHU A;  2Q81 A;  1CS3 A;  5DAD A;  4U2M A;  3ZRF B;  2E31 B;  3M4T A;  3HTM A;  4JGH C;  1A68 A;  3E4U A;  4CRH A;  3ZRC B;  3LNM B;  4HXI A;  4I6J C;  2R9R B;  3DCG B;  5BXB A;  4AWJ B;  2NZ0 B;  3GA1 A;  4W9C B;  1QDV A;  3C6N A;  1EXB E;  2MA9 C;  1HV2 A;  1EOF A;  3V7D A;  1VCB B;  4JTD B;  2YY9 A;  2P1N A;  2I2R A;  2OVR A;  4CXI A;  3DRY A;  4W9H H;  4J8Z A;  3BIM A;  4B9K E;  5BO4 C;  4B95 B;  4JTA B;  1R2B A;  2PPI A;  1FS2 B;  4ZOU A;  3KVT A;  2C9W C;  1BUO A;  4BKT B;  3WSO B;  3ZTD B;  2IF5 A;  4BKS B;  1DSX A;  5EUP A;  3ZUN B;  2VPK A;  3M8V A;  4CXT A;  4EOZ A;  4W9J B;  3ZNG B;  2A79 B;  5BXD A;  4W9H B;  3M5B A;  2E32 B;  3C6P A;  3LBZ A;  3FKC A;  3LUT B;  3M52 A;  5HZG C;  4N9F 5;  5A15 A;  3MKS A;  1R29 A;  5HYW B;  2VKP A;  3C6O A;  3OGK A;  4UYI A;  3L2O A;  3OGL A;  1NEX A;  3OHV A;  2OVQ A;  5FTA A;  2NN2 A;  1QDW A;  4ZGC A;  4UIJ A;  3HQI A;  4U77 A;  2FNJ C;  3B84 A;  2ASS A;  5H7G A;  1FQV B;  4CP3 A;  4AJY C;  2AST A;  4W9D B;  4W9L B;  5A6R A;  5BXH A;  1S1G A;  2P1Q A;  5DAF A;  4APF A;  4W9G B;  3ZKJ B;  3HVE B;  1NN7 A;  2IZV C;  4JTC B;  4W9K B;  1LDK D;  3ZTC B;  5JH5 B;  2OVP A;  5LLI B;  1FS1 B;  4BGC A;  1LM8 C;  1LQB B;  1EOE A;  2IHC A; 
#chains in the Genus database with same CATH homology
 3OGM A;  3DRX A;  1P22 B;  5H7H A;  4W9E B;  3HU6 A;  5IBK A;  1R28 A;  2JZ3 C;  4W9F B;  1EOD A;  4YY8 A;  4WQO C;  4CXJ A;  3HVE A;  2P1M A;  4W9I B;  2P1P A;  3DRZ A;  2P1O A;  1T1D A;  4U2N A;  4AP2 A;  4B9K B;  3I3N A;  2Z8H A;  3OHU A;  2Q81 A;  1CS3 A;  5DAD A;  4U2M A;  3ZRF B;  2E31 B;  3M4T A;  3HTM A;  4JGH C;  1A68 A;  3E4U A;  4CRH A;  3ZRC B;  3LNM B;  4HXI A;  4I6J C;  2R9R B;  3DCG B;  5BXB A;  4AWJ B;  2NZ0 B;  3GA1 A;  4W9C B;  1QDV A;  3C6N A;  1EXB E;  2MA9 C;  1HV2 A;  1EOF A;  3V7D A;  1VCB B;  4JTD B;  2YY9 A;  2P1N A;  2I2R A;  2OVR A;  4CXI A;  3DRY A;  4W9H H;  4J8Z A;  3BIM A;  4B9K E;  5BO4 C;  4B95 B;  4JTA B;  1R2B A;  2PPI A;  1FS2 B;  4ZOU A;  3KVT A;  2C9W C;  1BUO A;  4BKT B;  3WSO B;  3ZTD B;  2IF5 A;  4BKS B;  1DSX A;  5EUP A;  3ZUN B;  2VPK A;  3M8V A;  4CXT A;  4EOZ A;  4W9J B;  3ZNG B;  2A79 B;  5BXD A;  4W9H B;  3M5B A;  2E32 B;  3C6P A;  3LBZ A;  3FKC A;  3LUT B;  3M52 A;  5HZG C;  4N9F 5;  5A15 A;  3MKS A;  1R29 A;  5HYW B;  2VKP A;  3C6O A;  3OGK A;  4UYI A;  3L2O A;  3OGL A;  1NEX A;  3OHV A;  2OVQ A;  5FTA A;  2NN2 A;  1QDW A;  4ZGC A;  4UIJ A;  3HQI A;  4U77 A;  2FNJ C;  3B84 A;  2ASS A;  5H7G A;  1FQV B;  4CP3 A;  4AJY C;  2AST A;  4W9D B;  4W9L B;  5A6R A;  5BXH A;  1S1G A;  2P1Q A;  5DAF A;  4APF A;  4W9G B;  3ZKJ B;  3HVE B;  1NN7 A;  2IZV C;  4JTC B;  4W9K B;  1LDK D;  3ZTC B;  5JH5 B;  2OVP A;  5LLI B;  1FS1 B;  4BGC A;  1LM8 C;  1LQB B;  1EOE A;  2IHC A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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