4W9CB

Pvhl:elob:eloc in complex with (2s,4r)-1-(3,3-dimethylbutanoyl)-4-hydroxy-n-(4-(oxazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 2)
Total Genus 25

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
96
structure length
86
Chain Sequence
MYVKLISSDGHEFIVKREHALTSGTIKAMLSNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
S1 (18-22)TI1 (23-26)EMPTYTII1 (83-86)AH3 (67-83)TI2 (62-65)S3 (59-61)AH2 (40-47)S2 (28-32)AH1 (33-38)Updating...
connected with : NaN
molecule tags Ligase
source organism Homo sapiens
publication title Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
pubmed doi rcsb
molecule keywords Transcription elongation factor B polypeptide 2
total genus 25
structure length 86
sequence length 96
chains with identical sequence E, H, K
ec nomenclature
pdb deposition date 2014-08-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF03931 Skp1_POZ Skp1 family, tetramerisation domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.710.10 Alpha Beta 2-Layer Sandwich Potassium Channel Kv1.1; Chain A Potassium Channel Kv1.1; Chain A 4w9cB00
3HVEB 3OHVA 5A6RA 3HTMA 3GA1A 2VKPA 3C6NA 5FTAA 4I6JC 3DRZA 4W9LB 4B9KE 3V7DA 4B95B 4CP3A 3OGLA 1QDWA 3DCGB 5EUPA 3ZRCB 3C6OA 1EOEA 2IF5A 4CXIA 4CXTA 3B84A 2YY9A 3I3NA 1A68A 3ZTCB 1FQVB 4WQOC 1FS2B 4ZOUA 3ZNGB 3ZKJB 4BGCA 3HVEA 3L2OA 4JGHC 5DADA 1QDVA 5DAFA 5JH5B 4BKTB 2IZVC 4W9GB 2NN2A 2VPKA 3LBZA 3M4TA 3ZTDB 4CRHA 2OVQA 4W9EB 3BIMA 5LLIB 4CXJA 2P1QA 1R2BA 2ASTA 3M8VA 1P22B 1EXBE 1EODA 5BXHA 2P1OA 3HQIA 2E31B 4EOZA 1LDKD 3WSOB 3FKCA 5BXDA 4JTDB 1LQBB 3ZUNB 4U2MA 4N9F5 2P1NA 1FS1B 4W9JB 2A79B 4W9IB 3M5BA 4AWJB 4HXIA 1T1DA 2Z8HA 3LUTB 4U77A 1NEXA 3OHUA 4W9HH 2JZ3C 2OVPA 4BKSB 1NN7A 5HZGC 2PPIA 3C6PA 4U2NA 1CS3A 1R28A 2P1PA 4AP2A 2NZ0B 4J8ZA 4UIJA 4W9DB 4B9KB 1DSXA 1R29A 2ASSA 4W9CB 2C9WC 3KVTA 1VCBB 4JTAB 4W9HB 4W9FB 5H7HA 2IHCA 1BUOA 1HV2A 2P1MA 3ZRFB 5BO4C 2I2RA 2Q81A 1LM8C 4APFA 3OGMA 2E32B 4UYIA 1EOFA 2R9RB 3HU6A 4AJYC 3OGKA 4W9KB 2FNJC 1S1GA 5H7GA 3LNMB 5IBKA 5HYWB 3MKSA 3M52A 2MA9C 5A15A 3E4UA 2OVRA 4JTCB 5BXBA
chains in the Genus database with same CATH superfamily
3HVEB 3OHVA 5A6RA 3HTMA 3GA1A 2VKPA 3C6NA 5FTAA 4I6JC 3DRZA 4W9LB 4B9KE 4ZGCA 3V7DA 4B95B 4CP3A 3OGLA 1QDWA 3DCGB 5EUPA 3ZRCB 3C6OA 1EOEA 2IF5A 4CXIA 4CXTA 3B84A 2YY9A 3I3NA 1A68A 3ZTCB 1FQVB 4WQOC 1FS2B 4ZOUA 3ZNGB 3ZKJB 4BGCA 3HVEA 3L2OA 4JGHC 5DADA 1QDVA 5DAFA 5JH5B 4BKTB 2IZVC 4W9GB 2NN2A 2VPKA 3LBZA 3M4TA 3ZTDB 4CRHA 2OVQA 4W9EB 3BIMA 5LLIB 4CXJA 2P1QA 1R2BA 2ASTA 3M8VA 1P22B 1EXBE 1EODA 5BXHA 2P1OA 4YY8A 3HQIA 2E31B 4EOZA 1LDKD 3WSOB 3FKCA 5BXDA 4JTDB 1LQBB 3ZUNB 4U2MA 4N9F5 2P1NA 1FS1B 3DRYA 4W9JB 2A79B 4W9IB 3M5BA 4AWJB 4HXIA 1T1DA 2Z8HA 3LUTB 4U77A 1NEXA 3OHUA 4W9HH 2JZ3C 2OVPA 4BKSB 1NN7A 5HZGC 2PPIA 3C6PA 4U2NA 1CS3A 1R28A 2P1PA 4AP2A 2NZ0B 4J8ZA 3DRXA 4UIJA 4W9DB 1DSXA 1R29A 2ASSA 4B9KB 4W9CB 2C9WC 3KVTA 1VCBB 4JTAB 4W9HB 4W9FB 5H7HA 2IHCA 1BUOA 1HV2A 2P1MA 3ZRFB 5BO4C 2I2RA 2Q81A 1LM8C 4APFA 3OGMA 2E32B 4UYIA 1EOFA 2R9RB 3HU6A 4AJYC 3OGKA 4W9KB 2FNJC 1S1GA 5H7GA 3LNMB 5IBKA 5HYWB 3MKSA 3M52A 2MA9C 5A15A 3E4UA 2OVRA 4JTCB 5BXBA
chains in the Genus database with same CATH topology
3HVEB 3OHVA 5A6RA 3HTMA 3GA1A 2VKPA 3C6NA 5FTAA 4I6JC 3DRZA 4W9LB 4B9KE 4ZGCA 3V7DA 4B95B 4CP3A 3OGLA 1QDWA 3DCGB 5EUPA 3ZRCB 3C6OA 1EOEA 2IF5A 4CXIA 4CXTA 3B84A 2YY9A 3I3NA 1A68A 3ZTCB 1FQVB 4WQOC 1FS2B 4ZOUA 3ZNGB 3ZKJB 4BGCA 3HVEA 3L2OA 4JGHC 5DADA 1QDVA 5DAFA 5JH5B 4BKTB 2IZVC 4W9GB 2NN2A 2VPKA 3LBZA 3M4TA 3ZTDB 4CRHA 2OVQA 4W9EB 3BIMA 5LLIB 4CXJA 2P1QA 1R2BA 2ASTA 3M8VA 1P22B 1EXBE 1EODA 5BXHA 2P1OA 4YY8A 3HQIA 2E31B 4EOZA 1LDKD 3WSOB 3FKCA 5BXDA 4JTDB 1LQBB 3ZUNB 4U2MA 4N9F5 2P1NA 1FS1B 3DRYA 4W9JB 2A79B 4W9IB 3M5BA 4AWJB 4HXIA 1T1DA 2Z8HA 3LUTB 4U77A 1NEXA 3OHUA 4W9HH 2JZ3C 2OVPA 4BKSB 1NN7A 5HZGC 2PPIA 3C6PA 4U2NA 1CS3A 1R28A 2P1PA 4AP2A 2NZ0B 4J8ZA 3DRXA 4UIJA 4W9DB 1DSXA 1R29A 2ASSA 4B9KB 4W9CB 2C9WC 3KVTA 1VCBB 4JTAB 4W9HB 4W9FB 5H7HA 2IHCA 1BUOA 1HV2A 2P1MA 3ZRFB 5BO4C 2I2RA 2Q81A 1LM8C 4APFA 3OGMA 2E32B 4UYIA 1EOFA 2R9RB 3HU6A 4AJYC 3OGKA 4W9KB 2FNJC 1S1GA 5H7GA 3LNMB 5IBKA 5HYWB 3MKSA 3M52A 2MA9C 5A15A 3E4UA 2OVRA 4JTCB 5BXBA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3HVE B;  3OHV A;  5A6R A;  3HTM A;  3GA1 A;  2VKP A;  3C6N A;  5FTA A;  4I6J C;  3DRZ A;  4W9L B;  4B9K E;  3V7D A;  4B95 B;  4CP3 A;  3OGL A;  1QDW A;  3DCG B;  5EUP A;  3ZRC B;  3C6O A;  1EOE A;  2IF5 A;  4CXI A;  4CXT A;  3B84 A;  2YY9 A;  3I3N A;  1A68 A;  3ZTC B;  1FQV B;  4WQO C;  1FS2 B;  4ZOU A;  3ZNG B;  3ZKJ B;  4BGC A;  3HVE A;  3L2O A;  4JGH C;  5DAD A;  1QDV A;  5DAF A;  5JH5 B;  4BKT B;  2IZV C;  4W9G B;  2NN2 A;  2VPK A;  3LBZ A;  3M4T A;  3ZTD B;  4CRH A;  2OVQ A;  4W9E B;  3BIM A;  5LLI B;  4CXJ A;  2P1Q A;  1R2B A;  2AST A;  3M8V A;  1P22 B;  1EXB E;  1EOD A;  5BXH A;  2P1O A;  3HQI A;  2E31 B;  4EOZ A;  1LDK D;  3WSO B;  3FKC A;  5BXD A;  4JTD B;  1LQB B;  3ZUN B;  4U2M A;  4N9F 5;  2P1N A;  1FS1 B;  4W9J B;  2A79 B;  4W9I B;  3M5B A;  4AWJ B;  4HXI A;  1T1D A;  2Z8H A;  3LUT B;  4U77 A;  1NEX A;  3OHU A;  4W9H H;  2JZ3 C;  2OVP A;  4BKS B;  1NN7 A;  5HZG C;  2PPI A;  3C6P A;  4U2N A;  1CS3 A;  1R28 A;  2P1P A;  4AP2 A;  2NZ0 B;  4J8Z A;  4UIJ A;  4W9D B;  4B9K B;  1DSX A;  1R29 A;  2ASS A;  4W9C B;  2C9W C;  3KVT A;  1VCB B;  4JTA B;  4W9H B;  4W9F B;  5H7H A;  2IHC A;  1BUO A;  1HV2 A;  2P1M A;  3ZRF B;  5BO4 C;  2I2R A;  2Q81 A;  1LM8 C;  4APF A;  3OGM A;  2E32 B;  4UYI A;  1EOF A;  2R9R B;  3HU6 A;  4AJY C;  3OGK A;  4W9K B;  2FNJ C;  1S1G A;  5H7G A;  3LNM B;  5IBK A;  5HYW B;  3MKS A;  3M52 A;  2MA9 C;  5A15 A;  3E4U A;  2OVR A;  4JTC B;  5BXB A; 
#chains in the Genus database with same CATH topology
 3HVE B;  3OHV A;  5A6R A;  3HTM A;  3GA1 A;  2VKP A;  3C6N A;  5FTA A;  4I6J C;  3DRZ A;  4W9L B;  4B9K E;  4ZGC A;  3V7D A;  4B95 B;  4CP3 A;  3OGL A;  1QDW A;  3DCG B;  5EUP A;  3ZRC B;  3C6O A;  1EOE A;  2IF5 A;  4CXI A;  4CXT A;  3B84 A;  2YY9 A;  3I3N A;  1A68 A;  3ZTC B;  1FQV B;  4WQO C;  1FS2 B;  4ZOU A;  3ZNG B;  3ZKJ B;  4BGC A;  3HVE A;  3L2O A;  4JGH C;  5DAD A;  1QDV A;  5DAF A;  5JH5 B;  4BKT B;  2IZV C;  4W9G B;  2NN2 A;  2VPK A;  3LBZ A;  3M4T A;  3ZTD B;  4CRH A;  2OVQ A;  4W9E B;  3BIM A;  5LLI B;  4CXJ A;  2P1Q A;  1R2B A;  2AST A;  3M8V A;  1P22 B;  1EXB E;  1EOD A;  5BXH A;  2P1O A;  4YY8 A;  3HQI A;  2E31 B;  4EOZ A;  1LDK D;  3WSO B;  3FKC A;  5BXD A;  4JTD B;  1LQB B;  3ZUN B;  4U2M A;  4N9F 5;  2P1N A;  1FS1 B;  3DRY A;  4W9J B;  2A79 B;  4W9I B;  3M5B A;  4AWJ B;  4HXI A;  1T1D A;  2Z8H A;  3LUT B;  4U77 A;  1NEX A;  3OHU A;  4W9H H;  2JZ3 C;  2OVP A;  4BKS B;  1NN7 A;  5HZG C;  2PPI A;  3C6P A;  4U2N A;  1CS3 A;  1R28 A;  2P1P A;  4AP2 A;  2NZ0 B;  4J8Z A;  3DRX A;  4UIJ A;  4W9D B;  1DSX A;  1R29 A;  2ASS A;  4B9K B;  4W9C B;  2C9W C;  3KVT A;  1VCB B;  4JTA B;  4W9H B;  4W9F B;  5H7H A;  2IHC A;  1BUO A;  1HV2 A;  2P1M A;  3ZRF B;  5BO4 C;  2I2R A;  2Q81 A;  1LM8 C;  4APF A;  3OGM A;  2E32 B;  4UYI A;  1EOF A;  2R9R B;  3HU6 A;  4AJY C;  3OGK A;  4W9K B;  2FNJ C;  1S1G A;  5H7G A;  3LNM B;  5IBK A;  5HYW B;  3MKS A;  3M52 A;  2MA9 C;  5A15 A;  3E4U A;  2OVR A;  4JTC B;  5BXB A; 
#chains in the Genus database with same CATH homology
 3HVE B;  3OHV A;  5A6R A;  3HTM A;  3GA1 A;  2VKP A;  3C6N A;  5FTA A;  4I6J C;  3DRZ A;  4W9L B;  4B9K E;  4ZGC A;  3V7D A;  4B95 B;  4CP3 A;  3OGL A;  1QDW A;  3DCG B;  5EUP A;  3ZRC B;  3C6O A;  1EOE A;  2IF5 A;  4CXI A;  4CXT A;  3B84 A;  2YY9 A;  3I3N A;  1A68 A;  3ZTC B;  1FQV B;  4WQO C;  1FS2 B;  4ZOU A;  3ZNG B;  3ZKJ B;  4BGC A;  3HVE A;  3L2O A;  4JGH C;  5DAD A;  1QDV A;  5DAF A;  5JH5 B;  4BKT B;  2IZV C;  4W9G B;  2NN2 A;  2VPK A;  3LBZ A;  3M4T A;  3ZTD B;  4CRH A;  2OVQ A;  4W9E B;  3BIM A;  5LLI B;  4CXJ A;  2P1Q A;  1R2B A;  2AST A;  3M8V A;  1P22 B;  1EXB E;  1EOD A;  5BXH A;  2P1O A;  4YY8 A;  3HQI A;  2E31 B;  4EOZ A;  1LDK D;  3WSO B;  3FKC A;  5BXD A;  4JTD B;  1LQB B;  3ZUN B;  4U2M A;  4N9F 5;  2P1N A;  1FS1 B;  3DRY A;  4W9J B;  2A79 B;  4W9I B;  3M5B A;  4AWJ B;  4HXI A;  1T1D A;  2Z8H A;  3LUT B;  4U77 A;  1NEX A;  3OHU A;  4W9H H;  2JZ3 C;  2OVP A;  4BKS B;  1NN7 A;  5HZG C;  2PPI A;  3C6P A;  4U2N A;  1CS3 A;  1R28 A;  2P1P A;  4AP2 A;  2NZ0 B;  4J8Z A;  3DRX A;  4UIJ A;  4W9D B;  1DSX A;  1R29 A;  2ASS A;  4B9K B;  4W9C B;  2C9W C;  3KVT A;  1VCB B;  4JTA B;  4W9H B;  4W9F B;  5H7H A;  2IHC A;  1BUO A;  1HV2 A;  2P1M A;  3ZRF B;  5BO4 C;  2I2R A;  2Q81 A;  1LM8 C;  4APF A;  3OGM A;  2E32 B;  4UYI A;  1EOF A;  2R9R B;  3HU6 A;  4AJY C;  3OGK A;  4W9K B;  2FNJ C;  1S1G A;  5H7G A;  3LNM B;  5IBK A;  5HYW B;  3MKS A;  3M52 A;  2MA9 C;  5A15 A;  3E4U A;  2OVR A;  4JTC B;  5BXB A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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