4W9E | Genus

Total Genus 25

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	25
sequence length	96
structure length	86
Chain Sequence	MYVKLISSDGHEFIVKREHALTSGTIKAMLSNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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The Resolver thinks Pdb

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reading 86 atoms

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86 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Ligase
source organism	Homo sapiens
publication title	Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. pubmed doi rcsb
molecule keywords	Transcription elongation factor B polypeptide 2
total genus	25
structure length	86
sequence length	96
chains with identical sequence	E, H, K
ec nomenclature
pdb deposition date	2014-08-27

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
B	PF03931	Skp1_POZ	Skp1 family, tetramerisation domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.30.710.10	Alpha Beta	2-Layer Sandwich	Potassium Channel Kv1.1; Chain A	Potassium Channel Kv1.1; Chain A	4w9eB00

4U2NA 3HQIA 1S1GA 1VCBB 2YY9A 4JTCB 4W9GB 4JTAB 1R29A 4W9DB 3OGLA 2P1MA 1QDWA 2ASSA 4AP2A 4W9JB 4BKTB 5BXDA 5A6RA 5BXHA 2P1QA 4UYIA 5EUPA 2IZVC 1R28A 4B9KE 2IF5A 2PPIA 3C6PA 4W9LB 5JH5B 2NZ0B 3OGKA 4CXIA 4W9IB 1P22B 3LUTB 3ZKJB 3HTMA 1LQBB 4UIJA 1FQVB 4CXJA 3C6OA 1EXBE 3HVEA 3B84A 4CRHA 1BUOA 3KVTA 4HXIA 1EODA 2Z8HA 3I3NA 4AWJB 5HYWB 3M52A 4W9CB 1NN7A 1EOFA 2Q81A 3WSOB 2JZ3C 2I2RA 1CS3A 4CXTA 2OVRA 3ZRCB 2FNJC 3GA1A 3FKCA 2P1PA 3M4TA 4U77A 2VKPA 4W9KB 1EOEA 4AJYC 5H7HA 3L2OA 4W9HB 5HZGC 1R2BA 3OGMA 2A79B 2VPKA 4N9F5 4W9FB 1HV2A 4W9EB 5BXBA 2E32B 3HU6A 3HVEB 3DRZA 5IBKA 3ZRFB 3ZNGB 3ZTCB 4U2MA 4W9HH 4EOZA 2ASTA 4J8ZA 3LBZA 3M5BA 3E4UA 3DCGB 4WQOC 1LDKD 1T1DA 4APFA 4BGCA 2P1NA 4JTDB 2R9RB 1FS2B 1A68A 4JGHC 4BKSB 3C6NA 5H7GA 3ZUNB 3M8VA 1FS1B 5LLIB 4CP3A 4ZOUA 1NEXA 1LM8C 2P1OA 4B95B 2C9WC 5FTAA 3MKSA 3OHUA 5DADA 2NN2A 4I6JC 2OVQA 5BO4C 3V7DA 3OHVA 2E31B 5A15A 3BIMA 3ZTDB 4B9KB 3LNMB 5DAFA 2MA9C 2IHCA 1QDVA 1DSXA 2OVPA
chains in the Genus database with same CATH superfamily

4U2NA 3HQIA 1S1GA 1VCBB 2YY9A 4JTCB 4W9GB 4JTAB 1R29A 4W9DB 3OGLA 2P1MA 1QDWA 2ASSA 4AP2A 4W9JB 4BKTB 5BXDA 5A6RA 5BXHA 2P1QA 4UYIA 5EUPA 2IZVC 1R28A 4B9KE 2IF5A 2PPIA 3C6PA 4W9LB 5JH5B 2NZ0B 3OGKA 4CXIA 4W9IB 1P22B 3LUTB 3ZKJB 3HTMA 1LQBB 4UIJA 1FQVB 4CXJA 3C6OA 1EXBE 3HVEA 3B84A 4CRHA 1BUOA 3KVTA 4HXIA 1EODA 2Z8HA 3I3NA 4AWJB 5HYWB 3M52A 4W9CB 1NN7A 1EOFA 2Q81A 3WSOB 2JZ3C 2I2RA 1CS3A 4CXTA 3DRXA 2OVRA 3ZRCB 2FNJC 3GA1A 3DRYA 3FKCA 2P1PA 3M4TA 4U77A 2VKPA 4W9KB 1EOEA 4AJYC 5H7HA 3L2OA 4W9HB 5HZGC 1R2BA 3OGMA 2A79B 4ZGCA 2VPKA 4N9F5 4W9FB 1HV2A 4W9EB 5BXBA 2E32B 3HU6A 3HVEB 3DRZA 5IBKA 3ZRFB 3ZNGB 4YY8A 3ZTCB 4U2MA 4W9HH 4EOZA 2ASTA 4J8ZA 3LBZA 3M5BA 3E4UA 3DCGB 4WQOC 1LDKD 1T1DA 4APFA 4BGCA 2P1NA 4JTDB 2R9RB 1FS2B 1A68A 4JGHC 4BKSB 3C6NA 5H7GA 3ZUNB 3M8VA 1FS1B 5LLIB 4CP3A 4ZOUA 1NEXA 1LM8C 2P1OA 4B95B 2C9WC 5FTAA 3MKSA 3OHUA 5DADA 2NN2A 4I6JC 2OVQA 5BO4C 3V7DA 3OHVA 2E31B 5A15A 3BIMA 3ZTDB 4B9KB 3LNMB 5DAFA 2MA9C 2IHCA 1QDVA 1DSXA 2OVPA
chains in the Genus database with same CATH topology

4U2NA 3HQIA 1S1GA 1VCBB 2YY9A 4JTCB 4W9GB 4JTAB 1R29A 4W9DB 3OGLA 2P1MA 1QDWA 2ASSA 4AP2A 4W9JB 4BKTB 5BXDA 5A6RA 5BXHA 2P1QA 4UYIA 5EUPA 2IZVC 1R28A 4B9KE 2IF5A 2PPIA 3C6PA 4W9LB 5JH5B 2NZ0B 3OGKA 4CXIA 4W9IB 1P22B 3LUTB 3ZKJB 3HTMA 1LQBB 4UIJA 1FQVB 4CXJA 3C6OA 1EXBE 3HVEA 3B84A 4CRHA 1BUOA 3KVTA 4HXIA 1EODA 2Z8HA 3I3NA 4AWJB 5HYWB 3M52A 4W9CB 1NN7A 1EOFA 2Q81A 3WSOB 2JZ3C 2I2RA 1CS3A 4CXTA 3DRXA 2OVRA 3ZRCB 2FNJC 3GA1A 3DRYA 3FKCA 2P1PA 3M4TA 4U77A 2VKPA 4W9KB 1EOEA 4AJYC 5H7HA 3L2OA 4W9HB 5HZGC 1R2BA 3OGMA 2A79B 4ZGCA 2VPKA 4N9F5 4W9FB 1HV2A 4W9EB 5BXBA 2E32B 3HU6A 3HVEB 3DRZA 5IBKA 3ZRFB 3ZNGB 4YY8A 3ZTCB 4U2MA 4W9HH 4EOZA 2ASTA 4J8ZA 3LBZA 3M5BA 3E4UA 3DCGB 4WQOC 1LDKD 1T1DA 4APFA 4BGCA 2P1NA 4JTDB 2R9RB 1FS2B 1A68A 4JGHC 4BKSB 3C6NA 5H7GA 3ZUNB 3M8VA 1FS1B 5LLIB 4CP3A 4ZOUA 1NEXA 1LM8C 2P1OA 4B95B 2C9WC 5FTAA 3MKSA 3OHUA 5DADA 2NN2A 4I6JC 2OVQA 5BO4C 3V7DA 3OHVA 2E31B 5A15A 3BIMA 3ZTDB 4B9KB 3LNMB 5DAFA 2MA9C 2IHCA 1QDVA 1DSXA 2OVPA
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 4U2N A;  3HQI A;  1S1G A;  1VCB B;  2YY9 A;  4JTC B;  4W9G B;  4JTA B;  1R29 A;  4W9D B;  3OGL A;  2P1M A;  1QDW A;  2ASS A;  4AP2 A;  4W9J B;  4BKT B;  5BXD A;  5A6R A;  5BXH A;  2P1Q A;  4UYI A;  5EUP A;  2IZV C;  1R28 A;  4B9K E;  2IF5 A;  2PPI A;  3C6P A;  4W9L B;  5JH5 B;  2NZ0 B;  3OGK A;  4CXI A;  4W9I B;  1P22 B;  3LUT B;  3ZKJ B;  3HTM A;  1LQB B;  4UIJ A;  1FQV B;  4CXJ A;  3C6O A;  1EXB E;  3HVE A;  3B84 A;  4CRH A;  1BUO A;  3KVT A;  4HXI A;  1EOD A;  2Z8H A;  3I3N A;  4AWJ B;  5HYW B;  3M52 A;  4W9C B;  1NN7 A;  1EOF A;  2Q81 A;  3WSO B;  2JZ3 C;  2I2R A;  1CS3 A;  4CXT A;  2OVR A;  3ZRC B;  2FNJ C;  3GA1 A;  3FKC A;  2P1P A;  3M4T A;  4U77 A;  2VKP A;  4W9K B;  1EOE A;  4AJY C;  5H7H A;  3L2O A;  4W9H B;  5HZG C;  1R2B A;  3OGM A;  2A79 B;  2VPK A;  4N9F 5;  4W9F B;  1HV2 A;  4W9E B;  5BXB A;  2E32 B;  3HU6 A;  3HVE B;  3DRZ A;  5IBK A;  3ZRF B;  3ZNG B;  3ZTC B;  4U2M A;  4W9H H;  4EOZ A;  2AST A;  4J8Z A;  3LBZ A;  3M5B A;  3E4U A;  3DCG B;  4WQO C;  1LDK D;  1T1D A;  4APF A;  4BGC A;  2P1N A;  4JTD B;  2R9R B;  1FS2 B;  1A68 A;  4JGH C;  4BKS B;  3C6N A;  5H7G A;  3ZUN B;  3M8V A;  1FS1 B;  5LLI B;  4CP3 A;  4ZOU A;  1NEX A;  1LM8 C;  2P1O A;  4B95 B;  2C9W C;  5FTA A;  3MKS A;  3OHU A;  5DAD A;  2NN2 A;  4I6J C;  2OVQ A;  5BO4 C;  3V7D A;  3OHV A;  2E31 B;  5A15 A;  3BIM A;  3ZTD B;  4B9K B;  3LNM B;  5DAF A;  2MA9 C;  2IHC A;  1QDV A;  1DSX A;  2OVP A; 
#chains in the Genus database with same CATH topology
 4U2N A;  3HQI A;  1S1G A;  1VCB B;  2YY9 A;  4JTC B;  4W9G B;  4JTA B;  1R29 A;  4W9D B;  3OGL A;  2P1M A;  1QDW A;  2ASS A;  4AP2 A;  4W9J B;  4BKT B;  5BXD A;  5A6R A;  5BXH A;  2P1Q A;  4UYI A;  5EUP A;  2IZV C;  1R28 A;  4B9K E;  2IF5 A;  2PPI A;  3C6P A;  4W9L B;  5JH5 B;  2NZ0 B;  3OGK A;  4CXI A;  4W9I B;  1P22 B;  3LUT B;  3ZKJ B;  3HTM A;  1LQB B;  4UIJ A;  1FQV B;  4CXJ A;  3C6O A;  1EXB E;  3HVE A;  3B84 A;  4CRH A;  1BUO A;  3KVT A;  4HXI A;  1EOD A;  2Z8H A;  3I3N A;  4AWJ B;  5HYW B;  3M52 A;  4W9C B;  1NN7 A;  1EOF A;  2Q81 A;  3WSO B;  2JZ3 C;  2I2R A;  1CS3 A;  4CXT A;  3DRX A;  2OVR A;  3ZRC B;  2FNJ C;  3GA1 A;  3DRY A;  3FKC A;  2P1P A;  3M4T A;  4U77 A;  2VKP A;  4W9K B;  1EOE A;  4AJY C;  5H7H A;  3L2O A;  4W9H B;  5HZG C;  1R2B A;  3OGM A;  2A79 B;  4ZGC A;  2VPK A;  4N9F 5;  4W9F B;  1HV2 A;  4W9E B;  5BXB A;  2E32 B;  3HU6 A;  3HVE B;  3DRZ A;  5IBK A;  3ZRF B;  3ZNG B;  4YY8 A;  3ZTC B;  4U2M A;  4W9H H;  4EOZ A;  2AST A;  4J8Z A;  3LBZ A;  3M5B A;  3E4U A;  3DCG B;  4WQO C;  1LDK D;  1T1D A;  4APF A;  4BGC A;  2P1N A;  4JTD B;  2R9R B;  1FS2 B;  1A68 A;  4JGH C;  4BKS B;  3C6N A;  5H7G A;  3ZUN B;  3M8V A;  1FS1 B;  5LLI B;  4CP3 A;  4ZOU A;  1NEX A;  1LM8 C;  2P1O A;  4B95 B;  2C9W C;  5FTA A;  3MKS A;  3OHU A;  5DAD A;  2NN2 A;  4I6J C;  2OVQ A;  5BO4 C;  3V7D A;  3OHV A;  2E31 B;  5A15 A;  3BIM A;  3ZTD B;  4B9K B;  3LNM B;  5DAF A;  2MA9 C;  2IHC A;  1QDV A;  1DSX A;  2OVP A; 
#chains in the Genus database with same CATH homology
 4U2N A;  3HQI A;  1S1G A;  1VCB B;  2YY9 A;  4JTC B;  4W9G B;  4JTA B;  1R29 A;  4W9D B;  3OGL A;  2P1M A;  1QDW A;  2ASS A;  4AP2 A;  4W9J B;  4BKT B;  5BXD A;  5A6R A;  5BXH A;  2P1Q A;  4UYI A;  5EUP A;  2IZV C;  1R28 A;  4B9K E;  2IF5 A;  2PPI A;  3C6P A;  4W9L B;  5JH5 B;  2NZ0 B;  3OGK A;  4CXI A;  4W9I B;  1P22 B;  3LUT B;  3ZKJ B;  3HTM A;  1LQB B;  4UIJ A;  1FQV B;  4CXJ A;  3C6O A;  1EXB E;  3HVE A;  3B84 A;  4CRH A;  1BUO A;  3KVT A;  4HXI A;  1EOD A;  2Z8H A;  3I3N A;  4AWJ B;  5HYW B;  3M52 A;  4W9C B;  1NN7 A;  1EOF A;  2Q81 A;  3WSO B;  2JZ3 C;  2I2R A;  1CS3 A;  4CXT A;  3DRX A;  2OVR A;  3ZRC B;  2FNJ C;  3GA1 A;  3DRY A;  3FKC A;  2P1P A;  3M4T A;  4U77 A;  2VKP A;  4W9K B;  1EOE A;  4AJY C;  5H7H A;  3L2O A;  4W9H B;  5HZG C;  1R2B A;  3OGM A;  2A79 B;  4ZGC A;  2VPK A;  4N9F 5;  4W9F B;  1HV2 A;  4W9E B;  5BXB A;  2E32 B;  3HU6 A;  3HVE B;  3DRZ A;  5IBK A;  3ZRF B;  3ZNG B;  4YY8 A;  3ZTC B;  4U2M A;  4W9H H;  4EOZ A;  2AST A;  4J8Z A;  3LBZ A;  3M5B A;  3E4U A;  3DCG B;  4WQO C;  1LDK D;  1T1D A;  4APF A;  4BGC A;  2P1N A;  4JTD B;  2R9R B;  1FS2 B;  1A68 A;  4JGH C;  4BKS B;  3C6N A;  5H7G A;  3ZUN B;  3M8V A;  1FS1 B;  5LLI B;  4CP3 A;  4ZOU A;  1NEX A;  1LM8 C;  2P1O A;  4B95 B;  2C9W C;  5FTA A;  3MKS A;  3OHU A;  5DAD A;  2NN2 A;  4I6J C;  2OVQ A;  5BO4 C;  3V7D A;  3OHV A;  2E31 B;  5A15 A;  3BIM A;  3ZTD B;  4B9K B;  3LNM B;  5DAF A;  2MA9 C;  2IHC A;  1QDV A;  1DSX A;  2OVP A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4W9EB

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations