4W9GB

Pvhl:elob:eloc in complex with (2s,4r)-1-(3,3-dimethylbutanoyl)-4-hydroxy-n-(3-methyl-4-(thiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 6)
Total Genus 23

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
96
structure length
86
Chain Sequence
MYVKLISSDGHEFIVKREHALTSGTIKAMLSNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
S1 (18-22)TI1 (23-26)EMPTYTIV1 (83-86)AH3 (67-83)TI2 (62-65)S3 (59-61)S2 (28-32)AH2 (40-47)AH1 (33-38)Updating...
connected with : NaN
molecule tags Ligase
source organism Homo sapiens
publication title Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
pubmed doi rcsb
molecule keywords Transcription elongation factor B polypeptide 2
total genus 23
structure length 86
sequence length 96
chains with identical sequence E, H, K
ec nomenclature
pdb deposition date 2014-08-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF03931 Skp1_POZ Skp1 family, tetramerisation domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.710.10 Alpha Beta 2-Layer Sandwich Potassium Channel Kv1.1; Chain A Potassium Channel Kv1.1; Chain A 4w9gB00
2R9RB 1A68A 4W9FB 1QDWA 1QDVA 2E31B 4JTAB 4BKSB 4UIJA 4ZOUA 5EUPA 4CP3A 1LM8C 3OGKA 1S1GA 4WQOC 3C6OA 4JTDB 4B9KB 1FQVB 1VCBB 2MA9C 2Z8HA 4AP2A 3V7DA 4U2NA 5HYWB 4W9CB 3DCGB 1T1DA 3M52A 2JZ3C 4W9JB 1CS3A 4CRHA 1LDKD 4W9HH 2NZ0B 2FNJC 5LLIB 4W9KB 5BXBA 4W9GB 4W9DB 4BKTB 3OHUA 3HVEB 4W9IB 4AWJB 1BUOA 3ZUNB 3MKSA 3OGMA 5JH5B 5BO4C 2IHCA 2IF5A 2IZVC 3ZRFB 4B9KE 1FS2B 2P1PA 5H7HA 5DAFA 2YY9A 3OGLA 4W9LB 4B95B 2VPKA 4BGCA 2P1NA 2OVPA 4JTCB 5BXHA 2ASTA 4I6JC 5BXDA 3L2OA 4APFA 1NN7A 3C6PA 2ASSA 3ZKJB 3HQIA 3LUTB 1EODA 1DSXA 2PPIA 3M4TA 3HVEA 3OHVA 1P22B 4HXIA 3KVTA 1NEXA 3I3NA 3ZTCB 3FKCA 4N9F5 4CXJA 2OVQA 2P1MA 4W9HB 4CXTA 4AJYC 5FTAA 1HV2A 2I2RA 1R2BA 2Q81A 3WSOB 2VKPA 4W9EB 3E4UA 3LNMB 5A15A 4JGHC 5A6RA 1EOEA 2NN2A 1EXBE 3LBZA 3BIMA 3M5BA 4CXIA 5HZGC 4UYIA 2C9WC 2E32B 1EOFA 3ZTDB 5IBKA 4EOZA 3B84A 2A79B 3ZRCB 4U2MA 1FS1B 4J8ZA 3HU6A 1LQBB 4U77A 1R28A 3M8VA 3C6NA 1R29A 3GA1A 2P1OA 5H7GA 3DRZA 5DADA 2OVRA 2P1QA 3ZNGB 3HTMA
chains in the Genus database with same CATH superfamily
2R9RB 1A68A 4W9FB 1QDWA 1QDVA 2E31B 4JTAB 4BKSB 4YY8A 4UIJA 4ZOUA 5EUPA 4CP3A 1LM8C 3OGKA 1S1GA 4WQOC 3C6OA 4JTDB 4B9KB 1FQVB 1VCBB 2MA9C 2Z8HA 4AP2A 3V7DA 4U2NA 5HYWB 4W9CB 3DCGB 1T1DA 3M52A 2JZ3C 4W9JB 1CS3A 4CRHA 1LDKD 4W9HH 2NZ0B 2FNJC 5LLIB 4W9KB 5BXBA 4W9GB 4W9DB 4BKTB 3OHUA 3HVEB 4W9IB 4AWJB 3DRYA 1BUOA 3ZUNB 3MKSA 3OGMA 5JH5B 5BO4C 2IHCA 2IF5A 2IZVC 3ZRFB 4B9KE 1FS2B 2P1PA 5H7HA 5DAFA 2YY9A 3OGLA 4W9LB 4B95B 2VPKA 4BGCA 2P1NA 2OVPA 4JTCB 5BXHA 2ASTA 4I6JC 4ZGCA 5BXDA 3L2OA 4APFA 1NN7A 3C6PA 2ASSA 3ZKJB 3HQIA 3LUTB 1EODA 1DSXA 2PPIA 3M4TA 3HVEA 3OHVA 1P22B 4HXIA 3KVTA 1NEXA 3I3NA 3ZTCB 3FKCA 4N9F5 4CXJA 2OVQA 2P1MA 4W9HB 4CXTA 3DRXA 4AJYC 5FTAA 1HV2A 2I2RA 1R2BA 2Q81A 3WSOB 2VKPA 4W9EB 3E4UA 3LNMB 5A15A 4JGHC 5A6RA 1EOEA 2NN2A 1EXBE 3LBZA 3BIMA 3M5BA 4CXIA 5HZGC 4UYIA 2C9WC 2E32B 1EOFA 3ZTDB 5IBKA 4EOZA 3B84A 2A79B 3ZRCB 4U2MA 1FS1B 4J8ZA 3HU6A 1LQBB 4U77A 1R28A 3M8VA 3C6NA 1R29A 3GA1A 2P1OA 5H7GA 3DRZA 5DADA 2OVRA 2P1QA 3ZNGB 3HTMA
chains in the Genus database with same CATH topology
2R9RB 1A68A 4W9FB 1QDWA 1QDVA 2E31B 4JTAB 4BKSB 4YY8A 4UIJA 4ZOUA 5EUPA 4CP3A 1LM8C 3OGKA 1S1GA 4WQOC 3C6OA 4JTDB 4B9KB 1FQVB 1VCBB 2MA9C 2Z8HA 4AP2A 3V7DA 4U2NA 5HYWB 4W9CB 3DCGB 1T1DA 3M52A 2JZ3C 4W9JB 1CS3A 4CRHA 1LDKD 4W9HH 2NZ0B 2FNJC 5LLIB 4W9KB 5BXBA 4W9GB 4W9DB 4BKTB 3OHUA 3HVEB 4W9IB 4AWJB 3DRYA 1BUOA 3ZUNB 3MKSA 3OGMA 5JH5B 5BO4C 2IHCA 2IF5A 2IZVC 3ZRFB 4B9KE 1FS2B 2P1PA 5H7HA 5DAFA 2YY9A 3OGLA 4W9LB 4B95B 2VPKA 4BGCA 2P1NA 2OVPA 4JTCB 5BXHA 2ASTA 4I6JC 4ZGCA 5BXDA 3L2OA 4APFA 1NN7A 3C6PA 2ASSA 3ZKJB 3HQIA 3LUTB 1EODA 1DSXA 2PPIA 3M4TA 3HVEA 3OHVA 1P22B 4HXIA 3KVTA 1NEXA 3I3NA 3ZTCB 3FKCA 4N9F5 4CXJA 2OVQA 2P1MA 4W9HB 4CXTA 3DRXA 4AJYC 5FTAA 1HV2A 2I2RA 1R2BA 2Q81A 3WSOB 2VKPA 4W9EB 3E4UA 3LNMB 5A15A 4JGHC 5A6RA 1EOEA 2NN2A 1EXBE 3LBZA 3BIMA 3M5BA 4CXIA 5HZGC 4UYIA 2C9WC 2E32B 1EOFA 3ZTDB 5IBKA 4EOZA 3B84A 2A79B 3ZRCB 4U2MA 1FS1B 4J8ZA 3HU6A 1LQBB 4U77A 1R28A 3M8VA 3C6NA 1R29A 3GA1A 2P1OA 5H7GA 3DRZA 5DADA 2OVRA 2P1QA 3ZNGB 3HTMA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2R9R B;  1A68 A;  4W9F B;  1QDW A;  1QDV A;  2E31 B;  4JTA B;  4BKS B;  4UIJ A;  4ZOU A;  5EUP A;  4CP3 A;  1LM8 C;  3OGK A;  1S1G A;  4WQO C;  3C6O A;  4JTD B;  4B9K B;  1FQV B;  1VCB B;  2MA9 C;  2Z8H A;  4AP2 A;  3V7D A;  4U2N A;  5HYW B;  4W9C B;  3DCG B;  1T1D A;  3M52 A;  2JZ3 C;  4W9J B;  1CS3 A;  4CRH A;  1LDK D;  4W9H H;  2NZ0 B;  2FNJ C;  5LLI B;  4W9K B;  5BXB A;  4W9G B;  4W9D B;  4BKT B;  3OHU A;  3HVE B;  4W9I B;  4AWJ B;  1BUO A;  3ZUN B;  3MKS A;  3OGM A;  5JH5 B;  5BO4 C;  2IHC A;  2IF5 A;  2IZV C;  3ZRF B;  4B9K E;  1FS2 B;  2P1P A;  5H7H A;  5DAF A;  2YY9 A;  3OGL A;  4W9L B;  4B95 B;  2VPK A;  4BGC A;  2P1N A;  2OVP A;  4JTC B;  5BXH A;  2AST A;  4I6J C;  5BXD A;  3L2O A;  4APF A;  1NN7 A;  3C6P A;  2ASS A;  3ZKJ B;  3HQI A;  3LUT B;  1EOD A;  1DSX A;  2PPI A;  3M4T A;  3HVE A;  3OHV A;  1P22 B;  4HXI A;  3KVT A;  1NEX A;  3I3N A;  3ZTC B;  3FKC A;  4N9F 5;  4CXJ A;  2OVQ A;  2P1M A;  4W9H B;  4CXT A;  4AJY C;  5FTA A;  1HV2 A;  2I2R A;  1R2B A;  2Q81 A;  3WSO B;  2VKP A;  4W9E B;  3E4U A;  3LNM B;  5A15 A;  4JGH C;  5A6R A;  1EOE A;  2NN2 A;  1EXB E;  3LBZ A;  3BIM A;  3M5B A;  4CXI A;  5HZG C;  4UYI A;  2C9W C;  2E32 B;  1EOF A;  3ZTD B;  5IBK A;  4EOZ A;  3B84 A;  2A79 B;  3ZRC B;  4U2M A;  1FS1 B;  4J8Z A;  3HU6 A;  1LQB B;  4U77 A;  1R28 A;  3M8V A;  3C6N A;  1R29 A;  3GA1 A;  2P1O A;  5H7G A;  3DRZ A;  5DAD A;  2OVR A;  2P1Q A;  3ZNG B;  3HTM A; 
#chains in the Genus database with same CATH topology
 2R9R B;  1A68 A;  4W9F B;  1QDW A;  1QDV A;  2E31 B;  4JTA B;  4BKS B;  4YY8 A;  4UIJ A;  4ZOU A;  5EUP A;  4CP3 A;  1LM8 C;  3OGK A;  1S1G A;  4WQO C;  3C6O A;  4JTD B;  4B9K B;  1FQV B;  1VCB B;  2MA9 C;  2Z8H A;  4AP2 A;  3V7D A;  4U2N A;  5HYW B;  4W9C B;  3DCG B;  1T1D A;  3M52 A;  2JZ3 C;  4W9J B;  1CS3 A;  4CRH A;  1LDK D;  4W9H H;  2NZ0 B;  2FNJ C;  5LLI B;  4W9K B;  5BXB A;  4W9G B;  4W9D B;  4BKT B;  3OHU A;  3HVE B;  4W9I B;  4AWJ B;  3DRY A;  1BUO A;  3ZUN B;  3MKS A;  3OGM A;  5JH5 B;  5BO4 C;  2IHC A;  2IF5 A;  2IZV C;  3ZRF B;  4B9K E;  1FS2 B;  2P1P A;  5H7H A;  5DAF A;  2YY9 A;  3OGL A;  4W9L B;  4B95 B;  2VPK A;  4BGC A;  2P1N A;  2OVP A;  4JTC B;  5BXH A;  2AST A;  4I6J C;  4ZGC A;  5BXD A;  3L2O A;  4APF A;  1NN7 A;  3C6P A;  2ASS A;  3ZKJ B;  3HQI A;  3LUT B;  1EOD A;  1DSX A;  2PPI A;  3M4T A;  3HVE A;  3OHV A;  1P22 B;  4HXI A;  3KVT A;  1NEX A;  3I3N A;  3ZTC B;  3FKC A;  4N9F 5;  4CXJ A;  2OVQ A;  2P1M A;  4W9H B;  4CXT A;  3DRX A;  4AJY C;  5FTA A;  1HV2 A;  2I2R A;  1R2B A;  2Q81 A;  3WSO B;  2VKP A;  4W9E B;  3E4U A;  3LNM B;  5A15 A;  4JGH C;  5A6R A;  1EOE A;  2NN2 A;  1EXB E;  3LBZ A;  3BIM A;  3M5B A;  4CXI A;  5HZG C;  4UYI A;  2C9W C;  2E32 B;  1EOF A;  3ZTD B;  5IBK A;  4EOZ A;  3B84 A;  2A79 B;  3ZRC B;  4U2M A;  1FS1 B;  4J8Z A;  3HU6 A;  1LQB B;  4U77 A;  1R28 A;  3M8V A;  3C6N A;  1R29 A;  3GA1 A;  2P1O A;  5H7G A;  3DRZ A;  5DAD A;  2OVR A;  2P1Q A;  3ZNG B;  3HTM A; 
#chains in the Genus database with same CATH homology
 2R9R B;  1A68 A;  4W9F B;  1QDW A;  1QDV A;  2E31 B;  4JTA B;  4BKS B;  4YY8 A;  4UIJ A;  4ZOU A;  5EUP A;  4CP3 A;  1LM8 C;  3OGK A;  1S1G A;  4WQO C;  3C6O A;  4JTD B;  4B9K B;  1FQV B;  1VCB B;  2MA9 C;  2Z8H A;  4AP2 A;  3V7D A;  4U2N A;  5HYW B;  4W9C B;  3DCG B;  1T1D A;  3M52 A;  2JZ3 C;  4W9J B;  1CS3 A;  4CRH A;  1LDK D;  4W9H H;  2NZ0 B;  2FNJ C;  5LLI B;  4W9K B;  5BXB A;  4W9G B;  4W9D B;  4BKT B;  3OHU A;  3HVE B;  4W9I B;  4AWJ B;  3DRY A;  1BUO A;  3ZUN B;  3MKS A;  3OGM A;  5JH5 B;  5BO4 C;  2IHC A;  2IF5 A;  2IZV C;  3ZRF B;  4B9K E;  1FS2 B;  2P1P A;  5H7H A;  5DAF A;  2YY9 A;  3OGL A;  4W9L B;  4B95 B;  2VPK A;  4BGC A;  2P1N A;  2OVP A;  4JTC B;  5BXH A;  2AST A;  4I6J C;  4ZGC A;  5BXD A;  3L2O A;  4APF A;  1NN7 A;  3C6P A;  2ASS A;  3ZKJ B;  3HQI A;  3LUT B;  1EOD A;  1DSX A;  2PPI A;  3M4T A;  3HVE A;  3OHV A;  1P22 B;  4HXI A;  3KVT A;  1NEX A;  3I3N A;  3ZTC B;  3FKC A;  4N9F 5;  4CXJ A;  2OVQ A;  2P1M A;  4W9H B;  4CXT A;  3DRX A;  4AJY C;  5FTA A;  1HV2 A;  2I2R A;  1R2B A;  2Q81 A;  3WSO B;  2VKP A;  4W9E B;  3E4U A;  3LNM B;  5A15 A;  4JGH C;  5A6R A;  1EOE A;  2NN2 A;  1EXB E;  3LBZ A;  3BIM A;  3M5B A;  4CXI A;  5HZG C;  4UYI A;  2C9W C;  2E32 B;  1EOF A;  3ZTD B;  5IBK A;  4EOZ A;  3B84 A;  2A79 B;  3ZRC B;  4U2M A;  1FS1 B;  4J8Z A;  3HU6 A;  1LQB B;  4U77 A;  1R28 A;  3M8V A;  3C6N A;  1R29 A;  3GA1 A;  2P1O A;  5H7G A;  3DRZ A;  5DAD A;  2OVR A;  2P1Q A;  3ZNG B;  3HTM A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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