4W9HB

Pvhl:elob:eloc in complex with (2s,4r)-1-((s)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-n-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 7)
Total Genus 22

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
95
structure length
85
Chain Sequence
MYVKLISSDGHEFIVKREHALTSGTIKAMLSNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
S1 (18-22)TI1 (23-26)EMPTYTIV1 (83-86)AH3 (67-83)TI2 (62-65)S3 (59-61)S2 (28-32)AH2 (40-47)AH1 (33-38)Updating...
connected with : NaN
molecule tags Ligase
source organism Homo sapiens
publication title Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
pubmed doi rcsb
molecule keywords Transcription elongation factor B polypeptide 2
total genus 22
structure length 85
sequence length 95
chains with identical sequence E
ec nomenclature
pdb deposition date 2014-08-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF03931 Skp1_POZ Skp1 family, tetramerisation domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.710.10 Alpha Beta 2-Layer Sandwich Potassium Channel Kv1.1; Chain A Potassium Channel Kv1.1; Chain A 4w9hB00
3M5BA 2P1QA 3OGMA 1FS1B 5LLIB 3DCGB 2JZ3C 1QDVA 4W9JB 2FNJC 3OGKA 1QDWA 3M4TA 3HU6A 4AWJB 5H7HA 5BXHA 1R28A 1FS2B 4APFA 1FQVB 4W9GB 1P22B 1CS3A 3KVTA 1LDKD 2P1OA 1A68A 4AJYC 5A15A 5DAFA 2P1NA 4U2NA 5H7GA 4B95B 3OHUA 4EOZA 4JTDB 2R9RB 1EXBE 4CXTA 4W9LB 4B9KB 3WSOB 4I6JC 3C6PA 5JH5B 4WQOC 2NZ0B 3M8VA 4W9CB 3FKCA 2ASTA 3LUTB 1LQBB 2OVRA 4BGCA 4BKSB 5FTAA 3ZTDB 1T1DA 4CXJA 5BXDA 3C6NA 4U2MA 2VKPA 4JTAB 3DRZA 4UIJA 3GA1A 4W9IB 3ZUNB 3V7DA 3C6OA 1VCBB 3OGLA 3M52A 3ZRFB 2Q81A 4U77A 2I2RA 3ZNGB 1BUOA 3OHVA 4JTCB 4ZOUA 1R2BA 2P1PA 2A79B 2VPKA 4W9DB 4W9FB 2ASSA 1NEXA 5A6RA 3ZTCB 5EUPA 4W9HB 3HTMA 3HQIA 5BO4C 3E4UA 4HXIA 2P1MA 5HZGC 4B9KE 2IHCA 1EOFA 2MA9C 3HVEB 2E32B 2Z8HA 3HVEA 2E31B 4JGHC 3LNMB 3LBZA 4J8ZA 3ZKJB 2IZVC 5IBKA 2YY9A 3BIMA 5DADA 4W9EB 4N9F5 1S1GA 1EOEA 1DSXA 1HV2A 4CRHA 4AP2A 2IF5A 1NN7A 2OVQA 4BKTB 4CXIA 3I3NA 5BXBA 4W9KB 1EODA 2OVPA 1R29A 2NN2A 4W9HH 4CP3A 3L2OA 3ZRCB 3MKSA 5HYWB 4UYIA 2PPIA 3B84A 1LM8C 2C9WC
chains in the Genus database with same CATH superfamily
3M5BA 2P1QA 3OGMA 1FS1B 5LLIB 3DCGB 2JZ3C 1QDVA 4W9JB 2FNJC 3OGKA 1QDWA 3M4TA 3HU6A 4AWJB 5H7HA 5BXHA 1R28A 1FS2B 4APFA 1FQVB 4W9GB 1P22B 1CS3A 3KVTA 1LDKD 2P1OA 1A68A 4AJYC 5A15A 5DAFA 2P1NA 4U2NA 5H7GA 4B95B 3OHUA 4EOZA 4JTDB 2R9RB 1EXBE 4CXTA 4W9LB 4B9KB 3WSOB 4I6JC 3C6PA 5JH5B 4WQOC 2NZ0B 3M8VA 4W9CB 3FKCA 2ASTA 3LUTB 1LQBB 2OVRA 4BGCA 4BKSB 5FTAA 3ZTDB 1T1DA 4CXJA 5BXDA 3C6NA 4U2MA 2VKPA 4JTAB 3DRZA 4UIJA 3GA1A 4W9IB 3ZUNB 3V7DA 3C6OA 1VCBB 3OGLA 3M52A 3ZRFB 2Q81A 4U77A 2I2RA 3ZNGB 1BUOA 3OHVA 4JTCB 4ZOUA 1R2BA 2P1PA 2A79B 2VPKA 4W9DB 4W9FB 2ASSA 1NEXA 5A6RA 3DRXA 3ZTCB 5EUPA 4W9HB 3HTMA 3HQIA 5BO4C 3E4UA 4HXIA 2P1MA 5HZGC 4B9KE 2IHCA 1EOFA 2MA9C 3HVEB 2E32B 2Z8HA 3HVEA 2E31B 4JGHC 3LNMB 3LBZA 4J8ZA 3ZKJB 2IZVC 5IBKA 2YY9A 3BIMA 5DADA 4W9EB 4N9F5 1S1GA 1EOEA 1DSXA 1HV2A 4CRHA 4ZGCA 4AP2A 2IF5A 1NN7A 2OVQA 4BKTB 4CXIA 3I3NA 5BXBA 4W9KB 1EODA 2OVPA 1R29A 2NN2A 4W9HH 4CP3A 3L2OA 3ZRCB 4YY8A 3MKSA 5HYWB 4UYIA 2PPIA 3B84A 3DRYA 1LM8C 2C9WC
chains in the Genus database with same CATH topology
3M5BA 2P1QA 3OGMA 1FS1B 5LLIB 3DCGB 2JZ3C 1QDVA 4W9JB 2FNJC 3OGKA 1QDWA 3M4TA 3HU6A 4AWJB 5H7HA 5BXHA 1R28A 1FS2B 4APFA 1FQVB 4W9GB 1P22B 1CS3A 3KVTA 1LDKD 2P1OA 1A68A 4AJYC 5A15A 5DAFA 2P1NA 4U2NA 5H7GA 4B95B 3OHUA 4EOZA 4JTDB 2R9RB 1EXBE 4CXTA 4W9LB 4B9KB 3WSOB 4I6JC 3C6PA 5JH5B 4WQOC 2NZ0B 3M8VA 4W9CB 3FKCA 2ASTA 3LUTB 1LQBB 2OVRA 4BGCA 4BKSB 5FTAA 3ZTDB 1T1DA 4CXJA 5BXDA 3C6NA 4U2MA 2VKPA 4JTAB 3DRZA 4UIJA 3GA1A 4W9IB 3ZUNB 3V7DA 3C6OA 1VCBB 3OGLA 3M52A 3ZRFB 2Q81A 4U77A 2I2RA 3ZNGB 1BUOA 3OHVA 4JTCB 4ZOUA 1R2BA 2P1PA 2A79B 2VPKA 4W9DB 4W9FB 2ASSA 1NEXA 5A6RA 3DRXA 3ZTCB 5EUPA 4W9HB 3HTMA 3HQIA 5BO4C 3E4UA 4HXIA 2P1MA 5HZGC 4B9KE 2IHCA 1EOFA 2MA9C 3HVEB 2E32B 2Z8HA 3HVEA 2E31B 4JGHC 3LNMB 3LBZA 4J8ZA 3ZKJB 2IZVC 5IBKA 2YY9A 3BIMA 5DADA 4W9EB 4N9F5 1S1GA 1EOEA 1DSXA 1HV2A 4CRHA 4ZGCA 4AP2A 2IF5A 1NN7A 2OVQA 4BKTB 4CXIA 3I3NA 5BXBA 4W9KB 1EODA 2OVPA 1R29A 2NN2A 4W9HH 4CP3A 3L2OA 3ZRCB 4YY8A 3MKSA 5HYWB 4UYIA 2PPIA 3B84A 3DRYA 1LM8C 2C9WC
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3M5B A;  2P1Q A;  3OGM A;  1FS1 B;  5LLI B;  3DCG B;  2JZ3 C;  1QDV A;  4W9J B;  2FNJ C;  3OGK A;  1QDW A;  3M4T A;  3HU6 A;  4AWJ B;  5H7H A;  5BXH A;  1R28 A;  1FS2 B;  4APF A;  1FQV B;  4W9G B;  1P22 B;  1CS3 A;  3KVT A;  1LDK D;  2P1O A;  1A68 A;  4AJY C;  5A15 A;  5DAF A;  2P1N A;  4U2N A;  5H7G A;  4B95 B;  3OHU A;  4EOZ A;  4JTD B;  2R9R B;  1EXB E;  4CXT A;  4W9L B;  4B9K B;  3WSO B;  4I6J C;  3C6P A;  5JH5 B;  4WQO C;  2NZ0 B;  3M8V A;  4W9C B;  3FKC A;  2AST A;  3LUT B;  1LQB B;  2OVR A;  4BGC A;  4BKS B;  5FTA A;  3ZTD B;  1T1D A;  4CXJ A;  5BXD A;  3C6N A;  4U2M A;  2VKP A;  4JTA B;  3DRZ A;  4UIJ A;  3GA1 A;  4W9I B;  3ZUN B;  3V7D A;  3C6O A;  1VCB B;  3OGL A;  3M52 A;  3ZRF B;  2Q81 A;  4U77 A;  2I2R A;  3ZNG B;  1BUO A;  3OHV A;  4JTC B;  4ZOU A;  1R2B A;  2P1P A;  2A79 B;  2VPK A;  4W9D B;  4W9F B;  2ASS A;  1NEX A;  5A6R A;  3ZTC B;  5EUP A;  4W9H B;  3HTM A;  3HQI A;  5BO4 C;  3E4U A;  4HXI A;  2P1M A;  5HZG C;  4B9K E;  2IHC A;  1EOF A;  2MA9 C;  3HVE B;  2E32 B;  2Z8H A;  3HVE A;  2E31 B;  4JGH C;  3LNM B;  3LBZ A;  4J8Z A;  3ZKJ B;  2IZV C;  5IBK A;  2YY9 A;  3BIM A;  5DAD A;  4W9E B;  4N9F 5;  1S1G A;  1EOE A;  1DSX A;  1HV2 A;  4CRH A;  4AP2 A;  2IF5 A;  1NN7 A;  2OVQ A;  4BKT B;  4CXI A;  3I3N A;  5BXB A;  4W9K B;  1EOD A;  2OVP A;  1R29 A;  2NN2 A;  4W9H H;  4CP3 A;  3L2O A;  3ZRC B;  3MKS A;  5HYW B;  4UYI A;  2PPI A;  3B84 A;  1LM8 C;  2C9W C; 
#chains in the Genus database with same CATH topology
 3M5B A;  2P1Q A;  3OGM A;  1FS1 B;  5LLI B;  3DCG B;  2JZ3 C;  1QDV A;  4W9J B;  2FNJ C;  3OGK A;  1QDW A;  3M4T A;  3HU6 A;  4AWJ B;  5H7H A;  5BXH A;  1R28 A;  1FS2 B;  4APF A;  1FQV B;  4W9G B;  1P22 B;  1CS3 A;  3KVT A;  1LDK D;  2P1O A;  1A68 A;  4AJY C;  5A15 A;  5DAF A;  2P1N A;  4U2N A;  5H7G A;  4B95 B;  3OHU A;  4EOZ A;  4JTD B;  2R9R B;  1EXB E;  4CXT A;  4W9L B;  4B9K B;  3WSO B;  4I6J C;  3C6P A;  5JH5 B;  4WQO C;  2NZ0 B;  3M8V A;  4W9C B;  3FKC A;  2AST A;  3LUT B;  1LQB B;  2OVR A;  4BGC A;  4BKS B;  5FTA A;  3ZTD B;  1T1D A;  4CXJ A;  5BXD A;  3C6N A;  4U2M A;  2VKP A;  4JTA B;  3DRZ A;  4UIJ A;  3GA1 A;  4W9I B;  3ZUN B;  3V7D A;  3C6O A;  1VCB B;  3OGL A;  3M52 A;  3ZRF B;  2Q81 A;  4U77 A;  2I2R A;  3ZNG B;  1BUO A;  3OHV A;  4JTC B;  4ZOU A;  1R2B A;  2P1P A;  2A79 B;  2VPK A;  4W9D B;  4W9F B;  2ASS A;  1NEX A;  5A6R A;  3DRX A;  3ZTC B;  5EUP A;  4W9H B;  3HTM A;  3HQI A;  5BO4 C;  3E4U A;  4HXI A;  2P1M A;  5HZG C;  4B9K E;  2IHC A;  1EOF A;  2MA9 C;  3HVE B;  2E32 B;  2Z8H A;  3HVE A;  2E31 B;  4JGH C;  3LNM B;  3LBZ A;  4J8Z A;  3ZKJ B;  2IZV C;  5IBK A;  2YY9 A;  3BIM A;  5DAD A;  4W9E B;  4N9F 5;  1S1G A;  1EOE A;  1DSX A;  1HV2 A;  4CRH A;  4ZGC A;  4AP2 A;  2IF5 A;  1NN7 A;  2OVQ A;  4BKT B;  4CXI A;  3I3N A;  5BXB A;  4W9K B;  1EOD A;  2OVP A;  1R29 A;  2NN2 A;  4W9H H;  4CP3 A;  3L2O A;  3ZRC B;  4YY8 A;  3MKS A;  5HYW B;  4UYI A;  2PPI A;  3B84 A;  3DRY A;  1LM8 C;  2C9W C; 
#chains in the Genus database with same CATH homology
 3M5B A;  2P1Q A;  3OGM A;  1FS1 B;  5LLI B;  3DCG B;  2JZ3 C;  1QDV A;  4W9J B;  2FNJ C;  3OGK A;  1QDW A;  3M4T A;  3HU6 A;  4AWJ B;  5H7H A;  5BXH A;  1R28 A;  1FS2 B;  4APF A;  1FQV B;  4W9G B;  1P22 B;  1CS3 A;  3KVT A;  1LDK D;  2P1O A;  1A68 A;  4AJY C;  5A15 A;  5DAF A;  2P1N A;  4U2N A;  5H7G A;  4B95 B;  3OHU A;  4EOZ A;  4JTD B;  2R9R B;  1EXB E;  4CXT A;  4W9L B;  4B9K B;  3WSO B;  4I6J C;  3C6P A;  5JH5 B;  4WQO C;  2NZ0 B;  3M8V A;  4W9C B;  3FKC A;  2AST A;  3LUT B;  1LQB B;  2OVR A;  4BGC A;  4BKS B;  5FTA A;  3ZTD B;  1T1D A;  4CXJ A;  5BXD A;  3C6N A;  4U2M A;  2VKP A;  4JTA B;  3DRZ A;  4UIJ A;  3GA1 A;  4W9I B;  3ZUN B;  3V7D A;  3C6O A;  1VCB B;  3OGL A;  3M52 A;  3ZRF B;  2Q81 A;  4U77 A;  2I2R A;  3ZNG B;  1BUO A;  3OHV A;  4JTC B;  4ZOU A;  1R2B A;  2P1P A;  2A79 B;  2VPK A;  4W9D B;  4W9F B;  2ASS A;  1NEX A;  5A6R A;  3DRX A;  3ZTC B;  5EUP A;  4W9H B;  3HTM A;  3HQI A;  5BO4 C;  3E4U A;  4HXI A;  2P1M A;  5HZG C;  4B9K E;  2IHC A;  1EOF A;  2MA9 C;  3HVE B;  2E32 B;  2Z8H A;  3HVE A;  2E31 B;  4JGH C;  3LNM B;  3LBZ A;  4J8Z A;  3ZKJ B;  2IZV C;  5IBK A;  2YY9 A;  3BIM A;  5DAD A;  4W9E B;  4N9F 5;  1S1G A;  1EOE A;  1DSX A;  1HV2 A;  4CRH A;  4ZGC A;  4AP2 A;  2IF5 A;  1NN7 A;  2OVQ A;  4BKT B;  4CXI A;  3I3N A;  5BXB A;  4W9K B;  1EOD A;  2OVP A;  1R29 A;  2NN2 A;  4W9H H;  4CP3 A;  3L2O A;  3ZRC B;  4YY8 A;  3MKS A;  5HYW B;  4UYI A;  2PPI A;  3B84 A;  3DRY A;  1LM8 C;  2C9W C;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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