4W9JB

Pvhl:elob:eloc in complex with (2s,4r)-1-((s)-2-((s)-2-acetamido-4-methylpentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-n-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 13)
Total Genus 24

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
96
structure length
86
Chain Sequence
MYVKLISSDGHEFIVKREHALTSGTIKAMLSNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
S1 (18-22)TI1 (23-26)EMPTYTII1 (83-86)AH3 (67-83)TI2 (62-65)S3 (59-61)AH2 (40-47)S2 (28-32)AH1 (33-38)Updating...
connected with : NaN
molecule tags Transcription
source organism Homo sapiens
publication title Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
pubmed doi rcsb
molecule keywords Transcription elongation factor B polypeptide 2
total genus 24
structure length 86
sequence length 96
chains with identical sequence E, H, K
ec nomenclature
pdb deposition date 2014-08-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF03931 Skp1_POZ Skp1 family, tetramerisation domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.710.10 Alpha Beta 2-Layer Sandwich Potassium Channel Kv1.1; Chain A Potassium Channel Kv1.1; Chain A 4w9jB00
4CXJA 3C6OA 5BXBA 2ASTA 3ZRFB 2OVPA 3C6NA 3M4TA 3HTMA 2ASSA 4UIJA 4ZOUA 1NEXA 3HVEB 4UYIA 3LBZA 3M5BA 5JH5B 5A6RA 2A79B 2P1MA 3OHUA 5BXDA 3ZNGB 2E32B 2C9WC 4WQOC 4W9GB 4W9FB 4B9KB 4W9IB 2YY9A 3HVEA 5BO4C 3KVTA 3ZKJB 4W9EB 4W9HH 5LLIB 2IZVC 3ZRCB 3OHVA 2MA9C 2PPIA 4CXTA 4JTAB 4JTDB 3OGKA 5DADA 5EUPA 1T1DA 1LM8C 3OGMA 5FTAA 1DSXA 3M52A 4W9JB 3BIMA 3ZTCB 3ZTDB 4CP3A 1EODA 4AWJB 1QDVA 1R29A 4HXIA 2OVQA 4J8ZA 1VCBB 3HQIA 3V7DA 1FS1B 2P1NA 3OGLA 4U2MA 1EOEA 3I3NA 1FQVB 2IHCA 3MKSA 4W9KB 3WSOB 4APFA 4BGCA 3C6PA 4CRHA 4N9F5 3ZUNB 5HYWB 1LQBB 4I6JC 2JZ3C 4W9HB 4BKSB 3LUTB 4CXIA 3L2OA 2P1QA 1P22B 3M8VA 1BUOA 1NN7A 3DCGB 1QDWA 4U77A 2P1OA 3LNMB 2IF5A 4U2NA 2VPKA 5H7HA 4BKTB 5BXHA 5HZGC 2Z8HA 4B9KE 1R28A 1LDKD 2R9RB 4JTCB 4W9CB 5DAFA 5IBKA 1EXBE 2NZ0B 2P1PA 3B84A 4JGHC 1A68A 2VKPA 1FS2B 2OVRA 2NN2A 2I2RA 4AP2A 2E31B 3GA1A 4W9DB 5A15A 1EOFA 4W9LB 2Q81A 3FKCA 2FNJC 1HV2A 3DRZA 4EOZA 4AJYC 3HU6A 1S1GA 1R2BA 5H7GA 1CS3A 4B95B 3E4UA
chains in the Genus database with same CATH superfamily
4CXJA 3C6OA 5BXBA 2ASTA 3ZRFB 2OVPA 3C6NA 3M4TA 3HTMA 2ASSA 4UIJA 4ZOUA 4YY8A 1NEXA 3HVEB 4UYIA 3LBZA 3M5BA 5JH5B 5A6RA 2A79B 2P1MA 3OHUA 5BXDA 3ZNGB 2E32B 2C9WC 4WQOC 4W9GB 4W9FB 4B9KB 4W9IB 2YY9A 3HVEA 5BO4C 3KVTA 3ZKJB 4W9EB 4W9HH 5LLIB 2IZVC 3ZRCB 3OHVA 2MA9C 2PPIA 4CXTA 4JTAB 4JTDB 3OGKA 5DADA 5EUPA 1T1DA 1LM8C 3OGMA 3DRXA 5FTAA 1DSXA 3M52A 4W9JB 3BIMA 3ZTCB 3ZTDB 4CP3A 1EODA 4AWJB 4ZGCA 1QDVA 1R29A 4HXIA 2OVQA 4J8ZA 1VCBB 3HQIA 3V7DA 1FS1B 2P1NA 3OGLA 4U2MA 1EOEA 3I3NA 1FQVB 2IHCA 3MKSA 4W9KB 3WSOB 4APFA 4BGCA 3C6PA 4CRHA 4N9F5 3ZUNB 5HYWB 1LQBB 4I6JC 2JZ3C 4W9HB 4BKSB 3LUTB 4CXIA 3L2OA 2P1QA 1P22B 3M8VA 1BUOA 3DRYA 1NN7A 3DCGB 1QDWA 4U77A 2P1OA 3LNMB 2IF5A 4U2NA 2VPKA 5H7HA 4BKTB 5BXHA 5HZGC 2Z8HA 4B9KE 1R28A 1LDKD 2R9RB 4JTCB 4W9CB 5DAFA 5IBKA 1EXBE 2NZ0B 2P1PA 3B84A 4JGHC 1A68A 2VKPA 1FS2B 2OVRA 2NN2A 2I2RA 4AP2A 2E31B 3GA1A 4W9DB 5A15A 1EOFA 4W9LB 2Q81A 3FKCA 2FNJC 1HV2A 3DRZA 4EOZA 4AJYC 3HU6A 1S1GA 1R2BA 5H7GA 1CS3A 4B95B 3E4UA
chains in the Genus database with same CATH topology
4CXJA 3C6OA 5BXBA 2ASTA 3ZRFB 2OVPA 3C6NA 3M4TA 3HTMA 2ASSA 4UIJA 4ZOUA 4YY8A 1NEXA 3HVEB 4UYIA 3LBZA 3M5BA 5JH5B 5A6RA 2A79B 2P1MA 3OHUA 5BXDA 3ZNGB 2E32B 2C9WC 4WQOC 4W9GB 4W9FB 4B9KB 4W9IB 2YY9A 3HVEA 5BO4C 3KVTA 3ZKJB 4W9EB 4W9HH 5LLIB 2IZVC 3ZRCB 3OHVA 2MA9C 2PPIA 4CXTA 4JTAB 4JTDB 3OGKA 5DADA 5EUPA 1T1DA 1LM8C 3OGMA 3DRXA 5FTAA 1DSXA 3M52A 4W9JB 3BIMA 3ZTCB 3ZTDB 4CP3A 1EODA 4AWJB 4ZGCA 1QDVA 1R29A 4HXIA 2OVQA 4J8ZA 1VCBB 3HQIA 3V7DA 1FS1B 2P1NA 3OGLA 4U2MA 1EOEA 3I3NA 1FQVB 2IHCA 3MKSA 4W9KB 3WSOB 4APFA 4BGCA 3C6PA 4CRHA 4N9F5 3ZUNB 5HYWB 1LQBB 4I6JC 2JZ3C 4W9HB 4BKSB 3LUTB 4CXIA 3L2OA 2P1QA 1P22B 3M8VA 1BUOA 3DRYA 1NN7A 3DCGB 1QDWA 4U77A 2P1OA 3LNMB 2IF5A 4U2NA 2VPKA 5H7HA 4BKTB 5BXHA 5HZGC 2Z8HA 4B9KE 1R28A 1LDKD 2R9RB 4JTCB 4W9CB 5DAFA 5IBKA 1EXBE 2NZ0B 2P1PA 3B84A 4JGHC 1A68A 2VKPA 1FS2B 2OVRA 2NN2A 2I2RA 4AP2A 2E31B 3GA1A 4W9DB 5A15A 1EOFA 4W9LB 2Q81A 3FKCA 2FNJC 1HV2A 3DRZA 4EOZA 4AJYC 3HU6A 1S1GA 1R2BA 5H7GA 1CS3A 4B95B 3E4UA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4CXJ A;  3C6O A;  5BXB A;  2AST A;  3ZRF B;  2OVP A;  3C6N A;  3M4T A;  3HTM A;  2ASS A;  4UIJ A;  4ZOU A;  1NEX A;  3HVE B;  4UYI A;  3LBZ A;  3M5B A;  5JH5 B;  5A6R A;  2A79 B;  2P1M A;  3OHU A;  5BXD A;  3ZNG B;  2E32 B;  2C9W C;  4WQO C;  4W9G B;  4W9F B;  4B9K B;  4W9I B;  2YY9 A;  3HVE A;  5BO4 C;  3KVT A;  3ZKJ B;  4W9E B;  4W9H H;  5LLI B;  2IZV C;  3ZRC B;  3OHV A;  2MA9 C;  2PPI A;  4CXT A;  4JTA B;  4JTD B;  3OGK A;  5DAD A;  5EUP A;  1T1D A;  1LM8 C;  3OGM A;  5FTA A;  1DSX A;  3M52 A;  4W9J B;  3BIM A;  3ZTC B;  3ZTD B;  4CP3 A;  1EOD A;  4AWJ B;  1QDV A;  1R29 A;  4HXI A;  2OVQ A;  4J8Z A;  1VCB B;  3HQI A;  3V7D A;  1FS1 B;  2P1N A;  3OGL A;  4U2M A;  1EOE A;  3I3N A;  1FQV B;  2IHC A;  3MKS A;  4W9K B;  3WSO B;  4APF A;  4BGC A;  3C6P A;  4CRH A;  4N9F 5;  3ZUN B;  5HYW B;  1LQB B;  4I6J C;  2JZ3 C;  4W9H B;  4BKS B;  3LUT B;  4CXI A;  3L2O A;  2P1Q A;  1P22 B;  3M8V A;  1BUO A;  1NN7 A;  3DCG B;  1QDW A;  4U77 A;  2P1O A;  3LNM B;  2IF5 A;  4U2N A;  2VPK A;  5H7H A;  4BKT B;  5BXH A;  5HZG C;  2Z8H A;  4B9K E;  1R28 A;  1LDK D;  2R9R B;  4JTC B;  4W9C B;  5DAF A;  5IBK A;  1EXB E;  2NZ0 B;  2P1P A;  3B84 A;  4JGH C;  1A68 A;  2VKP A;  1FS2 B;  2OVR A;  2NN2 A;  2I2R A;  4AP2 A;  2E31 B;  3GA1 A;  4W9D B;  5A15 A;  1EOF A;  4W9L B;  2Q81 A;  3FKC A;  2FNJ C;  1HV2 A;  3DRZ A;  4EOZ A;  4AJY C;  3HU6 A;  1S1G A;  1R2B A;  5H7G A;  1CS3 A;  4B95 B;  3E4U A; 
#chains in the Genus database with same CATH topology
 4CXJ A;  3C6O A;  5BXB A;  2AST A;  3ZRF B;  2OVP A;  3C6N A;  3M4T A;  3HTM A;  2ASS A;  4UIJ A;  4ZOU A;  4YY8 A;  1NEX A;  3HVE B;  4UYI A;  3LBZ A;  3M5B A;  5JH5 B;  5A6R A;  2A79 B;  2P1M A;  3OHU A;  5BXD A;  3ZNG B;  2E32 B;  2C9W C;  4WQO C;  4W9G B;  4W9F B;  4B9K B;  4W9I B;  2YY9 A;  3HVE A;  5BO4 C;  3KVT A;  3ZKJ B;  4W9E B;  4W9H H;  5LLI B;  2IZV C;  3ZRC B;  3OHV A;  2MA9 C;  2PPI A;  4CXT A;  4JTA B;  4JTD B;  3OGK A;  5DAD A;  5EUP A;  1T1D A;  1LM8 C;  3OGM A;  3DRX A;  5FTA A;  1DSX A;  3M52 A;  4W9J B;  3BIM A;  3ZTC B;  3ZTD B;  4CP3 A;  1EOD A;  4AWJ B;  4ZGC A;  1QDV A;  1R29 A;  4HXI A;  2OVQ A;  4J8Z A;  1VCB B;  3HQI A;  3V7D A;  1FS1 B;  2P1N A;  3OGL A;  4U2M A;  1EOE A;  3I3N A;  1FQV B;  2IHC A;  3MKS A;  4W9K B;  3WSO B;  4APF A;  4BGC A;  3C6P A;  4CRH A;  4N9F 5;  3ZUN B;  5HYW B;  1LQB B;  4I6J C;  2JZ3 C;  4W9H B;  4BKS B;  3LUT B;  4CXI A;  3L2O A;  2P1Q A;  1P22 B;  3M8V A;  1BUO A;  3DRY A;  1NN7 A;  3DCG B;  1QDW A;  4U77 A;  2P1O A;  3LNM B;  2IF5 A;  4U2N A;  2VPK A;  5H7H A;  4BKT B;  5BXH A;  5HZG C;  2Z8H A;  4B9K E;  1R28 A;  1LDK D;  2R9R B;  4JTC B;  4W9C B;  5DAF A;  5IBK A;  1EXB E;  2NZ0 B;  2P1P A;  3B84 A;  4JGH C;  1A68 A;  2VKP A;  1FS2 B;  2OVR A;  2NN2 A;  2I2R A;  4AP2 A;  2E31 B;  3GA1 A;  4W9D B;  5A15 A;  1EOF A;  4W9L B;  2Q81 A;  3FKC A;  2FNJ C;  1HV2 A;  3DRZ A;  4EOZ A;  4AJY C;  3HU6 A;  1S1G A;  1R2B A;  5H7G A;  1CS3 A;  4B95 B;  3E4U A; 
#chains in the Genus database with same CATH homology
 4CXJ A;  3C6O A;  5BXB A;  2AST A;  3ZRF B;  2OVP A;  3C6N A;  3M4T A;  3HTM A;  2ASS A;  4UIJ A;  4ZOU A;  4YY8 A;  1NEX A;  3HVE B;  4UYI A;  3LBZ A;  3M5B A;  5JH5 B;  5A6R A;  2A79 B;  2P1M A;  3OHU A;  5BXD A;  3ZNG B;  2E32 B;  2C9W C;  4WQO C;  4W9G B;  4W9F B;  4B9K B;  4W9I B;  2YY9 A;  3HVE A;  5BO4 C;  3KVT A;  3ZKJ B;  4W9E B;  4W9H H;  5LLI B;  2IZV C;  3ZRC B;  3OHV A;  2MA9 C;  2PPI A;  4CXT A;  4JTA B;  4JTD B;  3OGK A;  5DAD A;  5EUP A;  1T1D A;  1LM8 C;  3OGM A;  3DRX A;  5FTA A;  1DSX A;  3M52 A;  4W9J B;  3BIM A;  3ZTC B;  3ZTD B;  4CP3 A;  1EOD A;  4AWJ B;  4ZGC A;  1QDV A;  1R29 A;  4HXI A;  2OVQ A;  4J8Z A;  1VCB B;  3HQI A;  3V7D A;  1FS1 B;  2P1N A;  3OGL A;  4U2M A;  1EOE A;  3I3N A;  1FQV B;  2IHC A;  3MKS A;  4W9K B;  3WSO B;  4APF A;  4BGC A;  3C6P A;  4CRH A;  4N9F 5;  3ZUN B;  5HYW B;  1LQB B;  4I6J C;  2JZ3 C;  4W9H B;  4BKS B;  3LUT B;  4CXI A;  3L2O A;  2P1Q A;  1P22 B;  3M8V A;  1BUO A;  3DRY A;  1NN7 A;  3DCG B;  1QDW A;  4U77 A;  2P1O A;  3LNM B;  2IF5 A;  4U2N A;  2VPK A;  5H7H A;  4BKT B;  5BXH A;  5HZG C;  2Z8H A;  4B9K E;  1R28 A;  1LDK D;  2R9R B;  4JTC B;  4W9C B;  5DAF A;  5IBK A;  1EXB E;  2NZ0 B;  2P1P A;  3B84 A;  4JGH C;  1A68 A;  2VKP A;  1FS2 B;  2OVR A;  2NN2 A;  2I2R A;  4AP2 A;  2E31 B;  3GA1 A;  4W9D B;  5A15 A;  1EOF A;  4W9L B;  2Q81 A;  3FKC A;  2FNJ C;  1HV2 A;  3DRZ A;  4EOZ A;  4AJY C;  3HU6 A;  1S1G A;  1R2B A;  5H7G A;  1CS3 A;  4B95 B;  3E4U A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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