4W9LB

Pvhl:elob:eloc in complex with (2s,4r)-1-((s)-2-((s)-2-acetamido-3,3-dimethylbutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-n-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 15)
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
96
structure length
86
Chain Sequence
MYVKLISSDGHEFIVKREHALTSGTIKAMLSNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
Updating...
connected with : NaN
molecule tags Ligase
source organism Homo sapiens
publication title Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
pubmed doi rcsb
molecule keywords Transcription elongation factor B polypeptide 2
total genus 23
structure length 86
sequence length 96
chains with identical sequence E, H, K
ec nomenclature
pdb deposition date 2014-08-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF03931 Skp1_POZ Skp1 family, tetramerisation domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.710.10 Alpha Beta 2-Layer Sandwich Potassium Channel Kv1.1; Chain A Potassium Channel Kv1.1; Chain A 4w9lB00
4AP2A 5BXHA 4CRHA 1NEXA 4CP3A 4BGCA 2VKPA 1FQVB 5H7GA 3HU6A 1T1DA 2P1MA 1R29A 2E32B 5BO4C 4CXIA 4J8ZA 3HVEB 3ZTDB 3OGKA 2IHCA 3WSOB 2Z8HA 3E4UA 4EOZA 5LLIB 3ZKJB 3LUTB 5BXBA 4U77A 4W9DB 3LBZA 5DAFA 3MKSA 2YY9A 3DRZA 4HXIA 2FNJC 5IBKA 3OGLA 1R28A 4W9HH 2P1QA 3KVTA 4W9CB 3LNMB 4UIJA 4JTDB 1VCBB 4BKTB 3HTMA 2JZ3C 3BIMA 5H7HA 1R2BA 1FS2B 5JH5B 2P1NA 1HV2A 4I6JC 4W9KB 3C6PA 3C6NA 4CXTA 4UYIA 1QDVA 4JGHC 3ZNGB 4U2MA 4N9F5 2E31B 5BXDA 1EOFA 4CXJA 1LQBB 4W9LB 4W9IB 1EXBE 3HVEA 4W9GB 3DCGB 3M4TA 2OVPA 4AJYC 1QDWA 2PPIA 3M5BA 3M52A 3ZUNB 3OHVA 2IF5A 4B95B 3B84A 3V7DA 1A68A 2NN2A 2OVQA 1NN7A 1FS1B 3C6OA 4JTAB 2I2RA 1LM8C 3HQIA 5DADA 2ASTA 1DSXA 4W9FB 4W9HB 2IZVC 4ZOUA 4BKSB 1EOEA 3ZRCB 3OHUA 5A15A 2NZ0B 3I3NA 4B9KB 3OGMA 5EUPA 3L2OA 3FKCA 2A79B 4WQOC 5A6RA 1BUOA 3ZTCB 3ZRFB 4W9JB 2Q81A 4APFA 2ASSA 5HZGC 4U2NA 3M8VA 2R9RB 2C9WC 1CS3A 1EODA 2OVRA 2VPKA 2P1PA 4AWJB 4W9EB 5HYWB 3GA1A 2MA9C 1LDKD 2P1OA 4B9KE 1S1GA 5FTAA 1P22B 4JTCB
chains in the Genus database with same CATH superfamily
4AP2A 5BXHA 4CRHA 1NEXA 4CP3A 4BGCA 2VKPA 1FQVB 5H7GA 3HU6A 1T1DA 2P1MA 1R29A 2E32B 5BO4C 4CXIA 4J8ZA 3HVEB 3ZTDB 3OGKA 2IHCA 3WSOB 2Z8HA 3E4UA 4EOZA 4ZGCA 5LLIB 3ZKJB 3LUTB 5BXBA 4U77A 4W9DB 3LBZA 5DAFA 3MKSA 2YY9A 3DRZA 4HXIA 2FNJC 5IBKA 3OGLA 1R28A 4W9HH 2P1QA 3KVTA 4W9CB 3LNMB 4UIJA 4JTDB 1VCBB 4BKTB 3HTMA 2JZ3C 3BIMA 5H7HA 1R2BA 1FS2B 5JH5B 2P1NA 1HV2A 4I6JC 4W9KB 3C6PA 3C6NA 4CXTA 4UYIA 1QDVA 4JGHC 3ZNGB 4U2MA 4N9F5 2E31B 5BXDA 1EOFA 4CXJA 1LQBB 4W9LB 4W9IB 1EXBE 3HVEA 4W9GB 3DCGB 3M4TA 2OVPA 4AJYC 1QDWA 2PPIA 3M5BA 3M52A 3ZUNB 3OHVA 2IF5A 4B95B 3B84A 3V7DA 1A68A 2NN2A 2OVQA 1NN7A 1FS1B 3C6OA 4JTAB 2I2RA 1LM8C 3HQIA 5DADA 2ASTA 1DSXA 4W9FB 4W9HB 2IZVC 4ZOUA 4BKSB 1EOEA 3ZRCB 3DRYA 3OHUA 5A15A 2NZ0B 3I3NA 4B9KB 3OGMA 5EUPA 3L2OA 3FKCA 2A79B 4WQOC 5A6RA 1BUOA 3ZTCB 3ZRFB 4W9JB 2Q81A 4APFA 2ASSA 5HZGC 4U2NA 3M8VA 2R9RB 2C9WC 1CS3A 1EODA 2OVRA 2VPKA 2P1PA 4AWJB 4W9EB 3DRXA 4YY8A 5HYWB 3GA1A 2MA9C 1LDKD 2P1OA 4B9KE 1S1GA 5FTAA 1P22B 4JTCB
chains in the Genus database with same CATH topology
4AP2A 5BXHA 4CRHA 1NEXA 4CP3A 4BGCA 2VKPA 1FQVB 5H7GA 3HU6A 1T1DA 2P1MA 1R29A 2E32B 5BO4C 4CXIA 4J8ZA 3HVEB 3ZTDB 3OGKA 2IHCA 3WSOB 2Z8HA 3E4UA 4EOZA 4ZGCA 5LLIB 3ZKJB 3LUTB 5BXBA 4U77A 4W9DB 3LBZA 5DAFA 3MKSA 2YY9A 3DRZA 4HXIA 2FNJC 5IBKA 3OGLA 1R28A 4W9HH 2P1QA 3KVTA 4W9CB 3LNMB 4UIJA 4JTDB 1VCBB 4BKTB 3HTMA 2JZ3C 3BIMA 5H7HA 1R2BA 1FS2B 5JH5B 2P1NA 1HV2A 4I6JC 4W9KB 3C6PA 3C6NA 4CXTA 4UYIA 1QDVA 4JGHC 3ZNGB 4U2MA 4N9F5 2E31B 5BXDA 1EOFA 4CXJA 1LQBB 4W9LB 4W9IB 1EXBE 3HVEA 4W9GB 3DCGB 3M4TA 2OVPA 4AJYC 1QDWA 2PPIA 3M5BA 3M52A 3ZUNB 3OHVA 2IF5A 4B95B 3B84A 3V7DA 1A68A 2NN2A 2OVQA 1NN7A 1FS1B 3C6OA 4JTAB 2I2RA 1LM8C 3HQIA 5DADA 2ASTA 1DSXA 4W9FB 4W9HB 2IZVC 4ZOUA 4BKSB 1EOEA 3ZRCB 3DRYA 3OHUA 5A15A 2NZ0B 3I3NA 4B9KB 3OGMA 5EUPA 3L2OA 3FKCA 2A79B 4WQOC 5A6RA 1BUOA 3ZTCB 3ZRFB 4W9JB 2Q81A 4APFA 2ASSA 5HZGC 4U2NA 3M8VA 2R9RB 2C9WC 1CS3A 1EODA 2OVRA 2VPKA 2P1PA 4AWJB 4W9EB 3DRXA 4YY8A 5HYWB 3GA1A 2MA9C 1LDKD 2P1OA 4B9KE 1S1GA 5FTAA 1P22B 4JTCB
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4AP2 A;  5BXH A;  4CRH A;  1NEX A;  4CP3 A;  4BGC A;  2VKP A;  1FQV B;  5H7G A;  3HU6 A;  1T1D A;  2P1M A;  1R29 A;  2E32 B;  5BO4 C;  4CXI A;  4J8Z A;  3HVE B;  3ZTD B;  3OGK A;  2IHC A;  3WSO B;  2Z8H A;  3E4U A;  4EOZ A;  5LLI B;  3ZKJ B;  3LUT B;  5BXB A;  4U77 A;  4W9D B;  3LBZ A;  5DAF A;  3MKS A;  2YY9 A;  3DRZ A;  4HXI A;  2FNJ C;  5IBK A;  3OGL A;  1R28 A;  4W9H H;  2P1Q A;  3KVT A;  4W9C B;  3LNM B;  4UIJ A;  4JTD B;  1VCB B;  4BKT B;  3HTM A;  2JZ3 C;  3BIM A;  5H7H A;  1R2B A;  1FS2 B;  5JH5 B;  2P1N A;  1HV2 A;  4I6J C;  4W9K B;  3C6P A;  3C6N A;  4CXT A;  4UYI A;  1QDV A;  4JGH C;  3ZNG B;  4U2M A;  4N9F 5;  2E31 B;  5BXD A;  1EOF A;  4CXJ A;  1LQB B;  4W9L B;  4W9I B;  1EXB E;  3HVE A;  4W9G B;  3DCG B;  3M4T A;  2OVP A;  4AJY C;  1QDW A;  2PPI A;  3M5B A;  3M52 A;  3ZUN B;  3OHV A;  2IF5 A;  4B95 B;  3B84 A;  3V7D A;  1A68 A;  2NN2 A;  2OVQ A;  1NN7 A;  1FS1 B;  3C6O A;  4JTA B;  2I2R A;  1LM8 C;  3HQI A;  5DAD A;  2AST A;  1DSX A;  4W9F B;  4W9H B;  2IZV C;  4ZOU A;  4BKS B;  1EOE A;  3ZRC B;  3OHU A;  5A15 A;  2NZ0 B;  3I3N A;  4B9K B;  3OGM A;  5EUP A;  3L2O A;  3FKC A;  2A79 B;  4WQO C;  5A6R A;  1BUO A;  3ZTC B;  3ZRF B;  4W9J B;  2Q81 A;  4APF A;  2ASS A;  5HZG C;  4U2N A;  3M8V A;  2R9R B;  2C9W C;  1CS3 A;  1EOD A;  2OVR A;  2VPK A;  2P1P A;  4AWJ B;  4W9E B;  5HYW B;  3GA1 A;  2MA9 C;  1LDK D;  2P1O A;  4B9K E;  1S1G A;  5FTA A;  1P22 B;  4JTC B; 
#chains in the Genus database with same CATH topology
 4AP2 A;  5BXH A;  4CRH A;  1NEX A;  4CP3 A;  4BGC A;  2VKP A;  1FQV B;  5H7G A;  3HU6 A;  1T1D A;  2P1M A;  1R29 A;  2E32 B;  5BO4 C;  4CXI A;  4J8Z A;  3HVE B;  3ZTD B;  3OGK A;  2IHC A;  3WSO B;  2Z8H A;  3E4U A;  4EOZ A;  4ZGC A;  5LLI B;  3ZKJ B;  3LUT B;  5BXB A;  4U77 A;  4W9D B;  3LBZ A;  5DAF A;  3MKS A;  2YY9 A;  3DRZ A;  4HXI A;  2FNJ C;  5IBK A;  3OGL A;  1R28 A;  4W9H H;  2P1Q A;  3KVT A;  4W9C B;  3LNM B;  4UIJ A;  4JTD B;  1VCB B;  4BKT B;  3HTM A;  2JZ3 C;  3BIM A;  5H7H A;  1R2B A;  1FS2 B;  5JH5 B;  2P1N A;  1HV2 A;  4I6J C;  4W9K B;  3C6P A;  3C6N A;  4CXT A;  4UYI A;  1QDV A;  4JGH C;  3ZNG B;  4U2M A;  4N9F 5;  2E31 B;  5BXD A;  1EOF A;  4CXJ A;  1LQB B;  4W9L B;  4W9I B;  1EXB E;  3HVE A;  4W9G B;  3DCG B;  3M4T A;  2OVP A;  4AJY C;  1QDW A;  2PPI A;  3M5B A;  3M52 A;  3ZUN B;  3OHV A;  2IF5 A;  4B95 B;  3B84 A;  3V7D A;  1A68 A;  2NN2 A;  2OVQ A;  1NN7 A;  1FS1 B;  3C6O A;  4JTA B;  2I2R A;  1LM8 C;  3HQI A;  5DAD A;  2AST A;  1DSX A;  4W9F B;  4W9H B;  2IZV C;  4ZOU A;  4BKS B;  1EOE A;  3ZRC B;  3DRY A;  3OHU A;  5A15 A;  2NZ0 B;  3I3N A;  4B9K B;  3OGM A;  5EUP A;  3L2O A;  3FKC A;  2A79 B;  4WQO C;  5A6R A;  1BUO A;  3ZTC B;  3ZRF B;  4W9J B;  2Q81 A;  4APF A;  2ASS A;  5HZG C;  4U2N A;  3M8V A;  2R9R B;  2C9W C;  1CS3 A;  1EOD A;  2OVR A;  2VPK A;  2P1P A;  4AWJ B;  4W9E B;  3DRX A;  4YY8 A;  5HYW B;  3GA1 A;  2MA9 C;  1LDK D;  2P1O A;  4B9K E;  1S1G A;  5FTA A;  1P22 B;  4JTC B; 
#chains in the Genus database with same CATH homology
 4AP2 A;  5BXH A;  4CRH A;  1NEX A;  4CP3 A;  4BGC A;  2VKP A;  1FQV B;  5H7G A;  3HU6 A;  1T1D A;  2P1M A;  1R29 A;  2E32 B;  5BO4 C;  4CXI A;  4J8Z A;  3HVE B;  3ZTD B;  3OGK A;  2IHC A;  3WSO B;  2Z8H A;  3E4U A;  4EOZ A;  4ZGC A;  5LLI B;  3ZKJ B;  3LUT B;  5BXB A;  4U77 A;  4W9D B;  3LBZ A;  5DAF A;  3MKS A;  2YY9 A;  3DRZ A;  4HXI A;  2FNJ C;  5IBK A;  3OGL A;  1R28 A;  4W9H H;  2P1Q A;  3KVT A;  4W9C B;  3LNM B;  4UIJ A;  4JTD B;  1VCB B;  4BKT B;  3HTM A;  2JZ3 C;  3BIM A;  5H7H A;  1R2B A;  1FS2 B;  5JH5 B;  2P1N A;  1HV2 A;  4I6J C;  4W9K B;  3C6P A;  3C6N A;  4CXT A;  4UYI A;  1QDV A;  4JGH C;  3ZNG B;  4U2M A;  4N9F 5;  2E31 B;  5BXD A;  1EOF A;  4CXJ A;  1LQB B;  4W9L B;  4W9I B;  1EXB E;  3HVE A;  4W9G B;  3DCG B;  3M4T A;  2OVP A;  4AJY C;  1QDW A;  2PPI A;  3M5B A;  3M52 A;  3ZUN B;  3OHV A;  2IF5 A;  4B95 B;  3B84 A;  3V7D A;  1A68 A;  2NN2 A;  2OVQ A;  1NN7 A;  1FS1 B;  3C6O A;  4JTA B;  2I2R A;  1LM8 C;  3HQI A;  5DAD A;  2AST A;  1DSX A;  4W9F B;  4W9H B;  2IZV C;  4ZOU A;  4BKS B;  1EOE A;  3ZRC B;  3DRY A;  3OHU A;  5A15 A;  2NZ0 B;  3I3N A;  4B9K B;  3OGM A;  5EUP A;  3L2O A;  3FKC A;  2A79 B;  4WQO C;  5A6R A;  1BUO A;  3ZTC B;  3ZRF B;  4W9J B;  2Q81 A;  4APF A;  2ASS A;  5HZG C;  4U2N A;  3M8V A;  2R9R B;  2C9W C;  1CS3 A;  1EOD A;  2OVR A;  2VPK A;  2P1P A;  4AWJ B;  4W9E B;  3DRX A;  4YY8 A;  5HYW B;  3GA1 A;  2MA9 C;  1LDK D;  2P1O A;  4B9K E;  1S1G A;  5FTA A;  1P22 B;  4JTC B;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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