4WH9A

Structure of the cdc25b phosphatase catalytic domain with bound inhibitor
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
177
structure length
177
Chain Sequence
HRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHSEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Inhibition of CDC25B Phosphatase Through Disruption of Protein-Protein Interaction.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords M-phase inducer phosphatase 2
total genus 62
structure length 177
sequence length 177
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2014-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00581 Rhodanese Rhodanese-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.250.10 Alpha Beta 3-Layer(aba) Sandwich Oxidized Rhodanese; domain 1 Rhodanese-like domain 4wh9A00
1QXNA 1C25A 1YM9A 4WH9A 2J6PA 3F4AA 3HWIA 2ORAA 3R2UA 1WHBA 3I2VA 2IFDA 1H4KX 2WLRA 3GK5A 5HBQA 1VEEA 1YT8A 3NHVA 3ILMA 2KL3A 1QB0A 1WV9A 4WH7A 1HZMA 3HZUA 3AAYA 2FSXA 3TG3A 3TP9A 3IWHA 1OKGA 5LAMA 3O3WA 1H4MX 2JTSA 3NTDA 3FS5A 3IPPA 2JTQA 2EG3A 1CWSA 2JTRA 1YMKA 3NTAA 2K0ZA 1YS0A 1RHDA 5HBLA 3UTNX 2MOLA 3NT6A 3P3AA 3ICRA 1T3KA 2GWFA 1TQ1A 3OP3A 2OUCA 1BOHA 3FOJA 3FLHA 1YMLA 2WLXA 3AAXA 4OCGA 3HIXA 1URHA 5HPAA 2UZQA 1UARA 4JGTA 3FNJA 3G5JA 3ICSA 4F67A 2IFVA 2VSWA 1CWRA 5HBOA 2HHGA 3ICTA 3D1PA 2DCQA 1E0CA 3I3UA 3IPOA 3MZZA 2EG4B 3K9RA 1ORBA 2MOIA 2MRMA 1GN0A 1CWTA 3TG1B 3OLHA 1BOIA 1RHSA 1GMXA 1DP2A 5LAOA 2A2KA 5HBPA 2EG4A 1YMDA
chains in the Genus database with same CATH superfamily
1QXNA 1C25A 1YM9A 4WH9A 2J6PA 3F4AA 3HWIA 2ORAA 3R2UA 1WHBA 2Q82A 3I2VA 2IFDA 1H4KX 2WLRA 3GK5A 5HBQA 1VEEA 1YT8A 3NHVA 3ILMA 2KL3A 1QB0A 1WV9A 4WH7A 1HZMA 3HZUA 3AAYA 2FSXA 3TG3A 3TP9A 3IWHA 1OKGA 5LAMA 3O3WA 1H4MX 2JTSA 3NTDA 3FS5A 3IPPA 2JTQA 2EG3A 1CWSA 2JTRA 1YMKA 3NTAA 2K0ZA 1YS0A 1RHDA 5HBLA 3UTNX 2MOLA 3NT6A 3P3AA 3ICRA 1T3KA 2GWFA 1TQ1A 3OP3A 2OUCA 1BOHA 3FOJA 3FLHA 1YMLA 2WLXA 3AAXA 4OCGA 3HIXA 1URHA 5HPAA 2UZQA 1UARA 4JGTA 3FNJA 3G5JA 3ICSA 4F67A 2IFVA 2VSWA 1CWRA 5HBOA 2HHGA 3ICTA 3D1PA 2DCQA 1E0CA 3I3UA 3IPOA 3MZZA 2EG4B 3K9RA 1ORBA 2MOIA 2MRMA 1GN0A 1CWTA 3TG1B 3OLHA 1BOIA 1RHSA 1GMXA 1DP2A 5LAOA 2A2KA 5HBPA 2EG4A 1YMDA
chains in the Genus database with same CATH topology
1QXNA 1C25A 1YM9A 4WH9A 2J6PA 3F4AA 3HWIA 2ORAA 3R2UA 1WHBA 3I2VA 2IFDA 1H4KX 2WLRA 3GK5A 5HBQA 1VEEA 1YT8A 3NHVA 3ILMA 2KL3A 1QB0A 1WV9A 4WH7A 1HZMA 3HZUA 3AAYA 2FSXA 3TG3A 3TP9A 3IWHA 1OKGA 5LAMA 3O3WA 1H4MX 2JTSA 3NTDA 3FS5A 3IPPA 2JTQA 2EG3A 1CWSA 2JTRA 1YMKA 3NTAA 2K0ZA 1YS0A 1RHDA 5HBLA 3UTNX 2MOLA 3NT6A 3P3AA 3ICRA 1T3KA 2GWFA 1TQ1A 3OP3A 2OUCA 1BOHA 3FOJA 3FLHA 1YMLA 2WLXA 3AAXA 4OCGA 3HIXA 1URHA 5HPAA 2UZQA 1UARA 4JGTA 3FNJA 3G5JA 3ICSA 4F67A 2IFVA 2VSWA 1CWRA 5HBOA 2HHGA 3ICTA 3D1PA 2DCQA 1E0CA 3I3UA 3IPOA 3MZZA 2EG4B 3K9RA 1ORBA 2MOIA 2MRMA 1GN0A 1CWTA 3TG1B 3OLHA 1BOIA 1RHSA 1GMXA 1DP2A 5LAOA 2A2KA 5HBPA 2EG4A 1YMDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1QXN A;  1C25 A;  1YM9 A;  4WH9 A;  2J6P A;  3F4A A;  3HWI A;  2ORA A;  3R2U A;  1WHB A;  3I2V A;  2IFD A;  1H4K X;  2WLR A;  3GK5 A;  5HBQ A;  1VEE A;  1YT8 A;  3NHV A;  3ILM A;  2KL3 A;  1QB0 A;  1WV9 A;  4WH7 A;  1HZM A;  3HZU A;  3AAY A;  2FSX A;  3TG3 A;  3TP9 A;  3IWH A;  1OKG A;  5LAM A;  3O3W A;  1H4M X;  2JTS A;  3NTD A;  3FS5 A;  3IPP A;  2JTQ A;  2EG3 A;  1CWS A;  2JTR A;  1YMK A;  3NTA A;  2K0Z A;  1YS0 A;  1RHD A;  5HBL A;  3UTN X;  2MOL A;  3NT6 A;  3P3A A;  3ICR A;  1T3K A;  2GWF A;  1TQ1 A;  3OP3 A;  2OUC A;  1BOH A;  3FOJ A;  3FLH A;  1YML A;  2WLX A;  3AAX A;  4OCG A;  3HIX A;  1URH A;  5HPA A;  2UZQ A;  1UAR A;  4JGT A;  3FNJ A;  3G5J A;  3ICS A;  4F67 A;  2IFV A;  2VSW A;  1CWR A;  5HBO A;  2HHG A;  3ICT A;  3D1P A;  2DCQ A;  1E0C A;  3I3U A;  3IPO A;  3MZZ A;  2EG4 B;  3K9R A;  1ORB A;  2MOI A;  2MRM A;  1GN0 A;  1CWT A;  3TG1 B;  3OLH A;  1BOI A;  1RHS A;  1GMX A;  1DP2 A;  5LAO A;  2A2K A;  5HBP A;  2EG4 A;  1YMD A; 
#chains in the Genus database with same CATH topology
 1QXN A;  1C25 A;  1YM9 A;  4WH9 A;  2J6P A;  3F4A A;  3HWI A;  2ORA A;  3R2U A;  1WHB A;  2Q82 A;  3I2V A;  2IFD A;  1H4K X;  2WLR A;  3GK5 A;  5HBQ A;  1VEE A;  1YT8 A;  3NHV A;  3ILM A;  2KL3 A;  1QB0 A;  1WV9 A;  4WH7 A;  1HZM A;  3HZU A;  3AAY A;  2FSX A;  3TG3 A;  3TP9 A;  3IWH A;  1OKG A;  5LAM A;  3O3W A;  1H4M X;  2JTS A;  3NTD A;  3FS5 A;  3IPP A;  2JTQ A;  2EG3 A;  1CWS A;  2JTR A;  1YMK A;  3NTA A;  2K0Z A;  1YS0 A;  1RHD A;  5HBL A;  3UTN X;  2MOL A;  3NT6 A;  3P3A A;  3ICR A;  1T3K A;  2GWF A;  1TQ1 A;  3OP3 A;  2OUC A;  1BOH A;  3FOJ A;  3FLH A;  1YML A;  2WLX A;  3AAX A;  4OCG A;  3HIX A;  1URH A;  5HPA A;  2UZQ A;  1UAR A;  4JGT A;  3FNJ A;  3G5J A;  3ICS A;  4F67 A;  2IFV A;  2VSW A;  1CWR A;  5HBO A;  2HHG A;  3ICT A;  3D1P A;  2DCQ A;  1E0C A;  3I3U A;  3IPO A;  3MZZ A;  2EG4 B;  3K9R A;  1ORB A;  2MOI A;  2MRM A;  1GN0 A;  1CWT A;  3TG1 B;  3OLH A;  1BOI A;  1RHS A;  1GMX A;  1DP2 A;  5LAO A;  2A2K A;  5HBP A;  2EG4 A;  1YMD A; 
#chains in the Genus database with same CATH homology
 1QXN A;  1C25 A;  1YM9 A;  4WH9 A;  2J6P A;  3F4A A;  3HWI A;  2ORA A;  3R2U A;  1WHB A;  3I2V A;  2IFD A;  1H4K X;  2WLR A;  3GK5 A;  5HBQ A;  1VEE A;  1YT8 A;  3NHV A;  3ILM A;  2KL3 A;  1QB0 A;  1WV9 A;  4WH7 A;  1HZM A;  3HZU A;  3AAY A;  2FSX A;  3TG3 A;  3TP9 A;  3IWH A;  1OKG A;  5LAM A;  3O3W A;  1H4M X;  2JTS A;  3NTD A;  3FS5 A;  3IPP A;  2JTQ A;  2EG3 A;  1CWS A;  2JTR A;  1YMK A;  3NTA A;  2K0Z A;  1YS0 A;  1RHD A;  5HBL A;  3UTN X;  2MOL A;  3NT6 A;  3P3A A;  3ICR A;  1T3K A;  2GWF A;  1TQ1 A;  3OP3 A;  2OUC A;  1BOH A;  3FOJ A;  3FLH A;  1YML A;  2WLX A;  3AAX A;  4OCG A;  3HIX A;  1URH A;  5HPA A;  2UZQ A;  1UAR A;  4JGT A;  3FNJ A;  3G5J A;  3ICS A;  4F67 A;  2IFV A;  2VSW A;  1CWR A;  5HBO A;  2HHG A;  3ICT A;  3D1P A;  2DCQ A;  1E0C A;  3I3U A;  3IPO A;  3MZZ A;  2EG4 B;  3K9R A;  1ORB A;  2MOI A;  2MRM A;  1GN0 A;  1CWT A;  3TG1 B;  3OLH A;  1BOI A;  1RHS A;  1GMX A;  1DP2 A;  5LAO A;  2A2K A;  5HBP A;  2EG4 A;  1YMD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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