The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
79
|
sequence length |
286
|
structure length |
261
|
Chain Sequence |
PPHGELQYLGQIQHILRGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDARIIMAWNPRDLPLMALPPHALQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEM
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.
pubmed doi rcsb |
| molecule keywords |
Thymidylate synthase
|
| molecule tags |
Transferase
|
| source organism |
Homo sapiens
|
| total genus |
79
|
| structure length |
261
|
| sequence length |
286
|
| ec nomenclature |
ec
2.1.1.45: Thymidylate synthase. |
| pdb deposition date | 2013-05-14 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00303 | Thymidylat_synt | Thymidylate synthase |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase; Chain A | Thymidylate synthase/dCMP hydroxymethylase domain |
#chains in the Genus database with same CATH superfamily 5J7W A; 4FGT A; 3NRR A; 4LRR A; 5FCT A; 3BFI A; 1SYN A; 3IRN A; 1JUJ A; 3GH2 X; 4H0R A; 1KCE A; 4KYA A; 1NJA A; 2VET A; 1TRG A; 1TDA A; 1JMG A; 3DL5 A; 3EDW X; 3IK1 A; 1JU6 A; 1EVG A; 1FWM A; 4GEV A; 4JEF A; 1HW3 A; 1LCE A; 1F4E A; 3N5E A; 1F4D A; 4IQQ A; 2A9W A; 3KGB A; 5H39 A; 1LCB A; 4EIN A; 1YPV A; 1JG0 A; 3BNZ A; 3QJ7 A; 3BGX A; 4E28 A; 1BKO A; 1JTU A; 3BHR A; 3EGY X; 4FOG A; 1TIS A; 3UWL B; 5HS3 A; 1TLS A; 4IRR A; 1BJG A; 1B5E A; 1F4B A; 3INV A; 1B02 A; 1BKP A; 1AXW A; 3CL9 A; 4Q0D A; 2BBQ A; 4F2V A; 3C0A A; 1BQ2 A; 4H0U A; 1KZJ A; 2G8D A; 1AIQ A; 2FTQ A; 2FTO X; 4PSG A; 3IX6 A; 3HB8 A; 1NJE A; 4E5O A; 3BYX A; 3H9K A; 1CI7 A; 1F28 A; 4ISK A; 5WRN A; 1JUT A; 2RD8 A; 3EF9 A; 1NCE A; 1TSM A; 1BSF A; 4G6W X; 3JSU A; 4DP3 A; 1QQQ A; 3IK0 A; 4XSE A; 1KZI A; 1BO8 A; 3V8H A; 3GG5 A; 3IJZ A; 1NJD A; 4ECK A; 3UWL A; 4O7U A; 5BY6 A; 1J3K C; 2G8X A; 3CLB A; 2TDD A; 1BQ1 A; 4GD7 A; 3IRO A; 4UP1 A; 1THY A; 1HW4 A; 2H2Q A; 1RTS A; 1EVF A; 1NJC A; 3IHI A; 1TSZ A; 2G8A A; 1VZC A; 1TJS A; 1BID A; 4XSD A; 3EBU A; 4O1X A; 1FFL A; 1HZW A; 1VZE A; 4DPH A; 3B5B A; 4GYH A; 4EB4 A; 1F4C A; 3C06 A; 2FTN A; 4FOX A; 1BP0 A; 3TMS A; 3EJL A; 1TDB A; 1TSW A; 3N5E B; 1VZD A; 2TSC A; 3EAW X; 1EV8 A; 4O1X D; 4O1U A; 1BP6 A; 1DNA A; 4KPW A; 1VZA A; 2TDM A; 3KJS A; 1TSL A; 1TDC A; 2KCE A; 1TSD A; 4EIL A; 1TSN A; 1QZF A; 1TYS A; 2VF0 A; 3UM8 A; 1TDU A; 1BSP A; 3ED7 A; 3K2H A; 3DGA C; 1DDU A; 4FOA A; 1TSY A; 1JMI A; 1TSX A; 2G86 A; 1J3I C; 1NJB A; 1TVU A; 1TVV A; 1ZPR A; 3HBB A; 1AJM A; 4KY4 A; 3B9H A; 4FQS A; 1LCA A; 2RDA A; 1HVY A; 1J3J C; 1F4F A; 3EHI X; 3I3R A; 1F4G A; 1JMF A; 1AOB A; 4KNZ A; 3IRM A; 5H38 A; 3QGT A; 3HJ3 A; 1BPJ A; 1AN5 A; 5H3A A; 2AAZ A; 1BO7 A; 1SEJ A; 2RD8 B; 3OB7 A; 3QG2 A; 1B49 A; 4EZ8 A; 2ONB A; 2OIP A; 4G2O X; 3DG8 C; 3UM6 A; 4DPD A; 1JMH A; 1VZB A; 3GH0 A; 1TSV A; 2TSR A; 3KJR A; 4Q0E A; 1TVW A; 3N5G A; 3UM5 A; 1TLC A; 1I00 A; 4XSC A; 1JTQ A; 4DQ1 A; 3DL6 A; 3BHL A; 3BZ0 A; 4H1I A; 4IQB A; 4TMS A; 1B5D A; 4ISW A; 1BDU A; 1EV5 A; 4KY8 A; 2G89 A; #chains in the Genus database with same CATH topology 5J7W A; 4FGT A; 3NRR A; 4LRR A; 5FCT A; 3BFI A; 1SYN A; 3IRN A; 1JUJ A; 3GH2 X; 4H0R A; 1KCE A; 4KYA A; 1NJA A; 2VET A; 1TRG A; 1TDA A; 1JMG A; 3DL5 A; 3EDW X; 3IK1 A; 1JU6 A; 1EVG A; 1FWM A; 4GEV A; 4JEF A; 1HW3 A; 1LCE A; 1F4E A; 3N5E A; 1F4D A; 4IQQ A; 2A9W A; 3KGB A; 5H39 A; 1LCB A; 4EIN A; 1YPV A; 1JG0 A; 3BNZ A; 3QJ7 A; 3BGX A; 4E28 A; 1BKO A; 1JTU A; 3BHR A; 3EGY X; 4FOG A; 1TIS A; 3UWL B; 5HS3 A; 1TLS A; 4IRR A; 1BJG A; 1B5E A; 1F4B A; 3INV A; 1B02 A; 1BKP A; 1AXW A; 3CL9 A; 4Q0D A; 2BBQ A; 4F2V A; 3C0A A; 1BQ2 A; 4H0U A; 1KZJ A; 2G8D A; 1AIQ A; 2FTQ A; 2FTO X; 4PSG A; 3IX6 A; 3HB8 A; 1NJE A; 4E5O A; 3BYX A; 3H9K A; 1CI7 A; 1F28 A; 4ISK A; 5WRN A; 1JUT A; 2RD8 A; 3EF9 A; 1NCE A; 1TSM A; 1BSF A; 4G6W X; 3JSU A; 4DP3 A; 1QQQ A; 3IK0 A; 4XSE A; 1KZI A; 1BO8 A; 3V8H A; 3GG5 A; 3IJZ A; 1NJD A; 4ECK A; 3UWL A; 4O7U A; 5BY6 A; 1J3K C; 2G8X A; 3CLB A; 2TDD A; 1BQ1 A; 4GD7 A; 3IRO A; 4UP1 A; 1THY A; 1HW4 A; 2H2Q A; 1RTS A; 1EVF A; 1NJC A; 3IHI A; 1TSZ A; 2G8A A; 1VZC A; 1TJS A; 1BID A; 4XSD A; 3EBU A; 4O1X A; 1FFL A; 1HZW A; 1VZE A; 4DPH A; 3B5B A; 4GYH A; 4EB4 A; 1F4C A; 3C06 A; 2FTN A; 4FOX A; 1BP0 A; 3TMS A; 3EJL A; 1TDB A; 1TSW A; 3N5E B; 1VZD A; 2TSC A; 3EAW X; 1EV8 A; 4O1X D; 4O1U A; 1BP6 A; 1DNA A; 4KPW A; 1VZA A; 2TDM A; 3KJS A; 1TSL A; 1TDC A; 2KCE A; 1TSD A; 4EIL A; 1TSN A; 1QZF A; 1TYS A; 2VF0 A; 3UM8 A; 1TDU A; 1BSP A; 3ED7 A; 3K2H A; 3DGA C; 1DDU A; 4FOA A; 1TSY A; 1JMI A; 1TSX A; 2G86 A; 1J3I C; 1NJB A; 1TVU A; 1TVV A; 1ZPR A; 3HBB A; 1AJM A; 4KY4 A; 3B9H A; 4FQS A; 1LCA A; 2RDA A; 1HVY A; 1J3J C; 1F4F A; 3EHI X; 3I3R A; 1F4G A; 1JMF A; 1AOB A; 4KNZ A; 3IRM A; 5H38 A; 3QGT A; 3HJ3 A; 1BPJ A; 1AN5 A; 5H3A A; 2AAZ A; 1BO7 A; 1SEJ A; 2RD8 B; 3OB7 A; 3QG2 A; 1B49 A; 4EZ8 A; 2ONB A; 2OIP A; 4G2O X; 3DG8 C; 3UM6 A; 4DPD A; 1JMH A; 1VZB A; 3GH0 A; 1TSV A; 2TSR A; 3KJR A; 4Q0E A; 1TVW A; 3N5G A; 3UM5 A; 1TLC A; 1I00 A; 4XSC A; 1JTQ A; 4DQ1 A; 3DL6 A; 3BHL A; 3BZ0 A; 4H1I A; 4IQB A; 4TMS A; 1B5D A; 4ISW A; 1BDU A; 1EV5 A; 4KY8 A; 2G89 A; #chains in the Genus database with same CATH homology 5J7W A; 4FGT A; 3NRR A; 4LRR A; 5FCT A; 3BFI A; 1SYN A; 3IRN A; 1JUJ A; 3GH2 X; 4H0R A; 1KCE A; 4KYA A; 1NJA A; 2VET A; 1TRG A; 1TDA A; 1JMG A; 3DL5 A; 3EDW X; 3IK1 A; 1JU6 A; 1EVG A; 1FWM A; 4GEV A; 4JEF A; 1HW3 A; 1LCE A; 1F4E A; 3N5E A; 1F4D A; 4IQQ A; 2A9W A; 3KGB A; 5H39 A; 1LCB A; 4EIN A; 1YPV A; 1JG0 A; 3BNZ A; 3QJ7 A; 3BGX A; 4E28 A; 1BKO A; 1JTU A; 3BHR A; 3EGY X; 4FOG A; 1TIS A; 3UWL B; 5HS3 A; 1TLS A; 4IRR A; 1BJG A; 1B5E A; 1F4B A; 3INV A; 1B02 A; 1BKP A; 1AXW A; 3CL9 A; 4Q0D A; 2BBQ A; 4F2V A; 3C0A A; 1BQ2 A; 4H0U A; 1KZJ A; 2G8D A; 1AIQ A; 2FTQ A; 2FTO X; 4PSG A; 3IX6 A; 3HB8 A; 1NJE A; 4E5O A; 3BYX A; 3H9K A; 1CI7 A; 1F28 A; 4ISK A; 5WRN A; 1JUT A; 2RD8 A; 3EF9 A; 1NCE A; 1TSM A; 1BSF A; 4G6W X; 3JSU A; 4DP3 A; 1QQQ A; 3IK0 A; 4XSE A; 1KZI A; 1BO8 A; 3V8H A; 3GG5 A; 3IJZ A; 1NJD A; 4ECK A; 3UWL A; 4O7U A; 5BY6 A; 1J3K C; 2G8X A; 3CLB A; 2TDD A; 1BQ1 A; 4GD7 A; 3IRO A; 4UP1 A; 1THY A; 1HW4 A; 2H2Q A; 1RTS A; 1EVF A; 1NJC A; 3IHI A; 1TSZ A; 2G8A A; 1VZC A; 1TJS A; 1BID A; 4XSD A; 3EBU A; 4O1X A; 1FFL A; 1HZW A; 1VZE A; 4DPH A; 3B5B A; 4GYH A; 4EB4 A; 1F4C A; 3C06 A; 2FTN A; 4FOX A; 1BP0 A; 3TMS A; 3EJL A; 1TDB A; 1TSW A; 3N5E B; 1VZD A; 2TSC A; 3EAW X; 1EV8 A; 4O1X D; 4O1U A; 1BP6 A; 1DNA A; 4KPW A; 1VZA A; 2TDM A; 3KJS A; 1TSL A; 1TDC A; 2KCE A; 1TSD A; 4EIL A; 1TSN A; 1QZF A; 1TYS A; 2VF0 A; 3UM8 A; 1TDU A; 1BSP A; 3ED7 A; 3K2H A; 3DGA C; 1DDU A; 4FOA A; 1TSY A; 1JMI A; 1TSX A; 2G86 A; 1J3I C; 1NJB A; 1TVU A; 1TVV A; 1ZPR A; 3HBB A; 1AJM A; 4KY4 A; 3B9H A; 4FQS A; 1LCA A; 2RDA A; 1HVY A; 1J3J C; 1F4F A; 3EHI X; 3I3R A; 1F4G A; 1JMF A; 1AOB A; 4KNZ A; 3IRM A; 5H38 A; 3QGT A; 3HJ3 A; 1BPJ A; 1AN5 A; 5H3A A; 2AAZ A; 1BO7 A; 1SEJ A; 2RD8 B; 3OB7 A; 3QG2 A; 1B49 A; 4EZ8 A; 2ONB A; 2OIP A; 4G2O X; 3DG8 C; 3UM6 A; 4DPD A; 1JMH A; 1VZB A; 3GH0 A; 1TSV A; 2TSR A; 3KJR A; 4Q0E A; 1TVW A; 3N5G A; 3UM5 A; 1TLC A; 1I00 A; 4XSC A; 1JTQ A; 4DQ1 A; 3DL6 A; 3BHL A; 3BZ0 A; 4H1I A; 4IQB A; 4TMS A; 1B5D A; 4ISW A; 1BDU A; 1EV5 A; 4KY8 A; 2G89 A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
